For more than 10 years, Elliott Bennett-Guerrero, MD, has lectured on anesthesiology and directed perioperative research at Duke University. In addition to these responsibilities, Elliott Bennett-Guerrero has overseen several clinical studies as a principal investigator.
Clinical trials constitute a critical stage of clinical research and it is important to understand what clinical trials are and what forms they take. In this slide deck, we will tell you more about the types and phases of clinical trials.
Clinical trials constitute a critical stage of clinical research and it is important for you to understand what clinical trials are and what forms they take. In this slide deck, we will tell you more about the types and phases of clinical trials. The idea is to help you form a basic understanding of clinical trials. This is a two-part series and the next segment will focus on the things you must remember when preparing to publish a clinical trial manuscript.
Coming soon - Part 2: Things to remember when preparing a clinical trial manuscript
Clinical trials constitute a critical stage of clinical research and it is important to understand what clinical trials are and what forms they take. In this slide deck, we will tell you more about the types and phases of clinical trials.
Clinical trials constitute a critical stage of clinical research and it is important for you to understand what clinical trials are and what forms they take. In this slide deck, we will tell you more about the types and phases of clinical trials. The idea is to help you form a basic understanding of clinical trials. This is a two-part series and the next segment will focus on the things you must remember when preparing to publish a clinical trial manuscript.
Coming soon - Part 2: Things to remember when preparing a clinical trial manuscript
Efficacy of Information interventions in reducing transfer anxiety from a cri...Ambika Rai
Efficacy of Information interventions in reducing transfer anxiety from a critical care setting to a general ward: A systematic review and a meta-analysis
It bridges the gap between vision and the day -to -day activities of large multidisciplinary organizations.
The vision is transformed into distinct implementation phases and discrete steps, called clinical studies, each with well defined milestones and deliverables.
Fixed Trial Designs Paradigm, in particular for Phase III
-Standard trial designs allow little learningduring the conduct of the trial
-“Established”adaptations are used in group-sequential trialswhere stopping for superiority or futility can be done according to pre-defined rules at interim analyses
-Clearly separated development phases(II and III)
-If applied to all clinical projects one misses opportunitiesfor better use of information and more ethical drug development
Clinical Trials: Trial Phases and design is a ppt on the different phases of the Clinical trials from Preclinical to Phase 4and the different trial designs that can be adapted to carry out the trial in humans. Preclinical phase is the phase in which trials are carried out in animals. On sucessful conduct of animal trials trials are continued in humans after filing an IND (Investigational New Drug application). The Phases in humans range from phase 1-4 besides which an additional phase called the phase 0 may be implemented in certain trials. The phase 0, also known as the microdosing phase reduces the entire duration of the trial. After Phase 3 of the trial an NDA (New Drug application) is filed to the regulatory authority, acceptance of which allows the drug to be released into the market. The phase 4 (Post Marketing surveillance) is the phase after the marketing of the drug which helps monitor adverse effects of the drug. Clinical trial dsigns are of different types based on intervention, randomisation and grouping. Few of which are case contol study, cohort study, cross sectional study and randomised contol trials. Randomised contol trials are of different types:
Parallel design: Patients are assigned and treatment is administered to two groups simultaneously: one with the investigational drug and the other with a placebo.
Crossover: Two groups are given two different treatments (A AND B) randomisation is on whether the group is given treatment A first or treatment B first, since both groups are given both the treatments.
Latin square design: 4 different treatments are given (placebo or standard) to 4 groups. The treatment are given in such a way that each patient gets each treatment atleast once.
Factorial design: 2 or more treatments are tested simultaneously such that treatment A vs control of treatment A and treatment B vs control of treatment B can be tested simultaneously.
