Cervical cancer is a major cause of cancer deaths in India. It is caused by the human papillomavirus (HPV) and other risk factors include multiple sexual partners, smoking, and low nutrition. Early detection through regular Pap smears can detect precancerous cells so the condition can be treated before it develops into cancer. Prevention includes limiting sexual partners, HPV vaccination, and regular screening. The HPV vaccine provides nearly 100% protection against HPV types known to cause cervical cancer if administered before potential exposure to the virus.
breast cancer
cancer
epidemiology
community medicine
awareness of breast cancer
سرطان الثدي
وبائيات سرطان الثدي
epidemiology of breast cancer
prevention of breast cancer
risk factors of breast cancer
epidemiology of breast cancer in iraq
sign and symptoms of breast cancer
location of breast cancer
The presentation describes various facts about breast and cervical cancer including burden of disease, survival outcomes, need for early diagnosis and screening recommendations.
breast cancer
cancer
epidemiology
community medicine
awareness of breast cancer
سرطان الثدي
وبائيات سرطان الثدي
epidemiology of breast cancer
prevention of breast cancer
risk factors of breast cancer
epidemiology of breast cancer in iraq
sign and symptoms of breast cancer
location of breast cancer
The presentation describes various facts about breast and cervical cancer including burden of disease, survival outcomes, need for early diagnosis and screening recommendations.
Cervical Cancer is common worldwide , ranking 3rd among all malignancies for women.
Second leading cause of cancer death.
Most of these cancers stem from infection with the Human Pappiloma Virus (HPV).
Dr. Pk Das Is one of the famous and highly qualified doctor of cancer. He is a cervical cancer specialist in Delhi NCR. Consult Dr.PK Das for all cervical cancer related queries.
Cancer of the cervix occurs when the cells of the cervix change in a way that leads to abnormal growth and invasion of other tissues or organs of the body.
Welcoming remarks by Dr Osborne E Nyandiva on Symposium: Cervical cancer and its prevention
Co-Presenter Dr Giama. We are happy to present to you this very crucial discussion on Cancer.
Cervical cancer is a type of cancer that develops in a woman's cervix (the entrance to the womb from the vagina).
Cancer of the cervix often has no symptoms in its early stages. If you do have symptoms, the most common is unusual vaginal bleeding, which can occur after sex, in between periods or after the menopause.
According to Dr. Vo Dang Hung, Director of TMMC Healthcare's Oncology Center. Breast Cancer is the most popular cancer among women. Know your risks and get frequent Breast Cancer Screenings to protect yourself.
Myths And Facts About Breast Cancer.
Breast cancer is the most common cancer in the world, with around 2.26 million new cases diagnosed each year. With around 0.7 million fatalities per year worldwide, it is one of the major causes of death among female cancer patients. It is quite common in those aged 25 to 70, with peak prevalence in women aged 50 to 69.
Breast cancer occurs when a pre-cancerous tumour progresses to a malignant tumour in a multi-stage process that is triggered by abnormal and uncontrolled growth of normal cells. These abnormalities are brought on by physical carcinogens (ultraviolet and ionising radiation), chemical carcinogens (alcohol, aflatoxin, tobacco smoke), and biological carcinogens (viral infections, bacteria, or parasites). Breast cancer risk is also increased by genetic factors. 5 to 10% of breast cancer instances are caused by genetic abnormalities passed down through a family’s generations.
Cervical Cancer is common worldwide , ranking 3rd among all malignancies for women.
Second leading cause of cancer death.
Most of these cancers stem from infection with the Human Pappiloma Virus (HPV).
Dr. Pk Das Is one of the famous and highly qualified doctor of cancer. He is a cervical cancer specialist in Delhi NCR. Consult Dr.PK Das for all cervical cancer related queries.
Cancer of the cervix occurs when the cells of the cervix change in a way that leads to abnormal growth and invasion of other tissues or organs of the body.
Welcoming remarks by Dr Osborne E Nyandiva on Symposium: Cervical cancer and its prevention
Co-Presenter Dr Giama. We are happy to present to you this very crucial discussion on Cancer.
Cervical cancer is a type of cancer that develops in a woman's cervix (the entrance to the womb from the vagina).
Cancer of the cervix often has no symptoms in its early stages. If you do have symptoms, the most common is unusual vaginal bleeding, which can occur after sex, in between periods or after the menopause.
