Target Audience
This activity has been designed to meet the educational needs of medical oncologists, radiation oncologists, surgical oncologists, APNs, RNs, pharmacists, managed care pharmacy directors, pathologists, medical directors, allied health professionals, and other physicians affiliated with medical facilities treating patients with head and neck cancers (HNC).
HNC are challenging to treat due to the complex and aggressive nature of these cancers. Timely diagnosis and referral to the appropriate specialist is imperative as early diagnosis can lead to reduced mortality. Clinical advances are evolving regarding the use of molecularly targeted therapies such as EGFR inhibitors and anti-angiogenic agents into the multidisciplinary treatment of HNC. Optimal disease management, rehabilitation, and survivorship care depend on access to a multidisciplinary team comprised of a spectrum of specialists and support services. As research advances, clinicians need to remain aware of this new evidence to understand the multidisciplinary clinical practice implications that can affect patient care. This series of live grand rounds, webinars, and enduring curriculum include a didactic presentation, case illustrations, and clinical resources and tools.
Target Audience
This activity has been designed to meet the educational needs of medical oncologists, radiation oncologists, surgical oncologists, APNs, RNs, pharmacists, managed care pharmacy directors, pathologists, medical directors, allied health professionals, and other physicians affiliated with medical facilities treating patients with head and neck cancers (HNC).
HNC are challenging to treat due to the complex and aggressive nature of these cancers. Timely diagnosis and referral to the appropriate specialist is imperative as early diagnosis can lead to reduced mortality. Clinical advances are evolving regarding the use of molecularly targeted therapies such as EGFR inhibitors and anti-angiogenic agents into the multidisciplinary treatment of HNC. Optimal disease management, rehabilitation, and survivorship care depend on access to a multidisciplinary team comprised of a spectrum of specialists and support services. As research advances, clinicians need to remain aware of this new evidence to understand the multidisciplinary clinical practice implications that can affect patient care. This series of live grand rounds, webinars, and enduring curriculum include a didactic presentation, case illustrations, and clinical resources and tools.
High Risk disease is defined as “apparent localized cancer that has a high propensity of micro-metastatic disease” (cancer that is not visible on convention radiography, such as bone and CT scans). These cancers, once removed via radiation or surgery, are likely to "return," but in fact, they were never removed in the first place because the cancer cells were outside the treated region.
Therefore, successful eradication of high risk disease requires both aggressive local control and systemic treatment with androgen deprivation therapy and extended field radiation. This lecture will review the most up-to-date data on dose-intensity radiation therapy, pelvic radiation, surgery with adjuvant radiation, and adjuvant hormone therapy. Finally, data on experimental chemotherapy and abiraterone (Zytiga) will be presented.
Acute Radiation Disease or Acute Radiation Syndromes.Dmitri Popov
An Acute Radiation Disease is a particular abnormal condition, a disorder of a structures or functions, or functions, that affects part or all of an irradiated organism. The causal study of disease is called pathology. Acute Radiation Disease is a medical condition associated with specific symptoms and signs.
The combined use of radiation therapy and chemotherapy in cancer treatment is a logical and reasonable approach that has already proven beneficial for several malignancies.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
High Risk disease is defined as “apparent localized cancer that has a high propensity of micro-metastatic disease” (cancer that is not visible on convention radiography, such as bone and CT scans). These cancers, once removed via radiation or surgery, are likely to "return," but in fact, they were never removed in the first place because the cancer cells were outside the treated region.
Therefore, successful eradication of high risk disease requires both aggressive local control and systemic treatment with androgen deprivation therapy and extended field radiation. This lecture will review the most up-to-date data on dose-intensity radiation therapy, pelvic radiation, surgery with adjuvant radiation, and adjuvant hormone therapy. Finally, data on experimental chemotherapy and abiraterone (Zytiga) will be presented.
Acute Radiation Disease or Acute Radiation Syndromes.Dmitri Popov
An Acute Radiation Disease is a particular abnormal condition, a disorder of a structures or functions, or functions, that affects part or all of an irradiated organism. The causal study of disease is called pathology. Acute Radiation Disease is a medical condition associated with specific symptoms and signs.
The combined use of radiation therapy and chemotherapy in cancer treatment is a logical and reasonable approach that has already proven beneficial for several malignancies.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
The bee swarm model of social change: How do institutions and grassroots push...Steve Zavestoski
Presentation by Tuomas Ylä-Anttila, Helsinki Research Group for Political Sociology in the University of Helsinki's Department of Social Research, at the seminar on “Sustainability Experimentation: Interplay between Grassroots and Institutions,” October 14, 2015 at the Finnish Environment Institute (SYKE).
