Introductory lecture to module on Management of Innovation and Technology . This presentation is the first lecture of the module " Management of Innovation and Technology" which was prepared for the students enrolled in the Masters in Biotechnology program, at Grenoble ecole de management, France. It introduces the students to the different technologies that are currently disrupting the economy, and is aimed at a business audience. Slides were updated on November 2015.
In this presentation, Praneeth introduces IoT and associated trends. Praneeth is interested in IoT applications in home automation space and he also has several ideas WRT to water management and transport management using IoT applications.
Artificial Intelligence is being supplanted by "Artificial Brain," i.e. neuromorphic technologies. Yet there still a whopping gap that neuromorphic systems need to close before they will become a match for successful AI applications.
Makers: Shubham Yadav, Aniket Dwivedi, Vedant Babade
presentation on internet of things (IOT) for seminar presentation and school projects.
included future of iot with its different application history and many more things.
In this presentation, Somadatta introduces the topic of IoT, associated trends and future predictions. His interest area lies in smart farming and smart devices to drive efficiency.
The Internet of Things, Ambient Intelligence, and the Move Towards Intelligen...George Vanecek
With the successful adoption of cloud-based services and the increasing capabilities of smart connected/wireless devices, the software and consumer electronics industries are turning towards innovating solutions within the Internet-of-Things (IoT) to offer consumers (and enterprises) smart solutions that take the dynamics of the real-world into consideration.
The vision is to bring the awareness of what happens in the real-world, how people live and how smart devices operate in the real world into the view and control of the digital world. Here the digital world is the totality of the Internet, the Web, and the private and public cloud services.
In this session, we will look at key technical trends and their increasing interdependency in the areas of real-world Sensing, Perception, Machine Learning, Context-awareness, dynamic Trust Determination, Semantic Web and Artificial Intelligence which are now enabling ambient intelligence and driving the emergence of Intelligence Systems within the Internet of Things. We will also look at the challenges that such interdependencies expose, and the opportunities that their solutions offer to the industry.
In this presentation, Praneeth introduces IoT and associated trends. Praneeth is interested in IoT applications in home automation space and he also has several ideas WRT to water management and transport management using IoT applications.
Artificial Intelligence is being supplanted by "Artificial Brain," i.e. neuromorphic technologies. Yet there still a whopping gap that neuromorphic systems need to close before they will become a match for successful AI applications.
Makers: Shubham Yadav, Aniket Dwivedi, Vedant Babade
presentation on internet of things (IOT) for seminar presentation and school projects.
included future of iot with its different application history and many more things.
In this presentation, Somadatta introduces the topic of IoT, associated trends and future predictions. His interest area lies in smart farming and smart devices to drive efficiency.
The Internet of Things, Ambient Intelligence, and the Move Towards Intelligen...George Vanecek
With the successful adoption of cloud-based services and the increasing capabilities of smart connected/wireless devices, the software and consumer electronics industries are turning towards innovating solutions within the Internet-of-Things (IoT) to offer consumers (and enterprises) smart solutions that take the dynamics of the real-world into consideration.
The vision is to bring the awareness of what happens in the real-world, how people live and how smart devices operate in the real world into the view and control of the digital world. Here the digital world is the totality of the Internet, the Web, and the private and public cloud services.
In this session, we will look at key technical trends and their increasing interdependency in the areas of real-world Sensing, Perception, Machine Learning, Context-awareness, dynamic Trust Determination, Semantic Web and Artificial Intelligence which are now enabling ambient intelligence and driving the emergence of Intelligence Systems within the Internet of Things. We will also look at the challenges that such interdependencies expose, and the opportunities that their solutions offer to the industry.
Why we should begin working on a global governance system for Artificial Gene...Jerome Glenn
Global Governance of the Transition from Artificial Narrow Intelligence to Artificial General Intelligence may take 10 to 15 years, AND some say AGI could happen with in 10 to 15 years, SO we study how this should or could be done now. Contact me if you are interested at Jerome.Glenn@Millennium.Project.org.