According to Dr. Vo Dang Hung, Director of TMMC Healthcare's Oncology Center. Breast Cancer is the most popular cancer among women. Know your risks and get frequent Breast Cancer Screenings to protect yourself.
Myths And Facts About Breast Cancer.
Breast cancer is the most common cancer in the world, with around 2.26 million new cases diagnosed each year. With around 0.7 million fatalities per year worldwide, it is one of the major causes of death among female cancer patients. It is quite common in those aged 25 to 70, with peak prevalence in women aged 50 to 69.
Breast cancer occurs when a pre-cancerous tumour progresses to a malignant tumour in a multi-stage process that is triggered by abnormal and uncontrolled growth of normal cells. These abnormalities are brought on by physical carcinogens (ultraviolet and ionising radiation), chemical carcinogens (alcohol, aflatoxin, tobacco smoke), and biological carcinogens (viral infections, bacteria, or parasites). Breast cancer risk is also increased by genetic factors. 5 to 10% of breast cancer instances are caused by genetic abnormalities passed down through a family’s generations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
1. RAJKUMARI AMRIT KUR COLLEGE OF NURSING
HEALTH EDUCATION
ON
PREVENTION OF CERVICAL CANCER
SUBMITTED TO:-MRS SARITA SHOKANDA SUBMITTED BY:-MS VERSHA CHAUHAN
ASSISSTANT PROFESSOR MSc Nsg 1st
year
2. R.A.K.College of Nursing R.A.K. College of Nursing
IDENTIFICATION DATA
1) Name of the student teacher :- Ms. Versha Chauhan
2) Class : - M.Sc. (Nsg.) 1st Year
3) Subject :- Community health nursing
4) Topic :- Cervical cancer
5) Group :- Family
6) Venue :- OPD BLOCK,R.F.T.C,CHHAWLA
7) Language: - Hindi
8) Method of Teaching : - Health Talk
9) Previous Knowledge : - Group has basic knowledge of A.V AIDS
GENERALOBJECTIVES
At the end of the health talk the group will be able to:-
1. Define cervical cancer.
2. Enlist the causes and risk factors of cervical cancer.
3. Enlist the symptoms of cervical cancer.
4. To know the prevention of cervical cancer.
5. To know about HPV vaccination.
3. TIME SPECIFIC
OBJECTIVE
CONTENT TEACHING LEARNING
ACTIVITY
AV
AIDS
EVALUATION
1min To introduce the
topic.
INTRODUCTION
Cervical cancer has beaten breast
cancer as the leading cause of cancer
deaths in women in India; it kills
around 33,000 women every year in
India. Cervical cancer is known to
occur because of a virus called
the Human Papilloma Virus (HPV)
transmitted through sexual contact.
Bad local hygiene, too many
children, not enough spacing
between children, low nutrition
levels and early marriage all
contribute to the risk factors. The
high risk group includes girls who
have had premature sex as teenagers,
those who have had multiple
pregnancies or multiple sex partners
and don’t use contraceptives. The
disease remains asymptomatic for a
long time till it starts invading
neighbouring tissues.
Approximately 0.6 percent of
women will be diagnosed with cervical
cancer at some point during their
lifetime, based on 2012-2014 data. The
current estimates indicate
approximately 132,000 new
cases diagnosed and 74,000 deaths
annually in India, accounting to nearly
1/3rd
of the global cervical cancer
4. deaths. Indian women face a 2.5%
cumulative lifetime risk and 1.4%
cumulative death risk from cervical
cancer.
Rates are also high in developing
nations, where more than 80% of
cervical cancer cases occur.
Worldwide, cervical cancer is the third
most common cancer among women
and the second most frequent cause of
cancer-related death, accounting for
nearly 300,000 deaths annually.( 2013)
India has a population of
approximately 365.71 million women
above 15 years of age, who are at risk
of developing cervical cancer. ... At
any given time, about 6.6% of women
in the general population are estimated
to harbor cervical HPV infection.
Cervical cancer, mainly caused by
Human Papillomavirus infection, is the
leading cancer in Indian women and
the second most common cancer in
women worldwide. Though there are
several methods of prevention of
cervical cancer, prevention by
vaccination is emerging as the most
effective option, with the availability of
two vaccines.
1 min To define
cervical cancer.
