Nityananda Rasa is an herbo-mineral formulation used to treat sleep disorders and other ailments. It contains equal quantities of purified mercury, sulfur, copper and tin calcinations, along with herbs like triphala, vidanga, and chitraka. When taken before meals, it is said to alleviate symptoms of sleep disorders, obesity, tumors, and other vata-kapha disorders by reducing excess kapha and vata doshas. Modern research has shown some of its ingredients like triphala, trikatu, and chitraka have anti-cancer properties supporting its traditional uses.

1. Under the Guidance of: By:
Dr.M.S.Doddamani Dr.Lavanya.S.A
Prof & HOD 3rd Year PG Scholar
Dept of RS & BK Dept of RS & BK
TGAMC TGAMC
Bellary Bellary
1

2. INTRODUCTION
 Rasashastra has numerous formulations, in those formulations all
paradayukta kalpa can be allocated into one side, in which Khalvi
rasayanas are one among them.
 The speciality of Khalvi Rasayana lies in binding different varieties of
drugs into a single molecular form and hereby minimizing the dose and
more efficacious in their action.
 Nityananda Rasa is one such rasoushadhi which is explained in 11 of
the Rasa classics . All the texts explains this rasayoga in Shleepada
rogadhikara.
 It is also mentioned in AFI, the reference has been taken from the
B.R.Shleepada Rogadhikara.
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3. REFERENCES:
 Rasa Ratnakara
 Rasa Koumudi
 Rasa Kamadhenu
 Rasendra Saara Sangraha
 Bhaishajya Ratnavali
 Rasa Chandamshu
 Rasa Chikitsa
 Rasayana sangraha
 Bhaishajya Saara Sangraha
 Rasendra Kalpadruma
 Rasa sangraha Siddhanta
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4. ह िंगुल सम्भविं सूतिं गन्धकिं मृतताम्रकम्।
कािंस्यिं वङ्गिं रितालिं तुत्थिं शङ्गुुः विाहिका॥
त्रिकिु त्रिफला लौ िं ववडङ्गिं पिुपञ्चकम्।
चववका वपप्पलीमूलिं वुषा च वचा तथा॥
शिी पाठा देवदारु एला च वृद्धदािकम्।
त्रिवृता चचिकिं दन्ती गृह त्वा तु पृथक्-पृथक्॥
एतानि समभगानि सञ्चूर्णयय गुडकीकृ तम्।
िीतकीिसिं दत्त्वा दशगुञ्जोन्न्मतिं शुभम्॥
एकै किं भक्षयेन्न्ित्यिं शीतञ्चािु वपबेज्जलम्।
Nityananda Rasa: 4

5. श्लीपदिं कफवातोत्थिं िक्तमािंसाचितञ्च यत्।
मेदोगतिं धातुगतिं नि न्न्त िाि सिंशयुः ॥
अबुयदिं गर्णडमालाञ्च वातिक्तिं सुदारुणम्।
कफवातोद्भविं िोगमन्िवृद्चध चचिन्तिीम्॥
वातिक्ते वातकफे गुदिोगे क्रिमौ तथा।
अन्निवृद्चधिं किोत्येष बलिं वणयञ्च सुस्थताम्॥
िीमद्ग ििाथेि निममतो ववश्वसम्पदे।
नित्यािन्दिसश्चायिं म ाश्लीपदिाशिुः ॥
िक्तजे वपत्तजे चावप श्लीपदे योजयेदभुम्।
िातुः पितििं क्रकन्ञ्चद् ववध्यते श्लीपदाभये॥
5

6. Ingredients: All in equal quantity
Rasa Dravyas Kashtoushadhis
Shuddha Parada Patha
Shuddha Gandhaka Shati
Tamra Bhasma Ela
Kansya Bhasma Devadaru
Vanga Bhasma Triphala
Shuddha Haratala Vidanga
Shuddha Tuttha Trivrit
Shankha Bhasma Pippalimoola
Varatika Danti
Loha bhasma Trikatu
Chavya
Chitraka
Vacha
Hapusha
Vruddhadharuka
6