Initial introduction of a new drug into humans
Closely monitored, patients or normal volunteers
Metabolism and pharmacological actions of drug in humans
Side effects associated with increasing doses
Early evidence of effectiveness
Design of well-controlled, scientifically valid phase 2 studies
What Are the Different Phases of Clinical Trials?Robert Hindes MD
Well versed in clinical trials and research, particularly those targeting the treatment of hepatitis C virus infection, Robert Hindes, MD, cofounded Trek Therapeutics, PBC, where he functions as the chief medical officer. A contributor to The Lancet Infectious Diseases and other medical journals, Robert Hindes, MD, has managed different phases of clinical trials.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Traditional Medicine (TM) has been subject to substantial debate with regard to the ethics governing research in this area. The controversies have generally revolved around the unreasonable harvesting of medicinal plants, ethical accountability of researchers towards local knowledge holders and the credibility of TM as a complementary and alternative mode of treatment.
This presentation stresses the importance of understanding the 6 ethical principles governing publication in TM journals:-
1. Sustenance
2. Scientific validation
3. Informed consent
4. Reporting standards
5. Proprietary issues
6. Ethical policies and declarations
Clinical Trial Registration
International Clinical Trials Registry Platform (ICTRP)
What is the Primary Register?
Clinical Trial Registry - India (CTRI)
Goal and Objectives of the Registry
How to Register?
Efficacy of Information interventions in reducing transfer anxiety from a cri...Ambika Rai
Efficacy of Information interventions in reducing transfer anxiety from a critical care setting to a general ward: A systematic review and a meta-analysis
It bridges the gap between vision and the day -to -day activities of large multidisciplinary organizations.
The vision is transformed into distinct implementation phases and discrete steps, called clinical studies, each with well defined milestones and deliverables.
Fixed Trial Designs Paradigm, in particular for Phase III
-Standard trial designs allow little learningduring the conduct of the trial
-“Established”adaptations are used in group-sequential trialswhere stopping for superiority or futility can be done according to pre-defined rules at interim analyses
-Clearly separated development phases(II and III)
-If applied to all clinical projects one misses opportunitiesfor better use of information and more ethical drug development
Clinical Trials: Trial Phases and design is a ppt on the different phases of the Clinical trials from Preclinical to Phase 4and the different trial designs that can be adapted to carry out the trial in humans. Preclinical phase is the phase in which trials are carried out in animals. On sucessful conduct of animal trials trials are continued in humans after filing an IND (Investigational New Drug application). The Phases in humans range from phase 1-4 besides which an additional phase called the phase 0 may be implemented in certain trials. The phase 0, also known as the microdosing phase reduces the entire duration of the trial. After Phase 3 of the trial an NDA (New Drug application) is filed to the regulatory authority, acceptance of which allows the drug to be released into the market. The phase 4 (Post Marketing surveillance) is the phase after the marketing of the drug which helps monitor adverse effects of the drug. Clinical trial dsigns are of different types based on intervention, randomisation and grouping. Few of which are case contol study, cohort study, cross sectional study and randomised contol trials. Randomised contol trials are of different types:
Parallel design: Patients are assigned and treatment is administered to two groups simultaneously: one with the investigational drug and the other with a placebo.
Crossover: Two groups are given two different treatments (A AND B) randomisation is on whether the group is given treatment A first or treatment B first, since both groups are given both the treatments.
Latin square design: 4 different treatments are given (placebo or standard) to 4 groups. The treatment are given in such a way that each patient gets each treatment atleast once.
Factorial design: 2 or more treatments are tested simultaneously such that treatment A vs control of treatment A and treatment B vs control of treatment B can be tested simultaneously.
Initial introduction of a new drug into humans
Closely monitored, patients or normal volunteers
Metabolism and pharmacological actions of drug in humans
Side effects associated with increasing doses
Early evidence of effectiveness
Design of well-controlled, scientifically valid phase 2 studies
What Are the Different Phases of Clinical Trials?Robert Hindes MD
Well versed in clinical trials and research, particularly those targeting the treatment of hepatitis C virus infection, Robert Hindes, MD, cofounded Trek Therapeutics, PBC, where he functions as the chief medical officer. A contributor to The Lancet Infectious Diseases and other medical journals, Robert Hindes, MD, has managed different phases of clinical trials.
