The document discusses species endemism and hotspots of endemism. It defines endemism as species that are unique to a defined geographic location and not found elsewhere. Areas with high rates of endemic species include islands, mountains, and regions like Madagascar, Southeast Asia, the Caribbean, and South Africa. However, many of these endemism hotspots are experiencing high rates of habitat destruction. The document also notes that protecting just 1.4% of the world's land containing hotspots could preserve 44% of vascular plants and 35% of terrestrial vertebrates, but these areas contain 20% of the human population and face threats from development.