7. Method of Preparation
Prepare Kajjali using Parada &
Gandhaka.
Add rest of the Rasa dravyas and
triturate to form a homogenous
mixture
Then add the kashtoushadhi
choornas and make a homogenous
mixture.
Give one Bhavana with Hareetaki
Rasa.
7

8. Bala
Varnakara
Shleepada
Arbuda
Gandamala
Antravriddhi
Vatarakta
Krimi
Agnimandya
Guda Roga
INDICATION
DOSE – 10 Gunja
Consume this medicine in
doses of One Pill once before
taking meals
8

9. Acc to Rasa Kamadhenu
& Rasa Ratnakara
In B.R Trivrit, chitraka and danti is added as a
ingredient, where as acc to R.Ka & R.R these
are used as bhavana dravya.
Bhavana is given once in each of these drugs.
Dose is 5 Gunja.
9

10. PARADA
GANDHAKA
10

11. Parada+
Gandhaka
•Guna- snigdha
•Veerya- ushna
•Vipaka -katu
Kajjali
Karma -tridosha hara,
yogavahi, increases the
bioavailability of the drug
11

12. TAMRA
BHASMA
12

13. 13

14. 14
Krimighna, lekhana,
chakshushya

15. SHANKHA
BHASMA
15

16. Samudra
Rasa – madhura
Guna – snigdha
and laghu
Vipaka – madhura
Veerya – ushna
Saindhava
Rasa – madhura
Veerya – sheeta
Guna – laghu
Dosha –
tridoshahara
Karma – rochana,
dipana
Vida
Rasa – kshara
Guna – ushna,
teekshna, sukshma
Karma – deepana,
rochana,
vatanulomana
Souvarchala
Rasa – Katu
Guna – Vishada,
Laghu, Sukshma
Veertya – Ushna
Vipaka - Katu
Audbhida
Rasa- Tikta, Katu,
Kshara
Guna – Teekshna,
Utkledi
PANCHA
LAVANA
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17. 17

18. 18

19. Articles Supporting the action of Each ingredients
Drugs Role Author
Triphala Triphala inhibits both in vitro and in vivo
xenograft growth of pancreatic tumor
cells by inducing apoptosis
Baliga.M.S
Triphala as nano – medicine acts as
anticancer
Amit Kumar
As anticancerous Sandhya.T,
K.M .Lathika,
B.N.Pandey
Anti- inflammatory effect in the
inflamed paw of arthritis induced rats
Rasool.M.
Triphala as potential immunostimulants
and immunosuppressants
Belapurkar.P
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20. Drugs Role Author
Danti Anti-Cancerous activity on Lymphocytic
leukaemia P-388 in vitro for all five esters.
Ravindra.G
Raju.R
Trikatu Pippali inhibits the growth and motility of triple
– negative breast cancer cells
Pippali acts on hepatic cancer Gopika.U.K
Piperaceae family – bioavailability enhances to
increase the availability of seleneum, vit-B, beta-
carotene and other nutritional compounds. It
possess anti-inflamatory, thermogenic, growth
stimulatory, anti – thyroid, anti tumor activities
and acts as chemo preventative, immuno
modulatory agent.
K.Vasavirama
Mahesh
Shunti – contains 6-shogaol(pungent
compound) which is superior to conventional
chemotherapy in targeting the root cause of
breast cancer
Sayer Ji
Piper nigrum showed anticonvulsant activity in
MES and PTZ induced animal model.
Sateesh
Belemkar,
Abhimanyu
Kumar
20

21. Drugs Role Author
Vidanga Isolated embelin from vidanga have significant
potency against MCF-7 breast cancer.
Neeraj Mishra
Ethanolic extract of vidanga exhibits a significant
lipid lowering activity in rats.
Uma Bhandari
Raman Kanojia
Chavya Methanol extract of stem bark reduced the
frequency of acetic acid induced writhing in
mice, reduced Carrageenan induced paw edema
volume in rat, delayed the onset as well as
reduced the frequency of castor oil induced
diarrhoeal episodes in mice.
Md.Taufiq
Effective on MDA-MB-468 breast cancer Somchai
(thailand)
Vriddhadru Root possess Immunomodulatory effect Aney Joseph
Samuel
Mathew
Ela Oil – acts on paipillomas K.V.R.Ram
Gopal
Has significant Anti-bacterial activity Purushotam
Koushik
21

