This document summarizes a study on the effects of copper-infused socks. 56 patients with various foot conditions like erythema, burning, itching, and scaling were observed while wearing the copper socks. For erythema, 51 patients improved and 22 resolved completely within an average of 9 days. A follow up study of 22 patients found that 19 maintained improvement or resolution after 36 days on average, while 3 reverted or did not improve. The copper socks showed promising results in reducing common foot conditions.
organic apple insect control program biological 7-16-14Kurt Schwartau
beetleGONE! is derived from a natural microbe called Bacillus thuringiensis subsp. galleriae. It is considered compliant with the USDA National organic program positive list. beetleGONE! fits well within an integrated pest management program IPM. It is complimentary to mating disruption, granulosis virus, other Bt strains active against Lepidoptera (moths), spray oil and other larvacides. It was developed in collaboration with Michigan State, U of Wisconsin, UC Davis, Joliet Community College and other organizations. It does not impact bees or other beneficial insects and may be applied while bees are foraging without worries.
• Femto Silver is able to kill the pathogens or most of the microorganism that
cause diseases within 6 minutes
• Destroy over 650 types of pathogens within a very short period of time.
• Strengthen your body immune system
• Femto Silver shows it has super strong and naturally antibacterial properties.
It can prevent secondary infection.
organic apple insect control program biological 7-16-14Kurt Schwartau
beetleGONE! is derived from a natural microbe called Bacillus thuringiensis subsp. galleriae. It is considered compliant with the USDA National organic program positive list. beetleGONE! fits well within an integrated pest management program IPM. It is complimentary to mating disruption, granulosis virus, other Bt strains active against Lepidoptera (moths), spray oil and other larvacides. It was developed in collaboration with Michigan State, U of Wisconsin, UC Davis, Joliet Community College and other organizations. It does not impact bees or other beneficial insects and may be applied while bees are foraging without worries.
• Femto Silver is able to kill the pathogens or most of the microorganism that
cause diseases within 6 minutes
• Destroy over 650 types of pathogens within a very short period of time.
• Strengthen your body immune system
• Femto Silver shows it has super strong and naturally antibacterial properties.
It can prevent secondary infection.
Study of Biocidal Activity of Copper A Reviewijtsrd
Copper ions, either alone or in copper complexes, have been used to disinfect liquids, solids and human tissue for centuries. Today copper is used as a water purifier, algaecide, fungicide, nematocide, molluscicide as well as an anti bacterial and anti fouling agent. Copper also displays potent anti viral activity. We have explained i the biocidal properties of copper ii the possible mechanisms by which copper is toxic to microorganisms and iii the systems by which many microorganisms resist high concentrations of heavy metals, with an emphasis on copper. Health care associated infections HAIs are a global problem associated with significant morbidity and mortality. Controlling the spread of antimicrobial resistant bacteria is a major public health challenge, and antimicrobial resistance has become one of the most important global problems in current times. The antimicrobial effect of copper has been known for centuries, and ongoing research is being conducted on the use of copper coated hard and soft surfaces for reduction of microbial contamination and, subsequently, reduction of HAIs. Dr. Pragya Tank "Study of Biocidal Activity of Copper: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50696.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/50696/study-of-biocidal-activity-of-copper-a-review/dr-pragya-tank
A New Tool to Fight Hospital-Acquired Infections:Antimicrobial Copper Touch S...Wilton Moran, MBA
Hospital-acquired infections are the healthcare industries biggest secret. Each year, about 100,000 people die from these infections. The culprits - germs that contaminate touch surfaces. Enter Antimicrobial Copper. Antimicrobial Copper offers a powerful new infection-prevention tool. Components made from antimicrobial copper are surfaces commonly touched by patients and healthcare workers. Neither staff behavioral changes nor other intervention are required. They are durable, work 24/7 and are a one-time cost that provide long-term benefits.