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Traditional Medicine (TM) has been subject to substantial debate with regard to the ethics governing research in this area. The controversies have generally revolved around the unreasonable harvesting of medicinal plants, ethical accountability of researchers towards local knowledge holders and the credibility of TM as a complementary and alternative mode of treatment.
This presentation stresses the importance of understanding the 6 ethical principles governing publication in TM journals:-
1. Sustenance
2. Scientific validation
3. Informed consent
4. Reporting standards
5. Proprietary issues
6. Ethical policies and declarations
Clinical Trial Registration
International Clinical Trials Registry Platform (ICTRP)
What is the Primary Register?
Clinical Trial Registry - India (CTRI)
Goal and Objectives of the Registry
How to Register?
Community foundations, health care staff and residents link arms to improve l...C.S. Mott Foundation
At its core, a community foundation is designed to help pool local resources to meet local needs while striving to actively involve residents in determining and prioritizing their community’s needs. Through its Cultivating Community Engagement Project, CFLeads, a national support organization for community foundations, is helping local philanthropies like the Foundation for the Mid South partner effectively with local nonprofits to meet local challenges.
Abstract:
We set DHT (Distributed Hash Table) centered P2P (Peer to Peer) program - Chord in to MANET (Mobile
Ad-hoc Network) in this paper. Then, we propose a new routing modified scheme Cross Modeled Chord
(CM-Chord) which bases on the unicast scheme with DHT. CM-Chord might be efficiently used to not only
provide conventional direct routing, but additionally indirect, key-based overlay routing. Our simulation
suggests that CM-Chord can markedly outperform conventional reactive Random routing (AODV). For that
reason, MANET nodes can run CM-Chord for software objective, particularly P2P applications.
Talent Talk Webinar Building A Strong Business CaseDavid Freeman
If you don’t have an applicant tracking system, tough times could lie ahead. With unemployment at an all time high, and rising monthly, expect significantly more resumes to deal with in your inbox. Your ability to find candidates with key skills, do more with less, and uncover expensive inefficiencies will be severely restricted. If you already have a talent acquisition system, you may be paying too much and not getting a proper return on that investment.
Regional Partnerships for Living Labs: the Case of Sicily and the MedLab Projectjexxon
A presentation of the process of building the TLL-Sicily Living Lab partnership and how this experience fed into the MedLab Project, for the eChallenges conference in Istanbul, October 22, 2009
The Four Phases of Clinical Trials Before Market ApprovalRobert Hindes MD
Trek Therapeutics co-founder Robert Hindes, MD was previously a member of the faculty at Yale University in Connecticut. A consultant with a strong background in the pharmaceutical industry, Robert Hindes, MD consults with drug manufacturers on clinical trials for new drugs.
process of discovery of a new drug
what are clinical trials
why clinical trials are conducted
overview of phases in a clinical trial
details about every phase
focus and purpose of conducting clinical trial
Clinical Research is a most knowledge-intensive and interesting field in the pharmaceutical industry. There are more than 2, 50,000 positions unemployed in global Pharmaceutical industry.
Clinical trials are divided into several phases to ensure the safety and effectiveness of new medical interventions, such as drugs, treatments, or medical devices, before they are approved for widespread use. Here are the typical phases of clinical trials:
Phase 0: Exploratory Study
Phase 0 trials are relatively new and not always a part of the clinical trial process. They involve a small number of participants and aim to gather initial data on how the drug or treatment behaves in the human body. These trials help researchers decide whether to move forward with larger Phase 1 trials.
Phase 1: Safety and Dosage Study
Phase 1 trials involve a small number of healthy volunteers or patients and focus on assessing the safety of the intervention and determining the appropriate dosage range. Researchers closely monitor participants for any adverse effects, evaluate how the intervention is metabolized, and gather initial data on its efficacy.
Phase 2: Expanded Safety and Efficacy Study
Phase 2 trials involve a larger number of patients who have the condition the intervention is intended to treat. These trials continue to assess safety, evaluate dosage regimens, and gather more data on the intervention's efficacy. Researchers may also explore different patient populations, dosages, or combinations with other treatments.
