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InsideScientific is an online educational environment
designed for life science researchers.
Our goal is to aid in the sharing and distribution of scientific
information regarding innovative technologies, protocols,
research tools and laboratory services.
Merry Lindsey, PhD
Graham Sattler
Rodent surgical monitoring
advocate, applications
specialist, and Product
Manager for Indus
biomedical solutions

Director of the Jackson
Center for Heart Research at
The University of Mississippi,
celebrated professor, and
expert in murine models of
myocardial infarction

Corey Reynolds PhD
Director of the Mouse
Phenotyping Core Lab at
Baylor College of Medicine,
advanced murine model
surgeon, IACUC and animal
care expert
How do you currently document your surgery for method consistency?
Lab Notebook
Recording on Data
Acquisition System
Photos of Surgical
Setup

Strip Recording
0%

10%

20%

30%

40%

50%

60%

70%

80%
Surgical Monitoring Overview
What can Surgical Monitoring
do for Me?
MouseMonitor S Capabilities
Critical Surgical Monitoring
Signals
Integrated Surgical Monitoring
Doesn’t Have to Be Hard
What Can Surgical Monitoring Do For Me?

Increased
Survival Rate

Consistent
Procedures

Better Surgical
Training

Consistent
Outcomes
Surgical Monitoring Essentials…
Non-Invasive 6-Lead ECG
Blood Oxygenation
Monitoring
Respiration Monitoring
Responsive Heating
Core Temperature
Measurement
Critical Surgical Monitoring Signals
Multiple physiologic signals must be monitored to effectively assess subject health

Monitor…
Heart Rate
Core Temperature
Blood Oxygenation
Maintain…
Safe Core Temperature
Signal Integration…
…it doesn’t have to be hard
ECG, Heart Rate & Respiration Rate
from a single set of electrodes
Perform Surgeries directly on Stainless
Steel top
Intuitive Touch Screen Controls
Factory Presets Enable Out of Box
Operation
All Signals Captured Non-Invasively
Rodent Surgical Monitoring In Review
Comprehensive monitoring
offers greater consistency
and confidence
Consistent Interventions +
Higher Survival Rate = Better
Outcomes
The MouseMonitor S is the
only preclinical research
device that measures every
key vital sign in one device

Click Here For More Information
How important do you view rodent surgical monitoring?
Very Important

Important

Somewhat
Important
0%

10%

20%

30%

40%

50%

60%
What does the MPC Offer?
The Mouse Phenotyping Core is a comprehensive facility offering expertise in the following areas:
Imaging
Metabolic Assays
Cardiovasuclar Assays
Respiratory Assays

Neuromuscular Assessment
Surgical services
What does the MPC Offer?
MPC Cont.
Fee-for-service Core located at BCM

Can accept animals (rats/mice) from
outside facilities post veterinary approval
Can run long term studies and provide
data analysis
Contact Information: Corey L. Reynolds
713-798-5040--------Clreynol@bcm.edu
Challenges in a Core Lab…
Species

Clients/PIs

Many Different
Procedures
Protocols
Recommendations By The NRC
Guide for the Care and Use of Laboratory Animals , 8th ed.

Providing Artificial Heating (p119)

Monitoring baseline vital signs, including:
Heart Rate (p119)

Core Temperature (p119)

Blood Oxygenation (p122)
What a Core Lab Needs…

Core
temperature
monitoring &
adjustable
heating.

ECG/Heart Rate
electrode
flexibility for
different-sized
species.

Blood
Oxygenation
(SpO2)
monitoring.

Compact
Comprehensive
Surgical
monitoring.
Advantages of Integrated Monitoring & Recording
Easy Screenshots
Easy Recordings
Advantages of Integrated Monitoring & Recording

Constant
Monitoring of
Animal Vitals
During Surgery

Documentation
of Monitoring

Very Liked by
IACUC
committee.
Applications In The Mouse Phenotyping Core
Multiple Hi-Resolution
ECG leads enable easier
Morphology Recognition
& Arrhythmia Detection

Sinus Rhythm with Bigeminal PVCs
Applications In The Mouse Phenotyping Core
Serial Ultrasound (Vevo)
B-Mode and ECG capture
for analysis
ECG data integrates
effectively with other
equipment as well
What factors influence how frequently you utilize surgical monitoring?
My current setup takes too
much time to use
I am working on setting up
my lab
I don’t currently have
suitable monitoring
equipment
My current setup doesn’t
work properly

0%

5%

10%

15%

20%

25%

30%

35%
Myocardial Infarction (by Left Coronary Artery Decending (LAD) Ligation)C

Universal definition of myocardial infarction. Kristian Thygesen, Joseph S.
Alpert and Harvey D. White on behalf of the Joint
ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction.
Eur Heart J (2007) 28 (20): 2525-2538.
Post-MI Cardiac Remodeling

Yabluchanskiy et al. Congest Heart Fail. 2013
Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
Lindsey Lab – Current Research Areas
Effects of MMP-9 deletion in aging mice post-MI
Effects of MMP-9 deletion post-MI in mice with P. gingivalis infection
Effects of MMPs derived peptides in vitro and in vivo

Effects of selective MMP inhibitors post-MI
ECG Before LAD Ligation
ECG 5 Min After LAD Ligation
Critical Needs in our Lab For In Vivo Models
Reliable & accurate ECG recording

Comfortable size of the pad

Multiple leads choice

External temperature probe

External and internal ECG electrodes

Portable tablet system

Controlled heated pad

Data management/export
Thank you for taking part in this event. We encourage all attendees to
register at www.insidescientific.com for notifications about future webinars.

