1. Disorders of olfaction can be conductive, resulting from nasal obstruction, or sensorineural, due to damage to the olfactory neuroepithelium.
2. Common causes of sensorineural disorders include upper respiratory infections, head trauma, tumors near the olfactory region, congenital defects, toxins, age-related changes, and neurodegenerative diseases.
3. Specific conditions that can cause olfactory disorders are post-viral olfactory dysfunction, Kallmann syndrome, septo-optic dysplasia, holoprosencephaly, exposure to metals or other toxins, Alzheimer's disease, Parkinson's disease, and epilepsy presenting with olfactory auras.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Spiritual Sense
1. Sight = Faith
Sight is to see beyond the things that you see.
2. Hear = Conviction with an action
Hear the word of God is help you to have the other spiritual Senses.
3. Touch = Experience
Touch help you to understand the obstacle in your life and it will lead you to be strong and courage.
4. Smell = Revelation
Smell help you to Focus on things on heaven.
5. Taste = Promise
Taste help you to Focus on God's promise.
Spiritual Sense is use to be alert in the work of evil. (ex. disappointment, gossip etc.)
Using your Spiritual senses is to discern good and evil.
Focusing in the spiritual senses help you to understand the things and help you to stand on your faith.
"Breath Easy: The Role of Orthodontics in Managing Obstructive Sleep Apnea"safabasiouny1
obstructive sleep apnea and orthodontics including diagnosis and treatment
Sleep disruption caused by breathing disorders are potentially life-threatening and therefore an important global health issue.
Sleep disorders, particularly untreated obstructive sleep apnea (OSA) has been known as a risk and possible causative factor in
1.
development of systemic hypertension,
2.
depression,
3.
stroke, angina
4.
cardiac dysrhythmias.
5.
can be associated with motor vehicle accidents,
6.
poor work performance and therefore, also makes a person prone to occupational accidents and reduced quality of life.
7.
adversely affects patients on their personal, social and professional levels.
Obstructive sleep apnea (OSA)
Definition: cessation of airflow for more than 10 seconds and hypopnoea is 50% reduction in air flow
It is Classified as central, obstructive and mixed and can be graded as mild, moderate and severe
DEFINATION
ATIOPATHOGENESIS
FEATURE AND PREDISPOSING FACTER
SYMPTOMS
DIAGNOSIS
DEFFERENTIAL DIAGNOSIS
TREATMENT
Also known as Singer’s or Screamer's Nodes
Vocal cord nodules are benign growths on both vocal cords that are caused by vocal abuse
They appear symmetrically on the free edge of vocal cord
At the junction of anterior 1/3 and posterior 2/3 *area of maximum vibration of vocal cord.
this ppt gives information about COPD , Asthma(the respiratory disease)As stated before, diseases of the heart affect the lungs and diseases of the lungs affect the heart.
This is because of the peculiar characteristics of pulmonary vasculature. The pressure in the pulmonary arteries is much lower than in the systemic arteries.
The pulmonary arterial system is466 SECTION III Systemic Pathology thinner than the systemic arterial system.
They are thin elastic vessels which can be easily distinguished from thick-walled bronchial arteries supplying the large airways and the pleura.
General diseases of vascular origin occurring in the lungs such as pulmonary oedema, pulmonary congestion, pulmonary embolism and pulmonary infarction, have all been already discussed.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
3. Pre requisites for smell-
• 1) Odorants should enter the nasal cavity- actively or passively.
(Actively by sniffing, and passively by diffusion.)
• 2) should pass in the olfactory cleft.
• 3) should be dissolved in largely aquous phase of the olfactory mucous.
4. Cross-sectional view of the olfactory epithelium showing
the columnar supporting cells (S) that extend the full length
of the epithelium. An olfactory neuron (O) with its dendrite
and basal cell (B) can be seen among supporting cells
(×1241). (From Morrison EE, Costanzo RM. Morphology of the
human olfactory epithelium. J Comp Neurol 1990;297:1. From
Wiley- Liss, a division of John Wiley & Sons.)
5.
6.
7.
8. ABNORMALITIES OF SMELL
Anosmia refers to an inability to detect qualitative olfactory sensations (i.e.
absence of smell function).
Partial anosmia defines an ability to perceive some (but not all) odours.
