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Enteric Disease Management
    Within the Pipestone System
  Dr. Barry R. Kerkaert
     Pipestone, MN
www.pipestonesystem.com

               Copyright 2010 โ€“ Pipestone Veterinary
                   Clinic, Pipestone, Minnesota
History
โ€ข Pipestone Veterinary Clinic โ€“ 1942
โ€ข Mixed animal practice
  โ€“ 3 Veterinarians in 1994
  โ€“ 18 Veterinarians in 2012
โ€ข First managed farm in 1990
โ€ข Today 46 managed sow farms
  โ€“ 50% of those are filtered
โ€ข Today manage 350,000 growing pigs
Our Brands:




Copyright 2010 โ€“ Pipestone Veterinary
    Clinic, Pipestone, Minnesota
Pipestone โ€“ Pipestone
Pipestone Veterinary Clinicsโ€“home of the Pipestone System




                                                                              Independence

Pipestone

             Lincoln
                  Lyon
                         Redwood

                             Brown
                 Murray Cottonwood
                                Watonwan Earth
                                     Blue

             Rock Nobles Jackson Martin Faribault




               Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
Mission & Values
โ€ข Mission
      โ€œHelping farmers today create the farms of
     tomorrowโ€
โ€ข Values
   โ€“ Integrity
   โ€“ Caring
   โ€“ Commitment
   โ€“ Growth
   โ€“ Teamwork


              Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
The Change Imperative

โ€œWhen the rate of external change
exceeds the rate of internal change,
the end of your business is in sight.โ€

        Jack Welch, CEO General Electric
USA Swine Industry
                   Production Structure
โ€ข Traditional
    โ€“ Family farms owned sows and land
       โ€ข 60 to 200 sows
       โ€ข Two farrowings per year
       โ€ข Manure applied to land
       โ€ข Seasonal labor
โ€ข 2012 โ€“ new
    โ€“ Wide variety of ownership and size
    โ€“ Sow farms larger
        โ€ข 1,000 to 5,000 sows breed to wean (for health reasons)
        โ€ข Wean 500 to 2,400 pigs per week
    โ€“ Nursery Finisher or Wean to Finish
        โ€ข All in / All out
Evolution/Revolution to 3-Site
         Production
50 Years of Improvement
Swine Efficiency 1959โ€“2009
โ€ข   Hogs marketed increased 29%
โ€ข   Breeding herd decreased 39%
โ€ข   Over 2X carcass wt. produced/sow/per
โ€ข   Feed efficiency increased 33% / lb. carcass wt.
โ€ข   Water use reduced 41%/lb. carcass wt.
โ€ข   Total land use reduced 59%
    ๏ƒผ 78%/1000 lb. carcass wt.
โ€ข Carbon footprint reduced 35%/lb. carcass wt.


                            Source: Pork Checkoff
Genetic               DAUGHTER               GRAIN
              Source                NUCLEUS             PRODUCTION



                                      (CHM)
              Stud                  F-1 gilt                โ€œFeed
                                    Production                MILLโ€



                                    SOW FARM



                                                                Management
                                NURSERY    WEAN                 Contracts
                                     &       TO
Farmer owns                     FINISHER   FINISH




                                 Slaughter Plant



                                   Further
                                    processing
                     FRESH                          PROCESSED

                 Retail store
Disease
โ€ข Respiratory

โ€ข Enteric

โ€ข Systemic (bacterial)
  โ€“ The suisโ€™s
Disease
โ€ข Respiratory
  โ€“ PRRSv
  โ€“ SIV
  โ€“ Mycoplasma
  โ€“ Circovirus
  โ€“ Bacterial (the suisโ€™s)
     โ€ข Strep suis
     โ€ข Actinobacillus suis
     โ€ข H. parasuis
PRRSv ($5 - $7 / pig)
โ€ข Objectives
  1. Produce and deliver negative pig
     โ€ข Vaccinate if delivered to high risk area
     โ€ข Leave unvaccinated if in low risk area
  2. Deliver a PRRSv positive vaccinated piglet
     โ€ข    Utilize an PRRSv MLV vaccine
โ€ข Tools
  โ€“ Location
  โ€“ Prevention (filters)
  โ€“ Elimination
Mycoplasma / Circovirus ($2 to $7)
โ€ข Objective:
  โ€“ Sow farms + / -
  โ€“ Deliver pigs that are vaccinated and ready to grow
Swine Influenza
โ€ข Objective:
  โ€“ Deliver negative piglets


