1. The document discusses drugs that affect the endocrine system, focusing on the hypothalamus and pituitary hormones.
2. It provides an overview of the hypothalamus and anterior pituitary hormones, describing how the hypothalamus regulates the pituitary gland and the roles of hormones like growth hormone, gonadotropins, prolactin, and adrenocorticotropic hormone.
3. The summary highlights the interactions between the hypothalamus and pituitary gland and some of the pharmacological effects and clinical uses of specific anterior pituitary hormones.
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
This note will be helpful for Pharmacy Students searching for analogues and inhibitors of various hormones in human body.
- anterior Pituitary hormones
- hormone functions
-inhibitors
-similar working drugs
-one day assignment size
Introduction to the endocrine system
Growth hormone: Mechanism of Action, secretion, regulation.
Prolactin
Sex hormones
Oral contraceptives
Corticosteroids
This note will be helpful for Pharmacy Students searching for analogues and inhibitors of various hormones in human body.
- anterior Pituitary hormones
- hormone functions
-inhibitors
-similar working drugs
-one day assignment size
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
Endocrine lecture HYPOTHALAMUS AND PITUITARY HORMONES 2023.pptx
1. Drugs affecting endocrine
system. Hypothalamus &
Pituitary Hormones.
SULAYMAN ADEMOLA
Department of Pharmacology
MEDICAL SCHOOL,IUIU
IUIU
2. BIBLIOGRAPHY
• Goodman and Gilman’s. The pharmacological basis of
therapeutics.
• Basic and Clinical Pharmacology. Bertram G. Katzung.
• Pharmacology. Rang and Dale’s. 6th edition.
• Pharmacology. 3rd edition. Lippincott´s.
3. SUMMARY
1. Introduction to endocrine system.
2. Introduction to Hypothalamus Hormones
3. Anterior pituitary hormones.
5. • Are recognized six main groups of drugs acting on
endocrine system. Some of them are employed in
clinical practice like replacement therapy because
these types of drugs can act as natural hormone
secretion.
• Others may act stimulating the natural hormonal
production, secretion or potentiating their
physiological action.
• But, also are employed in clinical practice a lot of
drugs which can act on contrary, by inhibition of
natural hormone action in biochemical or
physiological level.
Introduction
6. The Hypothalamus
Small structure at the base of
the brain.
Regulates many body
functions, including appetite
and body temperature.
Regulates the pituitary gland.
7. What is the endocrine system?
The primary
endocrine glands are
Hypothalamus (the
master gland), the
pituitary, pineal,
thyroid, parathyroid,
islets of Langerhans,
adrenals, ovaries in
the female and testes
in the male.
The function of the endocrine system is the
production and regulation of chemical
substances called hormones.
8. Hormones…
A hormone is a chemical transmitter. It is released
in small amounts from glands, and is transported
in the bloodstream to target organs or other cells.
Hormones are chemical messengers, transferring
information and instructions from one set of cells
to another.
9. The Pituitary Gland
• A sort of master gland.
• It is a cherry-sized
endocrine gland.
• The hormones it
secretes affect the
growth and secretion of
other endocrine glands.
• The real boss is the
hypothalamus.
10. Interaction between hypothalamus and
pituitary (hypothalamic-pituitary axis)
HIPÓFISIS
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Hipotálamo
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RM
O
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LIBERA
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S
GL
ÁNDULA
S
Hypothalamus
Anterior
pituitary
Endocrine Glands
ORGANS
Releasing Factors Inhibitory Factors
This interaction
is a feedback
control system.
13. Anterior Pituitary
• Derived during embryological development from
the roof of the mouth.
• Most of the hormones are released from the
anterior pituitary.
• Hormones released from the anterior pituitary
are dormant unless directed to be released by
the hypothalamus via Releasing Factors.
• They are:
Growth hormone (GH), Luteinizing hormone
(LH), Follicle stimulating hormone (FSH),
Prolactin (PRL), Adrenocorticotropic hormone
(ACTH), Thyroid stimulating hormone (TSH).
14. Hypothalamic Hormones:
Gondotropin RF Corticotropin RF
(CRF)
Thyrotropin RF Growth Hor RF
Pituitary Hormones:
Follicle SH &
Lutenizing Hor.
Thyrotropin SH
Adrenocorticoptropic
Hormone (ACTH)
Prolactin
Growth
Hormone
Target Gland or Structure:
Ovaries & Testes
(androgens, estrogen)
Adrenal Gland
(cortisol)
Cells of body
Thyroid Gland
(thyroxine)
Bones, breasts
& cells of body
15. Anterior Pituitary hormones & their
Receptors
They are classified according to their structure and the types of
receptors that they activate:
• GH & prolactin are single-chain protein hormones with
significant homology. Both hormones activate receptors of the
JAK/STAT superfamily (Janus kinase family of intracellular
tyrosine kinases and the Signal Transducer and Activator of
Transcription family of nuclear transcription factors).
