The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
The vertebrate brain
The vertebrate brain is the main part of the central nervous system. The brain and the spinal cord make up the central nervous system,
In most of the vertebrates the brain is at the front, in the head. It is protected by the skull and close to the main sense organs.
Brains are extremely complex and the part of human and animal body. The brain controls the other organs of the body, either by activating muscles or by causing secretion of chemicals such as hormones and neurotransmitters.
Muscular action allows rapid and coordinated responses to changes in the environment.
The brain of an adult human weights about 1300–1400 grams .
In vertebrates, the spinal cord by itself can cause reflex responses as well as simple movement such as swimming or walking. However, sophisticated control of behaviour requires a centralized brain.
The structure of all vertebrate brains is basically the same.
At the same time, during the course of evolution, the vertebrate brain has undergone changes, and become more effective.
In so-called 'lower' animals, most or all of the brain structure is inherited, and therefore their behaviour is mostly instinctive.
In mammals, and especially in man, the brain is developed further during life by learning. This has the benefit of helping them fit better into their environment. The capacity to learn is seen best in the cerebral cortex.
Three principles
The brain and nervous system is essentially a system which makes connections. It has input from sense organs and output to muscles. It is connected in several ways with the endocrine system, which makes hormones, and the digestive system and sex system. Hormones work slowly, so those changes are gradual.
The brain is a kind of department store. It has, all inter-connected, departments which do different things. They all help each other gather senses.
Much of what the body does is not conscious. Basically, much of the body runs on automatic (breathing, heart beat, hungry, hair growth) adjusted by the autonomic nervous system. The brain, too, does much of its work without a person noticing it. The unconscious mind refers to the brain activities which are hardly ever noticed.
Evolutionary change in heart of vertebrates
Heart is situated ventral to the oseophagus in the pericardial section of the coelom.
Heart is a highly muscular pumping organ that pumps blood into arteries and sucks it back through the veins.
In vertebrates it has undergone transformation by twisting from a straight tube to a complex multi-chambered organ.
. There has been an increase in the number of chambers in heart during evolution of vertebrates.
The heart is covered by a transparent protective covering, called pericardium. It is a single layer in fish.
Within pericardium there is a pericardial fluid, protects the heart from the external injury.
The evolution of the heart is based on the separation of oxygenated blood from deoxygenated blood for efficient oxygen transport.
INTRODUCTION
The jaw (Upper and lower) is any opposable articulated structure at the entrance of the mouth.
It is typically used for grasping and manipulating food.
Jaw suspension means the fusion of upper jaw and lower jaw or skull for efficient biting.
There are different ways in which these attachments are attained depending upon the modifications in visceral arches in vertebrates.
In most vertebrates, the jaws are bony or cartilaginous and oppose vertically.
The vertebrate jaw is derived from the most anterior two pharyngeal arches supporting the gills, and usually bears numerous teeth.
The vertebrate jaw probably originally evolved in the Silurian period and appeared in the Placoderm fish which further diversified in the Devonian.
It is believed that the hyoid system suspends the jaw from the brain case of the skull, permitting great mobility of the jaws.
The original selective advantage offered by the jaw may not be related to feeding, but rather to increased respiration efficiency.
The jaws were used in the buccal pump (observable in modern fish and amphibians) that pumps water across the gills of fish or air into the lungs in the case of amphibians.
Over evolutionary time the more familiar use of jaws (to humans), in feeding, was selected for and became a very important function in vertebrates. Many teleost fish have substantially modified jaws for suction feeding and jaw protrusion, resulting in highly complex jaws with dozens of bones involved.
Jaw Suspension or Suspensoria:
The method by which the upper and lower jaws are suspended or attached from the chondrocranium is known as jaw suspension or suspensorium.
Amongst the visceral arches, the first (mandibular) arch consists of
= a dorsal palato pterygoquadrate bar forming the upper jaw,
= and ventral Meckel’s cartilage forms the lower jaw.
The second (hyoid) arch consists of = a dorsal hyomandibular supporting and suspending the jaws with the cranium, and a ventral hyoid.
The remaining visceral arches support the gills and are, hence, called branchial arches. Thus, splanchnocranium forms the jaws and suspends them with the chondrocranium.
