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Examining New Research Capabilities
and Technology for Preclinical
Telemetry in Rodents
Sponsored by:
Anil K. Reddy, PhD
Baylor College of Medicine
& Indus Instruments
Nick Glover
InsideScientific
Graham Sattler
Indus Instruments
InsideScientific is an online educational environment
designed for life science researchers. Our goal is to aid in
the sharing and distribution of scientific information
regarding innovative technologies, protocols, research
tools and laboratory services.
Lifetime, Continuous Telemetric Monitoring
in Mice and Rats
MouseMonitor™ Telemetry • No more PC reboot data loss
- Implants can store data in internal
memory
• Collect data anywhere, even in the
vivarium
- Implants work on treadmills,
rotarods & mazes away from PCs
• Collect ECG continuously for more
than a year
• Wireless charging enables true long-
term data collection
Examining New Research
Capabilities and Technology for
Preclinical Telemetry in Rodents
Anil K. Reddy, PhD
Assistant Professor,
Medicine-Cardiovascular Sciences,
Baylor College of Medicine
Senior Scientist
Indus Instruments
Telemetry: Usage Expands in Preclinical Research
Significant Growth in Rodent
Telemetry Publications
• ~1100% in mice
• ~400% in rats
Source: Pubmed
& → Number of Publications
→ Percent Increase of Publications
Some Applications Not Suited
for Telemetry until Now
1
Telemetry: New Capabilities & Possibilities
2
Biotelemetry
in rats & mice
in a metal
cage or box
in a maze on a rotarod on a treadmill
on a wheel
in a water
challenge
Next: A review of some challenges facing researchers
using existing telemetry systems
Telemetry: Challenges
3
Challenges with existing
telemetry systems…
• Unable to collect long-term data due to finite battery life
• Manual power management
• Solitary animal housing
• Charging & communication design requires wide spacing
and shielding
• Poor system scaling for large studies
Challenge 1: Long-Term Data Collection
Limited Data Collection Flexibility:
• Short implant battery life
• Require continuous PC operation
• Generate massive quantities of data
MouseMonitor Telemetry
Enabling Technologies:
• Memory inside implant
• Wireless charging of implant rechargeable battery
• Powerful scheduled recording capabilities
4
Cumbersome & Limited Power Management:
• Fixed battery life (2-6 months)
• Require manual power switching to conserve power
• No automated low power mode
• Limited data collection scheduling capability
Challenge 2: Power Management
5
MouseMonitor Telemetry
Enabling Technologies:
• Flexible recording & scheduling capabilities
• Low power mode with automatic power optimization
• Ultra low power electronics
• Wireless charging of implant rechargeable battery
Challenge 3: Solitary Animal Housing
Implanted animals must be housed singly, leading to…
• Negative impacts of social isolation
• Wide cage spacing means fewer visual cues
• No group grooming or huddling behavior
• Metallic cage barriers mean fewer visual cues
Social housing means better
surgical recovery and outcomes
6
MouseMonitor Telemetry
Enabling Technologies:
• Digital communications & unique implant IDs
• Multiple animals per cage implant charging
Works with multiple animals per cage
No communication cross-talk or need for metallic barriers
Challenge 4: Significant Space Requirements
7
System Needs Large Installation Space:
• One communicating base needed for each implant
• Wide cage spacing means fewer visual cues
• Multiple layers of hardware data aggregation
• Metallic cage barriers mean fewer visual cues
MouseMonitor Telemetry
Enabling Technologies:
• Simple communications setup; one Communication
Module & PC for up to 100 implants
• Digital communications & unique implant IDs
• Multiple animals per cage implant charging
8 implant system installed on a custom
mobile lab cart in 18” x 48” x 54” space
Solutions needed:
1. Rechargeable battery
– long-term data over animal life span
2. Improved power management
– recording scheduling & low power mode
3. New approach to data acquisition
4. Communication & charging technologies
that allow animals to be socially housed
8
Telemetry: Challenges & Solutions
Challenges with existing
telemetry systems…
• Unable to collect long-term data
due to finite battery life
• Manual power management
• Solitary animal housing
• Charging & communication design
requires wide spacing and shielding
• Poor system scaling for large studies
System Overview: In Vivo Measurements
Heart RateElectrocardiogramTemperature
… and more capabilities coming in 2016
Activity
9
System Overview:
System Setup
• Communication Module
works with up to 100
implants
• Chargers works with
multiple animals per cage
• PC Configuration software
makes it easy to find
study data
10
• Data Recorded to
Implant Internal Memory
 Records while PC off or
PC restarting
 Can store 2 weeks of
continuous ECG data
 Can store months of
temperature & activity
data
• Data Transmitted to PC
When in Range
System Overview:
Data Handling
11
System Overview: Configuration Software
12
A) Continuous Data
• Continuous 24/7 ECG
• Periodic Temperature, Heart
Rate & Activity
B) Periodic Data
• Scheduled Captures of ECG
• Periodic Temperature, Heart
Rate & Activity
Data Acquisition Scheduling & Flexibility
13
MouseMonitor™ Telemetry
Continuous Data
14
Continuous Data: 10 week Zoom View
15
Continuous Data: 1 minute Zoom View
16
Continuous Data: 10 second Zoom View
17
Continuous Data: 1 second Zoom View
18
MouseMonitor™ Telemetry
Periodic Data
19
Periodic Data: 1 week Zoom View
20
Periodic Data: 1 week Zoom View
21
Periodic Data: 1 week Zoom View
22
Periodic Data: 10 second Zoom View
23
Periodic Data: 1 second Zoom View
24
Indus Logo?
