Evidence Based Nursing Practice: Current Scenario & eay forwardPrabhjot Saini
Explains about Research practice gap, present scenario, research utilization, constraints & barriers for research utilization, how to find evidences for EBP and strategiesto do it
Evidence Based Nursing Practice: Current Scenario & eay forwardPrabhjot Saini
Explains about Research practice gap, present scenario, research utilization, constraints & barriers for research utilization, how to find evidences for EBP and strategiesto do it
UK based multicentric trial involving 364 critically ill patients who were deemed difficult to wean, was conducted to prove shorter time to liberation from mechanical ventilation with non invasive weaning compared to invasive weaning.
ICN Victoria presents Dr Dashiell Gantner, research fellow at the Monash University in Melbourne. Here he talks about translating ICU research into clinical practice.
Construction of an Implementation Science for Scaling Out Interventions HopkinsCFAR
The Johns Hopkins Bloomberg School of Public Health Center for Implementation Research
The Johns Hopkins Center for AIDS Research
& the Dean’s Office invite you to
The Center for Implementation Research Implementation Science Speaker Series
Construction of an Implementation Science for Scaling Out Interventions
Wednesday, May 7, 2014
12:15pm – 1:15pm
W1020 Becton Dickinson – 615 N. Wolfe Street
C Hendricks Brown, Ph. D.
Director, Center for Prevention Implementation Methodology (Ce-PIM)
Director, Prevention Science and Methodology Group (PSMG)
Professor, Department of Psychiatry and Behavioral Sciences and Department of Preventive Medicine
Northwestern University, Feinberg School of Medicine
Using Implementation Science to transform patient care (Knowledge to Action C...NEQOS
Master Class presentation and workshop materials from the NENC AHSN Collaborating for Better Care Partnership's Master Class, led by Professor Jeremy Grimshaw' on 1st September 2014
The ICU team created a standard “Progressive Early Mobility Program” for their patients. The expectation was set - this would be the norm for all appropriate patients.
What is implementation science and why should you careLisa Muldrew
This seminar will discuss the emerging field of implementation science with a focus on its application within clinical settings. Topics will include an overview of implementation science, how implementation science is positioned within the translation continuum, common conceptual models and analytic frameworks used in implementation science and a study example.
Original ArticleThe Establishment of Evidence-BasedPract.docxhoney690131
Original Article
The Establishment of Evidence-Based
Practice Competencies for Practicing
Registered Nurses and Advanced Practice
Nurses in Real-World Clinical Settings:
Proficiencies to Improve Healthcare Quality,
Reliability, Patient Outcomes, and Costs
Bernadette Mazurek Melnyk, RN, PhD, CPNP/PMHNP, FNAP, FAANP, FAAN •
Lynn Gallagher-Ford, RN, PhD, DPFNAP, NE-BC • Lisa English Long, RN, MSN, CNS •
Ellen Fineout-Overholt, RN, PhD, FAAN
Keywords
evidence-based
practice,
competencies,
healthcare quality
ABSTRACT
Background: Although it is widely known that evidence-based practice (EBP) improves healthcare
quality, reliability, and patient outcomes as well as reduces variations in care and costs, it is still
not the standard of care delivered by practicing clinicians across the globe. Adoption of specific
EBP competencies for nurses and advanced practice nurses (APNs) who practice in real-world
healthcare settings can assist institutions in achieving high-value, low-cost evidence-based health
care.
Aim: The aim of this study was to develop a set of clear EBP competencies for both practicing
registered nurses and APNs in clinical settings that can be used by healthcare institutions in their
quest to achieve high performing systems that consistently implement and sustain EBP.
Methods: Seven national EBP leaders developed an initial set of competencies for practicing
registered nurses and APNs through a consensus building process. Next, a Delphi survey was
conducted with 80 EBP mentors across the United States to determine consensus and clarity
around the competencies.