From The Guardian to Cisco, big business to small, it seems that everybody is talking about the Internet of Things — but what exactly is IoT and why does it matter?
Taking a deep dive, we explore the many faces of IoT in Healthcare. Technology research and advisory company, Gartner, currently place the Internet of Things at the peak of inflated expectations and there are certainly challenges. But IoT also holds real promise for healthcare and it is already making an impact today.
We demonstrate why the Internet of Things has a far reaching impact across all determinants of health and how it could lead to a broader model of healthcare. We look at some of the technologies that are available to buy or that are already in development today, whilst also exploring some of the very real challenges that integrating such technologies into healthcare presents. Finally, we offer some ideas about how you can get involved, whether you are a healthcare professional or not.
Document by McKinsey Quarterly (Michael Chui, Markus Löffler, and Roger Roberts)
More objects are becoming embedded with sensors and gaining the ability to communicate. The resulting information networks promise to create new business models, improve business processes, and reduce costs and risks.
This PPT contains the basic information regarding the Brain Computer Interface technology. You can find the detailed presentation file here under the heading "Brain Computer Interface WORD FILE"
Why we should begin working on a global governance system for Artificial Gene...Jerome Glenn
Global Governance of the Transition from Artificial Narrow Intelligence to Artificial General Intelligence may take 10 to 15 years, AND some say AGI could happen with in 10 to 15 years, SO we study how this should or could be done now. Contact me if you are interested at Jerome.Glenn@Millennium.Project.org.
From The Guardian to Cisco, big business to small, it seems that everybody is talking about the Internet of Things — but what exactly is IoT and why does it matter?
Taking a deep dive, we explore the many faces of IoT in Healthcare. Technology research and advisory company, Gartner, currently place the Internet of Things at the peak of inflated expectations and there are certainly challenges. But IoT also holds real promise for healthcare and it is already making an impact today.
We demonstrate why the Internet of Things has a far reaching impact across all determinants of health and how it could lead to a broader model of healthcare. We look at some of the technologies that are available to buy or that are already in development today, whilst also exploring some of the very real challenges that integrating such technologies into healthcare presents. Finally, we offer some ideas about how you can get involved, whether you are a healthcare professional or not.
Document by McKinsey Quarterly (Michael Chui, Markus Löffler, and Roger Roberts)
More objects are becoming embedded with sensors and gaining the ability to communicate. The resulting information networks promise to create new business models, improve business processes, and reduce costs and risks.
This PPT contains the basic information regarding the Brain Computer Interface technology. You can find the detailed presentation file here under the heading "Brain Computer Interface WORD FILE"
Differenze tra DreamSpark premium e DreamSpark. Quali sono i servizi offerti. Come si attiva Microsoft Azure for DreamSpark. (DreamSpark è il vecchio nome di Microsoft Imagine)
Find the right Cisco Certification training from IndiaOptions-No.1 Networking & Training Institute in Cochin | Thrissur | Trivandrum | Kerala . We provide best CCNA,CCNP,CCIE & All Networking Courses. www.indiaoptions.in
Guatemala Health System Assessment 2015HFG Project
Guatemala’s public health system benefits from a well-established regulatory framework, many years of institutional history, dedicated and experienced health sector workers, and an absence of dependence on external sources for financial support. Furthermore, the Peace Accords of 1996 established the basis for the future development of the system for the benefit all Guatemalans. Nevertheless, and in spite of its solid institutional legacy, during recent decades a number of problems have developed which have compromised the public health sector’s effectiveness. The result is a system which is fragmented, inefficient and fails to provide an equal level of health services to all Guatemalans. The country’s recent political instability has only brought these problems into sharper focus.
Strengthening Guatemala’s health system requires a thorough understanding of the system’s unique strengths and weaknesses. The HFG project conducted a Health System Assessment (HSA) for USAID/Guatemala with the primary objective of mapping the health system’s strengths and weaknesses and preparing recommendations to guide health system strengthening efforts in the country.
