Factors associated with a poor outcome after witnessed out-of-hospital sudden cardiac arrest include an initial rhythm of pulseless electrical activity or asystole, time elapsed prior to effective resuscitation through delayed bystander CPR or defibrillation, prolonged CPR lasting over 5 minutes, absence of vital signs after CPR, advanced age, prior history of cardiac disease, having two or more chronic illnesses, remaining in a coma after CPR, and developing pneumonia, renal failure, sepsis, stroke, or severe heart failure after receiving CPR.