Oral cancer is one of the deadliest diseases affecting the human population, being one among the top ten causes of death occurring worldwide. Its high morbidity and mortality rate has not changed for the past 30 years, even after revolutions that are happening in its diagnosis and management. This alarming stage is a sequelae of its late diagnosis, with 80% of cases being diagnosed at late stages. A good number of screening techniques have been time tested for the predictive value in diagnosing oral cancer in an early premalignant stage. Although surgical biopsy is a gold standard for diagnosing, it needs professional services. Hence screening methods which are noninvasive and highly sensitive are accepted as an alternative of histopathology. Vital staining and vizilite are widely accepted methods among all the screening techniques and are widely used in a clinical setup.