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
The primitive blueprint for the heart and circulatory system emerged with the arrival of the third mesodermal germ layer in bilaterians. Since then, hearts in animals have evolved from a single layered tube to a multiple chambered heart in due course of time.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
The basic fundamental plan of the aortic arches is similar in different vertebrates during embryonic stages.
But in adult the condition of the arrangement is changed either being lost or modified considerably.
The number of aortic arches is gradually reduced as the scale of evolution of vertebrates is ascended.
The embryonic aortic arches were basically six pairs.
But with progressive evolution , there has been consequent reduction in numbers of aortic arches.
In the basic pattern the major arterial channels consists of
A ventral aorta emerging from the heart and passing forward beneath the pharynx
A dorsal aorta paired above the pharynx and passing caudal above the digestive tract.
Six pairs of aortic arches connecting ventral aorta to with the dorsal aorta.
1st aortic arch= Mandibular aortic arch
2nd Aortic arch= hyoid aortic arch
3rd ,4th ,5th and 6th aortic arches in case of aquatic animal , known as branchial aortic arches.
Vittelogenesis is a word developed from Latin vitellus-yolk, and genero-produce
Vitellogenesis (also known as yolk deposition) is the process of yolk formation via nutrients being deposited in the oocyte, or female germ cell involved in reproduction of lecithotrophic organisms. In insects, it starts when the fat body stimulates the release of juvenile hormones and produces vitellogenin protein.
Yolks is the most usual form of food storage in the egg.
Yolks appear in the oocyte in the secondary period of their growth called vittelogenesis.
Thus,the formation and deposition of yolks is known as vittelogenesis
Characteristic
Yolks is a complex variable assembled component.
The principle component are protein,phospholipid and fats in different combination.
Depending upon these component yolks is distinguished into protein yolks and fatty acid
For eg- the avian contain 48.19% water , 16.6 % protein, 32.6% phospholipids and fats and 1% carbohydrates.
DENTITION IN MAMMALS
The study of arrangement structure and number of types of teeth collectively is called as dentition. Teeth are present in the foetal as well as in adults of mammals, based on the presence of teeth Mammals are two types.
Edentata : In some animals teeth are absent hence called as edentate. e.g., Echidna or spiny ant-eater (Tachyglossus) the teeth are absent in all stages of life.
Dentata : Teeth are present in all mammals though a secon¬dary toothless condition is found in some mammals. Modern turtles and birds lack teeth. The adult platypus (Ornithorhynchus) bears epidermal teeth but no true teeth are present. In platypus embryonic teeth are replaced by horny epidermal teeth in adult.
Classification According to the Shape and Size of the Teeth:
Homodont:
Homodont or Isodont type of teeth is a condition where the teeth are all alike in their shape and size in the toothed whales e.g., Pinnipedians. Fishes, amphibians, reptiles and in the extinct toothed birds.
Heterodont
Heterodont condition is the usual feature in mammals, i.e. the teeth are distinguished according to their shape, size and function. The function is also different at different parts of the tooth row.
According to the Mode of Attachment of Teeth:
Thecodont : The teeth are lodged in bony sockets or alveoli of the jaw bone and capillaries and nerves enter the pulp cavity through the open tips of the hollow roots e.g., mammals, crocodiles and in some fishes.
Acrodont: The teeth are fused to the surface of the underlying jawbone. They have no roots and are attached to the edge of the jawbone by fibrous membrane e.g., fishes, amphibians and some reptiles.
Pleurodont:
The teeth are attached to the inner-side of the jawbone. The tooth touches the bone only with the outer surface of its root. In acrodont and pleurodont types of dentition, there are no roots, and nerves and blood vessels do not enter the pulp cavity at the base, e.g., Necturus (Amphibia) and some reptiles.
According to the Succession or Replace¬ment of Teeth:
INTRODUCTION
The term urogenital refers to something that has both urinary and genital origins. The word urogenital is used because the urinary and reproductive systems in males merge.
These are grouped together because of their proximity to each other, their common embryological origin and the use of common pathways (ex. urethra).
Kidneys and urinary ducts form the urinary system.
The Urinary system performs two important homeostatic processes like excretion and osmoregulation. This system is intimately associated both anatomically, and in terms of embryonic origin with the genital system.