this presentation deals with the history , advent and existence of calcium hydroxide in dentistry. I have also added a few articles that talk on the recent studies carried on to replace calcium hydroxide and so on. I guess this would be useful somehow to the undergrad and post grad students as well as will serve as a revision holder for experienced practitioners
Testing the ability against Bacillus cereus of actinobacteria strains isolate...Agriculture Journal IJOEAR
This study aimed to test the antibacterial activity of Bacillus cereus of actinobacterial isolates isolated from marine sponges in the Kien Giang Sea, Vietnam. That can select the strains with high resistance to identify them. There were 198 actinobacterial isolates tested. Based on the ability of antimicrobial activity to B. cereus, 82/198 had the against B. cereus, in which there were six isolates with high (7.3%), 52 medium (25.6%), and 21 weak resistance (67.1%). Selection of six isolates with the best resistance to B. cereus (ND1.7a, ND2.7c, HD1-3e, HD1-6a, HD2.3b, and H6b) identified by PCR and 16S rRNA gene sequencing. The results identified five strains of Streptomyces (Streptomyces tateyamensis ND1.7a, Streptomyces althioticus HD1.3e, Streptomyces flaveolus HD1.6a, Streptomyces olivaceus HD2.3d, and Streptomyces albidoflavus H6b) and one strain of genus Microbacterium (Microbacterium tumbae ND2.7c).
How the Irradiation is going to apply for Food & Food Products, how and when it was started, what are the major advantages of Irradiating Food Products, and Recent advances in the Irradiation Process of Food Products
this is about the application of nanotechnology in agriculture. that how we can secure the growth of plants and crops and make our crops better. in this ppt the use of nano-particles has discussed to avoid different pests and diseases by ruining the crops.
Small Arms Lethality variables 1.6e DRAFTJA Larson
small arms lethality is a complex equation.
military operations are generally a team event.....more like football or soccer than tennis......
therefore teamwork and safety adds complexity
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
How to Give Better Lectures: Some Tips for Doctors
Copper As A Med Treatment
1. Joint Accessions Research and Best Practices Symposium – April 18, 2007
Innovative Technology For
Medicine
COPPER
Richard C. Zatcoff, D.P.M.
DABPS, FACFAS, FACFAOM
2. Historic PerspectiveHistoric Perspective
• The ancient Greeks (400 BC) discover the
sanitizing power of copper. They prescribed
copper for pulmonary diseases and for purifying
drinking water.
• Copper strips were nailed to ships’ hulls by the
early Phoenicians to inhibit fouling.
• American Pioneers put silver and copper coins in
large wooden water casks to assure safe drinking
water.
3. • In World War II, Japanese soldiers put
pieces of copper in their water bottles to
help prevent dysentery.
• NASA uses copper for water
purification
4. Resistance to copperResistance to copper
While copper has been used for thousands of
years, as opposed to antibiotics, no micro-
organism has evolved which is resistant to
constant exposure to copper.
Although some organisms have reduced
sensitivity to excess copper, as a rule, exposure
of micro-organisms to high concentrations of
copper results in damage to cellular
components.
6. Essential Metals for Human Health
Copper Calcium
Cobalt Chromium
Iron Potassium
Magnesium Manganese
Sodium Nickel
Zinc
7. The adult body contains
between 1.4 – 2.1 mg of copper
per kilogram of body weight.
8. •Highest concentration of copper
found in brain and liver
•Approx. 50% of total copper
content of the body is found in
the bones and muscles
9. AbsorptionAbsorption
•Newly absorbed copper is transported to
body tissues by plasma protein carriers
especially ceruloplasmin
•Copper combines with certain proteins
to produce enzymes.
Linder, Wooten, et. al., AM. J. CLIN. NOTR. 67.1998
Levenson, AM. J. CLIN. NOTR. 67.1998
10. Additional Properties of CopperAdditional Properties of Copper
• Anti-bacterial
• Anti-fungal
• Anti-viral
11. Today soluble copper is used as a:
Water Purifier
Algicide
Fungicide
Molluscicide
Bactericide
14. Cell membrane permeability and lipid peroxidation.
Displacement of essential metals from their native
binding sites.
