This document summarizes two scientific studies. The first study found that reducing levels of the PTEN protein in cells could lead to skin cancer and tumor progression due to a decrease in cellular repair. Increasing PTEN protein activity may help prevent skin cancer. The second study identified fragile sites in DNA where breakage begins, leading to uncontrolled cell division and cancer development. Understanding the molecular basis of DNA breakage and PTEN's role in cellular repair provides insights that could help scientists develop improved cancer treatments or a cure.

1. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells Targeting PTEN May Prevent Skin Cancer MOLECULAR BIOLOGYSIMÓN RESTREPO ARISMENDY UPB

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4. INTRODUCTIONSoundslikeaneasything, butit´s a verycomplex molecular processEven a tinymistake in the DNA replication can cause terrible diseaslikecancer

5. TARGETING PTEN MAY PREVENT CANCERScienceDaily (july26, 2011)

6. TARGETING PTEN MAY PREVENT CANCERPTEN proteins promote cellular repairNon-melanome skin cancer is the most common cancer in the United States.

7. TARGETING PTEN MAY PREVENT CANCERCells with low PTEN protein were more likely to hace UVB-induced skin cancers.Reduced levels of PTEN proteins could lead to cancer and tumor progression.

8. TARGETING PTEN MAY PREVENT CANCERIncreasing PTEN protein activity could reduce skin cancer and tumor progression.

9. OBSERVATIONThis study, has made a breakthrough the understanding the PTEN protein function and the way to prevent skin cancer and tumor progression, which is a huge and a really important step in the war against oncology diseases.

10. SCIENTIST IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE, A HALLMARK OF CANCER CELLSSCIENCEDAILY (JULY 19, 2011)

11. Scientistidentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCellsThe DNA encodes the entire genetic information required for building the proteins of the cell.Under stress condition, DNA usually breaks.

12. Scientistidentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCellsDNA breaks leads in an uncontrolled cell division and at the end in a cancer developmentThe study shed a light on the regulation of DNA replication along the fragile sites

13. ScientistIdentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCellsFragilesites, wherethe DNA breakagebegins, is a sitethatslow and also can stop DNA replication.

14. OPINIONThis study, has made a breakthrough the understanding the PTEN protein function and the way to prevent skin cancer and tumor progression, which is a huge and a really important step in the war against oncology diseases.

15. MedicalUtility

16. MedicalUtility.Bothstudiescouldletthescientisthave more tooltokeepinvestingationaround more genetictroublesthatcouldend in cancer

17. MedicalUtilityFoundingcancergenetic causes and allthe molecular processthatincreaseposibilty of developingthisdiseas, couldend in somenutritionregimthatgivestheposibiltytopreventsomespecificcancer.

18. MedicalutilityScientistcoulddevelopbettertreatmentsoreven a cure forcancer.

19. BIBLIOGRAPHYTargetinPTEN maypreventskinCancer. American AssociationforCancerResearch. 2011, July 26. ScienceDaily [online]. RetrievedAugust 6, 2011, from http://www.sciencedaily.com/releases/2011/07/110726132351.htm Scientistsidentify molecular basisfor DNA breakage, a hallmark of cancercells.. HebrewUniversity of Jerusalem. 2011, July 19. ScienceDaily [online]. RetrievedAugust 6, 2011, fromhttp://www.sciencedaily.com/releases/2011/07/110719094023.htm Martinez S Lina María. Biologia Molecular. 6 ed. Medellin. UPB. Fac Medicina. 2011, 74-75p

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