The genital system includes the gonads which generate gametes and the genital ducts that serve as passages for the gametes.
Though functionally different the two organ systems the urinary and the genital system are treated together as the urino- genital system, since both develop from the same segmental blocks of trunk mesoderm or adjacent tissues and share many of the ducts.
Thus although the two systems have nothing common functionally they are closely associated in their use of common ducts and are studied under the broad heading of urinogenital system.
The function of the excretory system is crucial in considering the possible environment of the ‘vertebrate life ’. Several main functions can be attributed to all vertebrate excretory systems:
Excretion of nitrogenous waste products.
Maintaining homeostasis with regard to ions (i.e. salt balance).
Regaining valuable substances (glucose, salts, amino acids, etc.)
Maintaining a physiological osmotic value (i.e. water balance).
The excretory system is formed by a series of paired, segmental nephrons that begin with a nephrostome opening into the coelomic cavity.
A pair of glomeruli per segment, supplied by branches from the aorta, projects into the coelomic cavity close to these nephrostomes.
At a later stage of development, the glomerulus/nephrostome area becomes separated from the rest of the coelomic cavity by an epithelial fold.
The nephrons connect to a duct that is formed by caudal growth of the most anterior nephric tubules. These paired urinary ducts open near the anal region.
The urinary system includes the kidneys and the ducts that carry away their product, urine. The genital system includes the gonads and their ducts that carry away the products they form, sperm or eggs. Embryologically, urinary and reproductive organs arise from the same or
adjacent tissues and maintain close anatomical association
throughout the organism’s life.
The primitive blueprint for the heart and circulatory system emerged with the arrival of the third mesodermal germ layer in bilaterians. Since then, hearts in animals have evolved from a single layered tube to a multiple chambered heart in due course of time.
The integumentary system comprises the skin and its appendages. Skin + derivatives= Integument.
It aims to protect the body from various kinds of damage, such as loss of water or damages from outside.
The integumentary system in chordates includes hair, scales, feathers, hooves, and nails.
It may serve to water proof, and protect the deeper tissues.
Excrete wastes, and regulate body temperature.
It is the attachment site for sensory receptors to detect pain, sensation, pressure, and temperature.
The basic fundamental plan of the aortic arches is similar in different vertebrates during embryonic stages.
But in adult the condition of the arrangement is changed either being lost or modified considerably.
The number of aortic arches is gradually reduced as the scale of evolution of vertebrates is ascended.
The embryonic aortic arches were basically six pairs.
But with progressive evolution , there has been consequent reduction in numbers of aortic arches.
In the basic pattern the major arterial channels consists of
A ventral aorta emerging from the heart and passing forward beneath the pharynx
A dorsal aorta paired above the pharynx and passing caudal above the digestive tract.
Six pairs of aortic arches connecting ventral aorta to with the dorsal aorta.
1st aortic arch= Mandibular aortic arch
2nd Aortic arch= hyoid aortic arch
3rd ,4th ,5th and 6th aortic arches in case of aquatic animal , known as branchial aortic arches.
Vittelogenesis is a word developed from Latin vitellus-yolk, and genero-produce
Vitellogenesis (also known as yolk deposition) is the process of yolk formation via nutrients being deposited in the oocyte, or female germ cell involved in reproduction of lecithotrophic organisms. In insects, it starts when the fat body stimulates the release of juvenile hormones and produces vitellogenin protein.
Yolks is the most usual form of food storage in the egg.
Yolks appear in the oocyte in the secondary period of their growth called vittelogenesis.
Thus,the formation and deposition of yolks is known as vittelogenesis
Characteristic
Yolks is a complex variable assembled component.
The principle component are protein,phospholipid and fats in different combination.
Depending upon these component yolks is distinguished into protein yolks and fatty acid
For eg- the avian contain 48.19% water , 16.6 % protein, 32.6% phospholipids and fats and 1% carbohydrates.
DENTITION IN MAMMALS
The study of arrangement structure and number of types of teeth collectively is called as dentition. Teeth are present in the foetal as well as in adults of mammals, based on the presence of teeth Mammals are two types.