Rindi Bitcoin and Blockchains for Beginners - Sample PresentationCaterina Rindi
These are some of the basics that I will cover in my presentations on bitcoin and blockchain for a non-technical audience. I can go into depth on each slide, talk folks into creating their own bitcoin wallet and send them their first satoshis, as well as explore more potential uses of blockchains. Caterina Rindi.
Stories? Scenarios? BDD? Are these just more words in the ever-growing list of jargon that developers have to know? Or are they something more important than new terms to memorise?
In this session we'll look at how BDD fits into the software development work-flow, how to tell user stories through features, and how to automate them in Behat.
These techniques will help to ensure you're writing well designed and tested software that focuses on what the users want from a system.
Ferramentas para desenvolvimento no blockchain EthereumOriginalMy.com
Apresentamos o desenvolvimento para blockchain Ethereum utilizando:
- Solidity Browser
- Geth
- Mist
- Trufffle
Utilizando o Mercado Pokémon como plataforma de exemplo.
Read Curriculum vitae of Shwetabh Kumar as Project Manager at Deloitteshwetabhkumar
Hello, My name is Shwetabh Kumar and I am from Hyderabad. Presently I am associated with Deloitte Company as a Project Manager. Skilled in designing and developing modules/products, managing and tracking project execution, executing test scenarios, releasing products to production.
Pioneering the Future: Recent Innovations and New Technology Ideasapurvasawant25
In 2023, technology innovation is reaching new heights. Quantum computing, with its immense processing power, is poised to tackle complex problems in cryptography and materials science. AI continues to advance, with smarter algorithms reshaping industries like healthcare and finance. The widespread adoption of 5G technology promises faster connectivity and unlocks the potential of augmented reality and the Internet of Things. Sustainable energy solutions, from improved solar panels to grid management, are addressing environmental concerns. Biotechnology innovations, such as gene editing and personalized medicine, are transforming healthcare. The year 2023 marks a promising era of tech innovation that's set to redefine our world.
Please cite as: Kamel Boulos MN. Creating self-aware and smart healthy cities. Invited plenary keynote address followed by sub-plenary round table at WHO 2014 International Healthy Cities Conference, Athens, Greece, 25 October 2014. http://www.healthycities2014.org/ehome/89657/192014/?&
PPT updated in May 2015.
Oct 2017: See also https://www.slideshare.net/sl.medic/how-the-internet-of-things-and-people-can-help-improve-our-health-wellbeing-and-quality-of-life
Key technologies of the future. A must read for budding engineers and faculty.
The contents will be very useful for deciding areas and topics for seminars, projects and workshops.
Courtesy: TIFAC and Internet
Vertex Perspectives | AI Optimized Chipsets | Part IVVertex Holdings
In this instalment, we delve into other emerging technologies including neuromorphic chips and quantum computing systems, to examine their promise as alternative AI-optimized chipsets.
In this presentation, Krati intrduces the concept of IoT and discusses technological as well as platform trends. She describes an innovative proposal to develop a smart mattress that will help in 'productive sleep'.
Latest trends in information technologyAtifa Aqueel
This ppt includes the latest trends in information technology such as big data analytics, cloud computing, virtual reality, 5G wireless technology etc.
Similar to Convergence of Transitioning Technologies (20)
Essentials of Automations: The Art of Triggers and Actions in FMESafe Software
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
SAP Sapphire 2024 - ASUG301 building better apps with SAP Fiori.pdfPeter Spielvogel
Building better applications for business users with SAP Fiori.