Risk Based Testing: Deferring the Right Bugsindus329
QA InfoTech is a professional Quality Assurance and Software Testing service provider with qualified Testing Experts who are committed to provide creative QA / Testing solutions to challenging technical projects.
Presentazione progetto treviso 18.2.2012Eva Previti
Progetto Treviso di Sinistra Trevigiana, aperto alla discussione con i cittadini per la costruzione di un programma elettorale forte. In previsione delle elezioni comunali del 2013
Dans le cadre de l’émission « Vie politique » du 11 septembre 2016 sur TF1, Kantar Sofres a réalisé une étude de l’image de Marine Le Pen auprès des Français. Il apparaît que la présidente du Front National (FN) est avant toute chose reconnue pour sa forte personnalité mais sa capacité à apporter des solutions est mise en doute.
http://fr.kantar.com/elections/presidentielle/2017/marine-le-pen-qu-en-pensent-les-francais/
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. What’s changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Software Delivery At the Speed of AI: Inflectra Invests In AI-Powered QualityInflectra
In this insightful webinar, Inflectra explores how artificial intelligence (AI) is transforming software development and testing. Discover how AI-powered tools are revolutionizing every stage of the software development lifecycle (SDLC), from design and prototyping to testing, deployment, and monitoring.
Learn about:
• The Future of Testing: How AI is shifting testing towards verification, analysis, and higher-level skills, while reducing repetitive tasks.
• Test Automation: How AI-powered test case generation, optimization, and self-healing tests are making testing more efficient and effective.
• Visual Testing: Explore the emerging capabilities of AI in visual testing and how it's set to revolutionize UI verification.
• Inflectra's AI Solutions: See demonstrations of Inflectra's cutting-edge AI tools like the ChatGPT plugin and Azure Open AI platform, designed to streamline your testing process.
Whether you're a developer, tester, or QA professional, this webinar will give you valuable insights into how AI is shaping the future of software delivery.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
How might basic research on low dose ionizing radiation influence future radiation protection programs morgan
1. How Might Basic Research on
Low Dose Ionizing Radiation
Influence Future Radiation
Protection Programs
William F. Morgan, Ph.D., D.Sc.
Biological Sciences Division
Pacific Northwest National Laboratory
Richland, Washington
USA
2. Disclosures:
Member of NCRP, ICRP and
consultant for UNSCEAR - vested
interest in this issue.
But these are my opinions!
Outline of presentation:
Why it is important
My research interests
Future directions
3. Mans Radiation Burden
Cosmic rays
Air (radon)
Building material
Water
Food
Earth
Air travel
Testing fallout
TV & luminous
watches
Nuclear power
plants (20%)
Radioactive waste
Diagnostic &
therapeutic
radiation*
*> 200 million procedures/year (USA), 2 billion worldwide
6. CT Over-Exposure To A Young Patient
Fell from bed and complained of neck pain the following morning
Plain x-rays and then a CT scan of neck ordered by ER
CT table did not index (move) and radiologic technologist manually instituted 151 slices over a
period of more than 1 hour
The patient was successfully rescanned by another technician
About 2-3 hours after the first CT attempt he developed a red line around his face at the level of
the 151 CT scan slices
7. US scientists are
warning that radiation
from controversial full-
body airport scanners
has been dangerously
underestimated and
could lead to an
increased risk of skin
cancer - particularly in
children.
http://www.news.com.au/travel/news/naked-
scanners-may-increase-cancer-risk
8. This is why we have radiation
protection programs and what
radiation protection is all about!
So where does the information
regarding the health effects of
ionizing radiation come from?
9. Most of our understanding of radiation effects
comes following a single acute exposure
10. Radiation Effects Research Foundation
(Hiroshima) a unique resource
~ 43% survivors still alive
In the laboratory acute exposures
practical and convenient
Radiation Dose
Effect
?
13. Research Interests
Understanding effects of exposure
to low dose (<100mGy), low dose
rate ionizing radiation, the potential
consequences of such exposure(s)
and how to translate these data to
radiation risk.
14. How to extrapolate biological
effects at low doses to risk?
Are extrapolations from “high
dose” acute exposures
appropriate when human
exposure is primarily chronic
low dose exposure?
