The document provides an overview of climate projections available for South Asia, including those from global climate models (GCMs), regional climate models (RCMs), and downscaling techniques. It discusses sources of projections like the Coupled Model Intercomparison Project (CMIP), the Coordinated Regional Climate Downscaling Experiment (CORDEX), and the Providing Regional Climates for Impacts Studies (PRECIS) model. The document emphasizes the challenge of making sense of the various models, scenarios, and methods, and advocates for distilling the information through co-production with users to develop clear and robust messages for decision-makers.
Copernicus Atmosphere Monitoring Service - An introductionCopernicus ECMWF
Copernicus Atmosphere Monitoring Service: An introduction by
Vincent-Henri Peuch, Head of Copernicus Atmosphere Monitoring Service provided for the ECMWF Copernicus Services Info Day, Brussels, 2 February 2015.
How is the climate changing? Climate monitoring based on observations Copernicus ECMWF
"How is the climate changing? Climate monitoring based on observations" presentation prepared by Dick Dee and Adrian Simmons, European Centre for Medium-Range Weather Forecasts (ECMWF) for the Common Future Conference session on Copernicus Climate Change Service: a European answer to Climate Change Challenges held in Paris (France), 09 July 2015.
Copernicus Atmosphere Monitoring Service - An introductionCopernicus ECMWF
Copernicus Atmosphere Monitoring Service: An introduction by
Vincent-Henri Peuch, Head of Copernicus Atmosphere Monitoring Service provided for the ECMWF Copernicus Services Info Day, Brussels, 2 February 2015.
How is the climate changing? Climate monitoring based on observations Copernicus ECMWF
"How is the climate changing? Climate monitoring based on observations" presentation prepared by Dick Dee and Adrian Simmons, European Centre for Medium-Range Weather Forecasts (ECMWF) for the Common Future Conference session on Copernicus Climate Change Service: a European answer to Climate Change Challenges held in Paris (France), 09 July 2015.
The Value of Diversifying Uncertain Renewable Generation through the Transmis...Power System Operation
The Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission System
DSD-SEA 2019 Use of Earth Observation Data to Enhance Water Resource Manageme...Deltares
Presentation by Mr. Miguel Laverde, Asian Disaster Preparedness Center (Thailand) at the Seminar Hydro Software to support policy development and real-time decision making, during the Deltares Software Days South-East Asia 2019. Wednesday, 27 November 2019, Bangkok.
The EPA Catchments Unit held its 2018 annual Catchment Management Network Meeting on 14 November. All our local authorities and many other public bodies are invited to this meeting to talk about how to protect and improve Ireland's waters.
Web delivery of giant climate data sets to facilitate open scienceJames Hiebert
The world's best climate scientists are busy churning out computed projections of our planet's future atmosphere and ocean. However, major barriers exist to publishing geospatiotemporal climate data in an open and transparent manner. This is primarily due to the sheer volume of information that these data represent. A handful of variables for a handful of model realizations by dozens of models for scores of scenarios over centuries of time on tens to hundreds of thousands of grid points create big data. Secondary challenges include the novelty of high-resolution climate data and the complexity and sometimes enigmatic nature of climate data interpretation. Finally, scientific teams often lack either the background, the resources, or the mandate required to facilitate strategic data sharing, aside from dropping their output files onto an FTP site.
In the spirit of open data and open science, the Pacific Climate Impacts Consortium (PCIC), a regional climate services provider in British Columbia, Canada, has been making a concerted effort to use geospatial FOSS in order to expand the availability, comprehensibility and transparency of big climate data sets from the Coupled Model Intercomparison Project (CMIP5) experiment. This presentation will describe some of the technical challenges to serving large geospatiotemporal climate data sets over the web, including some of the nuances of climate data. Additionally, I will explain the requirements of the geospatial climate community, and outline the FOSS solutions that we have employed to serve big climate data sets over the web.
CCXG Global Forum March 2018, Transparency of reporting in technology support...OECD Environment
CCXG Global Forum March 2018, Transparency of reporting in technology support received and needed, general ideas from the Costa Rican caseby Andrea Meza
The Value of Diversifying Uncertain Renewable Generation through the Transmis...Power System Operation
The Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission SystemThe Value of Diversifying Uncertain Renewable Generation through the Transmission System
DSD-SEA 2019 Use of Earth Observation Data to Enhance Water Resource Manageme...Deltares
Presentation by Mr. Miguel Laverde, Asian Disaster Preparedness Center (Thailand) at the Seminar Hydro Software to support policy development and real-time decision making, during the Deltares Software Days South-East Asia 2019. Wednesday, 27 November 2019, Bangkok.
The EPA Catchments Unit held its 2018 annual Catchment Management Network Meeting on 14 November. All our local authorities and many other public bodies are invited to this meeting to talk about how to protect and improve Ireland's waters.
