This PPT covers curvilinear motion of an object in a very systematic and lucid manner. I hope this PPT will be helpful for instructor's as well as students.
In Engineering Mechanics the static problems are classified as two types: Concurrent and Non-Concurrent force systems. The presentation discloses a methodology to solve the problems of Concurrent and Non-Concurrent force systems.
In Engineering Mechanics the static problems are classified as two types: Concurrent and Non-Concurrent force systems. The presentation discloses a methodology to solve the problems of Concurrent and Non-Concurrent force systems.
Learn Online Courses of Subject Engineering Mechanics of First Year Engineering. Clear the Concepts of Engineering Mechanics Through Video Lectures and PDF Notes. https://ekeeda.com/streamdetails/subject/Engineering-Mechanics
Definition of force,types of forces,law of forces,system of forces, moment of a force, couple,moment of a couple,types of moments,features of couple and principle of moments.
Learn Online Courses of Subject Engineering Mechanics of First Year Engineering. Clear the Concepts of Engineering Mechanics Through Video Lectures and PDF Notes. https://ekeeda.com/streamdetails/subject/Engineering-Mechanics
Definition of force,types of forces,law of forces,system of forces, moment of a force, couple,moment of a couple,types of moments,features of couple and principle of moments.
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This presentation covers scalar quantity, vector quantity, addition of vectors & multiplication of vector. I hope this PPT will be helpful for Instructors as well as students.
Motion in a Straight Line Class 11 Physics
As students embark on the journey into the fascinating realm of physics in Class 11, one of the fundamental topics that captivates their attention is "Motion in a Straight Line." This foundational concept forms the bedrock of kinematics, the branch of physics concerned with the description of motion. In this chapter, students explore the dynamics of objects moving along a linear path, unraveling the principles that govern their displacement, velocity, and acceleration. From understanding the basic distinctions between scalar and vector quantities to delving into the equations that quantify motion, Class 11 students embark on a captivating exploration of the fundamental laws that underpin the linear journey of objects in motion. Motion in a straight line not only serves as a gateway to more intricate concepts in physics but also provides a lens through which students perceive and analyze the dynamics of the world around them.
For more information, visit. www.vavaclasses.com
In this relative motion and relative speed concept is demonstrated with help of examples, graphically and mathematically. The concepts of Einstein and Galileo
Introduction to physics--Branches of Physics--Importance of physicsKhanSaif2
This presentation covers about physics, branches of physics and importance of physics in a very interactive manner. I hope this presentation will be helpful for teachers as well as students.
This presentation covers concepts such as surface tension, surface energy, liquid drops and bubbles, wetting, capillarity at the elementary school level. Comment down in a box for improvement.
Physical Quantities--Units and Measurement--Conversion of UnitsKhanSaif2
This presentation covers physical quantities and their types, units and their types, conversion of units and order of magnitude in a very interactive manner. I hope this presentation will be helpful for teachers as well as students.
This PPT covers relative motion between particles in a very systematic and lucid manner. I hope this PPT will be helpful for instructor's as well as students.
This PPT covers projectile motion of an object in a very systematic and lucid manner. I hope this PPT will be helpful for instructors as well as students.
This PPT covers linear motion of an object in a very systematic and lucid manner. I hope this PPT will be helpful for instructor's as well as students.
This ppt covers composition and functions of blood in a systematic and interactive manner. I hope this PPT will be helpful for instructor's as well as students.
This presentation covers basics of cell structure and functions of different cell organelles in detail with interactive illustrations. I hope this presentation will be beneficial for instructor's as well as students.
Force, types of forces and system of forcesKhanSaif2
This presentation covers concept of force and different types of forces as well as different system of forces. I hope this PPT will be helpful for instructors as well as students.
This presentation covers internal structures of heart like atria and ventricles & external structures like emerging blood vessels and grooves on the heart. I hope this PPT will be helpful for instructors as well as teachers.
This presentation covers vertical motion under gravity, effect of air resistance on free fall & graphs of free fall. I hope this PPT will be helpful for instructors as well as students.
This presentation covers measurement of physical quantities, system of units, dimensional analysis & error analysis. I hope this PPT will be helpful for instructors as well as students.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. The motion of an object along
a curved path is called
a curvilinear motion.
Curvilinear motion
3. Motion of car along a
curved road
Motion of cable car along a
steel cable
Curvilinear motion in a plane
4. Motion of roller coaster along
its track.
Motion of fighter jets during
national parade.
Curvilinear motion in a space
5. Position
r
𝑥 𝑖O
𝑥
𝑦
𝑦 𝑗
A r = 𝑥 𝑖 + 𝑦 𝑗
The position of particle at point A
in vector form is represented as,
The distance of particle from
origin is
r = 𝑥2 + 𝑦2
Particle′s path
7. Magnitude & direction of displacement
ri
O
𝑥
𝑦
A
B
rf
∆r
Magnitude:
∆r
∆𝑥
∆𝑦 θ
∆r = ∆𝑥 2 + ∆𝑦 2
Direction:
θ = tan−1
∆𝑦
∆𝑥
8. Average velocity
ri
O
𝑥
𝑦
A
B
rf
∆r
The average velocity of particle
from point A to point B is given by
vavg vavg =
∆r
∆t
=
∆𝑥 𝑖 + ∆𝑦 𝑗
∆t
vavg =
∆𝑥
∆t
𝑖 +
∆𝑦
∆t
𝑗
vavg = vavg−𝑥 𝑖 + vavg−𝑦 𝑗
9. Magnitude & direction of average velocity
ri
O
𝑥
𝑦
A
B
rf
∆r
vavg
Magnitude:
vavg = vavg−𝑥
2
+ vavg−𝑦
2
Direction:
θ = tan−1
vavg−𝑦
vavg−𝑥
vavg
vavg−𝑥
vavg−𝑦 θ
13. Average acceleration
vA
A
B
vB
O
𝑦
𝑥
The average acceleration of particle
from point A to point B is given by
aavg =
∆v
∆t
=
∆v 𝑥 𝑖 + ∆v 𝑦 𝑗
∆t
aavg =
∆v 𝑥
∆t
𝑖 +
∆v 𝑦
∆t
𝑗
aavg = aavg−𝑥 𝑖 + aavg−𝑦 𝑗
∆v
aavg
14. Magnitude & direction of average acceleration
vA
A
B
vB
O
𝑦
𝑥
aavg
aavg−𝑥
aavg−𝑦
Magnitude:
aavg = aavg−𝑥
2
+ aavg−𝑦
2
Direction:
θ = tan−1
aavg−𝑦
aavg−𝑥
θ
16. Magnitude & direction of instantaneous acceleration
vA
A
O
𝑦
𝑥
a
a 𝑥
a 𝑦
θ
a = a 𝑥
2 + a 𝑦
2
Magnitude:
Direction:
θ = tan−1
a 𝑦
a 𝑥
17. Tangential & normal component of acceleration
a
at
an
at = tangential componet of
acceleration
It changes the speed of particle
an = normal componet of
acceleration
It changes the direction of particle
v
A
18. Tangential & normal component of acceleration
Speed is constant Speed is increasing Speed is decreasing
v
a = an
v
a
at
an
v
a
at
an
A A A