DEFINITION
Cervical cancer is a malignant tumor
deriving from cells of the "cervix uteri",
which is the lower part, the "neck" of the
womb, the female reproductive organ.
Student teacher defines cervical cancer
with the help of charts.
CHARTS Define cervical
cancer?
5. 2 min To explain the
causes of
cervical cancer.
CAUSES OF CERVICAL CANCER
Some common causes of cervical cancer
are:
Smoking.
Family history.
Sexually transmitted disease.
Human papillomavirus (HPV).
Intake of birth control pills.
Having multiple sexual partners.
Student teacher explains causes of
cervical cancer.
CHARTS Enlist the causes of
cervical cancer?
2 min To explain the
risk factors of
cervical cancer.
RISK FACTORS
Here are some of the risk factors about
which every woman should be aware of.
Human papilloma virus (HPV) infection
Smoking
Chlamydia infection
Immunosuppression
Intake of inappropriate diet
Usage of Intrauterine device (IUD)
Having multiple full-term pregnancies
Pregnancy at a young age
Poverty
Use of hormones like Diethylstilboestrol
(DES)
Family history
Student teacher explains the risk factors
of cervical cancer.
CHARTS Enlist the risk factors
of cervical cancer?
5 min To explain the
symptoms of
cervical cancer.
SYMPTOMS OF CERVICAL CANCER
In early stages (even in the precancerous
stages), cervical cancers usually do not
cause symptoms. Only during the later
stages of cancer is when one or more of
these symptoms may be noticeable:
Student teacher explains the symptoms
of cervical cancer.
CHARTS Enlist the symptoms
of cervical cancer?
6. Abnormal bleeding
Unusual vaginal bleeding is the symptom
most strongly linked to cervical cancer,
according to the American Cancer
Society, this could be bleeding after
intercourse or between periods. Heavier-than-
normal periods or bleeding after menopause are
also potential signs of cervical cancer,
Pelvic pain
Along with abnormal bleeding, The pain
could be diffuse, or it could show up in any
area of your pelvis. It could also range from a
sharp pain to a dull ache. Especially if the pain
is new or doesn't seem related to your
menstrual cycle, you'll want to let your doctor
know about it. Pain during sex or urination are
also warning signs
Strange discharge: A cloudy, foul-
smelling discharge is also a potential red flag.
"[The discharge] could also be watery, Of
course, there are many causes of abnormal
vaginal discharge that have nothing to do with
cancer. So don't freak out. Just talk with your
doctor.
Fatigue
We can add cervical cancer to the long list
of health issues that could make you
feel fatigued or sluggish. "This isn't the first
symptom to look for, but it could be present.
However, the above symptoms can also be
caused by infections or other health
problems. Hence, it is very important to
consult your gynaecologist.
7. 2 min To describe the
diagnosis of
cervical cancer.
DIAGNOSIS
The process of transformation of a
precancerous state to cervical cancer takes
approximately 10 years or more. During this
period, a simple test called Pap smear can
detect this precancerous state.
Pap smears are recommended for all
sexually active women, the test being
repeated at three yearly intervals if normal
and at 5 yearly intervals if both Pap smear
and testing for high risk strains of HPV are
negative.
VIA, a simple test, which basically consists
of applying vinegar to the cervix and then
inspecting it, can be easily administered by
health workers. In a landmark study by Tata
Memorial Centre, Mumbai, mass screening
of women was found to reduce the risk of
dying due to cervical cancer by a whopping
30 %. It is known that mass screening for
cervical cancer once in 10 years can reduce
the incidence of this disease by 60 %!
PAP test
HPV DNA test: - Like the Pap test, the
HPV DNA test involves collecting
cells from the cervix for lab testing.
CT (computerized tomography) scan
MRI (magnetic resonance imaging
scan)
Pelvic ultrasound
Student teachers describes the diagnosis
of cervical cancer.
CHARTS Enumerate some of
the diagnostic test of
cervical cancer?
8. 2 min To discuss the
treatment of
cervical cancer.
TREATMENT
The affected area of the cervix can be
effectively treated by a gynecologist using
simple treatment methods. Here are some of
the treatment options for cervical cancer:
Precancerous changes in the cervix may be
treated with cryosurgery and laser surgery.
The treatment options for women with
cervical cancer are surgery, radiation
therapy, chemotherapy or a combination of
two or more of these methods.