Hyposmia or microsmia refers to decreased sensitivity to odours.
Hyperosmia reflects increased sensitivity to common odours. It reflects a
patient’s heightened response to an odour, rather than an increased ability to
smell. This problem has been reported in some conditions associated with a
change in hormone balance, such as in pregnancy and Addison’s disease
(adrenal-cortical insufficiency), as well as migraine, drug withdrawal, epilepsy
(intericatal period), multiple chemical sensitivity and psychosis.
9. Dysosmia (sometimes termed cacosmia or parosmia) is distorted or
perverted smell perception to odour stimulation.
Phantosmia is a dysosmic sensation perceived in the absence of an
odour stimulus (also known as olfactory hallucination).
Olfactory agnosia refers to an inability to recognize an odour
sensation, even though olfactory processing, language and general
intellectual functions are essentially intact, as in some stroke patients.
Presbyosmia – a decline in smell sense with age.
Osmophobia – a dislike or fear of certain smells.
10. Loss of olfactory function can be subdivided into two classes:
(1)conductive or transport impairments result from obstruction of
the nasal passages (for example, chronic nasal inflammation,
polyposis, etc.)
(2) sensorineural impairments result from damage to the olfactory
neuroepithelium, central tracts and connections (for example, viruses,
airborne toxins, tumours, seizures, etc.).
11. In some circumstances, it is difficult to classify an olfactory
disorder into one of these classes, (conductive or sensorineural)
because of both blockage of airflow to the receptors and damage to
the receptors or other elements of the olfactory neuroepithelium,
can be present.
For example, Chronic rhinosinusitis, can produce damage to the
olfactory membrane in addition to blocking airflow, and altered
membrane function over time, can lead to degeneration within the
olfactory bulb.
12. 1. Conductive Olfactory Disorders
The conditions which can decrease the nasal airflow and block the
access of odorants to the olfactory epithelium; however, patients may
still have some retronasal airflow, allowing the ability to detect the
flavor of food.
Causes of decreased nasal airflow include nasal septal deformities,
nasal polyposis, tracheostomy, or nasal cavity tumors, post op
adhesions.
Although rhinosinusitis may cause a conductive loss, and a change in
the sense of smell is one of the most predictive symptoms of true
rhinosinusitis, evidence also points to a sensorineural olfactory loss
especially with long-standing inflammatory disease.
13. 2. Sensorineural Olfactory Disorders
2.1. Upper Respiratory Infections
Loss of olfaction after a URI is one of the most common causes of smell
disorders, and occurs more commonly in women and the elderly.
Olfactory dysfunction during a URI can initially be conductive, but
persistence of loss of smell after resolution of other symptoms indicates
sensorineural injury to the olfactory epithelium.
In patients with post-viral olfactory dysfunction, the presence of
rhinovirus, coronavirus, parainfluenza virus, and Epstein-Barr virus
have been detected in the nasal discharge.
Other infectious causes that have been reported include hepatitis, herpes
simplex encephalitis, pneumonia and variant Creutzfeldt–Jacob disease.
14. It is not clear what predisposes someone to virus- and bacteria-induced
smell dysfunction, or the precise mechanisms behind it. Patients may
present with hyposmia, anosmia, or dysosmia. There is a higher incidence of
hyposmia (post URI), than is seen with other sensorineural causes of
olfactory disorders.
In a study of olfactory biopsies of 4 patients with anosmia and 11 patients
with hyposmia due to a viral illness, ‘Jafek and colleagues’ noted that
patients with anosmia had markedly reduced numbers of receptors and those
receptors were abnormal compared with those patients with hyposmia.
Given the ability of the olfactory receptor neurons to regenerate,
spontaneous recovery of some smell function is theoretically possible over a
prolonged period. However, complete recovery is less likely, the longer the
patient has the loss, and is inversely related to the degree of dysfunction.
15. 2.2. Head trauma
Head trauma often results in smell loss, particularly where rapid
acceleration/deceleration of the brain occurs (i.e. coup/contrecoup injury).
• The prevalence of olfactory loss following head trauma is around 15
percent and is proportional to the severity of the injury.
• Blunt trauma to the occiput has been found to produce greater
olfactory loss than trauma to the front of the head.
