1. The document discusses various strategies to overcome tumor hypoxia, including improving oxygen delivery to tumors, using hypoxic cell radiosensitizers, and hypoxia-activated cytotoxic drugs. 2. It provides examples of compounds that have shown promise in improving tumor oxygenation, such as motexafin gadolinium, as well as hypoxia-activated cytotoxic drugs like tirapazamine. 3. Hypoxia-selective gene therapy is also discussed as a potential strategy to selectively kill hypoxic tumor cells.