Interference with oxidative phosphorylation and
osmotic balance.
Alterations in the conformational structure of nucleic
acids and proteins.
Redox cycling between Cu+2+2
and Cu+1
catalyzes the
production of highly hydroxyl radicals, with
subsequent damage to biomolecules, such as
lipids, proteins, DNA and RNA.
Borkow G, et al. Current Medicinal Chemistry. 2005;12:2163-2175
18. • Bacteria require Cu+1
and Cu+2+2
to
survive
• CsoR – protein that allows the
causative agent of bacteria including
TB and S. aureus to respond to Cu
Giedroc D, Chem and Eng News, Dec 11, 2006, Vol 84: #50, pg 12
19. Cu+1
or Cu+2+2
CsoR- Settles back
on bacterial DNA
blocking further gene
transcription
CsoR
Bacterial DNA
CsoR Cu+1
or Cu+2+2
Bacterial transcription - genes, leading to
a protein pump that kicks out copper
Decreased
Cu
Possible Primary Cu Sensing Protein in Majority of Bacteria
Giedroc D, Chem and Eng News, Dec 11, 2006, Vol 84: #50, pg 12
20. Requirement for Cu in angiogenesis
Ziche M, et al. J. Natl Cancer Inst. 1982 Aug; 69(2):475-482
Harris E.D., Nutr Rev 2004 Feb; 62(2):60-4
21. Wound HealingWound Healing
• Copper helps to form cross-links in
collagen and elastin.
• Helps promote, maintain, and
repair connective tissues.
• Active during proliferation and
remodeling phases.
Diegelmann, Evans, Front. BIOSCI. 2004
22. Cupron Copper Gauze PadCupron Copper Gauze Pad
10cm x 10cm10cm x 10cm
3% Cupron3% Cupron
Gamma IrradiatedGamma Irradiated
24. Start treatment 2 Weeks of treatment
4 Weeks of treatment 10 Weeks of treatment
71 YO WM Diabetic
25. 4 Months of treatment
Start treatment 2 Weeks of treatment
55 YO WF Diabetic
9 Months of Treatment
1-30-2007
26. 5 Months of treatment
2 Weeks of treatmentStart treatment
75 YO WM Diabetic,PVD
27. #160 04-03-06
3 months before treatment
2 months of treatment
12 months of treatment
81 YO WM Diabetic, PVD
28. Biocidal, not just biostatic
Broad spectrum:
Destroy Gram+ and Gram- bacteria
Destroy fungi
Destroy viruses
Last for the life of the fabric
Be durable:
Withstand chemical exposure
Withstand hot water exposure
It must be safe for human use
Qualities that an anti-microbial fabric should have
29. Plating of Cellulose with Copper
Oxide Compounds
a
X 2,000
b
Cellulose Fiber
c
X 2,000
d
Copper-Coated Fiber
X 2,000
e f
Washed Copper-
Coated Fiber
30.
31. X 200
X 1,500
Inclusion of Copper Oxide into
Polymeric Materials
• Polyester,
• Polypropylene,
• Polyurethane,
• Polyolefin,
• Polyethylene, and
• Nylon fabrics
32. In Vitro StudiesIn Vitro Studies
with Copper Treatedwith Copper Treated
Fibers/FabricsFibers/Fabrics
33. Staphylococcus aureus
CFU per sample
103
104
105
106
120 min
0 min
Production Fabrics
Printed Cupron
Fabric
Control Fabric
(no copper)
Dyed Cupron
Fabric
Anti-bacterial Activity
Subcontract laboratory performing tests:
AminoLab Laboratory Services, Weizman Industrial Park, Nes Ziona 79400, Israel
Gram+
34. Escherichia coli
CFU per sample
103
104
105
106
120 min
0 min
Production Fabrics
Printed Cupron
Fabric
Dyed Cupron
Fabric
Control Fabric
(no copper)
Subcontract laboratory performing tests:
AminoLab Laboratory Services, Weizman Industrial Park, Nes Ziona 79400, Israel
Gram-
37. e.g. Inactivation of Viruses:
• Bronchitis Vaccine Virus - Jordan & Nassar (1971)
Vet. Rec. 89:609-10.