• Following head trauma, the loss of smell is usually, but not always,
immediate. However, it may take a while for the patient to recognize
the presence of the dysfunction.
• Fracturing of the cribriform plate is not a prerequisite for smell loss.
16. Common mechanisms include-
• Disruption from shearing forces of the olfactory fila through the
sinonasal tract, and
• Direct contusion and ischaemia to the olfactory bulb and frontal
and temporal poles.
Animal research shows that intracranial haemorrhage and ischaemia can
lead to degeneration of the olfactory epithelium without transection of
the olfactory nerves. Iatrogenic trauma, such as surgery, can cause smell
impairment and has been seen with such procedures as sinus surgery
and craniotomy.
19. 2.3. Tumours and mass lesions
A number of tumours in and around the olfactory bulbs or tracts can
cause olfactory disturbance.
Examples include
• olfactory groove meningiomas,
• frontal lobe gliomas and
• suprasellar ridge meningiomas arising from the dura of the cribriform
plate.
• mesial temporal lobe tumours.
20. • Structural lesions affecting smell may also affect vision…..
• Also, olfactory tumours may extend into the frontal lobes resulting
in symptoms of dementia and possibly the release of primitive
reflexes (for example, grasping, snout and glabellar).
• Mass lesions around the olfactory region can result in a
Foster-Kennedy syndrome, which consists of:
(1) ipsilateral anosmia;
(2) ipsilateral optic atrophy and
(3) contralateral papilloedema (d/t raised intracranial pressure.)
21. Pseudo-Foster-Kennedy syndrome has been reported in patients with
increased intracranial pressure, without any evidence of mass lesion
on MRI.
Fig. showing Fundoscopic findings of papilloedema in one eye and optic atrophy in the other.
22. 2.4. Congenital Loss
• Accounts for about 3% of anosmia.
• Usually an isolated finding.
• Patients often present during their preteen or teenage years with an
inability to smell, often discovered by family members. Patients with
a congenital lack of olfactory ability may not recognize their
olfactory dysfunction and have no recollection of detecting odors.
They may have distinct food preferences due to their inability to
appreciate the flavor of food while retaining the ability to detect the
fundamental taste sensations from the taste buds.
23. • Recent studies have demonstrated that genetic mutations in the gene
SCN9A, which encodes the voltage-gated sodium channel Nav1.7, cause
congenital anosmia.
• SCN9A loss of function mutations were originally studied in patients with
congenital analgesia, although studies in both humans and mice have
demonstrated patients with these mutations also have an inability to
detect odors.
Associations exist between congenital anosmia and several abnormalities
including
• Kallmann syndrome,
• de Morsier’s syndrome,
• holoprosencephaly,
• anterior neuropore anomalies.
24. Kallmann syndrome consists of anosmia and hypogonadotropic
hypogonadism and has autosomal or X-linked forms.
• Patients usually lack olfactory bulbs and the gonadotropin-releasing
hormone, resulting in hypogonadism.
• The defects are due to a lack of migration of GnRH-releasing cells
from the olfactory placode to the hypothalamus and a lack of
migration of the olfactory neurons to the olfactory bulb and
hypothalamus.
• Magnetic resonance imaging (MRI) findings may reveal aplasia or
hypoplasia of the olfactory bulb, or associated encephalocele or
abnormality in the frontal lobe.
25. Lack of olfactory bulbs or tracts
(arrows) in a 21year old woman with
congenital anosmia on a T2weighted
High resolution coronal magnetic
resonance image.
26. Septo-optic dysplasia (SOD), (de Morsier syndrome) is a
rare congenital malformation syndrome featuring-
1) optic nerve hypoplasia,
2) pituitary gland dysfunction, and
3) absence of the septum pellucidum (a midline part of the brain).
Two of these features need to be present for a clinical diagnosis — only 30%
of patients have all three.
Patients with septo-optic dysplasia (de Morsier’s syndrome) can have
hyposmia, visual symptoms and precocious puberty.
27. Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic
disorder in which the prosencephalon (the forebrain of the embryo) fails
to develop into two hemispheres.
• The condition can be mild or severe. According to the National Institute
of Neurological Disorders and Stroke(NINDS), "in most cases of holo-
prosencephaly, the malformations are so severe that babies die before
birth."