Phase 3: Confirmatory Study
Phase 3 trials are large-scale studies involving a significant number of patients to confirm the intervention's safety, effectiveness, and monitor any side effects. These trials often include a randomized and controlled design, comparing the new intervention against existing standard treatments or placebos. Phase 3 trials provide critical data for regulatory agencies to evaluate whether the intervention should be approved for widespread use.
Phase 4: Post-Marketing Surveillance Study
Phase 4 trials take place after the intervention has received regulatory approval and is available to the general public. They aim to monitor the intervention's long-term safety, effectiveness, and identify any rare or long-term side effects. Phase 4 trials may involve a larger and more diverse population than earlier phases.
Similar to Dr. Elliott Bennett-Guerrero and the Four Phases of Clinical Studies (20)
A New York resident, Dr. Elliott Bennett-Guerrero has a doctor of medicine degree and is currently the professor and vice chairman in the Department of Anesthesiology at Stony Brook Medicine. Dr. Elliott Bennett-Guerrero led a clinical trial in which Stony Brook tested a new coronavirus treatment.
Convalescent blood plasma therapy was a proposed treatment for coronavirus patients. The therapy consists of transfusing plasma from a person that has recovered from an infection with coronavirus. The therapy was mostly used in patients that were hospitalized or those who recently developed the condition for a few days. Multiple studies showed that the therapy could increase desirable antibodies to COVID, but in general this was not very helpful in terms of likelihood of recovery from the infection or reduction in symptoms.
Dr. Elliott Bennett-Guerrero is a professor of anesthesiology and vice-chair for clinical research at Stony Brook Medicine. Some of Dr. Elliott Bennett-Guerrero's research work focuses on treatment methods for the coronavirus disease, and on the safety of blood transfusions.
Blood transfusions are generally safe; however, there is still a possibility of complications. One of such complications is the acute immune hemolytic reaction, in which a person's immune system resists the transfusion and produces antibodies that attack the blood cells. The hemolytic reaction occurs when the donor's blood cells are not compatible with those of the recipient patient. When the immune system fights back against the transfusion, it releases a substance that can damage and harm the kidneys.
Acute immune hemolytic reactions may cause symptoms such as fever, bloody urine, or even cause a person to faint. The symptoms may appear during the procedure, or after it ends, and in some cases, a few days after. In extreme cases, the reaction can result in significant damage to a person's internal organs, including acute kidney failure. However, the reaction may pass without major damage to the body system. Doctors treat mild hemolytic reactions with pain relievers such as acetaminophen and in some cases with medications that can prevent kidney failure. Complications like this can be avoided by carefully screening all blood before transfusion.
A respected clinician, dual board-certified in anesthesiology and critical care medicine, Elliott Bennett-Guerrero, MD, is a professor of anesthesiology at Stony Brook Medicine in New York. In addition, he also serves as vice chairman for clinical research and innovation in the department of anesthesiology. At Stony Brook, Dr. Elliott Bennett-Guerrero led a significant COVID-19-related randomized trial of convalescent plasma in COVID-19-infected hospitalized patients.
In 2021, over three peer-reviewed publications suggested that convalescent plasma could help people recover from COVID-19 infection better, while the viral strain of concern was SARS-CoV- 2. The majority of these publications did not compare the efficacy of convalescent plasma in disease treatment with standard plasma. To address this concern and solidify scientific evidence, a group of researchers in New York conducted a double-bind randomized control trial that compared COVID-19 patients who were recipients of convalescent plasma with another group of COVID-19 patients who received standard plasma. As mentioned in the study category, the patients were selected randomly.
Convalescent plasma is different from standard plasma because it is collected from people who have recovered from the virus. These people have a high level of anti-viral proteins called anti-COVID antibodies. Antibodies fight diseases by hampering viral replication and mitigating the rate of cellular infection by viruses. Plasma is a blood component free of red blood cells and platelets.