Findings: Two rounds of the Delphi survey resulted in total consensus by the EBP mentors,
resulting in a final set of 13 competencies for practicing registered nurses and 11 additional
competencies for APNs.
Linking Evidence to Action: Incorporation of these competencies into healthcare system ex-
pectations, orientations, job descriptions, performance appraisals, and clinical ladder promotion
processes could drive higher quality, reliability, and consistency of healthcare as well as reduce
costs. Research is now needed to develop valid and reliable tools for assessing these competen-
cies as well as linking them to clinician and patient outcomes.
BACKGROUND
Evidence-based practice (EBP) is a life-long problem-solving
approach to the delivery of health care that integrates the best
evidence from well-designed studies (i.e., external evidence)
and integrates it with a patient’s preferences and values
and a clinician’s expertise, which includes internal evidence
gathered from patient data. When EBP is delivered in a context
of caring and a culture as well as an ecosystem or environment
that supports it, the best clinical decisions are made that
yield positive patient outcomes (see Figure 1; Melnyk &
Fineout-Overholt, 2011).
Research supports that EBP promotes high-value health
care, including enhancing the quality and reliability of health
care, improving health outcomes,.
Original ArticleThe Establishment of Evidence-BasedPract.docxvannagoforth
Original Article
The Establishment of Evidence-Based
Practice Competencies for Practicing
Registered Nurses and Advanced Practice
Nurses in Real-World Clinical Settings:
Proficiencies to Improve Healthcare Quality,
Reliability, Patient Outcomes, and Costs
Bernadette Mazurek Melnyk, RN, PhD, CPNP/PMHNP, FNAP, FAANP, FAAN •
Lynn Gallagher-Ford, RN, PhD, DPFNAP, NE-BC • Lisa English Long, RN, MSN, CNS •
Ellen Fineout-Overholt, RN, PhD, FAAN
Keywords
evidence-based
practice,
competencies,
healthcare quality
ABSTRACT
Background: Although it is widely known that evidence-based practice (EBP) improves healthcare
quality, reliability, and patient outcomes as well as reduces variations in care and costs, it is still
not the standard of care delivered by practicing clinicians across the globe. Adoption of specific
EBP competencies for nurses and advanced practice nurses (APNs) who practice in real-world
healthcare settings can assist institutions in achieving high-value, low-cost evidence-based health
care.
Aim: The aim of this study was to develop a set of clear EBP competencies for both practicing
registered nurses and APNs in clinical settings that can be used by healthcare institutions in their
quest to achieve high performing systems that consistently implement and sustain EBP.
Methods: Seven national EBP leaders developed an initial set of competencies for practicing
registered nurses and APNs through a consensus building process. Next, a Delphi survey was
conducted with 80 EBP mentors across the United States to determine consensus and clarity
around the competencies.
Findings: Two rounds of the Delphi survey resulted in total consensus by the EBP mentors,
resulting in a final set of 13 competencies for practicing registered nurses and 11 additional
competencies for APNs.
Linking Evidence to Action: Incorporation of these competencies into healthcare system ex-
pectations, orientations, job descriptions, performance appraisals, and clinical ladder promotion
processes could drive higher quality, reliability, and consistency of healthcare as well as reduce
costs. Research is now needed to develop valid and reliable tools for assessing these competen-
cies as well as linking them to clinician and patient outcomes.
BACKGROUND
Evidence-based practice (EBP) is a life-long problem-solving
approach to the delivery of health care that integrates the best
evidence from well-designed studies (i.e., external evidence)
and integrates it with a patient’s preferences and values
and a clinician’s expertise, which includes internal evidence
gathered from patient data. When EBP is delivered in a context
of caring and a culture as well as an ecosystem or environment
that supports it, the best clinical decisions are made that
yield positive patient outcomes (see Figure 1; Melnyk &
Fineout-Overholt, 2011).
Research supports that EBP promotes high-value health
care, including enhancing the quality and reliability of health
care, improving health outcomes, ...