Web delivery of giant climate data sets to facilitate open scienceJames Hiebert
The world's best climate scientists are busy churning out computed projections of our planet's future atmosphere and ocean. However, major barriers exist to publishing geospatiotemporal climate data in an open and transparent manner. This is primarily due to the sheer volume of information that these data represent. A handful of variables for a handful of model realizations by dozens of models for scores of scenarios over centuries of time on tens to hundreds of thousands of grid points create big data. Secondary challenges include the novelty of high-resolution climate data and the complexity and sometimes enigmatic nature of climate data interpretation. Finally, scientific teams often lack either the background, the resources, or the mandate required to facilitate strategic data sharing, aside from dropping their output files onto an FTP site.
In the spirit of open data and open science, the Pacific Climate Impacts Consortium (PCIC), a regional climate services provider in British Columbia, Canada, has been making a concerted effort to use geospatial FOSS in order to expand the availability, comprehensibility and transparency of big climate data sets from the Coupled Model Intercomparison Project (CMIP5) experiment. This presentation will describe some of the technical challenges to serving large geospatiotemporal climate data sets over the web, including some of the nuances of climate data. Additionally, I will explain the requirements of the geospatial climate community, and outline the FOSS solutions that we have employed to serve big climate data sets over the web.
CCXG Global Forum March 2018, Transparency of reporting in technology support...OECD Environment
CCXG Global Forum March 2018, Transparency of reporting in technology support received and needed, general ideas from the Costa Rican caseby Andrea Meza
El 29 de febrero y el 1 de marzo de 2016, la Fundación Ramón Areces analizó la relación entre 'Big Data y el cambio climático' en unas jornadas. ¿Puede el Big Data ayudar a reducir el cambio climático? ¿Cómo contribuirá ese análisis masivo de datos a prevenir y gestionar catástrofes naturales? Son solo algunas de las preguntas a las que intentarán responder los ponentes. Las ciencias vinculadas al clima tienen en el Big Data una herramienta muy prometedora para afrontar diferentes fenómenos asociados al cambio climático.
Building Climate Resilience: Translating Climate Data into Risk Assessments Safe Software
Climate change affects us all. It is an urgent issue that requires practical solutions to mitigate its impacts. Data is at the center of understanding this challenge. In this informative webinar, we will explore how data can be leveraged to translate climate change projections into tangible hazard and risk assessments at the local level.
The webinar will cover a range of topics: including flood, fire, heat, drought, population health, and critical infrastructure, among others. We will also highlight our partner and customer experiences in this field and present key results from our participation in recent OGC pilots on Climate Resilience and Disaster Response. We will also be joined by special guests sharing their experience in the AgriTech sector, where gathering metrics and data from sensors is helping to reduce the demand from farming on precious resources like water for irrigation.
Through live demos, attendees will gain practical knowledge in accessing climate services from USGS & Environment Canada and how to convert climate model NetCDF outputs into more GIS-friendly formats like geodatabase & GeoJSON.
Finally, we will address the significant gaps and challenges that remain in assessing climate-related hazards and risks, and explore how FME can play a critical role in addressing these gaps. Join us for this important discussion on how you can use FME to build resilience and mitigate the impacts of climate change.
SWaRMA_IRBM_Module8_#1, Knowledge management and communication, Laurie et alICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#6, Godavari visit to observe IWRM technologies, Samden ...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#5, Sediment management at Afghanistan, Abdul A. ZazayICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#4, Sediment management including landslide and river ban...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#3, Groundwater and springshed management, Madhav Dhakal ...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#2, Improved watershed management, Sanjeev Bhuchar and Ho...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module6_#1, GLOF Risk Reduction, Finu Shrestha et al ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module5_#5, Water diplomacy and cooperation in Afghanistan, Sadia...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWARMA_IRBM_Module5_#4, Why riparian countries should cooperate in transbound...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module5_#3, Transboundary cooperation in HKH basins:overview of i...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module5_#2, Key principles of international water law, Ram Babu D...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module5_#1, Water diplomacy and regional cooperation, Anjal Praka...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module4_#1, Governance, Policy and institutional framework, Arabi...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module3_#1, Gendered vulnerabilities and the socioeconomic driver...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module2_#8, Scenario planning in IRBM, Shahriar WahidICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module2_#7, Basin planning experience from Australia, Andrew Joh...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module2_#6, Flood management in Nepal, Dilip GautamICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module2_#5, Role of hydrometeorological monitoring for IRBM in Ne...ICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
SWaRMA_IRBM_Module2_#4, Water ecosystem interaction, Susan CuddyICIMOD
This presentation is the part of 12-day (28 January–8 February 2019) training workshop on “Multi-scale Integrated River Basin Management (IRBM) from the Hindu Kush Himalayan Perspective” organized by the Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative of the International Centre for Integrated Mountain Development (ICIMOD), and targeted at participants from Afghanistan.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.