Easy to Setup
and Use
25
• Unique implant IDs make
it easy to quickly find the
data for a specific animal
• Implants automatically
charge when in range of a
charger
• Ask about our custom
mobile lab cart solutions
for a compact system that
fits in small spaces
MouseMonitor Telemetry™ Advantages
• Designed to enable new applications
• Installs in a compact space
• Enables long-term data collection
• Allows socially housed subjects
• Schedule recordings with both
continuous & periodic data
• Easy to setup & use
26
Downloadable Online Resources
MouseMonitor Telemetry Downloads: (www.mousemonitor.com/telemetry/downloads)
Downloads
• Overview Flyer
• Sample IACUC
Protocol
• Quickstart Guide
• Sterilization
Procedure
27
Resources & Contact Info
MouseMonitor Telemetry Website: (www.mousemonitor.com/telemetry)
Contact Information
Graham Sattler
Product Development Manager
gsattler@indusinstruments.com
Phone: 281-286-1130
Dr. Anil K. Reddy
Assistant Professor of Medicine
Cardiovascular Sciences,
Baylor College of Medicine
areddy@bcm.edu
Phone: 713-798-6831
Senior Scientist
areddy@indusinstruments.com
Phone: 281-286-1130
28
Thank You!
For additional information on the MouseMonitor™
Telemetry system and additional solutions for
preclinical research please visit:
http://www.indusinstruments.com

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Examining New Research Capabilities and Technology for Preclinical Telemetry in Rodents

  • 1. Examining New Research Capabilities and Technology for Preclinical Telemetry in Rodents Sponsored by: Anil K. Reddy, PhD Baylor College of Medicine & Indus Instruments Nick Glover InsideScientific Graham Sattler Indus Instruments
  • 2. InsideScientific is an online educational environment designed for life science researchers. Our goal is to aid in the sharing and distribution of scientific information regarding innovative technologies, protocols, research tools and laboratory services.
  • 3. Lifetime, Continuous Telemetric Monitoring in Mice and Rats MouseMonitor™ Telemetry • No more PC reboot data loss - Implants can store data in internal memory • Collect data anywhere, even in the vivarium - Implants work on treadmills, rotarods & mazes away from PCs • Collect ECG continuously for more than a year • Wireless charging enables true long- term data collection
  • 4. Examining New Research Capabilities and Technology for Preclinical Telemetry in Rodents Anil K. Reddy, PhD Assistant Professor, Medicine-Cardiovascular Sciences, Baylor College of Medicine Senior Scientist Indus Instruments
  • 5. Telemetry: Usage Expands in Preclinical Research Significant Growth in Rodent Telemetry Publications • ~1100% in mice • ~400% in rats Source: Pubmed & → Number of Publications → Percent Increase of Publications Some Applications Not Suited for Telemetry until Now 1
  • 6. Telemetry: New Capabilities & Possibilities 2 Biotelemetry in rats & mice in a metal cage or box in a maze on a rotarod on a treadmill on a wheel in a water challenge Next: A review of some challenges facing researchers using existing telemetry systems
  • 7. Telemetry: Challenges 3 Challenges with existing telemetry systems… • Unable to collect long-term data due to finite battery life • Manual power management • Solitary animal housing • Charging & communication design requires wide spacing and shielding • Poor system scaling for large studies
  • 8. Challenge 1: Long-Term Data Collection Limited Data Collection Flexibility: • Short implant battery life • Require continuous PC operation • Generate massive quantities of data MouseMonitor Telemetry Enabling Technologies: • Memory inside implant • Wireless charging of implant rechargeable battery • Powerful scheduled recording capabilities 4
  • 9. Cumbersome & Limited Power Management: • Fixed battery life (2-6 months) • Require manual power switching to conserve power • No automated low power mode • Limited data collection scheduling capability Challenge 2: Power Management 5 MouseMonitor Telemetry Enabling Technologies: • Flexible recording & scheduling capabilities • Low power mode with automatic power optimization • Ultra low power electronics • Wireless charging of implant rechargeable battery