WEBSERIES COMING SOON…
PV Loops to Measure Cardiac Function
Implantable Biotelemetry
Non-Invasive Blood Pressure Monitoring

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Advancements in Rodent Surgical Monitoring

  • 1.
  • 2. InsideScientific is an online educational environment designed for life science researchers. Our goal is to aid in the sharing and distribution of scientific information regarding innovative technologies, protocols, research tools and laboratory services.
  • 3. Merry Lindsey, PhD Graham Sattler Rodent surgical monitoring advocate, applications specialist, and Product Manager for Indus biomedical solutions Director of the Jackson Center for Heart Research at The University of Mississippi, celebrated professor, and expert in murine models of myocardial infarction Corey Reynolds PhD Director of the Mouse Phenotyping Core Lab at Baylor College of Medicine, advanced murine model surgeon, IACUC and animal care expert
  • 4. How do you currently document your surgery for method consistency? Lab Notebook Recording on Data Acquisition System Photos of Surgical Setup Strip Recording 0% 10% 20% 30% 40% 50% 60% 70% 80%
  • 5. Surgical Monitoring Overview What can Surgical Monitoring do for Me? MouseMonitor S Capabilities Critical Surgical Monitoring Signals Integrated Surgical Monitoring Doesn’t Have to Be Hard
  • 6. What Can Surgical Monitoring Do For Me? Increased Survival Rate Consistent Procedures Better Surgical Training Consistent Outcomes
  • 7. Surgical Monitoring Essentials… Non-Invasive 6-Lead ECG Blood Oxygenation Monitoring Respiration Monitoring Responsive Heating Core Temperature Measurement
  • 8. Critical Surgical Monitoring Signals Multiple physiologic signals must be monitored to effectively assess subject health Monitor… Heart Rate Core Temperature Blood Oxygenation Maintain… Safe Core Temperature
  • 9. Signal Integration… …it doesn’t have to be hard ECG, Heart Rate & Respiration Rate from a single set of electrodes Perform Surgeries directly on Stainless Steel top Intuitive Touch Screen Controls Factory Presets Enable Out of Box Operation All Signals Captured Non-Invasively
  • 10. Rodent Surgical Monitoring In Review Comprehensive monitoring offers greater consistency and confidence Consistent Interventions + Higher Survival Rate = Better Outcomes The MouseMonitor S is the only preclinical research device that measures every key vital sign in one device Click Here For More Information
  • 11. How important do you view rodent surgical monitoring? Very Important Important Somewhat Important 0% 10% 20% 30% 40% 50% 60%
  • 12. What does the MPC Offer? The Mouse Phenotyping Core is a comprehensive facility offering expertise in the following areas: Imaging Metabolic Assays Cardiovasuclar Assays Respiratory Assays Neuromuscular Assessment Surgical services
  • 13. What does the MPC Offer? MPC Cont. Fee-for-service Core located at BCM Can accept animals (rats/mice) from outside facilities post veterinary approval Can run long term studies and provide data analysis Contact Information: Corey L. Reynolds 713-798-5040--------Clreynol@bcm.edu
  • 14. Challenges in a Core Lab… Species Clients/PIs Many Different Procedures Protocols
  • 15. Recommendations By The NRC Guide for the Care and Use of Laboratory Animals , 8th ed. Providing Artificial Heating (p119) Monitoring baseline vital signs, including: Heart Rate (p119) Core Temperature (p119) Blood Oxygenation (p122)
  • 16. What a Core Lab Needs… Core temperature monitoring & adjustable heating. ECG/Heart Rate electrode flexibility for different-sized species. Blood Oxygenation (SpO2) monitoring. Compact Comprehensive Surgical monitoring.
  • 17. Advantages of Integrated Monitoring & Recording Easy Screenshots Easy Recordings
  • 18. Advantages of Integrated Monitoring & Recording Constant Monitoring of Animal Vitals During Surgery Documentation of Monitoring Very Liked by IACUC committee.
  • 19. Applications In The Mouse Phenotyping Core Multiple Hi-Resolution ECG leads enable easier Morphology Recognition & Arrhythmia Detection Sinus Rhythm with Bigeminal PVCs
  • 20. Applications In The Mouse Phenotyping Core Serial Ultrasound (Vevo) B-Mode and ECG capture for analysis ECG data integrates effectively with other equipment as well
  • 21. What factors influence how frequently you utilize surgical monitoring? My current setup takes too much time to use I am working on setting up my lab I don’t currently have suitable monitoring equipment My current setup doesn’t work properly 0% 5% 10% 15% 20% 25% 30% 35%
  • 22. Myocardial Infarction (by Left Coronary Artery Decending (LAD) Ligation)C Universal definition of myocardial infarction. Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Eur Heart J (2007) 28 (20): 2525-2538.
  • 23. Post-MI Cardiac Remodeling Yabluchanskiy et al. Congest Heart Fail. 2013
  • 24. Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
  • 25. Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
  • 26. Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
  • 27. Lindsey Lab: MMPs & Impacts on Cardiac Remodeling
  • 28. Lindsey Lab – Current Research Areas Effects of MMP-9 deletion in aging mice post-MI Effects of MMP-9 deletion post-MI in mice with P. gingivalis infection Effects of MMPs derived peptides in vitro and in vivo Effects of selective MMP inhibitors post-MI
  • 29. ECG Before LAD Ligation
  • 30. ECG 5 Min After LAD Ligation
  • 31. Critical Needs in our Lab For In Vivo Models Reliable & accurate ECG recording Comfortable size of the pad Multiple leads choice External temperature probe External and internal ECG electrodes Portable tablet system Controlled heated pad Data management/export
  • 32. Thank you for taking part in this event. We encourage all attendees to register at www.insidescientific.com for notifications about future webinars. WEBSERIES COMING SOON… PV Loops to Measure Cardiac Function Implantable Biotelemetry Non-Invasive Blood Pressure Monitoring