22. Drugs Role Author
Vacha It exerts its action by inhibiting different
mechanisms of free radical generation or
scavenging activity in in-vitro assays
M.Devaki
H.N.Yajurvedi
Oil of vacha is having anti cancerous activity Pravin , Dhiraj
singh Rajput
Volatile oil from roots inhibited the growth of
M.tuberculosis in a concentration of 10mg/ml.
It also inhibited the growth of gram-negative
organisms.
Cardiac depressant activity was observed with
asarone. Both showed moderate degree of
hypotensive action in anesthetized dogs.
Devadaru Immunomodulatory activity. Volatile oil
significantly inhibit neutrophil adhesion to
nylon fibers and also inhibit type III
hypersensitivity reaction.
Sumeet gupta
The alcoholic extract of stem was found to
have anti-cancer activity against human
epidermal carcinoma of the nasopharynx in
tissue culture.
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23. Drugs Role Author
Paata Methanol Extract inhibits cancer
growth & reversing many pathogenic
states associated with growth of this
cancer in mice
Meena.J
Snthy.K.S
Trivrit Methanolic extract acts on Breast
cancer
Kohli.K.R
Nipankar Kadbhane
Chitraka Anti-proliferative effects of plumbago
on SK-mel 128 melanoma cell lines
Alexander Ronald
Ramachandran
Plumbagin exhibited specific anti-
microbial activity against yeast.
Plumbagin administered to
hyperlipidaemic rabbits reduced serum
cholesterol by 53.86% and LDL-
Cholesterol by 61.91%.
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24. Research Reports
Tamra Bhasma:
 Anti-Hyperlipidaemicand cardio-protective activity of Tamra
bhasma in experimental models were evaluated. Significant
decrease in serum triglyceride levels was reported.
 Tamra bhasma given in a dose of 125mg thrice daily along with
honey in case of asthma was fount to have relief of 86.16% and
87.22% relief in main and associate symptoms. An increase in
peak expiratory flow rate was reported.
Vanga Bhasma:
 Vanga bhasma possesses significant anti-hyperglycaemic effect
against alloxan induced hyperglycaemic rats only after lon term
administration
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25. Loha Bhasma:
 Loha bhasma has significant effect in improving HDL, RBC, ESR. The
tikta rasa, laghu and ruksha guna reduced kapha-medodushti and
deepaniya guna of loha bhasma improved HDL. Removal of avarodha
of raktavaha srotas by loha bhasma resulted in improvement of RBC
By facilitation of proper nourishment to rakta dhatu. Shothahara
property of loha bhasma improved ESR.
 Loha bhasma is very effective in reversing anaemia induced by
phenyl hydrazine in wistar rats.It is a very effective Haematinic agent.
Kansya bhasma:
 Kansya bhasma has anthelmintic properties. Copper helps in
building non-specific immunity of the body, which helps the body fight
off all types of microbes as well as parasites.
 Kansya bhasma also has anti-microbial, anti-bacterial and anti-
protozoal activities.
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26. Research Reports:
Copper:
 Anti-parasitic activity of the synthesized (by polyol process) copper
nanoparticles and copper acetate solution has been reported.
 A study has exhibited that lung cancer cells respond to green synthesized
copper oxide nanoparticles with dose dependent concentration,revealed
augmented cytotoxicity in A59 cells.
Tin:
 Two new organotin-based chemotherapeutic agents have been designed and
prepared. Both exhibit potential in vitro cytotoxic activity against
mammary, liver and prostate cancer cell lines.
 The body weight studies showed that Vitamin-C stabilized Tin oxide Nano-
Particles promote a higher body weight gain compared to raw Tin oxide
nano particles.
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27. Arsenic Trisulphide:
 Arsenic Trisulphide nanoparticles and Traditional regular sized
particles can inhibit the proliferation of MUTZ-1 cells and induce
apoptosis, which may be through activating caspase-3 pathways
and increasing the proportion of G2/ M phase.
 Arsenic compounds (As2S3 & As2O3) can inhibit growth and
induce apoptosis in human ovarian and cervical cancer cells at
clinically achievable concentrations.
Calcium Carbonate:
 CaCO3 nanoparticles have exhibited promising potential as drug
carriers targeting cancer tissues and cells.
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28. Probable mode of action:
 Kajjali has ushna guna and katu vipaka which acts as yogavahi and
tridoshaghna.
 Tamra, kamsya and vanga bhasma does the lekhana karma which
helps in kaphaharana. Tamra bhasma also acts as rasayana.
 Shuddha haratala has the property of Vata kaphaharana due to its
katu, Tikta, kashaya rasa, ushna veerya and katu vipaka. It also
acts as deepana Sh.Tuttha is considered as kshara karma
karamparam which also helps in kapha and medoharana.
 Majority of the kashtoushadhis possess katu, Tikta, kashaya rasa,
ushna veerya and katu vipaka which also acts as vata kapha
shamaka. These drugs also possess the shothahara property.
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29.  In the phalashruti explained for Nityananda Rasa all the
diseases are predominant in kapha and vata dosha which is
considered as the root cause. Each and every ingredient in
Nityananda Rasa possess the quality of vata and kaphaharana.
 As mentioned earlier the drugs also does the rasayana karma
(immuno-modulator) which is more essential in these diseases.
 Drugs like Haratala , kamsya bhasma, chitraka, shunti acts as
deepana which is necessary for the rectification of agni as the
impairment of agni is considered to be the root cause for every
disease.
 As shleepada, arbuda and galaganda are meda pradhana
vyadhi, the drug also does the lekhana of kapha along with
meda.
29