  • 10. Challenge 3: Solitary Animal Housing Implanted animals must be housed singly, leading to… • Negative impacts of social isolation • Wide cage spacing means fewer visual cues • No group grooming or huddling behavior • Metallic cage barriers mean fewer visual cues Social housing means better surgical recovery and outcomes 6 MouseMonitor Telemetry Enabling Technologies: • Digital communications & unique implant IDs • Multiple animals per cage implant charging Works with multiple animals per cage No communication cross-talk or need for metallic barriers
  • 11. Challenge 4: Significant Space Requirements 7 System Needs Large Installation Space: • One communicating base needed for each implant • Wide cage spacing means fewer visual cues • Multiple layers of hardware data aggregation • Metallic cage barriers mean fewer visual cues MouseMonitor Telemetry Enabling Technologies: • Simple communications setup; one Communication Module & PC for up to 100 implants • Digital communications & unique implant IDs • Multiple animals per cage implant charging 8 implant system installed on a custom mobile lab cart in 18” x 48” x 54” space
  • 12. Solutions needed: 1. Rechargeable battery – long-term data over animal life span 2. Improved power management – recording scheduling & low power mode 3. New approach to data acquisition 4. Communication & charging technologies that allow animals to be socially housed 8 Telemetry: Challenges & Solutions Challenges with existing telemetry systems… • Unable to collect long-term data due to finite battery life • Manual power management • Solitary animal housing • Charging & communication design requires wide spacing and shielding • Poor system scaling for large studies
  • 13. System Overview: In Vivo Measurements Heart RateElectrocardiogramTemperature … and more capabilities coming in 2016 Activity 9
  • 14. System Overview: System Setup • Communication Module works with up to 100 implants • Chargers works with multiple animals per cage • PC Configuration software makes it easy to find study data 10
  • 15. • Data Recorded to Implant Internal Memory  Records while PC off or PC restarting  Can store 2 weeks of continuous ECG data  Can store months of temperature & activity data • Data Transmitted to PC When in Range System Overview: Data Handling 11
  • 17. A) Continuous Data • Continuous 24/7 ECG • Periodic Temperature, Heart Rate & Activity B) Periodic Data • Scheduled Captures of ECG • Periodic Temperature, Heart Rate & Activity Data Acquisition Scheduling & Flexibility 13
  • 19. Continuous Data: 10 week Zoom View 15
  • 20. Continuous Data: 1 minute Zoom View 16
  • 21. Continuous Data: 10 second Zoom View 17
  • 22. Continuous Data: 1 second Zoom View 18
  • 24. Periodic Data: 1 week Zoom View 20
  • 25. Periodic Data: 1 week Zoom View 21
  • 26. Periodic Data: 1 week Zoom View 22
  • 27. Periodic Data: 10 second Zoom View 23
  • 28. Periodic Data: 1 second Zoom View 24
  • 29. Indus Logo? Easy to Setup and Use 25 • Unique implant IDs make it easy to quickly find the data for a specific animal • Implants automatically charge when in range of a charger • Ask about our custom mobile lab cart solutions for a compact system that fits in small spaces
  • 30. MouseMonitor Telemetry™ Advantages • Designed to enable new applications • Installs in a compact space • Enables long-term data collection • Allows socially housed subjects • Schedule recordings with both continuous & periodic data • Easy to setup & use 26
  • 31. Downloadable Online Resources MouseMonitor Telemetry Downloads: (www.mousemonitor.com/telemetry/downloads) Downloads • Overview Flyer • Sample IACUC Protocol • Quickstart Guide • Sterilization Procedure 27
  • 32. Resources & Contact Info MouseMonitor Telemetry Website: (www.mousemonitor.com/telemetry) Contact Information Graham Sattler Product Development Manager gsattler@indusinstruments.com Phone: 281-286-1130 Dr. Anil K. Reddy Assistant Professor of Medicine Cardiovascular Sciences, Baylor College of Medicine areddy@bcm.edu Phone: 713-798-6831 Senior Scientist areddy@indusinstruments.com Phone: 281-286-1130 28
  • 33. Thank You! For additional information on the MouseMonitor™ Telemetry system and additional solutions for preclinical research please visit: http://www.indusinstruments.com