Student teachers discusses the treatment
of cervical cancer.
CHARTS What type of
treatment is used for
cervical cancer?
2 min To discuss the
prognosis of
cervical cancer.
PROGNOSIS
When followed up and treated properly, pre-
cancerous conditions of cervical cancer are
completely curable. There is 92% chance of
a five-year survival for cancer that has
spread to the inside of the cervix walls but
not outside the cervix area. The five-year
survival rate falls steadily as the cancer
spreads into other areas.
Student teachers discusses the prognosis
of cervical cancer.
PPT What is the prognosis
of cervical cancer?
5 min To describe the
prevention of
cervical cancer.
PREVENTION
Here are a few things you can do to prevent
cervical cancer:
Limit the number of sexual partners
Student teacher describes the prevention
of cervical cancer.
CHARTS What precautions to
be taken for
prevention of cervical
cancer?
9. Quit smoking and avoid second-
hand smoke
Always use condoms
Schedule your Pap tests
Follow-up on abnormal Pap smears
Get the HPV vaccines
Majorityof the women become
infected with HPV at some point in
their lives, soon after the onset of sexual
activity.
The lifetime risk for genital HPV is 50–
80% and genital warts is approximately
5%.
In women who undergo routine
screening, the risk of having an
abnormal Papanicolou (Pap) smear is
35%, CIN 20% and ICC is <1%
approximately.
Both HPV Vaccination (Primary
Prevention) and Screening (Secondary
prevention) is important for prevention
of cervical cancer.
WHY VACCINATION IS THE BEST
FORM OF PREVENTION
There is no clear evidence that barrier
methods of contraception, most notably
use of condoms, confer a protection
against HPV infection.
Secondly, except for genital warts, the
infection is asymptomatic.
10. Adherence to routine screening bythe
susceptible female population through
periodic Pap smears even in developed
countries has been unsatisfactory.
In developing countries like India,
large-scale routine screening is difficult
to achieve.
DEVELOPMENT OF HPV VACCINE
HISTORY
Recombinant DNA technologyis used
to express the L1 major capsid protein
of HPV in yeasts (Saccharomyces
cerevisiae), which self-assemble to form
emptyshells resembling a virus, called
virus-like particles (VLPs).
The VLPs have the same outer L1
protein coat as HPV but contain no
genetic material.
The vaccine uses these VLPs as
antigens to induce a strongprotective
immune response.
TYPES OF HPV VACCINE
Two vaccines licensed globallyare
available in India; a quadrivalent
vaccine (Gardasil™ marketed by
Merck) and a bivalent vaccine
(Cervarix™ marketed byGlaxo Smith
Kline).
Clinical trials with both vaccines have
used efficacyagainst CIN-2/3 and
11. adenocarcinoma in situ (AIS) caused by
HPV.
These vaccines do not protect against
the serotype with which infection has
alreadyoccurred before vaccination.
GARDASIL
Gardasil™ is a mixture of L1 proteins
of HPV serotypes 16, 18, 6 and 11 with
aluminum-containing adjuvant.
Clinical trials with three doses at 0, 2
and 6 months in more than 16,000
women aged 16–26 years from five
continents, including Asia, have shown
100% efficacy.
CERVARIX
Cervarix™ is a mixture of L1 proteins
of HPV serotypes 16 and 18 with AS04
as an adjuvant.
Clinical trials with three doses at 0, 1
and 6 months in more than 18,000
women globallyhas shown 90%
efficacyagainst type 16/18- related
CIN-2/3 and AIS.
Follow-up studies in a subset of
participants over 4–5 years showed no
evidence of waning immunity.
EFFICACY OF VACCINES
Participants who were alreadypositive
to anyvaccine HPV types before
12. vaccination acquired protection against
disease caused byother vaccine types.
Additionally, 99–100% efficacywas
reported against vaccine-type related
genital warts, vaginal intraepithelial
neoplasia and vulvar intraepithelial
neoplasia.
EFFICACY OF VACCINES
Immunogenicitystudies in females
aged 9– 15 years showed antibodytiters
non-inferior to those aged 16–26 years.
In a combined analysis of all
participants over 3 years and a subset
through 5 years, efficacyagainst
vaccine-HPV type disease was 95.8%
and efficacyagainst vaccine- type-
related CIN or external genital lesions
was 100%.