โ€ข Comments:
  โ€“ Very difficult to do consistently
ISU VDL
Dr. Jeff Lubbe BIVI
Salmonella
โ€ข Stress and contamination disease
โ€ข Objective:
  โ€“ Mitigate stresses on pigs causing the clinical
    disease
โ€ข Control
  โ€“ Vaccine for Salmonella Choleraesuis
  โ€“ Feed medication and or vaccination for Salmonella
    Typhimurium
Jeff Luebbe BIVI
Our Enteric Philosophy
โ€ข Control of gut
  โ€“ Vaccine
     โ€ข Ileitis
     โ€ข Salmonella
     โ€ข E-coli
  โ€“ Medication
     โ€ข Stategically
Todayโ€™s Feed Cost (7-20-2012)
โ€ข Corn $7.81/bu
โ€ข SBM $541.00/ton
โ€ข DDGS $278/ton


             $127 / hd!
Pipestone SGF Wean-Finish Feed Allocations & Medication Plan
 Diet         Wt         Budget                 Medication                 Cost      Cost
             Range        #/Hd                                            Per Ton   Per Pig
N1 Pellet     12-15       2.0     Mecadox(25g/ton)/Terramycin(400g/ton)    $18.68    $.02
 SB NPII      15-20       6.0     Mecadox(25g/ton)/Terramycin(400g/ton)    $18.68    $.06
SB NPII-B     20-27       6.0     Mecadox(25g/ton)/Terramycin(400g/ton)    $18.68    $.06
 SB N4        27-40        24     No Medication- Water Vaccinate             -         -

 SB N5        40-51        19     No Medication- Water Vaccinate             -         -
 SB GF1      51-76.4       49     Denagard (35g/ton)                       $15.96    $.39
 SB GF2     76.4-95.9      42     Stafac 20 (10g/ton)                      $1.65     $.03
 SB GF3     95.9-136.3     96     Stafac 20 (10g/ton)                      $1.65     $.08
 SB GF4     136.3-177     109     Stafac 20 (10g/ton)                      $1.65     $.09
 SB GF5      177-206       90     Stafac 20 (10g/ton)                      $1.65     $.07
 SB GF6      206-231      78      Stafac 20 (10g/ton)                      $1.65     $.06
 SB GF7      231-275      140     Non Medicated โ€“ Paylean (4.5 g/ton)        -         -
 SB GF8      Step-Up      100     Non Medicated โ€“ Paylean (6.75 g/ton)    TOTAL      $.86
Research and Information historically
โ€ข Information
  โ€“ PigCHAMP
  โ€“ Grow โ€“ Finish
     โ€ข Spread sheets or custom
โ€ข Research
  โ€“ On farm trials
     โ€ข Has limitations
  โ€“ Relationship with Universities
โ€ข Vendor research
Pipestone Research Committee (2009)
โ€ข Director โ€“ Dr. Scott Dee
โ€ข Members
  โ€“ Dr. Joel Nerem
  โ€“ Dr. Spencer Wayne
  โ€“ Dr. Cameron Schmitt
  โ€“ Dr. Barry Kerkaert
  โ€“ Dr. Luke Minion
  โ€“ Dan Hanson
Research and information today

โ€ข Timely

โ€ข Precision

โ€ข Complexity

โ€ข Partners

โ€ข Collaboration
Perspective on research
โ€ข New products
  โ€“ Supported by data
โ€ข Avoid internal bias from experience
โ€ข Limitations
  โ€“ Research vs. commercial out come (70%)
  โ€“ Information from other systems / sources
โ€ข Value
  โ€“ Creation
  โ€“ Intellectual property
Research investment
Perspective on Partners
โ€ข Innovative

โ€ข Collaboration

โ€ข Value

โ€ข Joint mission to improve

โ€ข Not feed
Areas of interest
โ€ข Animal health
  โ€“ PRRSv

  โ€“ Ileitis

  โ€“ Mycoplasma

  โ€“ Circovirus
Areas of interest
โ€ข Bio โ€“ security measures

โ€ข Air filtration

โ€ข Manure
Areas of interest
โ€ข Genetics

โ€ข Animal welfare

โ€ข Meat quality

โ€ข Energy / Feed presentation
Most recent trial
โ€ข Ileitis vaccine trial
Comparative efficacy of Enterisol ยฎ Ileitis versus
             Tylanยฎ feed grade.
Trial Objective
โ€ข To determine if Enterisolยฎ Ileitis vaccine performs
  better than Tylanยฎ feed grade in a step down
  program as a way to control the effects of a Lawsonia
  intracellularis infection.