• Herpesvirus types 1 and 2 - Coleman et al (1973)
Antimicrob. Agents Chemother 4:259-62.
• Poliovirus - Totsuka & Ohtaki (1974)
Jpn. J. Microbiol18:107-12.
• Bacteriophages - Yamamoto et al (2001)
Biochem. Biophys. Acta. 91:257.
• HIV-1 – Sagripanti & Lightfoote MM (1996)
AIDS Res. Hum. Retroviruses 12:333-7.
• Enteroviruses, Rotaviruses, etc.
Copper Biocidal ActivityCopper Biocidal Activity
Is Very Well DocumentedIs Very Well Documented
38. Antiviral potency
of Cupron Filters
Virus Infectivity
Reduction
HIV-1 <.99 99%
Punta Toro <.99 99%
Rhinovirus 2 99.99%
Pichinde 99.99%
CMV 99.95%
Measles 99.95%
Influenza A 99.5%
WNV 99.5%
RSV 99%
Parainfluenza 3 96%
Yellow Fever 95%
VEE 94%
Vaccinia 80%
HIV-1 - Dr. Borkow at the Kaplan
Medical Center;
CMV - Dr. Yonat Shemer, Ben
Gurion University;
WNV – Harlan Laboratories;
Other viruses - Dr. Robert W.
Sidwell,
Director of The Institute for
Antiviral Research, Utah State
University, Utah, under a
subcontract from the NIH.
Percent of reduction of
the infectivity of viruses
following their passage
through Cupron filters
39. Animal StudiesAnimal Studies
Guinea Pig Maximization Test (ISO 10993-10
(1994) guideline). BSL Bioservice Scientific
Laboratories GmbH, Munich 80797, Germany
Rabbit Skin Irritation Test. (Biological Evaluation
of Medical Devices – ISO 10993-10) Harlan
Biotech Israel, Kiryat Weizmann, Rehovot
No Skin Irritation or
Allergenicity
48. 56 Patient-Clinical Study*56 Patient-Clinical Study*
Clinically TestedClinically Tested
Patients were compared to historical controls.Patients were compared to historical controls.
Patients with CupronPatients with Cupron®®
yarn socks were observed foryarn socks were observed for
improvement or resolution in the following conditions:improvement or resolution in the following conditions:
-Erythema-Erythema -Vesicular eruptions-Vesicular eruptions
-Burning/itching-Burning/itching -Fissures-Fissures
-Scaling-Scaling -Drainage-Drainage
-Edema-Edema -Odor-Odor
*2004-2005 Study,
R.C. Zatcoff, D.P.M.
Upstate Podiatry,
Greenville, SC
49. Another ObservationAnother Observation
9-9-04 10-7-04
*Dr. Zatcoff, Upstate
Podiatry, Greenville, SC
The healing power of copper-ion
technology first eliminates microbial
growth and then commences
angiogenesis.
50. 51 YO WF Diabetic51 YO WF Diabetic
09-08 09-22
61. #8906* 49 YO BF - Diabetic#8906* 49 YO BF - Diabetic
62. Mitigating FactorsMitigating Factors
Participant Compliance – Wear TimeParticipant Compliance – Wear Time
Possible degradation of Cupron FibersPossible degradation of Cupron Fibers
Persistent infection from nail reservoirPersistent infection from nail reservoir
Co-morbidity effectsCo-morbidity effects
63. A. ERYTHEMA (51 patients):A. ERYTHEMA (51 patients):
All 51 patients improved; 22 (42%) resolved completely over anAll 51 patients improved; 22 (42%) resolved completely over an
average period of 9 days (range 4-28 days).average period of 9 days (range 4-28 days). The 95% confidenceThe 95% confidence
interval for resolution was (0.29, 0.58).interval for resolution was (0.29, 0.58).