• TSH, FSH & LH are dimeric proteins that activate G protein-
coupled receptors. They share a common chain. Their chains,
though somewhat similar to each other, differ enough to confer
receptor specificity.
• ACTH is a single peptide that is cleaved from a larger precursor
that also contains the peptide endorphin. It acts through a G
protein-coupled receptor.
16. GROWTH HORMONE (GH)
• It is a peptide hormone with 191-amino acids.
• Structurally similar to prolactin and chorionic
somatomammotropin.
• GH stimulates somatic growth and regulates metabolism.
• Growth hormone–releasing hormone (GHRH) is its major
stimulator.
• Somatostatin is the major inhibitor of its synthesis and release.
17. GROWTH HORMONE (GH)
• GH controls synthesis of insulin-like growth factor 1 (IGF-1,
also called somatomedin-C), which largely controls growth.
• Although IGF-1 is produced by many tissues, the liver is the
major source.
• A variant of IGF-1 occurs in muscle, where it plays a role in
enhancing muscle strength. It is less under control of GH than
is the liver variant.
18. GH- Pharmacological effects
• The metabolic effects of GH are biphasic.
• Initially exerts insulin-like effects, increasing
glucose uptake in muscle and fat, stimulating
amino acid uptake and protein synthesis in liver
and muscle, and inhibiting lipolysis in adipose
tissue.
• Several hours later, more profound anti–insulin-like
metabolic effects occur:
Inhibition of glucose uptake and use, causing
blood glucose and lipolysis to increase, which
increases plasma free fatty acids.
19. GH- Pharmacological effects cont.
• Promotes longitudinal growth indirectly through:
Somatomedins (IGFs).
GH stimulates growth plate cartilage & liver
synthesis of: IGF-I & IGF-II
Somatomedins are mediators of processes
promoting bone growth:
–cellular proliferation,
–increased proline to hydroxyproline conversion
(cartilage synthesis).
GH deficiency Reduced somatomedin Short
stature
25. GH- Pharmacokinetics
• Endogenous GH has a half-life of 20-25 min and is
predominantly cleared by the liver.
• Recombinant human GH (rhGH) is administered
SC 3-6 times per week.
• Peak levels occur in 2-4 hrs and active blood
levels persist for approximately 36 hrs.
• Somatropin injectable suspension is a long-acting
preparation of rhGH enclosed within
microspheres. These microspheres degrade
slowly after SC injection such that the rhGH is
released over about 1 month.
26. GH- Uses
Growth failure in pediatric patients associated with:
• GH deficiency.
• Turner’s syndrome (chromosomal anomaly in girls).
• Chronic renal failure.
• Small for gestational age babies unable to catch up by 2.
• Prader-Willi syndrome(genetic disease associated with growth f
ailure, obesity & carbohydrate intolerance).
Growth hormone deficiency in adults.
Wasting in patients with HIV infection (Increased lean body mass,
weight, and physical endurance).
(?) adult athletes – to increase muscle mass.
(?) anti-aging.
(?) Idiopathic short stature (Non-GH deficient short stature
(NGHDSS) children).
27. GH- Adverse effects
• Creutzfeldt-Jakob disease (is a brain damage).
• Children generally tolerate the treatment well: rarely-
hypothyroidism, scoliosis, intracranial hypertension.
Following rapid growth:
- Slipped capital femoral epiphyses: limp;
lower extremity pain (rare).
• In adults: peripheral edema, myalgia, arthralgia, pancreatitis,
gynecomastia. Leukemia incidence (slight increase may not
be causal). Screening suggested for hypothyroidism &
diabetes during GH treatment.
28. GH- Preparations
Recombinant forms are used.
• somatropin (191-amino acid form).
• somatrem (192 amino acid form (additional methionine).
29. GH- Antagonists
• Needed from the tendency of GH-producing cells to
form secreting tumors.
• Pituitary adenomas occur most commonly in adults.
• Acromegaly adversely affects the skeletal, muscular,
CVS, respiratory and metabolic systems.
• Small GH-secreting adenomas can be treated with GH
antagonists.
• Larger pituitary adenomas are treated with
transsphenoidal surgery or radiation.
- Somatostatin & somatostatin analogs.
- Bromocriptine- a dopamine receptor agonist reduce
the production of GH.
- Pegvisomant- prevents GH from activating its receptor.
30. SOMATOSTATIN
• Major inhibitor of GH synthesis and release.
• Also inhibits the release of TSH, insulin and
glucagon; it decreases the release of most GI
hormones and reduces gastric acid and
pancreatic secretion.
• Octreotide and Lanreotide are long-acting
analogues of somatostatin, used for the
treatment of tumours secreting vasoactive
intestinal peptide, carcinoid tumours,
glucagonomas and various pituitary adenomas.
They has a place in the therapy of acromegaly
and of bleeding oesophageal varices.
31. SOMATOSTATIN
• Generally given SC.
• Peak action is at 2 hours,
• Suppressant effect lasts for up to 8 hours.