• What is SAP Fiori and why it matters to you
• How a better user experience drives measurable business benefits
• How to get started with SAP Fiori today
• How SAP Fiori elements accelerates application development
• How SAP Build Code includes SAP Fiori tools and other generative artificial intelligence capabilities
• How SAP Fiori paves the way for using AI in SAP apps
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
A tale of scale & speed: How the US Navy is enabling software delivery from l...sonjaschweigert1
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
- How to build efficient development pipeline roles and component templates
- How to deliver security artifacts that matter for ATO’s (SBOMs, vulnerability reports, and policy evidence)
- How to streamline operations with automated policy checks on container images
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Alt. GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using ...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
The Metaverse and AI: how can decision-makers harness the Metaverse for their...Jen Stirrup
The Metaverse is popularized in science fiction, and now it is becoming closer to being a part of our daily lives through the use of social media and shopping companies. How can businesses survive in a world where Artificial Intelligence is becoming the present as well as the future of technology, and how does the Metaverse fit into business strategy when futurist ideas are developing into reality at accelerated rates? How do we do this when our data isn't up to scratch? How can we move towards success with our data so we are set up for the Metaverse when it arrives?
How can you help your company evolve, adapt, and succeed using Artificial Intelligence and the Metaverse to stay ahead of the competition? What are the potential issues, complications, and benefits that these technologies could bring to us and our organizations? In this session, Jen Stirrup will explain how to start thinking about these technologies as an organisation.
Pushing the limits of ePRTC: 100ns holdover for 100 daysAdtran
At WSTS 2024, Alon Stern explored the topic of parametric holdover and explained how recent research findings can be implemented in real-world PNT networks to achieve 100 nanoseconds of accuracy for up to 100 days.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdfPaige Cruz
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
8. Definition of a Robot….But the definition is changing
A robot is a machine that can physically communicate with its
environment.
It is a machine that is capable of :
Sensing its environment
Processing that information
Responding to that information
AI Brain that is
programmed
Body Chassis
with sensors
and wiring
Mechanical
means of
movement
9. Domains of use
• Auxiliary/ Support robots
• Domestic robots
• Robot Companions
• Advanced Competences
10. Robots that substitute human intervention
Areas of usage:
1. Replacing manual operations
2. High levels of precision
3. Increased Speed
4. Increasing Scale
5. Hazardous Environments
Auxiliary Robots
11.
12. Support robots
Robotic Surgery - minimally invasive surgery that uses
miniaturized surgical instruments that fit through a series of
quarter-inch incisions.
•Virtual and Augmented Reality
•Decision Aid
•Remote Learning
•Scar-less surgery
• Reduced Training Costs
13. Domestic robots • Roomba is able to change direction
on encountering obstacles, to detect
dirty spots on the floor, and to sense
steep drops to keep it from falling
down stairs
• It can adapt to perform other more
creative tasks using an embedded
computer.
• Robots are now so dexterous, smart
and cheap that they rival the
efficiency of low-cost outsourced
labor
14. • Baxter and Roomba
invented by former MIT
prof Rodney Brooks
• Baxter learns by
observing…No
reprogramming .
• It’s sensors detects
humans…. so it safe to
work around it.
• Baxter = $22,000.
• Kiva equipped warehouse
can handle 4 times the
volume of an un-
automated warehouse
Baxter: The Blue-Collar Robot
20. March 2015: Brain–computer
interfaces based on
electroencephalography (EEG)
allow paralyzed woman to fly a
F-35 JET with her mind.
Oct 2015: Scientists at
BRAINGATE connect Brain to a
Basic Tablet—Paralyzed Patient
Googles.
Neural Engineering and Neural Prostheses
Neuro engineering = electrical + mechanical engineering +
nanotechnology + computer science + cellular, molecular & cognitive
neuroscience
Neural prostheses directly interface the brain with computers.
An aspirin sized microarray chip is implanted into the brain, and
neural signals associated with intent are decoded by sophisticated
algorithms in real time and used to control mouse cursors.
23. Artificial General Intelligence (AGI)
• General intelligence
The ability of a system to achieve a variety of complex tasks in
different complex environments using limited computational
resources
“Specialized AI”, rather than “Artificial General Intelligence”
(AGI) still dominates the AI domain– Specific tasks instead of
multi-disciplinarity.