ERYTHEMA, 9 DAY AVERAGE FOLLOW-UP
0
5
10
15
20
25
30
35
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
64. A1. Longer term study (22 patients):A1. Longer term study (22 patients):
Nineteen (86%) maintained their improvement or resolved, 95% CI (0.65,Nineteen (86%) maintained their improvement or resolved, 95% CI (0.65,
0.97). Three patients (14%) did not maintain improvement or reverted0.97). Three patients (14%) did not maintain improvement or reverted
to “present”, 95% CI (0.03, 0.34). The average length of follow-up wasto “present”, 95% CI (0.03, 0.34). The average length of follow-up was
36 days. Diabetics and patients older than 65 shared in the36 days. Diabetics and patients older than 65 shared in the
improvement, both early and long-term.improvement, both early and long-term.
ERYTHEMA, AVERAGE FOLLOW-UP OF 36 DAYS
0
5
10
15
20
25
30
35
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
65. B. SCALING (56 patients):B. SCALING (56 patients):
Fifty-five (55) of the 56 improved (98%), 5 resolved (9%), and 1 stayedFifty-five (55) of the 56 improved (98%), 5 resolved (9%), and 1 stayed
the same. The 95% confidence interval for some improvement is (0.90,the same. The 95% confidence interval for some improvement is (0.90,
1.00); for resolution (0.03, 0.20). Both of the p-values are highly1.00); for resolution (0.03, 0.20). Both of the p-values are highly
significant for efficacy.significant for efficacy.
SCALING, AVERAGE TREATMENT OF 9 DAYS
0
10
20
30
40
50
60
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
66. B1.B1. Longer term study (24 patients):Longer term study (24 patients):
Twenty-one (88%) held improvement or resolved, 3 reverted with anTwenty-one (88%) held improvement or resolved, 3 reverted with an
average follow-up of 34 days. The 95% confidence interval is (0.68,average follow-up of 34 days. The 95% confidence interval is (0.68,
0.97) with a p-value <0.001. Again, diabetics and elderly shared in the0.97) with a p-value <0.001. Again, diabetics and elderly shared in the
improvement.improvement.
SCALING, AVERAGE FOLLOW-UP 34 DAYS
0
10
20
30
40
50
60
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
67. C.FISSURING (37 patients):C.FISSURING (37 patients):
All 37 patients improved; 15 (40%) resolved completely with an averageAll 37 patients improved; 15 (40%) resolved completely with an average
follow-up of 10 days, 95% CI (0.25, 0.58). This is highly significant.follow-up of 10 days, 95% CI (0.25, 0.58). This is highly significant.
FISSURING, AVERAGE FOLLOW-UP OF 10 DAYS
0
5
10
15
20
25
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
68. C1.C1. Longer term study (17 patients):Longer term study (17 patients):
All 17 patients improved, 6 (35%) resolved completely in an averageAll 17 patients improved, 6 (35%) resolved completely in an average
follow-up of 39 days, 95% CI (0.14, 0.62). Again, diabetics and elderlyfollow-up of 39 days, 95% CI (0.14, 0.62). Again, diabetics and elderly
shared in the improvement.shared in the improvement.
FISSURING, AVERAGE FOLLOW-UP OF 39 DAYS
0
5
10
15
20
25
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
69. D. BURNING OR ITCHING (23 patients):D. BURNING OR ITCHING (23 patients):
Nineteen of the 23 improved (83%), four stayed the same or reverted inNineteen of the 23 improved (83%), four stayed the same or reverted in
the average follow-up period of 8 days. The 95% confidence interval isthe average follow-up period of 8 days. The 95% confidence interval is
(0.61, 0.95) with a p-value of 0.003, again highly significant.(0.61, 0.95) with a p-value of 0.003, again highly significant.