โ€ข A pen level study with the primary parameter being
  feed efficiency (FE)
Materials and
Methods                    Trt    Trt Name                    Treatment Group Description
                                                40 pens of 26 pigs vaccinated with Enterisol Ileitis at day 0
                                   Enterisol and fed 10 grams Stafac per ton starting on day 40 until day
  โ€ขTrial conducted at      1     Ileitis/Stafac 120.
  Pipestone Vet Clinic                         40 pens of 26 pigs fed 100 grams of Tylan per ton from day
  research barn from 6-                        40 to day 58, followed by feeding 40 grams of Tylan per ton
                           2        Tylan      until day 120.
  28 to 12-19, 2011
  โ€ข 2080 weaned pigs
  from 2 sister sow
  farms in the Pipestone
  system.
  โ€ขPigs weighed and
  allocated to two
  treatment groups
Materials and Methods
โ€ข 2-3 pigs per pen (10% of
  population) were inoculated
  with Lawsonia intracellularis
  gut homogenate at log 4.5 x
  109
Table 2. Least square means for performance data by main effect (treatment).
                                 Performance Vaccine Treatment
                                             Results
Response variable                                      Enterisol Ileitis          Tylan    P-value1
d40-market feed to gain, lbs                                 2.97                 3.05      0.13
d-7-126 feed to gain, lbs                                   2.38 a                2.43 b    0.05
d-7-market feed to gain, lbs                                2.62                  2.70      0.06
1
    ANOVA P-value.
ab
     Means with different superscripts indicate difference at Pโ‰ค0.05 (Student's t).




0.08 / 2.70         X     $127      =     $3.76
Vaccine, Feed meds, and Treatment
                       Costs
Table 8. Least square means for treatment cost by main effect (treatment).
                                               Vaccine Treatment
Response variablei                         Enterisol Ileitis       Tylan     P-value1
Medication program cost per pig, ($)2           1.29a              1.54b     <.0001
d-7-market injectable/water med cost per
pig, ($)3                                        0.96              0.98        0.18
Conclusions
โ€ข A Lawsonia intracellularis seeder challenge model is
  possible in a large scale commercial study.

โ€ข Pigs on the Enterisol Ileitis/Stafac program had a 2.9%
  improvement in FE (P<0.05)

โ€ข Total return on investment favored the Enterisol
  Ileitis/Stafac group by $3.05.

โ€ข Today
   โ€ข $0.25 + $3.76 = $4.01   (vaccine and Stafac)
โ€œChange is:
        often desirable,
        frequently necessary,
        always inevitable.โ€
Our hobbies. . . . . . . .
THANK YOU

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Dr. Barry Kerkaert - Applying Research to Decision Making to Maximize Returns at Pipestone