Edentata : In some animals teeth are absent hence called as edentate. e.g., Echidna or spiny ant-eater (Tachyglossus) the teeth are absent in all stages of life.
Dentata : Teeth are present in all mammals though a secon¬dary toothless condition is found in some mammals. Modern turtles and birds lack teeth. The adult platypus (Ornithorhynchus) bears epidermal teeth but no true teeth are present. In platypus embryonic teeth are replaced by horny epidermal teeth in adult.
Classification According to the Shape and Size of the Teeth:
Homodont:
Homodont or Isodont type of teeth is a condition where the teeth are all alike in their shape and size in the toothed whales e.g., Pinnipedians. Fishes, amphibians, reptiles and in the extinct toothed birds.
Heterodont
Heterodont condition is the usual feature in mammals, i.e. the teeth are distinguished according to their shape, size and function. The function is also different at different parts of the tooth row.
According to the Mode of Attachment of Teeth:
Thecodont : The teeth are lodged in bony sockets or alveoli of the jaw bone and capillaries and nerves enter the pulp cavity through the open tips of the hollow roots e.g., mammals, crocodiles and in some fishes.
Acrodont: The teeth are fused to the surface of the underlying jawbone. They have no roots and are attached to the edge of the jawbone by fibrous membrane e.g., fishes, amphibians and some reptiles.
Pleurodont:
The teeth are attached to the inner-side of the jawbone. The tooth touches the bone only with the outer surface of its root. In acrodont and pleurodont types of dentition, there are no roots, and nerves and blood vessels do not enter the pulp cavity at the base, e.g., Necturus (Amphibia) and some reptiles.
According to the Succession or Replace¬ment of Teeth:
Urinary.pptx knowledge about tracts and inauguration of the dayakshayamritanshuru40
The urinary tract is the system in the body that is responsible for producing, storing, and eliminating urine. It includes the kidneys, ureters, bladder, and urethra. The kidneys filter waste products from the blood to produce urine, which then travels through the ureters to the bladder for storage. When the bladder is full, urine is expelled from the body through the urethra. The urinary tract plays a crucial role in maintaining the body's fluid balance and removing waste products from the bloodstream.
Embryology is literally “the study of the
embryo”. More generally it refers to
“the study of prenatal development”
Defination:
‘’The study of the process of growth and differentiation of the embryo, starting from fertilization of an ovum and progressing to a fully formed individual animal.’’
Although a mammalian body is made up of an array of organ system, tissues and individual cells which function in a highly coordinated manner but they are all derived from a single cell, fertilized ovum.
Ontogeny : stages of development of an individual
Teratology : study of abnormal development (congenital malformations)
Developmental Stages Of Embryo:
Fertilization
Cleavage
Gastrulation
Organogenesis
Maturation
CELL CYCLE
Cells associated with formation and regeneration are somatic cells and they divide through mitosis.
Cells associated with reproduction are known as germ cells including male female gametes, they divide through meiosis.
Somatic cells undergo a series of molecular and morphological changes as part of the cell cycle. The changes occur in four phases G1, S, G2, and M and also a quiescent Go phase.
G1 and G2 phase are known as resting phases. The cells are metabolically active fulfilling its requirements for the next phase of cycle.
In S phase DNA synthesis occurs before chromosomal replication.
Collectively G1,S and G2 phase form the interphase which is the preparatory phase before mitotic phase.
Certain fully differentiated cells such as neurons do not divide further and enter Go phase.
PHASES OF MITOSIS
PROPHASE: in this phase the chromatin material begins to condense in the form of chromosomes and the centrioles begin to form spindle fibers or asters.
METAPHASE: in this phase nuclear envelop breaks and microtubules developed from spindle fibers bind to kinetochore of chromatids and arrange them in middle region forming a metaphase plate.
ANAPHASE: in this phase kinetochore microtubules constrict seperating the conjoined chromatids and movig them to opposite poles.
TELOPHASE: the two groups of identical chromosomes on opposite poles de-condense and a nuclear envelope forms around both of them and it marks end of mitosis.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
1. SYED MUHAMMAD KHAN (BS HONS. ZOOLOGY)
pg. 1
Development of Kidney In Vertebrates
Organogenesis is a process in which the three germ layers formed from gastrulation,
ectoderm, endoderm, and mesoderm form the internal organs of the organism. It is the
phase of embryonic development that starts at the end of gastrulation and goes until
birth.