The researchers saw a significant increase in antibody levels in those who received convalescent plasma compared to those given regular standard plasma. The study, however, did not observe a significant improvement in clinical outcomes, although it may have been underpowered to show small improvements attributable to the plasma.
A graduate of Harvard Medical School, Dr. Elliott Bennett Guerrero is the vice chairman and a professor of Anesthesiology at Stony Brook Medicine. In this capacity, Elliott Bennett Guerrero led a clinical trial for a coronavirus treatment with blood plasma.
In 2020, Stony Brook Medicine conducted research to see if the administration of blood plasma from individuals that have survived an infection with coronavirus -19 (COVID-19) can help patients who are hospitalized with COVID-19 infection . Convalescent plasma contains antibodies to COVID-19 and was theorized to have potential to help people who have not yet mounted an immune response to the virus. The study found that the administration of convalescent plasma increased antibodies to the virus that causes COVID-19 infection, but did not improve patient's survival or other clinical outcomes.
This clinical trial's results were published in Critical Care Medicine, which is the official journal of the Society of Critical Care Medicine (SCCM). The SCCM is the largest organization dedicated to improving the care of critically ill patients. It has members in more than 100 countries. More information about the SCCM can be found at: https://www.sccm.org
A graduate of Harvard Medical School, Elliott Bennett-Guerrero is a professor and vice-chairman of Stony Brook Medicine's department of anesthesiology. Elliott Bennett-Guerrero has conducted several studies related to COVID-19 including the use of convalescent blood plasma. A randomized clinical trial he led was published in the journal Critical Care Medicine: Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial. Critical Care Medicine. 2021 Jul 1;49(7):1015-1025. PMID: 33870923.
Convalescent blood plasma treatment has been used for patients that have the COVID-19 virus, however, studies have not shown it to be beneficial in most hospitalized patients. It involves plasma transfusion from people who have already recovered from the condition. The treatment and therapy is likely to be most beneficial in people that are in the early stage of the condition or who have a weak immune system and cannot mount their own antibody response to the infection.
The therapy can have rare side effects and risks that include allergic reactions . Although it can have risks, there were more than 500,000 people treated in the United States with the therapy and few felt any side effects.
An experienced and active ICU physician, Elliott Bennett-Guerrero is also medical director for perioperative quality and patient safety at Stony Brook Medicine. Elliott Bennett-Guerrero has conducted studies in search of new coronavirus treatments.
Stony Brook Medicine conducted a study on whether convalescent blood plasma from people with a prior Covid-19 infection can be used to help others recover from it. The clinical trial was published in Critical Care Medicine, which is the official journal of the Society of Critical Care Medicine. In the trial, Stony Brook used a test to verify whether a person who had Covid-19 had a sufficient number of IgG and IgM antibodies for use in treatment. This test analyzes a drop of blood from a fingertip and offers results in approximately 15 minutes. The study then randomized hospitalized patients with COVID-19 infection to receive either 2 bags of this "convalescent" plasma or 2 bags of standard plasma (not high in antibodies to COVID-19. The study showed that this treatment increased antibodies to COVID-19 but it did not demonstrate an improvement in patient outcome.
An accomplished anesthesiologist, Dr. Elliott Bennett-Guerrero serves as both a professor and vice president of the Department of Anesthesiology, as well as medical director for Perioperative Quality and Patient Safety, at Stony Brook Medicine. In April 2020, Dr. Elliott Bennett-Guerrero initiated a clinical study on a potential cure for ill patients who have tested positive for COVID-19.
The rapid increase in mortality rate associated with the spread of the novel coronavirus infection has spurred the urgent need for research-driven therapies. In an effort to address this issue, researchers at Stony Brook Medicine revisited a century-old approach to treating infectious diseases known as convalescent plasma. This involves introducing antibody-rich plasma from a healthy patient (who had recovered from the virus) to a sick patient's blood serum to optimize immune response to the infection.