BURNING OR ITCHING, AVERAGE FOLLOW-UP OF 8
DAYS
0
2
4
6
8
10
12
14
16
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
70. D1. Longer term study (8 patients):D1. Longer term study (8 patients):
All 8 patients were unchanged over an averageAll 8 patients were unchanged over an average
follow-up of 46 days, meaning that their initialfollow-up of 46 days, meaning that their initial
improvement was maintained. The numbers wereimprovement was maintained. The numbers were
too small to study diabetics and elderly.too small to study diabetics and elderly.
BURNING OR ITCHING, AVERAGE FOLLOW-UP OF
46 DAYS
0
2
4
6
8
10
12
14
16
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
71. E. VESICULAR ERUPTIONS (23 patients):E. VESICULAR ERUPTIONS (23 patients):
All 23 patients improved; 13 (56%) resolvedAll 23 patients improved; 13 (56%) resolved
completely, 95% CI (0.34, 0.76).completely, 95% CI (0.34, 0.76).
VESICULAR ERUPTIONS, AVERAGE FOLLOW-UP OF
8 DAYS
0
2
4
6
8
10
12
14
16
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
72. E1. Longer term study (10 patients):E1. Longer term study (10 patients):
All 10 patients maintained their improvement orAll 10 patients maintained their improvement or
resolved (6) over an average follow-up of 45 days.resolved (6) over an average follow-up of 45 days.
The proportions were similar for both diabetics andThe proportions were similar for both diabetics and
patients over the age of 65.patients over the age of 65.
VESICULAR ERUPTIONS, AVERAGE FOLLOW-UP OF
45 DAYS
0
2
4
6
8
10
12
14
16
SAME OR WORSE IMPROVED RESOLVED
NUMBERSOFPATIENTS
73. CONCLUSIONCONCLUSION
Compared to historical controls, patients with Cupron ® socksCompared to historical controls, patients with Cupron ® socks
had significant improvement or resolution in the followinghad significant improvement or resolution in the following
conditions:conditions:
- Erythema- Erythema - Vesicular eruptions- Vesicular eruptions
- Burning/itching- Burning/itching - Fissures- Fissures
- Scaling- Scaling - Drainage- Drainage
- Edema- Edema - Odor- Odor
Moreover, since nearly 40% (19 of 51) of the group was eitherMoreover, since nearly 40% (19 of 51) of the group was either
diabetic or older than 65 (10 were both diabetic and older thandiabetic or older than 65 (10 were both diabetic and older than
65), this study is statistically significant for improvement or65), this study is statistically significant for improvement or
resolved for all the above conditions for people with diabetes,resolved for all the above conditions for people with diabetes,
including elderly diabetics.including elderly diabetics.
Statistical Review – Michael S. Smith, MD MSStatistical Review – Michael S. Smith, MD MS
74. Continuous Antimicrobial
Product Protection
The Widest Spectrum anti-microbial
known today
Anti-odor
Anti-microbial
Anti-Fungal (including Athlete’s Foot,
Yeast Infections, Ring Worm)
Anti-Mite
Anti-Viral (including HIV, SARS, West
Nile, Hepatitis, Influenza)
Promotes Healing of Sores and Wounds
Fully Patent Protected
Available in Polyester, Nylon,
Polypropylene, Cotton, Tencel
Published in the Yale Medical Journal
A solution based product
Biocidal, not just biostatic
Broad spectrum in its ability
to destroy Gram+ (MRSA)
and Gram-(VRE) bacteria
Broad spectrum in its ability
to destroy fungi
Broad spectrum in its ability
to destroy viruses
Ability to promote wound
healing
Cosmetic benefits of better
looking skin
Fungi Bacteria