Longer follow-up studies are under
way.
DOSAGE AND SCHEDULE
The vaccine dose is 0.5 mL given
intramuscularly, either in the deltoid
muscle or in the antero-lateral thigh.
It is available as a sterile suspension for
injection in a single-dose vial or a
prefilled syringe.
HPV vaccines can be given
simultaneouslywith other vaccines
such as Hepatitis B and Tdap.
13. At present, there is no data to support
the use of boosters.
DOSAGE AND SCHEDULE
The recommended age for initiation of
vaccination is 9–12 years.
Catch-up vaccination is permitted up to
the age of 26 years.
A total of three doses at 0, 2and 6
months are recommended with
Gardasil™ or 0, 1 and 6 months with
Cervarix™ (minimum interval of 4
weeks between the first and the second
dose, 12 weeks between the second and
third dose and 24 weeks between the
first and third dose).
DOSAGE AND SCHEDULE
If the HPV vaccine schedule is
interrupted, the vaccine series need not
to be restarted.
If the series is interrupted after the first
dose, the second dose should be
administered as soon as possible, with
an interval of at least 12 weeks between
the second and third doses.
If onlythe third dose is delayed, it
should be administered as soon as
possible.
SIDE EFFECT AND
CONTRAINDICATIONS
14. The most common adverse reactions
are local reactions like pain (mild to
moderate) in 83%, swelling with
erythema in 25% and systemic adverse
effects such as fever in 4% of the
vaccinees.
No serious vaccine-related adverse
events have been reported.
The HPV vaccine is currentlynot
licensed for use in female patients
younger than 9 years or older than 26
years or for use in male patients.
SIDE EFFECT AND
CONTRAINDICATIONS
It is contraindicated in people with a
historyof immediate hypersensitivityto
yeast or to anyvaccine component.
The vaccine should be deferred in
patients with moderate or severe acute
illnesses.
The vaccine maybe administered in a
sitting or lying down position and the
patient should be observed for 15 min
post-vaccination for syncope.
The vaccine is not recommended for
use in pregnant women.
Although it has not been causally
associated with adverse outcomes of
pregnancy, data are limited.
Anyexposure to the vaccine during
pregnancymust be immediately
reported.
15. Lactating women and
immunosuppressed female patients can
receive the vaccine.
The efficacyand the degree of immune
response could be poor in the
immunosuppressed group.
HPV VACCINATION IN MALE
HPV vaccine is not licensed for use
among males in India.
Efficacystudies among males are under
way. Australia is the first countryto
approve the quadrivalent HPV vaccine
in males (between 9 and 15years old),
and the vaccine was approved for
administration to males between the
ages of 9 and 26 years in other
developed nations.
8 min To discuss about
pap smear.
Up to 80% of women diagnosed with
invasive cancer of the cervix have not
had a Pap smear in the past 5 years.
Cancer of the cervix is largely a
preventable disease.
THE RISKS OF HAVING A PAP
SMEAR
There are absolutely no known medical
risks associated with Pap smear
Student teacher discusses about pap
smear.
CHARTS
&
VEDIO
What is pap smear
and what are the facts
related to pap smear?
16. screening. (However, there are medical
risks from not having a Pap smear.)
A woman may experience a small
amount of spotting (light vaginal
bleeding) immediately after a Pap
smear, but heavy or excessive bleeding
is not normal.
2 min To conclude the
topic.
CONCLUSION:
Human Papilloma Virus (HPV) vaccination is a
primary preventive measure (serotype-specific
with limited cross-protection) of carcinoma
cervix. A cost-effective second-generation
human papilloma virus (HPV) vaccine is
needed for many developing countries to
address various issues specifically linked to the
region. However, till such time, secondary
prevention through periodic cervical cancer
screening should be in place to use the existing
infrastructure and cost-effective screening
methods such as Pap smear and HPV DNA
tests. There is no risk of getting a human
papilloma virus (HPV) infection from the
vaccine as the vaccine does not contain live
virus. Human papilloma virus (HPV)
vaccination and regular screening are the most
effective ways to prevent cervical cancer.
Student teacher concluded the topic.
BIBLIOGRAPHY:-
1. BRUNNER & SUDDARTH’S, textbook of medical surgical nursing, 12th
edition, volume 1, page no. 1457-1459.