According to Dr. Elliott Bennett-Guerrero, the lead researcher, an infected patient may gain an immune system benefit enabling recovery from the illness through an antibody-rich plasma transfusion. He also added that the approach is potentially beneficial at the early stages of the disease, when patients are yet to develop sufficient levels of antibodies to fight the infection. This study was approved by the FDA on April 2, 2020.
Based in Stony Brook, New York, Dr. Elliott Bennett-Guerrero leads the Department of Anesthesiology at Stony Brook Medicine as the vice chair of clinical research and innovation. Concurrent to this role, Dr. Elliott Bennett-Guerrero helps educate the new generation of medical professionals as a professor of anesthesiology.
A professor and vice chair for clinical research at Stony Brook School of Medicine, Dr. Elliott Bennett-Guerrero also serves as medical director of perioperative quality and patient safety in the Department of Anesthesiology. In his leadership role with the university, Dr. Elliott Bennett-Guerrero focuses a portion of his research on the safety and effectiveness of blood transfusions.
Despite the routine use of prophylactic systemic antibiotics, surgical-site infection continues to be associated with significant morbidity and cost after colorectal sur- gery. The gentamicin–collagen sponge, an implantable topical antibiotic agent, is approved for surgical implantation in 54 countries. Since 1985, more than 1 million patients have been treated with the sponges.
Some observational studies have reported that transfusion of red-cell units that have been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoingcardiac surgery may be especially vulnerable to the adverse effects of transfusion.
Perioperativebloodtransfusionsarecostlyandhavesafetyconcerns.Asa result, there have been multiple initiatives to reduce transfusion use. However, the degree to which perioperative transfusion rates vary among hospitals is unknown.
Objective Toassesshospital-levelvariationinuseofallogeneicredbloodcell(RBC), fresh-frozen plasma, and platelet transfusions in patients undergoing coronary artery bypass graft (CABG) surgery.
Despitetheroutineuseofprophylacticsystemicantibiotics,sternalwoundin- fection still occurs in 5% or more of cardiac surgical patients and is associated with signifi- cant excess morbidity, mortality, and cost. The gentamicin-collagen sponge, a surgically implantable topical antibiotic, is currently approved in 54 countries. A large, 2-center, ran- domized trial in Sweden reported in 2005 that the sponge reduced surgical site infection by 50% in cardiac patients.
An experienced anesthesiologist and perioperative specialist, Dr. Elliott Bennett-Guerrero recently accepted a position as professor and vice chair for clinical research and innovation at Stony Brook University School of Medicine. Complementing his professional work, Dr. Elliott Bennett-Guerrero has written several scholarly articles on blood transfusions in cardiac surgery.
A former participant in PBS’ Doctors’ Diaries, Dr. Elliott Bennett-Guerrero serves as the director of Perioperative Clinical Research at the Duke Clinical Research Institute. Dr. Elliott Bennett-Guerrero concurrently hosts lectures as a professor of anesthesiology at the Duke University School of Medicine.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Dr. Elliott Bennett-Guerrero and the Four Phases of Clinical Studies
1.
2. For more than 10 years, Elliott Bennett-
Guerrero, MD, has lectured on anesthesiology
and directed perioperative research at Duke
University. In addition to these responsibilities,
Elliott Bennett-Guerrero has overseen several
clinical studies as a principal investigator.
Clinical studies are comprised of four testing
levels that determine the approval or
disapproval of a particular drug or treatment,
with each stage answering a series of research
questions. The following is a general summary
of each phase:
3. Phase I —During the initial evaluation of the
medicine or procedure’s safety, researchers
utilize a small test group to determine a
dosage range and discover any side
effects.
Phase II —This period provides additional
insight on safety and assesses the drug or
treatment’s efficacy. Lasting up to several
years, Phase II involves a larger number of
participants.
4. Phase III —The third phase includes
continued supervision of safety, efficacy,
and any side effects. Further, researchers
compare results to existing products and
procedures.
Phase IV —Lastly, researchers conduct
aftermarket observation to identify and
issues linked to long-term use or involving
certain populations segments.