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FEMALE REPRODUCTIVE SYSTEM
OVARY
FALLOPIAN TUBE
VAGINA
Prof.J.Anbalagan,
anbuamu@rediffmail.com
FEMALE REPRODUCTIVE ORGANS
Prof.J.Anbalagan
OOGENESIS
• OOGONIUM
• PRIMARY OOCYTE
– 44+XX
• SECONDARY OOCYTE
– 22+X, 1 POLAR BODY
• MATURE OVUM
– 22+X, 3 POLAR BODY
Prof.J.Anbalagan
OVARY
• Surrounded by simple
cuboidal cells
– Germinal epithelium
• Deeper
– Tunica albuginea
Prof.J.Anbalagan
OVARY• Cortex
– Ovarian follicles
• at different stages of
maturations
– Stroma
• with spindle shaped
cells
• Medulla
– Loose connective tissue
with elastic fibers
– Blood vessels
Prof.J.Anbalagan
Stages of maturation
• Primordial follicle
• Primary follicle
• Secondary follicle
• Antral follicle
• Mature follicle (Graffian follicle)
Prof.J.Anbalagan
PRIMORDIAL FOLLICLE
• Primordial germ cells migrate
from yolk sac
• Arranged as primordial follicles
• 5th IUL– 6 million primordial
follicles
• At birth- 2 million follicles
• Puberty- 40,000 follicles
• 400 follicles mature in
reproductive cycle
Prof.J.Anbalagan
Growth of ovarian follicles
• PRIMARY FOLLICLES
– Oocyte with prominent
nucleus and nucleolus
– Zona pellucida appears
(glycoprotein)
– Surrounded by
cuboid/columnar
granulose cells
Zona pellucida
Prof.J.Anbalagan
Secondary follicle
• Increase in Oocyte size
• Granulosa cells becomes
multilayered
• Surrounded by stromal
cells-
– Theca interna
– Theca externa
Prof.J.Anbalagan
Antral follicle
• Appearance of spaces
between granulosa
cells
• Fluid accumulation
• Few cell adhere to
ovum-
– cumulus oophorus
Prof.J.Anbalagan
Mature Graafian follicle
• Fluid amount increases
• Ovum pushed to one side
• Surrounded by cumulus oophorus
• External follicle surrounded by
theca interna and theca externa
• Increased intra follicular pressure
• Follicle ruptures
• Ovulation
• Secondary oocyte in prophase
stage
Prof.J.Anbalagan
Mature Graafian follicle
Prof.J.Anbalagan
Corpus luteum
• After ovulation
• Follicular cells collapses
• Invaded by blood vessels
• Follicular cells become polyhedral
• Accumulates lipid vacuoles, yellow
pigments
• Corpus luteum of menstruation- 10-12
days
• Corpus luteum of pregnancy- 4 months
• Corpus luteum albican- after involution
Prof.J.Anbalagan
Corpus luteum
Prof.J.Anbalagan
Atretic follicles
• Number of follicles
undergoes maturation
• One succeeds
• Remaining degenerates
• Atretic stage occurs in all
stages of maturation
• Ovum dies and fibrous tissue
grows into the follicle
Prof.J.Anbalagan
FALLOPIAN TUBE
Prof.J.Anbalagan
FALLOPIAN TUBE
• Mucous membrane
thrown into folds
• Each fold shows core of
lamina propria
• Folds shows primary,
secondary and tertiary
branches
Prof.J.Anbalagan
• Lined by columnar
epithelium
• Ciliated
• non ciliated cells
(secretory)
• Muscular layer-circular
+ longitudinal
• Serosa – highly
vascular
Prof.J.Anbalagan
VAGINA
• Tubular organ
• Mucous
• muscular layer
• tunica adventitia
• Connective tissue (elastic
fibers) and blood vessels
Prof.J.Anbalagan
VAGINA
• Mucous membrane
– Lamina propria-dense with
elastic fibers, lymphatic
nodules
– Stratified squamous non
keratinized epithelium
– Superficial cells rich in
glycogen
• Sub mucosa with connective
tissue and blood vessels
• Intermingled longitudinal and
circular muscle
Prof.J.Anbalagan
MEDULLA
CORTEX
OVARY
Prof.J.Anbalagan
pf
GF
Prof.J.Anbalagan
VASCULAR SEROSA MUSCLULAR
LAYER
Prof.J.Anbalagan
VAGINA
Stratified non keratinized
Lamina propria
Prof.J.Anbalagan
• Draw a labeled diagram
showing the histological
features of
– Ovary
– Fallopian tube
• Name the coverings of
ovary
• Discuss the functions of
corpus luteum
• Discuss the different