UK based multicentric trial involving 364 critically ill patients who were deemed difficult to wean, was conducted to prove shorter time to liberation from mechanical ventilation with non invasive weaning compared to invasive weaning.
ICN Victoria presents Dr Dashiell Gantner, research fellow at the Monash University in Melbourne. Here he talks about translating ICU research into clinical practice.
Construction of an Implementation Science for Scaling Out Interventions HopkinsCFAR
The Johns Hopkins Bloomberg School of Public Health Center for Implementation Research
The Johns Hopkins Center for AIDS Research
& the Dean’s Office invite you to
The Center for Implementation Research Implementation Science Speaker Series
Construction of an Implementation Science for Scaling Out Interventions
Wednesday, May 7, 2014
12:15pm – 1:15pm
W1020 Becton Dickinson – 615 N. Wolfe Street
C Hendricks Brown, Ph. D.
Director, Center for Prevention Implementation Methodology (Ce-PIM)
Director, Prevention Science and Methodology Group (PSMG)
Professor, Department of Psychiatry and Behavioral Sciences and Department of Preventive Medicine
Northwestern University, Feinberg School of Medicine
Using Implementation Science to transform patient care (Knowledge to Action C...NEQOS
Master Class presentation and workshop materials from the NENC AHSN Collaborating for Better Care Partnership's Master Class, led by Professor Jeremy Grimshaw' on 1st September 2014
The ICU team created a standard “Progressive Early Mobility Program” for their patients. The expectation was set - this would be the norm for all appropriate patients.
What is implementation science and why should you careLisa Muldrew
This seminar will discuss the emerging field of implementation science with a focus on its application within clinical settings. Topics will include an overview of implementation science, how implementation science is positioned within the translation continuum, common conceptual models and analytic frameworks used in implementation science and a study example.
Original ArticleThe Establishment of Evidence-BasedPract.docxhoney690131
Original Article
The Establishment of Evidence-Based
Practice Competencies for Practicing
Registered Nurses and Advanced Practice
Nurses in Real-World Clinical Settings:
Proficiencies to Improve Healthcare Quality,
Reliability, Patient Outcomes, and Costs
Bernadette Mazurek Melnyk, RN, PhD, CPNP/PMHNP, FNAP, FAANP, FAAN •
Lynn Gallagher-Ford, RN, PhD, DPFNAP, NE-BC • Lisa English Long, RN, MSN, CNS •
Ellen Fineout-Overholt, RN, PhD, FAAN
Keywords
evidence-based
practice,
competencies,
healthcare quality
ABSTRACT
Background: Although it is widely known that evidence-based practice (EBP) improves healthcare
quality, reliability, and patient outcomes as well as reduces variations in care and costs, it is still
not the standard of care delivered by practicing clinicians across the globe. Adoption of specific
EBP competencies for nurses and advanced practice nurses (APNs) who practice in real-world
healthcare settings can assist institutions in achieving high-value, low-cost evidence-based health
care.
Aim: The aim of this study was to develop a set of clear EBP competencies for both practicing
registered nurses and APNs in clinical settings that can be used by healthcare institutions in their
quest to achieve high performing systems that consistently implement and sustain EBP.
Methods: Seven national EBP leaders developed an initial set of competencies for practicing
registered nurses and APNs through a consensus building process. Next, a Delphi survey was
conducted with 80 EBP mentors across the United States to determine consensus and clarity
around the competencies.
Findings: Two rounds of the Delphi survey resulted in total consensus by the EBP mentors,
resulting in a final set of 13 competencies for practicing registered nurses and 11 additional
competencies for APNs.
Linking Evidence to Action: Incorporation of these competencies into healthcare system ex-
pectations, orientations, job descriptions, performance appraisals, and clinical ladder promotion
processes could drive higher quality, reliability, and consistency of healthcare as well as reduce
costs. Research is now needed to develop valid and reliable tools for assessing these competen-
cies as well as linking them to clinician and patient outcomes.