ADR: Pain at the injection site and GI disturbances. Gallstones,
postprandial hyperglycaemia and acute hepatitis has occurred
in a few cases.
32. GONADOTROPIC HORMONES and Analogues
• FSH– stimulates gametogenesis.
• LH– regulates gonadal steroid hormone production.
• Human chorionic gonadotrophin (hCG): extracted
from urine of pregnant women. Contains the biologic
activity of LH. It is secreted by the chorion and
placenta. Stimulates ovarian corpus luteum to
produce progesterone and to maintain placenta.
• Human menopausal gonadotrophin (hMG):
extracted from urine of postmenopausal women.
Contains a mixture of LH and FSH.
33. GONADOTROPIC HORMONES
• Both control the production of the sex
hormones.
• Their synthesis and release are stimulated by
GnRH and suppressed by estrogen and
testosterone by negative feedback mechanism.
• Pulsatile GnRH is required to stimulate the
gonadotroph cells to produce and release LH &
FSH.
• Sustained, nonpulsatile administration of GnRH
or GnRH analogs inhibit the release of FSH &
LH by the pituitary in both women and men,
resulting in hypogonadism.
34. GONADOTROPIC HORMONES
• In women, they stimulate ovarian follicular
development and ovulation.
• In men, FSH acts in Sertoli cells and is
essential for spermatogenesis; LH acts on
Leydig cells of the testes to stimulate
testosterone biosynthesis.
35. GONADOTROPIC HORMONES
• Therapeutic Uses:
• Female infertility
• controlled ovarian hyperstimulation in assisted
reproductive technology (ART) such as in vitro
fertilization.
• anovulation
• Male infertility: oligospermia – hCG + hMG
• Adverse Effects:
• Multiple pregnancies (15-20%)
• Ovarian hyperstimulation (OHSS) (0.5-4%)
• Headache, Depression, Precocious puberty
• Edema, Gynecomastia in men
37. Prolactin (PRL)
• Produced in lactotrophs (constitute about 30% of the
cells of the anterior pituitary).
• The pituitary doubles in size during pregnancy, largely
because of hyperplasia and hypertrophy of lactotrophs.
• In humans, its major function is stimulating milk
production when appropriate circulating levels of
estrogens, progestins, corticosteroids, and insulin are
present. Its release also occurs during sexual activity
and stress.
• It may be a sensitive indicator of pituitary dysfunction; it
is the hormone most frequently produced in excess by
pituitary tumors and it may be one of the hormones to
become deficient from infiltrative disease or tumor
compression of the pituitary.
38. Prolactin (PRL)
• Estrogens increase both prolactin secretion and
proliferation of lactotrophs through release, from a
subset of lactotrophs, of the neuropeptide galanin.
• Prolactin production is inhibited by the catecholamine
dopamine acting through the D2 subtype of dopamine
receptors.
• Agonists of Dopamine (bromocriptine, pergolide,
cabergoline, quinagolide) suppress prolactin
release. Bromocriptine and pergolide are
antiparkinson drugs.
• Dopamine antagonists (used mainly as antipsychotic
drugs) are potent stimulants of prolactin release
(chlorpromazine, thioridazine, fluphenazine,
haloperidol, etc.).
39. Adrenocorticotropic hormone (ACTH)
• Also known as corticotropin.
• Corticotropin-releasing hormone (CRH) is the
primary stimulator of its release.
• ACTH induces the adrenal cortex to release cortisol
and several weak androgens, such as
dehydroepiandrosterone (DHEA).
• Circulating cortisol and other corticosteroids
(including exogenous corticosteroids) inhibit the
release of CRH and ACTH.
• The CRH-ACTH-cortisol axis is a central component
of the response to stress. Without ACTH, the
adrenal cortex atrophies and cortisol release virtually
ceases.
40. ACTH- Preparations
• ACTH is available as a synthetic derivative in the forms of
cosyntropin (trade name cortrosyn), and synacthen.
• Both are very rarely used in place of glucocorticoids to treat
secondary adrenal insufficiency, but are used primarily to
conduct the ACTH stimulation test.
41. Moon face in a patient suffering
Cushing’s syndrome
Signs & symptoms associated with prolonged exposure
to inappropriately high levels of hormone cortisol. Can
be caused by taking glucocorticoid drugs, or diseases that
result in excess cortisol, ACTH or CRH levels.
42. Thyroid hormones
• Thyrotrophin-releasing hormone (TRH), released
from the hypothalamus in response to various
stimuli, is the major stimulus for the release of TSH
(thyrotrophin) from the anterior pituitary.
• Thyroid gland releases two different types of
hormones:
1. Tetraiodothyronine or Thyroxine (T4) and
Triiodothyronine (T3). They have functions in
growth, metabolism and the regulation of thyroid
function.
2. Calcitonin (involved in the control of plasma
Ca2+).
43. • THE WORLD MAKES ROOM FOR PEOPLE
• WHO KNOW WHERE THEY ARE GOING