stages of ovarian follicle
Prof.J.Anbalagan
Prof.J.Anbalagan

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Female reproductive system1 copy

  • 1. FEMALE REPRODUCTIVE SYSTEM OVARY FALLOPIAN TUBE VAGINA Prof.J.Anbalagan, anbuamu@rediffmail.com
  • 3. OOGENESIS • OOGONIUM • PRIMARY OOCYTE – 44+XX • SECONDARY OOCYTE – 22+X, 1 POLAR BODY • MATURE OVUM – 22+X, 3 POLAR BODY Prof.J.Anbalagan
  • 4. OVARY • Surrounded by simple cuboidal cells – Germinal epithelium • Deeper – Tunica albuginea Prof.J.Anbalagan
  • 5. OVARY• Cortex – Ovarian follicles • at different stages of maturations – Stroma • with spindle shaped cells • Medulla – Loose connective tissue with elastic fibers – Blood vessels Prof.J.Anbalagan
  • 6. Stages of maturation • Primordial follicle • Primary follicle • Secondary follicle • Antral follicle • Mature follicle (Graffian follicle) Prof.J.Anbalagan
  • 7. PRIMORDIAL FOLLICLE • Primordial germ cells migrate from yolk sac • Arranged as primordial follicles • 5th IUL– 6 million primordial follicles • At birth- 2 million follicles • Puberty- 40,000 follicles • 400 follicles mature in reproductive cycle Prof.J.Anbalagan
  • 8. Growth of ovarian follicles • PRIMARY FOLLICLES – Oocyte with prominent nucleus and nucleolus – Zona pellucida appears (glycoprotein) – Surrounded by cuboid/columnar granulose cells Zona pellucida Prof.J.Anbalagan
  • 9. Secondary follicle • Increase in Oocyte size • Granulosa cells becomes multilayered • Surrounded by stromal cells- – Theca interna – Theca externa Prof.J.Anbalagan
  • 10. Antral follicle • Appearance of spaces between granulosa cells • Fluid accumulation • Few cell adhere to ovum- – cumulus oophorus Prof.J.Anbalagan
  • 11. Mature Graafian follicle • Fluid amount increases • Ovum pushed to one side • Surrounded by cumulus oophorus • External follicle surrounded by theca interna and theca externa • Increased intra follicular pressure • Follicle ruptures • Ovulation • Secondary oocyte in prophase stage Prof.J.Anbalagan
  • 13. Corpus luteum • After ovulation • Follicular cells collapses • Invaded by blood vessels • Follicular cells become polyhedral • Accumulates lipid vacuoles, yellow pigments • Corpus luteum of menstruation- 10-12 days • Corpus luteum of pregnancy- 4 months • Corpus luteum albican- after involution Prof.J.Anbalagan
  • 15. Atretic follicles • Number of follicles undergoes maturation • One succeeds • Remaining degenerates • Atretic stage occurs in all stages of maturation • Ovum dies and fibrous tissue grows into the follicle Prof.J.Anbalagan
  • 17. FALLOPIAN TUBE • Mucous membrane thrown into folds • Each fold shows core of lamina propria • Folds shows primary, secondary and tertiary branches Prof.J.Anbalagan
  • 18. • Lined by columnar epithelium • Ciliated • non ciliated cells (secretory) • Muscular layer-circular + longitudinal • Serosa – highly vascular Prof.J.Anbalagan
  • 19. VAGINA • Tubular organ • Mucous • muscular layer • tunica adventitia • Connective tissue (elastic fibers) and blood vessels Prof.J.Anbalagan
  • 20. VAGINA • Mucous membrane – Lamina propria-dense with elastic fibers, lymphatic nodules – Stratified squamous non keratinized epithelium – Superficial cells rich in glycogen • Sub mucosa with connective tissue and blood vessels • Intermingled longitudinal and circular muscle Prof.J.Anbalagan
  • 24. VAGINA Stratified non keratinized Lamina propria Prof.J.Anbalagan
  • 25. • Draw a labeled diagram showing the histological features of – Ovary – Fallopian tube • Name the coverings of ovary • Discuss the functions of corpus luteum • Discuss the different stages of ovarian follicle Prof.J.Anbalagan