• When the embryo's forebrain does not divide to form bilateral cerebral
hemispheres (the left and right halves of the brain), it causes defects in
the development of the face and in brain structure and function.
• In less severe cases, babies are born with normal or near-normal brain
development and facial deformities that may affect the eyes, nose, and
upper lip.
29. 2.5. Toxins
Olfactory dysfunction attributed to toxin exposure is relatively low (2%), but
a large number of toxins are associated with olfactory loss.
These include-
• Environmental pollutants.
• Specific metal fumes (Cadmium, Chromium, Nickel, Mercury, Lead etc).
• Gas exposure from industrial plants (formaldehyde, methyl bromide).
• Solvents including toluene and paint solvents.
• Tobacco smoke.
30. Mechanism of injury
• The olfactory receptor neurons are in direct contact with the
environment, leaving them vulnerable to inhaled toxins.
• By-products of metabolism of the odorants by ‘Cytochrome P450 mono
oxygenase system’ in the supporting cells.
Damage to the olfactory epithelium can occur with
• 1)acute, high levels of toxin exposure or with
• 2)chronic low level exposure, causing more gradual olfactory decline.
31. • If the regenerating cells (Basal Cells) are spared, the olfactory neurons
may regenerate after acute toxic injury, but with more severe injury to the
olfactory epithelium or with chronic injury and increasing age, the
regenerative potential may decrease, causing noticeable olfactory loss.
• Within the supporting cells and Bowman’s glands are high levels of
xenobiotic enzymes, including cytochrome P450 monooxygenases and
other biotransformation enzymes. These enzymes detoxify inhaled or
systemic substances, presumably to protect the olfactory neurons and
CNS, or to process odorant molecules for receptor activation. Byproducts
of these enzymes may include toxic metabolites, which themselves may
damage the olfactory epithelium.
32. Metals, in the form of dust or fumes, can be toxic to the olfactory
system. The most well-known is Cadmium, used in the production of
batteries, semiconductors, and electroplating.
Factory workers exposed to Chromium, which is often used with nickel
in industrial manufacturing and steel production, can have increased
olfactory thresholds.
Other metals linked to olfactory loss include manganese, mercury,
aluminum, and lead.
33. • Tobacco smoke exposure is associated with hyposmia in active
smokers. Studies find increased olfactory receptor neuron apoptosis
with tobacco smoke exposure.
• In one study, the olfactory scores of former smokers were not
significantly different than the scores in lifelong nonsmokers,
suggesting that the olfactory ability can return with cessation of
smoking.
34. 2.6. Age
• Under the age of 65 years, approximately 1% of the population has
major difficulty in smelling.
• Between 65 and 80 years, this increases remarkably, with about half of
the population experiencing a demonstrable decrement in the ability to
smell.
• Over the age of 80, this figure rises to nearly 75%.
There is accumulation of damage over the years, and a single event, such
as a bad cold, can be the precipitating factor.
35. The age-related changes in smell function are due to-
• Damage to the olfactory receptors.
• Decreased activity of Basal cell to regenerate.
• Replacement of olfactory epithelium by respiratory epithelium.
• Occlusion of the foramina of the cribiform plate, pinching off the
axons of the olfactory receptor cells as they enter the brain cavity.
• Decreases in number of glomeruli within the olfactory bulb.
36. Low magnification of the surface of the
nasal cavity taken from a transition region.
Patches of respiratory epithelium (R; dark
areas) can be seen within the olfactory (O)
region (×28).
(From Morrison EE, Costanzo RM. Morphology of
the human olfactory epithelium. J Comp Neurol
1990;297:1. From Wiley-Liss, a division of John
Wiley & Sons.)
37. 2.7. Neurodegenerative disorders
• In patients with Alzheimer and Parkinson diseases, 90% exhibit
olfactory dysfunction in the early stages of the diseases.
• Olfactory loss may be the first clinical sign of these neurodegenerative
diseases, preceding signs of dementia in Alzheimer disease (AD) or
motor symptoms in Parkinson disease (PD) by several years.
• Neurofibrillary tangles and neuritic plaques appear in the olfactory bulb,
anterior olfactory nucleus, and olfactory cortex in patients with AD.
• First degree family members of patients with AD were found to have
significantly reduced smell identification scores, pointing to genetic
predisposition in the development of the disease.
