Cushing syndrome, also known as hypercortisolism, arises from prolonged exposure to excess cortisol, often due to corticosteroid medications or a pituitary tumor. Symptoms include weight gain, skin changes, fatigue, and emotional disturbances. Diagnosis involves urine, blood, and imaging tests, with treatments like medication, surgery, and reducing corticosteroid use.

1. -RASHMI RITHUSHA.V
MBBS Student
SRMMCH&RC

2.  It occurs when the body is exposed to high
levels of the hormone cortisol for a long
time.
 also called hypercortisolism.

3.  Cushing disease is caused by a pituitary
gland tumor (usually benign) that over-
secretes the hormone ACTH, thus
overstimulating the adrenal glands' cortisol
production.
 Cushing syndrome refers to the signs and
symptoms associated with excess cortisol in
the body, regardless of the cause.

4.  high stress levels, including stress related to
an acute illness, surgery, injury, or
pregnancy, especially in the final trimester
 athletic training
 malnutrition
 alcoholism
 depression, panic disorders, or high levels of
emotional stress
 The most common cause of Cushing
syndrome is the use of corticosteroid
medications, such as prednisone, in high
doses for a long period.

5.  a pituitary gland tumor in which the pituitary
gland releases too much adrenocorticotropic
hormone, which is also known as Cushing’s
disease
 ectopic ACTH syndrome, which causes tumors
that usually occur in the lung, pancreas,
thyroid, or thymus gland
 an adrenal gland abnormality or tumor

6.  Weight gain and fatty tissue deposits,
particularly around the midsection and upper
back, in the face (moon face), and between
the shoulders (buffalo hump)
 Pink or purple stretch marks (striae) on the
skin of the abdomen, thighs, breasts and
arms
 Thinning, fragile skin that bruises easily
 Slow healing of cuts, insect bites and
infections
 Acne

7. Women with Cushing syndrome may
experience:
 Thicker or more visible body and facial hair
(hirsutism)
 Irregular or absent menstrual periods
Men with Cushing syndrome may experience:
 Decreased fertility
 Erectile dysfunction

8.  Severe fatigue
 Muscle weakness
 Depression, anxiety and irritability
 Loss of emotional control
 Cognitive difficulties
 New or worsened high blood pressure
 Headache
 Bone loss, leading to fractures over time
 In children, impaired growth

12.  urine & blood test
 saliva test
 imaging test
 petrosal sinus
sampling
 reducing
corticosteroid use
 surgery
 radiation therapy
 medications

13.  https://www.mayoclinic.org/diseases-
conditions/cushing-syndrome/.
 https://www.webmd.com/a-to-z-
guides/cushing-syndrome
 https://pituitarysociety.org/.../cushings/sy
mptoms-of-cushings-disease