Questions In the Context
Of Radiation Protection
15. .01 .05 .1 101.0 4.0 100
A-bomb Survivor data
Supra-linearity
Dose (Sv)
Background
The dilemma for radiation protection: what is
the scientific basis for radiation standards to protect the public
from exposures to low levels of ionizing radiation (<0.1 Sv) where
there are considerable uncertainties in the epidemiological data.
Sub-linearity
Hormesis
LNT
RadiationRelatedCancerRisk
16. Radiation Protection Considerations
Science is only one input to risk management
What are the other inputs?
Tradition
Not scaring people
Politics
Social values
Economic considerations
Technological considerations
We have a long legacy of mistrust to deal with!
Plus some widely diverging opinions
Hormesis - tolerance - acceptance - total denial
17. Ionizing radiation Has The Potential
To Cause Detrimental Effects:
All radiation is bad and should be eliminated or
reduced to a level as low as reasonably
achievable (ALARA).
18. On the other hand - complex biological systems have
physiological barriers against damage and disease. Primary
damage linear with dose, secondary damage not. Cellular
processes block damage propagation to clinical disease.
19.
20. The Radiendocrinator (ca. 1930)
Gold plated Radiendocrinator sold in its velvet lined pocket for $150. Beta-
gamma GM detector ~ 200 mR/hr.
22. Epidemiology versus Biology
Epidemiology is fraught with
uncertainties…..So what is the
biological data (presumably the
mechanisms) that can help us
understand the potential effects
of exposure to ionizing radiation?
23. Any exposure has the potential for risk
Genetics
Environment
Diet
Lifestyle
The Current Paradigm For Risk
25. 25
In addition to targeted effects we must
consider the impact of non-targeted effects
Targeted cell
Survives and
proliferates
Secreted / shed factors
gap junction
communication
Bystander cell
26. Radiation-Induced Genomic Instability
Increased rate of genomic alterations in the
progeny of irradiated cells
Irradiation
Manifests as:
chromosomal rearrangements
micronuclei
aneuploidy
delayed mutation
(spectrum different)
gene amplification
cell killing
Non clonal - not necessarily a
fixed genetic change that is
passed on.
31. Radiation-Induced Instability Can
Occur In Non-Targeted Cells:
Instability observed in cells not traversed
by an alpha particle
Kadhim et al. Nature 355, 738-40 (1992)
Shielded grid experiment
Lorrimore et al. PNAS 95, 5730-3 (1998)
secreted factor?
cell to cell gap junction communication*?
dead / dying cells*?
*Not in our cell system
32. Radiation Induced Bystander Effects:
Effects observed in cells that were not
irradiated but were “bystanders” at the time of
irradiation
Single cell microbeam irradiation
1 cell irradiated
Single particle
33. Radiation induced bystander effects:
Effects observed in cells that were not
irradiated but were “bystanders” at the time
of irradiation
Single cell microbeam irradiation
1 cell irradiated
gene expression
mutation
transformation
micronuclei
cell killing
Why?
34. Bystander effects in
an in vivo human
skin model (3D).
Belyakov et al. PNAS 102,
14203-7 (2005)
Beneficial? Eliminating damaged or initiated cells
Detrimental? Inducing damage in non-irradiated cells
35. Implanted
LLC cells
Abscopal “Anti-Tumor” Effects In Vivo
5 x 10Gy
12 x 2Gy
fractionated
Significant delay in LLC cell growth.
Camphausen et al. Cancer Res. 63, 1990-1993 (2003)
36. 76 year old male with back pain
Thoracic and abdominal CT scans
thoracic vertebral bone metastasis
and hepatocellular carcinoma
36Gy to the bone mass
regression of hepatic lesions
Ohba et al. Gut 43, 575-577, (1998)
Retrospective
analysis of
serum
concentration
s of IL-1 beta,
IL-2, IL-4, IL-6,
HGF, and
TNF-alpha
Abscopal
Effects:
38. Clastogenic Factors In Plasma From:
Accidentally irradiated individuals
Goh & Sumner, Radiation Res. 35, 171-181 (1968)
Therapeutically irradiated individuals
Hollowell & Littlefield, PSEBM. 129, 240-244 (1968)
A-bomb survivors
Pant & Kamada, Hiroshima J. Med. Sci. 26, 149-154 (1977)
Chernobyl clean up workers
Emerit et al., J. Cancer Res. Clin. Oncol. 120, 558-561 (1994)
Children exposed after Chernobyl
Emerit et al., Mutation Res. 373, 47-54 (1997)
CF-Nelson rats
Fagnet et al., Cancer Genet. Cytogenet. 12, 73-83 (1984)
Patients with chromosome fragility syndromes
Bloom syndrome, Fanconi anemia, XP and AT
39. .01 .05 .1 101.0 4.0 100
A-bomb Survivor data
Supra-linearity
Dose (Sv)
Background
The dilemma for radiation protection: what is
the scientific basis for radiation standards to protect the public
from exposures to low levels of ionizing radiation (<0.1 Sv) where
there are considerable uncertainties in the epidemiological data.