38. • Smell deficits are more common in PD than in other diseases with
parkinsonian symptoms, and may help to differentiate PD from other
diseases such as essential tremor.
• Smell identification is the most accurate predictor of the presence of PD
compared with healthy controls in motor and nonmotor diagnostic tests
for PD.
• Because of the implication of viruses and environmental toxins in the
development of AD and PD with the finding of early olfactory loss, some
theorize that these diseases may be caused by agents entering the brain
through an olfactory route.
39. Huntington disease is also characterized by olfactory deficits and
findings of degeneration of central olfactory degeneration.
Multiple Sclerosis: a recent study suggested that hyposmia was present in
almost 50% of patients within a known MS group.
40. 2.8. Epilepsy and migraine
• Olfactory auras, also described as hallucinations, are rare.
• When present, they are often associated with seizures and headaches.
Olfactory auras consist of sudden unexplained sensations of smell that
are usually, but not always, unpleasant and are rarely isolated events.
• In epilepsy, mesial temporal lobe structures involved in the usual
processing of odour information – such as the amygdala and
hippocampus – have been implicated as the generators of ictal
olfactory sensations (simple or complex partial seizures) that often
evolve into secondarily generalized seizures.
• Common aetiologies include mesial temporal sclerosis and tumours.
41. CLINICAL EVALUATION OF SMELL FUNCTION
Proper assessment of a patient’s smell function requires
(1) a detailed clinical history.
(2) quantitative olfactory testing, and
(3) a thorough physical examination emphasizing the head and neck with
appropriate brain and rhinosinus imaging.
42. HISTORY TAKING
• Does the patient have a problem with smell, taste or both?
• Mode of onset, duration of impairment and pattern of occurrence?
Sudden olfactory loss can be consistent with possible head trauma,
ischaemia, infection or a psychiatric condition.
Gradual loss may indicate a progressive and obstructive lesion in or
around the naso sinus region, particularly if the loss is unilateral.
Intermittent loss may suggest an inflammatory process in association
with nasal and sinus disease.
Seasonal variation ? (Allergic rhinitis)
43. Any history of precipitating antecedent events, such as head trauma, viral
upper respiratory infections, chemical or toxin exposures and nasosinus
surgeries?
Does the patient have any nasal discharge that is mucous-appearing (for
example, allergy), purulent (for example, infection), or clear (CSF
rhinorrhoea after trauma)?
History of headache suggests sinusitis, migraine or intracranial tumour.
Comorbidities such as renal failure, liver disease, hypothyroidism,
diabetes or dementia?
44. Are smells present without an obvious stimulus?
A simple partial seizure or aura may not be obvious and other signs of
ictal activity should be explored (for example, limb shaking, difficulties
with speech, unresponsiveness, automatisms, loss of consciousness).
Given the strong relationship of Alzheimer’s disease and idiopathic
Parkinson’s disease to smell impairment, one should also look for
memory- and parkinsonism related complaints in older patients.
45. Personal History:
Appetite may decrease owing to decreased/altered flavour.
Addiction to alcohol, cigarette smoking,
drug abuse- intranasal cocaine.
Menstrual history: Delayed puberty in association with anosmia (with or
without midline craniofacial abnormalities, deafness and renal anomalies)
suggests the possibility of Kallmann’s syndrome or some variant thereof.
46. Physical examination and evaluation
Patients complaining of smell disturbance typically require a general
assessment of the head and neck and more detailed otolaryngological
and neurological examinations.
Any signs of trauma such as healing wounds, scarring or distorted nasal
or skull architecture?
Inspection of the nasal passages to view the peripheral nasal cavity for
signs of polyps, congestion, deviation of septum or inflammation.
Nasal endoscopy, employing both flexible and rigid scopes, is needed to
ensure thorough assessment of the olfactory meatal area.
47. The additional presence of polyps, masses and adhesions of the turbinates to
the septum may adequately obstruct airflow.
The presence of mucopus above the Eustachian tube orifice suggests
posterior ethmoid and/or sphenoid sinus disease.
A pale mucous membrane suggests allergy, usually as a result of oedema
within the lamina propria.
Atrophy of the lamina propria is suggested by unusual spaciousness, dryness
and crusting, as is seen in atrophic rhinitis.