BACKGROUND
Evidence-based practice (EBP) is a life-long problem-solving
approach to the delivery of health care that integrates the best
evidence from well-designed studies (i.e., external evidence)
and integrates it with a patient’s preferences and values
and a clinician’s expertise, which includes internal evidence
gathered from patient data. When EBP is delivered in a context
of caring and a culture as well as an ecosystem or environment
that supports it, the best clinical decisions are made that
yield positive patient outcomes (see Figure 1; Melnyk &
Fineout-Overholt, 2011).
Research supports that EBP promotes high-value health
care, including enhancing the quality and reliability of health
care, improving health outcomes,.
Original ArticleThe Establishment of Evidence-BasedPract.docxvannagoforth
Original Article
The Establishment of Evidence-Based
Practice Competencies for Practicing
Registered Nurses and Advanced Practice
Nurses in Real-World Clinical Settings:
Proficiencies to Improve Healthcare Quality,
Reliability, Patient Outcomes, and Costs
Bernadette Mazurek Melnyk, RN, PhD, CPNP/PMHNP, FNAP, FAANP, FAAN •
Lynn Gallagher-Ford, RN, PhD, DPFNAP, NE-BC • Lisa English Long, RN, MSN, CNS •
Ellen Fineout-Overholt, RN, PhD, FAAN
Keywords
evidence-based
practice,
competencies,
healthcare quality
ABSTRACT
Background: Although it is widely known that evidence-based practice (EBP) improves healthcare
quality, reliability, and patient outcomes as well as reduces variations in care and costs, it is still
not the standard of care delivered by practicing clinicians across the globe. Adoption of specific
EBP competencies for nurses and advanced practice nurses (APNs) who practice in real-world
healthcare settings can assist institutions in achieving high-value, low-cost evidence-based health
care.
Aim: The aim of this study was to develop a set of clear EBP competencies for both practicing
registered nurses and APNs in clinical settings that can be used by healthcare institutions in their
quest to achieve high performing systems that consistently implement and sustain EBP.
Methods: Seven national EBP leaders developed an initial set of competencies for practicing
registered nurses and APNs through a consensus building process. Next, a Delphi survey was
conducted with 80 EBP mentors across the United States to determine consensus and clarity
around the competencies.
Findings: Two rounds of the Delphi survey resulted in total consensus by the EBP mentors,
resulting in a final set of 13 competencies for practicing registered nurses and 11 additional
competencies for APNs.
Linking Evidence to Action: Incorporation of these competencies into healthcare system ex-
pectations, orientations, job descriptions, performance appraisals, and clinical ladder promotion
processes could drive higher quality, reliability, and consistency of healthcare as well as reduce
costs. Research is now needed to develop valid and reliable tools for assessing these competen-
cies as well as linking them to clinician and patient outcomes.
BACKGROUND
Evidence-based practice (EBP) is a life-long problem-solving
approach to the delivery of health care that integrates the best
evidence from well-designed studies (i.e., external evidence)
and integrates it with a patient’s preferences and values
and a clinician’s expertise, which includes internal evidence
gathered from patient data. When EBP is delivered in a context
of caring and a culture as well as an ecosystem or environment
that supports it, the best clinical decisions are made that
yield positive patient outcomes (see Figure 1; Melnyk &
Fineout-Overholt, 2011).
Research supports that EBP promotes high-value health
care, including enhancing the quality and reliability of health
care, improving health outcomes, ...