  • 1. Enteric Disease Management Within the Pipestone System Dr. Barry R. Kerkaert Pipestone, MN www.pipestonesystem.com Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
  • 2. History โ€ข Pipestone Veterinary Clinic โ€“ 1942 โ€ข Mixed animal practice โ€“ 3 Veterinarians in 1994 โ€“ 18 Veterinarians in 2012 โ€ข First managed farm in 1990 โ€ข Today 46 managed sow farms โ€“ 50% of those are filtered โ€ข Today manage 350,000 growing pigs
  • 3. Our Brands: Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
  • 4. Pipestone โ€“ Pipestone Pipestone Veterinary Clinicsโ€“home of the Pipestone System Independence Pipestone Lincoln Lyon Redwood Brown Murray Cottonwood Watonwan Earth Blue Rock Nobles Jackson Martin Faribault Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
  • 5. Mission & Values โ€ข Mission โ€œHelping farmers today create the farms of tomorrowโ€ โ€ข Values โ€“ Integrity โ€“ Caring โ€“ Commitment โ€“ Growth โ€“ Teamwork Copyright 2010 โ€“ Pipestone Veterinary Clinic, Pipestone, Minnesota
  • 6. The Change Imperative โ€œWhen the rate of external change exceeds the rate of internal change, the end of your business is in sight.โ€ Jack Welch, CEO General Electric
  • 7. USA Swine Industry Production Structure โ€ข Traditional โ€“ Family farms owned sows and land โ€ข 60 to 200 sows โ€ข Two farrowings per year โ€ข Manure applied to land โ€ข Seasonal labor โ€ข 2012 โ€“ new โ€“ Wide variety of ownership and size โ€“ Sow farms larger โ€ข 1,000 to 5,000 sows breed to wean (for health reasons) โ€ข Wean 500 to 2,400 pigs per week โ€“ Nursery Finisher or Wean to Finish โ€ข All in / All out
  • 9. 50 Years of Improvement Swine Efficiency 1959โ€“2009 โ€ข Hogs marketed increased 29% โ€ข Breeding herd decreased 39% โ€ข Over 2X carcass wt. produced/sow/per โ€ข Feed efficiency increased 33% / lb. carcass wt. โ€ข Water use reduced 41%/lb. carcass wt. โ€ข Total land use reduced 59% ๏ƒผ 78%/1000 lb. carcass wt. โ€ข Carbon footprint reduced 35%/lb. carcass wt. Source: Pork Checkoff
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. Genetic DAUGHTER GRAIN Source NUCLEUS PRODUCTION (CHM) Stud F-1 gilt โ€œFeed Production MILLโ€ SOW FARM Management NURSERY WEAN Contracts & TO Farmer owns FINISHER FINISH Slaughter Plant Further processing FRESH PROCESSED Retail store
  • 16. Disease โ€ข Respiratory โ€ข Enteric โ€ข Systemic (bacterial) โ€“ The suisโ€™s
  • 17. Disease โ€ข Respiratory โ€“ PRRSv โ€“ SIV โ€“ Mycoplasma โ€“ Circovirus โ€“ Bacterial (the suisโ€™s) โ€ข Strep suis โ€ข Actinobacillus suis โ€ข H. parasuis
  • 18. PRRSv ($5 - $7 / pig) โ€ข Objectives 1. Produce and deliver negative pig โ€ข Vaccinate if delivered to high risk area โ€ข Leave unvaccinated if in low risk area 2. Deliver a PRRSv positive vaccinated piglet โ€ข Utilize an PRRSv MLV vaccine โ€ข Tools โ€“ Location โ€“ Prevention (filters) โ€“ Elimination
  • 19. Mycoplasma / Circovirus ($2 to $7) โ€ข Objective: โ€“ Sow farms + / - โ€“ Deliver pigs that are vaccinated and ready to grow
  • 20. Swine Influenza โ€ข Objective: โ€“ Deliver negative piglets โ€ข Comments: โ€“ Very difficult to do consistently
  • 23. Salmonella โ€ข Stress and contamination disease โ€ข Objective: โ€“ Mitigate stresses on pigs causing the clinical disease โ€ข Control โ€“ Vaccine for Salmonella Choleraesuis โ€“ Feed medication and or vaccination for Salmonella Typhimurium
  • 25.
  • 26. Our Enteric Philosophy โ€ข Control of gut โ€“ Vaccine โ€ข Ileitis โ€ข Salmonella โ€ข E-coli โ€“ Medication โ€ข Stategically
  • 27. Todayโ€™s Feed Cost (7-20-2012) โ€ข Corn $7.81/bu โ€ข SBM $541.00/ton โ€ข DDGS $278/ton $127 / hd!