48. Visual acuity, visual field and optic disc examinations aid in the
detection of possible intracranial mass lesions resulting in increased
intracranial pressure (papilloedema) and optic atrophy, especially when
considering Foster Kennedy syndrome.
49. Quantitative olfactory testing
Several standardized and practical psychophysical tests have been developed
over the last several years, including a number of brief self-administered tests
ranging from the three-item Pocket Smell TestTM to the 40-item University
of Pennsylvania Smell Identification Test (UPSIT).
The UPSIT is commercially known as the Smell Identification TestTM and is
the most widely used olfactory test, having been administered to an estimated
400,000 patients since its development.
The UPSIT can be self administered in 10–15 minutes by most patients in the
waiting room, and scored in less than a minute by nonmedical personnel.
50. This test consists of four booklets containing ten microencapsulated (‘scratch
and sniff ’) odourants apiece. Test results are in terms of a percentile score of
a patient’s performance relative to age- and sex-matched controls, and
olfactory function can be classified on an absolute basis into one of six
categories:
1. normosmia,
2. mild microsmia,
3. moderate microsmia,
4. severe microsmia,
5. anosmia and
6. probable malingering.
51. The four booklets of the
40-odourant University of
Pennsylvania Smell
Identification Test (UPSIT;
commercially known as the
Smell Identification Test
TM ).
Each page contains a
microencapsulated odourant that
is released by means of a pencil
tip.
52. Since chance performance is 10 out of 40, very low UPSIT scores reflect
avoidance, and hence recognition of the correct answer, allowing for
determination of malingering. The reliability of this test is very high (test–
retest, r = 0.94).
Smell threshold test using Phenyl ethyl alcochol.
The recording of olfactory event-related potentials (OERP) is available in
some specialized medical centres as an additional means of assessing the
integrity of the olfactory system.
Using brain electroencephalography (EEG), the test consists of discerning
synchronized brain activity recorded from overall EEG activity following
brief presentations of odourants.
53. TREATMENT OF SMELL DISORDERS
The most effective treatments available are those for conductive anosmia,
where there is an obstruction of airflow through the nose to the olfactory
neuroepithelium.
After diagnosis is confirmed using tools such as nasal endoscopy and CT
scanning of the sinuses, the next appropriate course of action may include
topical or systemic steroids.
Conductive and sensorineural olfactory losses are often distinguishable
using a brief course of systemic steroid therapy, since patients with
conductive impairment frequency respond positively to the treatment,
although long-term systemic steroid therapy is not advised.
54. Proper allergy management is essential and may require the use of an
antihistamine.
When a bacterial infection is suspected (for example, infectious
rhinosinusitis), a course of antibiotics should be used.
Surgery should be considered for:
(1) very large and medically refractory polyps, or
(2) situations where a malignant neoplasm is suspected.
55. Sensorineural impairment of olfaction is typically more difficult to
manage and the prognosis for patients suffering from long-standing total
loss due to upper respiratory illness or head trauma is poor.
The majority of patients who recover smell function subsequent to trauma
do so within 12 weeks of injury.
Patients who give up smoking typically have dose-related improvement
in olfactory function and flavour sensation over time.
Central lesions, such as CNS tumours that impinge on olfactory bulbs and
tracts can often be resected with significant improvement in olfactory
function.
56. When epilepsy or migraine is suspected, a course of antiepileptic or
antimigraine medications may prove beneficial.
Medically refractory epilepsy resulting in olfactory disturbance can be
successfully treated with surgery
In patients with multiple sclerosis, immunomodulatory therapies, including
interferon-beta and occasional steroids, is the mainstay of treatment.
When depression or psychosis is suspected, a course of an antidepressant
and appropriate psychiatric referral may be necessary.
57. In patients with complete anosmia, supportive measures are
necessary to protect them from further harm. Thus,
1. Smoke and carbon monoxide detectors need to be installed and
properly working.
2. When possible, electrical appliances should be used instead of gas
appliances.
3. Expiration dates for food products should be scrutinized and old food
items checked by someone with normal smell function or discarded.
4. A balanced diet, particularly in the elderly, must be kept to prevent
weight loss and malnutrition.
Adding flavour enhancers (for example, monosodium glutamate, food
colouring, chicken or beef stock) to foods can also help with their
appeal.