This document presents a study on the effect of irregular mass distribution on the seismic response of reinforced concrete frame structures. Four 12-story building models with different eccentricity ratios between the mass and stiffness centers were analyzed using equivalent static force and response spectrum methods. The results show that maximum lateral displacement at the roof level increases as the eccentricity ratio increases. Irregular mass distribution is found to be harmful for seismic performance of buildings. The study concludes it is important to have regular and uniform mass distribution in structures to reduce seismic effects.