  • 28. Pipestone SGF Wean-Finish Feed Allocations & Medication Plan Diet Wt Budget Medication Cost Cost Range #/Hd Per Ton Per Pig N1 Pellet 12-15 2.0 Mecadox(25g/ton)/Terramycin(400g/ton) $18.68 $.02 SB NPII 15-20 6.0 Mecadox(25g/ton)/Terramycin(400g/ton) $18.68 $.06 SB NPII-B 20-27 6.0 Mecadox(25g/ton)/Terramycin(400g/ton) $18.68 $.06 SB N4 27-40 24 No Medication- Water Vaccinate - - SB N5 40-51 19 No Medication- Water Vaccinate - - SB GF1 51-76.4 49 Denagard (35g/ton) $15.96 $.39 SB GF2 76.4-95.9 42 Stafac 20 (10g/ton) $1.65 $.03 SB GF3 95.9-136.3 96 Stafac 20 (10g/ton) $1.65 $.08 SB GF4 136.3-177 109 Stafac 20 (10g/ton) $1.65 $.09 SB GF5 177-206 90 Stafac 20 (10g/ton) $1.65 $.07 SB GF6 206-231 78 Stafac 20 (10g/ton) $1.65 $.06 SB GF7 231-275 140 Non Medicated โ€“ Paylean (4.5 g/ton) - - SB GF8 Step-Up 100 Non Medicated โ€“ Paylean (6.75 g/ton) TOTAL $.86
  • 29.
  • 30. Research and Information historically โ€ข Information โ€“ PigCHAMP โ€“ Grow โ€“ Finish โ€ข Spread sheets or custom โ€ข Research โ€“ On farm trials โ€ข Has limitations โ€“ Relationship with Universities โ€ข Vendor research
  • 31. Pipestone Research Committee (2009) โ€ข Director โ€“ Dr. Scott Dee โ€ข Members โ€“ Dr. Joel Nerem โ€“ Dr. Spencer Wayne โ€“ Dr. Cameron Schmitt โ€“ Dr. Barry Kerkaert โ€“ Dr. Luke Minion โ€“ Dan Hanson
  • 32. Research and information today โ€ข Timely โ€ข Precision โ€ข Complexity โ€ข Partners โ€ข Collaboration
  • 33. Perspective on research โ€ข New products โ€“ Supported by data โ€ข Avoid internal bias from experience โ€ข Limitations โ€“ Research vs. commercial out come (70%) โ€“ Information from other systems / sources โ€ข Value โ€“ Creation โ€“ Intellectual property
  • 35. Perspective on Partners โ€ข Innovative โ€ข Collaboration โ€ข Value โ€ข Joint mission to improve โ€ข Not feed
  • 36. Areas of interest โ€ข Animal health โ€“ PRRSv โ€“ Ileitis โ€“ Mycoplasma โ€“ Circovirus
  • 37. Areas of interest โ€ข Bio โ€“ security measures โ€ข Air filtration โ€ข Manure
  • 38. Areas of interest โ€ข Genetics โ€ข Animal welfare โ€ข Meat quality โ€ข Energy / Feed presentation
  • 39. Most recent trial โ€ข Ileitis vaccine trial
  • 40. Comparative efficacy of Enterisol ยฎ Ileitis versus Tylanยฎ feed grade.
  • 41. Trial Objective โ€ข To determine if Enterisolยฎ Ileitis vaccine performs better than Tylanยฎ feed grade in a step down program as a way to control the effects of a Lawsonia intracellularis infection. โ€ข A pen level study with the primary parameter being feed efficiency (FE)
  • 42. Materials and Methods Trt Trt Name Treatment Group Description 40 pens of 26 pigs vaccinated with Enterisol Ileitis at day 0 Enterisol and fed 10 grams Stafac per ton starting on day 40 until day โ€ขTrial conducted at 1 Ileitis/Stafac 120. Pipestone Vet Clinic 40 pens of 26 pigs fed 100 grams of Tylan per ton from day research barn from 6- 40 to day 58, followed by feeding 40 grams of Tylan per ton 2 Tylan until day 120. 28 to 12-19, 2011 โ€ข 2080 weaned pigs from 2 sister sow farms in the Pipestone system. โ€ขPigs weighed and allocated to two treatment groups
  • 43. Materials and Methods โ€ข 2-3 pigs per pen (10% of population) were inoculated with Lawsonia intracellularis gut homogenate at log 4.5 x 109
  • 44. Table 2. Least square means for performance data by main effect (treatment). Performance Vaccine Treatment Results Response variable Enterisol Ileitis Tylan P-value1 d40-market feed to gain, lbs 2.97 3.05 0.13 d-7-126 feed to gain, lbs 2.38 a 2.43 b 0.05 d-7-market feed to gain, lbs 2.62 2.70 0.06 1 ANOVA P-value. ab Means with different superscripts indicate difference at Pโ‰ค0.05 (Student's t). 0.08 / 2.70 X $127 = $3.76
  • 45. Vaccine, Feed meds, and Treatment Costs Table 8. Least square means for treatment cost by main effect (treatment). Vaccine Treatment Response variablei Enterisol Ileitis Tylan P-value1 Medication program cost per pig, ($)2 1.29a 1.54b <.0001 d-7-market injectable/water med cost per pig, ($)3 0.96 0.98 0.18
  • 46. Conclusions โ€ข A Lawsonia intracellularis seeder challenge model is possible in a large scale commercial study. โ€ข Pigs on the Enterisol Ileitis/Stafac program had a 2.9% improvement in FE (P<0.05) โ€ข Total return on investment favored the Enterisol Ileitis/Stafac group by $3.05. โ€ข Today โ€ข $0.25 + $3.76 = $4.01 (vaccine and Stafac)
  • 47. โ€œChange is: often desirable, frequently necessary, always inevitable.โ€
  • 48.
  • 49. Our hobbies. . . . . . . .