Original ArticleThe Establishment of Evidence-BasedPract.docxgerardkortney
Original Article
The Establishment of Evidence-Based
Practice Competencies for Practicing
Registered Nurses and Advanced Practice
Nurses in Real-World Clinical Settings:
Proficiencies to Improve Healthcare Quality,
Reliability, Patient Outcomes, and Costs
Bernadette Mazurek Melnyk, RN, PhD, CPNP/PMHNP, FNAP, FAANP, FAAN •
Lynn Gallagher-Ford, RN, PhD, DPFNAP, NE-BC • Lisa English Long, RN, MSN, CNS •
Ellen Fineout-Overholt, RN, PhD, FAAN
Keywords
evidence-based
practice,
competencies,
healthcare quality
ABSTRACT
Background: Although it is widely known that evidence-based practice (EBP) improves healthcare
quality, reliability, and patient outcomes as well as reduces variations in care and costs, it is still
not the standard of care delivered by practicing clinicians across the globe. Adoption of specific
EBP competencies for nurses and advanced practice nurses (APNs) who practice in real-world
healthcare settings can assist institutions in achieving high-value, low-cost evidence-based health
care.
Aim: The aim of this study was to develop a set of clear EBP competencies for both practicing
registered nurses and APNs in clinical settings that can be used by healthcare institutions in their
quest to achieve high performing systems that consistently implement and sustain EBP.
Methods: Seven national EBP leaders developed an initial set of competencies for practicing
registered nurses and APNs through a consensus building process. Next, a Delphi survey was
conducted with 80 EBP mentors across the United States to determine consensus and clarity
around the competencies.
Findings: Two rounds of the Delphi survey resulted in total consensus by the EBP mentors,
resulting in a final set of 13 competencies for practicing registered nurses and 11 additional
competencies for APNs.
Linking Evidence to Action: Incorporation of these competencies into healthcare system ex-
pectations, orientations, job descriptions, performance appraisals, and clinical ladder promotion
processes could drive higher quality, reliability, and consistency of healthcare as well as reduce
costs. Research is now needed to develop valid and reliable tools for assessing these competen-
cies as well as linking them to clinician and patient outcomes.
BACKGROUND
Evidence-based practice (EBP) is a life-long problem-solving
approach to the delivery of health care that integrates the best
evidence from well-designed studies (i.e., external evidence)
and integrates it with a patient’s preferences and values
and a clinician’s expertise, which includes internal evidence
gathered from patient data. When EBP is delivered in a context
of caring and a culture as well as an ecosystem or environment
that supports it, the best clinical decisions are made that
yield positive patient outcomes (see Figure 1; Melnyk &
Fineout-Overholt, 2011).
Research supports that EBP promotes high-value health
care, including enhancing the quality and reliability of health
care, improving health outcomes,.
At the end of this presentation you will be able to:
Define evidence-based practice
Describe process & outline steps of EBP
Understand PICO elements & search strategy
Identify resources to support EBP
The focus of this presentation is nursing practice, although it is still of value to physicians and other health care professionals.
Quality improvement is integral to the practice of medicine. Sometimes, QI strays over into clinical research. This presentation provides an overview of the intersection between QI and research
EBP is a systemic interconnecting of scientifically generated evidence with the tacit knowledge of the expert practitioner to achieve a change in a particular practice for the benefit of a well-defined client/ patient group.
14Application 1 Identification of a Practice Issue for th.docxdrennanmicah
1
4
Application 1: Identification of a Practice Issue for the Evidence-Based Practice (EBP) Project
Note: Have an APA Level 1 header for Each Area Noted below in Blue (a level 1 header is centered, bolded, using upper and lower case letters—see APA manual area 3.03)
Grading Area
Points Possible
Points Earned
Potential areas for earning points:
Header: Summary of Practice Issue
Summary of practice issue. (Note: The issue you select must be suitable for completing the entire EBP Project in 8410.)
2
1.5
Header: Exploration of Research Literature
Exploration of the research literature on
this issue.