32. E-Commerce Transaction Fees (2.9%) = $18 Billion
Retail Credit Card Transaction fees (2.5%) = $260
Billion
Global Bank Transaction Fees = $524 Billion
Global Remittances --- 8.9% to 30% (Inter-
Africa)
$49 Billion of the $524 Billion in 2013.
Global Transaction Fees Estimated to reach
$681 billion in 2016.
33.
34. 340,282,366,920,938,463,463,374,607,431,768,211,456
…more !!!
Growth of the Number of Things
Connected to the Internet: CISC0
(2013)
$14.4
Trillion
in
Value
at
Stake
http://www.cisco.com/web/about/ac79/docs/innov
/IoE_Economy.pdf
http://www.accenture.com/Microsites/fsinsights/capital-markets-uk/Documents/Accenture-Global-
Boom-in-Fintech-Investment.pdf
Investment in Fintech ventures =
3X Growth, from $930 million in
2008 to $2.97billion in 2013
35. The 21 Bitcoin Computer is
the first computer with
native hardware and
software support for the
Bitcoin Protocol.
Easily build bitcoin-payable
apps, services, and devices
Cost $ 399
This level of investment is changing how entrepreneurs do business
and how large enterprises are thinking about future revenue models.
36. Key Objectives:
Distributed Transaction Processing & Applications
without the need for centralized control
infrastructure
Robust Security where no trusted third party is
required to secure transactions.
Solutions:
Peer-to-peer decentralized networks
A value-exchange protocol like the Blockchain
Autonomous Device Coordination
Empowered
Law
Bitrated.com
CryptoCorp
Colored Coins
Codius
37. ETHEREUM
• The block chain is a powerful idea that could be applied to more than just
transaction records.
• One use can be to develop computerized, self-enforcing contracts that make
automatic payments when a task is complete.
• This can be extended to voting systems, crowdfunding platforms, and even
other cryptocurrencies.
• All these interaction need TRUST!
• Ethereum is suited to these situations --- when users do not trust one another
and where central control is a weakness !
• In 2014, to make it easier to develop such applications, Gavin Wood and Vitalik
Buterin devised a way to combine the block chain with a programming
language. At present it is the first Turing complete language in the space
38. Bitcoin Blockchain ,non-
bitcoin currency
Non-bitcoin currency & non-Bitcoin
Blockchain
Own capital
Hire people
Issue shares
Produce profits
Pay Dividends
To shareholders who
host DACs
39.
40. Big Data, IoT & Quantum Computing
ECONOMICS COMPLEXITY ECONOMICS
CONSENSUS SYSTEMS ENGINEERING
REPUTATION ANONYMIZATION & PRIVACY
TECH as TOOL PART OF US
41. Bio-Tech= Bio + Tech+ Info
• Smart Textiles
– Aesthetic
– Performance
Enhancing
• How do you power
them?
• How do they
communicate?
• Can we use the body as
an interface?
• WIFI
• SOLAR
• BODY HEAT
43. A Quantum leap in Computer Science
• Spin = 1 Spin = 0 qbit
• 2 qbits- 00, 01, 10, and 11.
• A one liter molecular computer with ~1018 logic
elements might cost a few dollars.
• 1027 logic operations per second at 1 gigahertz
• Almost 10,000,000 Blue Gene supercomputers
($100,000,000 each) in parallel
• Roughly the computational power of 1011 humans
44. • June 26, 2015: D-Wave Systems broke the 1000 qubit
quantum computing barrier.
At 1000 qubits, the processor considers 21000 possibilities
simultaneously
• Sept 3, 2015: Intel Invests US$50 Million to Advance
Quantum Computing
• Oct 5, 2015: Using Industrial Manufacturing
technologies, University of New South Wales created
the first t quantum logic gate in silicon
Finance, Security and most importantly, Health care
sectors will be impacted.