The endoderm gives rise to gastrointestinal and respiratory organs.
The mesoderm forms the blood, heart, kidney, muscles, and connective tissues.
The ectoderm forms epidermis, the brain, and the nervous system.
The urogenital system (kidneys, gonads, and their respective duct systems) is
generated by the intermediate mesoderm. The human kidney is an incredible organ
whose importance cannot be overestimated. Its functional unit, the nephron, contains
more than 10,000 cells and at least 12 different cell types, each cell type having a
specific function and being located in a particular place in relation to the others along
the length of the nephron.
Stages of Kidney Development
Mammalian kidney development progresses through three major stages. The first two
stages are temporary; only the third and last persists as a functional kidney.
Stage# 1 – Pronephros:
Early in development, the pronephric duct arises in the intermediate mesoderm. The
anterior region of the duct induces the adjacent mesenchyme to form the pronephros, or
tubules of the initial kidney. The pronephric tubules form functioning kidneys in fish and
amphibian larvae, but they are not believed to be active in amniotes. In mammals, the
pronephric tubules and the anterior portion of the pronephric duct degenerate, but the
more caudal portions of the pronephric duct persist and serve as the central component
2. SYED MUHAMMAD KHAN (BS HONS. ZOOLOGY)
pg. 2
of the excretory system throughout development. This remaining duct is often referred
to as the Nephric duct / Wolffian duct.
Stage# 2 – Mesonephros:
As the pronephric tubules degenerate, the middle portion of the nephric duct induces a
new set of kidney tubules in the adjacent mesenchyme. This set of tubules constitutes
the mesonephros / mesonephric kidney. In some mammalian species, the mesonephros
functions briefly in urine filtration, but in mice and rats, it does not function as a working
kidney. Human mesonephros filters blood and makes urine. In humans, as more tubules
are induced caudally, the anterior mesonephric tubules are destroyed through
apoptosis. Human mesonephros also provides important developmental functions
during its brief existence:
First, it is one of the main sources of the hematopoietic stem cells necessary for
blood cell development.
Second, in male mammals, some of the mesonephric tubules persist to become the
tubes that transport the sperm from the testes to the urethra (the epididymis and vas
deferens).
Stage# 3 – Metanephros:
The permanent kidney of amniotes, the metanephros, is generated by some of the
same components as the earlier, transient kidney types. It is thought to originate
through a complex set of interactions between epithelial and mesenchymal components
of the intermediate mesoderm. In the first steps, the metanephrogenic mesenchyme is
committed and forms in the posterior regions of the intermediate mesoderm, where it
induces the formation of epithelial branches, called ureteric buds. These buds
eventually become the collecting ducts and ureters that take the urine to the bladder.
The ureteric buds induce the mesenchymal tissue (of metanephrogenic mesenchyme)
3. SYED MUHAMMAD KHAN (BS HONS. ZOOLOGY)
pg. 3
to form the nephrons of the mammalian kidney. As the mesenchyme differentiates, it
tells the ureteric bud to branch and grow.
Figure: General scheme of development in the vertebrate kidney. (A) Pronephros. (B)
Mesonephros. (C) Metanephros.
Reciprocal Interactions of Developing Kidney Tissues
The two intermediate mesodermal tissues (the ureteric bud and the metanephrogenic
mesenchyme) interact and reciprocally induce each other to form the kidney.
The metanephrogenic mesenchyme causes the ureteric bud to elongate and branch.
The tips of these branches induce the loose mesenchyme cells to form epithelial
aggregates which form the structure of a renal nephron.
4. SYED MUHAMMAD KHAN (BS HONS. ZOOLOGY)
pg. 4
While this transformation is happening, the epithelializing nodules fuse with the ureteric
bud ducts. This fusion creates a connection between the ureteric bud and the newly
formed tubule, allowing material to pass from one into the other. These tubules, derived
from the mesenchyme form the secretory nephrons of the functioning kidney, and the
branched ureteric bud gives rise to the renal collecting ducts and to the ureter, which
drains the urine from the kidney.