30. Research Article
1. Effect of kuberaksha patra churna, vriddhadaru mula
churna and kandughna taila in Shlipada.
Goli Penchala Prasad & M.L.Naidu
30
Group 1 Group 2 Group 3
Drug Kuberaksha
patra churna &
Vruddha daru
mula choorna
• Group 1
medicines
Internally
• Kandughna taila
for E/A
Nityananda Rasa
Dose 5g twice daily • 5g Twice Daily
• Once in a day
1 TID
Duration 30 days 30 days 30 days
No of
Patients
45 45 43

31. Conclusion:
On comparison Group-2 drugs which includes both GR-1
internal drugs & Kandughna Taila external application had shown
better results in comparison with GR-1 and control drug i.e.GR-3.
External application of Kandughna taila probably takes
care of skin to restrict the periodic episodes, secondary bacterial
infections and restriction of adenolymphangitis. This may be the
main reason in minimizing periodic episodes in GR-2 in follow up
studies.
The significant effect on ESR of Group-3, Nityananda
Rasa indicates its role in reducing internal infection more potently
than GR-1 & GR-2.
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32. Market Availability
Sl
No
Pharmacy Presentation Price
1 Baidyanath 40 Tab 45/-
2 Venkateshwara
Ayurveda Nilaya
- -
3 Bhaskar Ayurvedic
pharmacy
- -
4 Dabur 60 Tab 80/-
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33. CONCLUSION
 Nityananda rasa is an effective khalveeya rasayana used mainly in the
treatment of Shleepada and arbuda.
 In total there are 11 references available for this yoga among which only
the dose and bhavana dravya differs according to few authors.
 Nityanand Rasa has therapeutic properties like lekhana, rasayana.
 It can be used for curative therapy. Ingredients used in the formulation
will act as immunomodulator. It can be used as rejuvenator & helps in
correction of metabolic defects
 This yoga has various indication, even then it is considered as best drug in the
treatment of shleepada and arbuda in day to day practise.
 Further research works is necessary to evaluate the mode of action of this drug.
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