Sub-linearity
Hormesis
LNT
RadiationRelatedCancerRisk
40. Linear Non-Threshold is a Model/Hypothesis:
As such it has been used and abused!
Goal: public and worker protection
Assumes: Correctly that
Tissues/organs differentially sensitive
Risk varies with
Age
Sex
Socio economic status
Diet and lifestyle
Genetic makeup and race
Dose and dose rate
Radiation quality
41. Questions: How to design a system that limits risk?
How do we assign a potential human health risk?
Caveats: This system must take into account :
The most sensitive organ (breast)*?
The most sensitive individual*?
Where do you draw this line for regulatory purposes?
* Ethical and legal questions
Radiation
resistant
Radiation
sensitive
42. Extrapolation From Experimental Systems:
Cells tissues organs man
What does in vitro cell culture tell us
about a response in humans?
What do in vivo models tell us about a
response in humans - how do you
extrapolate from an an animal model to
the human population? Should you?
43. How do you communicate radiation risk when
the “so called experts” do not agree?
Disasters/crises make the news!
The public reads/listens to the news.
The public votes for politicians
Politicians dictate policy
Regulators have to implement the policy
So where is the science?
Lets take for example the increasing use of
CT scans
44. Brenner & Hall; “Computed tomography - An increasing source of radiation
exposure” NEJM 357, 2277-2284 (2007)
Scott, Sanders, Mitchel & Boreham; “CT scans may reduce rather than
increase the risk of cancer” J. Amer. Phys & Surg. 13, 8-11 (2008)
45. What About in the Low Dose Region?
BEIR VII cited 1386 peer reviewed publications
French Academie des Sciences cited 306 publications
Overlap in publications cited = 68
46. My thoughts.
Epidemiology is unlikely to provide definitive
information - always “uncertainty”.
Radiobiology - mechanisms not risk.
The current system works - mortality data from
nuclear power workers - “healthy workers”
Hard to fault regulatory bodies for endorsing the
middle ground of a LNT cancer risk model
Life is dangerous - keep radiation in perspective.
47. OK - but given ionizing radiation is
probably the best studied human
carcinogen, how can we understand
its mechanism of action?
The Pacific Northwest National Laboratories
Integrated Systems Biology Approach to
Understanding Potential Effects Associated
with Exposure to Ionizing Radiation.
51. What is Systems Biology?
The quantitative study of biological networks and
pathways as integrated systems rather than as a
set of isolated parts.
Requires a long term investment in:
Expertise
biologists, chemists, physicists
instrumentation & applied technology specialists
mathematicians & computational scientists
skilled laboratory technicians
Time - infrastructure and expertise
Technologies & development
Ego suppression
52. 52
A System Is A Result Of Interacting Parts:
An “interesting” part is one
for which the
consequences of
interaction is non-trivial
The sum of the system is
greater than the sum of
the parts.
Biological systems are
defined by multiple
redundant and
interdependent signaling
networks and metabolic
pathways
53. 53
Context Cannot Be Accurately Predicted
Without Multiple Sources Of Data
Well-designed studies with
appropriate controls
Gene expression data does
not predict protein
abundance
Protein abundance data does
not predict protein function
Single time points do not
provide directionality for
correlation to functional
outcomes
Network reconstruction requires
heterogeneous data for dose and
dose rate-dependent and temporal
measurements
55. 55
Key Event Networks connect molecular
networks to population dynamics
Edwards & Preston (2008), Tox Sci, 106(2):312-318
56. Hopefully PNNL’s systems
radiation biology program will
contribute to understanding the
long term health effects of
exposure to ionizing radiations
But even if we do - will protection
standards ever be based on
scientific evidence?