3
2.75
High level of scholarship commensurate with doctoral level evident
1
1
Potential areas for losing points:
Grammar, Spelling, and APA errors
Up to 2 pt. deduction
-0
Went Over Page Limit (2 pages max)
Up to 2 pt. deduction
-0
*Improper credit & citation issue
1-6 pt. deduction
-0
Sent back to re-do
1 pt deduction
-1
Late Submission
(posted X.XX.20XX, due X.XX.20XX )
20% deduction (1.2 pts) per day late (per syllabus)
n/a: posted on time
6 Total Points possible
4.25 Total Points Earned
In this assignment you were consider a practice issue at your practicum site, summarize that issue, and outline the research literature associated with it. Please see my edits/notes below. Good job!
Some things for ALL to remember/consider (you may have done this already-this is just a gentle reminder):
· Use a heading for each of the main areas noted in the assignment grading rubric for all assignments (I posted the rubrics in the announcement area-the headers to be used are in blue font).
· Related to your topic of interest, does the agency have a process/policy/clinical practice guideline/practice approach/nurse education/patient education in place already? All of them? Are they being implemented according to the best evidence? If not, could that be an appropriate focus for your project?
· How will you go about updating the processes/policies/education materials so they are more consistent with national recommendations/guidelines/research?
· What is your revised PICOT for this EBP (PICOT was not a mandatory part of the paper—but it is nice to tie this all together at the end of your paper with that information).
· *All students should review their Safe Assign reports regularly (use the draft folders to run a report prior to submitting your assignment). You should not have more than 3 words in a row that are the same as another source unless you use quotation marks and properly cite that source (with author, year, and page number). You need to reword your paper to avoid this. You should reserve using quotations for the rare instances wherein you cannot reword information without losing meaning. Also, you need to cite each sentence with information that a layperson would not know. There are many resources online that you can use to review proper citation and common plagiarism errors. All students should review the Walden Plagiarism Tutorial at h.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
3. Objectives
• Decrease failed extubations
• Develop assessment tool for extubation
readiness for PICU patients with non-chronic
lung/musculoskeletal conditions
• Increase nursing and RT comfort/satisfaction
and collaboration
• Standardize multi-disciplinary team approach to
extubation
• Develop a culture of evidence based practice
4. Our Beginnings
• 2010
– EBP workshop (Hawaii State Center for Nursing)
• Introduction to the Iowa Model of EBP
– PICO development
– Based on Triggers
– To decrease the need for reintubation and
improve staff collaboration in the extubation
process for intubated PICU patients with non-
chronic lung conditions by implementing a
weaning readiness assessment score/tool
which includes acceptable ventilator settings,
sedation level and ability to protect airway prior
to extubation
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6. Triggers
• 4 failed extubations in past 12 month prior to project
• Traumatic physically and psychologically to patients and
parents
• Lack of agreement/collaboration among caregivers about
when a patient is ready for extubation
• No standardized approach or criteria for extubation
• Decisions not necessarily based on evidence
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8. Is There
a Sufficient
Research
Base?
Assemble Relevant Research & Related Literature
Critique & Synthesize Research for Use in Practice
Pilot the Change in Practice
1. Select Outcomes to be Achieved
2. Collect Baseline Data
3. Design Evidence-Based
Practice (EBP) Guideline(s)
4. Implement EBP on Pilot Units
5. Evaluate Process & Outcomes
6. Modify the Practice Guideline
Base Practice on Other
Types of Evidence
1. Case Reports
2. Expert Opinion
3. Scientific Principles
4. Theory
Conduct
Research
Yes No
= a decision Point
The Iowa Model of
Evidence Based Practice to Promote Quality
Care
9. Literature?
• Pediatric literature limited
– RTC not necessarily done for children
– Adult studies translated to pediatric care
• Fit to the settings
• Levels of Evidence
– One guideline non pediatric
– 2 extubation readiness tools used by other hospital
PICU
– 7 articles Pediatric based
• 1 level II
• 2 level VI
• 4 level VII
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10. Nursing/RT Staff Survey
• 66% of staff indicated varied practice for
extubation
• 33% of staff indicated multidisciplinary
collaboration during extubation process
• 83% of staff indicated an extubation
readiness tool would be helpful
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13. Paper Trial of Extubation
Protocol
• >1 year of trial
• Multiple extubations delayed due to
criteria not met
• During Trial period - 0 failed extubations
when protocol followed
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17. Lessons Learned
• Consider the culture of the unit:
– “If we don’t have failed extubations we are not
doing our job.”
– Communicate….
• Frequently
• Follow-up
• Have set team meetings: time & place
• Point persons are vital
• Identify the roles
• Time frames and deadlines
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18. More Lessons Learned
• Trialing takes time (piloting the change)
• Expect Multiple changes
– 3 revisions to paper form of extubation readiness
protocol
• Acknowledge the set backs
• Connect with IT early
• How do we operationalize this?
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19. Clinical Results
• Extubation Readiness tool is part of the
PICU standard order set for intubation
• No failed extubation to date for those
patients meeting criteria!!
• Staff survery showed increased feelings of
collaboration and consistency in practice
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21. Nurse/RT Survey Results
Post Protocol Implementation
• 0% of staff indicated varied practice for
extubation (prevously 66%)
• 68% of staff indicated multidisciplinary
collaboration during extubation process
(previously 33%)
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22. Contact
• Kolea Chong RN, BSN, CCRN
– Kolea.chong@kapiolani.org
– Kapiolani Medical Center for Women & Children
• Susan Bankhead MSN, CCRN, CNML
– Susan.bankhead@kapiolani.org
– Kapiolani Medical Center for Women & Children
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23. References
Baumeister, B.L., El-Khatib, M., Smith, P.G., Blumer, J.L. (1997) Evaluation of predictors of weaning
of mechanical ventilation in pediatric patients. Pediatric Pulmonology, 24(5): 344-52.
Farias, J.A., Alia, I., Esteban, A., Golubicki, A.N., Olazarri, F.A. (1998) Weaning from Mechanical
Ventilation In Pediatric Intensive Care Patients. Intensive Care Medicine, 24(10); 1070-5.
MacIntyre, N.R., Cook, D.J., Ely, E.W., Epstein, S.K., Fink, J.B., Heffner, J.E., et al (2002) Evidence-
Based Guidelines for Weaning and Discontinuing Ventilatory Support. Respiratory Care, 47(1):
69-89.
Meade, M.O., Ely, E.W. (2002) Protocols to Improve the Care of Critically Ill Pediatric and Adult
Patients. JAMA, 228(20): 2601-03
Newth, C.J., Venkataraman, S., Willson, D.F., Meert, K.L., Harrison, R., Dean, J.M. et.al (2009)
Weaning and extubation readines in pediatric patients. Pediatric Critical Care Medicine, 10(1): 1-
11.
Titler, M.G., Kleiber, C., Steelman, V., Rakel, B., Budreau, G., Everett, L.Q., Buckwalter, K.C., Tripp
Reimer, T., & Goode, C. (2001). The Iowa Model of Evidence-Based Practice to Promote Quality
Care. Critical Care Nursing Clinics of North America, 13(4):497-509.
Venkataraman, S.T., Khan, N., Brown, A. (2000) Validation of predictors of extubation success and
failure in mechanically ventilated infants and children. Critical Care Medicine, 28(8): 2991-2996.
Wratney, A.T., Cheifetz, I.M. (2006) AARC Clinical Practice Guideline; Removal of the Endotracheal
Tube-2007 Revision and Update. Respiratory Care, 52(1): 81-93.
Wratney, A.T., Cheifets, I.M. (2006) Extubation Criteria in Infants and Children. Respir Care Clin N
Am., 12(3); 469-81.
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24. • This EBP project was generously supported, in
part, by the Hawaii State Center for Nursing
• This project was supported by grant number
R13HS017892 from the Healthcare Research
and Quality. The content is solely the
responsibility of the authors and does not
necessarily represent the official views of the
Agency for Healthcare Research and Quality.
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