45. Super Computing
The Universe is made up of matter and energy and is
governed by mathematical equations.
Humans are remarkably creative, intelligent and
adept at uncovering underlying mathematical
equations, yet they need computers to solve
problems at a grand scale for societal problems.
Really big problems require very large computational
capabilities.
Supercomputing leverages and integrates the best
technologies to help scientists transform their
research into new discoveries.
Supercomputing is the invisible engine that impacts
safety, security and quality of life in today’s society.
From predicting hurricanes to finding more efficient
energy sources to designing new drugs to cure
diseases, supercomputing is fundamental to society
50. 3D Printed Integrated Circuits • Conductive Ink lets
you print objects
and circuits in one
machine.
• This reduces cost,
time and the
business
relationship with
suppliers.
• The company has
also created inks
that can print
lithium-ion
batteries.
• This liquid power
source can be
deposited
between
components to
reduce size.
51. 3D Printing in the Bio Tech Sector
Anatomics: 3D Prints Titanium Ribs and Sternum for Cancer Patient
Using CT scans of the patient’s chest, they created
a precise 3D model, and then printed the implant
• As 3D printing allows products to be
custom-matched to an exact body shape, it
is being used to make better titanium bone
implants, prosthetic limbs and orthodontic
devices.
• Experiments in printing soft tissue are
underway, and may soon allow printed veins
and arteries to be used in operations.
• Today’s research into medical applications of
3D printing covers nano-medicine,
pharmaceuticals and printing of organs.
• 3D printing is now being used to customize
medicines and reduce, if not eliminate,
organ donor shortage.
52. 3D Printing Drugs
• Nearly 100% of all prescription drugs are mass produced by pharmaceutical
companies in commonly prescribed doses and in a handful of shapes.
• The shape and size of a pill can greatly change the effect it has .
“The future of medicine design
and manufacture is likely to
move away from mass
production of tablets/capsules of
limited dose range towards
extemporaneous fabrication of
unit dosage forms of any dose,
personalized to the patient,”
To correlate geometry with dissolution behavior.
Conclusion: Tablets showed no dependence on
the surface area but rather on surface are to
volume ratio, indicating that geometrical shape
has an influence on drug release profile.
October 13, 2015: FDA approves Aprecia’s
SPRITAM ,the 1st 3D-printed drug product for the
treatment of epilepsy seizures (adults & children)
53. 3D Bio Printing
• Bio-ink is made from living cells and behaves much like a liquid, making it easy to
print a desired shape.
• To make bio-ink, a slurry of cells is loaded into a cartridge and inserted into a
specially designed printer, along with another cartridge containing a gel known as
bio-paper.
• When the printer is triggered , the cartridges alternate layers to build a three
dimensional structure, with the bio-paper creating a supportive matrix that the ink
can thrive on.
• Applications:
• Tissue engineering: materials and hydrogels, growth factors, cells, collagen, cholesterol
• Drug delivery: bio-resorbable polymers, drugs , cells, genes, DNA, proteins , cholesterol
• Medical diagnostics and Biosensors: DNA, proteins and peptides, antibodies, enzymes, cells
• Structural genomics: lipids, proteins
Example:
World’s first 3D printable liver tissue
54. Companies Leading 3D Bioprinting
Company Location Salient Features
Organovo USA
Provides pharmaceutical companies with aa3exVive3D™
Liver Tissue for drug toxicity testing. Major partner: L'Oréal
Ultimate goal : 3D print human tissue for failing organs, and
eventually entire organs
Cyfuse Biomedical Japan
Bioprinter : Regenova allows them to create components
such as blood vessels, digestive & urinary organs, cartilage,
tubular tissues, & miniature livers.
BioBots USA
Affordable desktop bioprinters to researchers,
pharmaceutical companies
Aspect Biosystems Canada Drug discovery and lab-on-a-printer technology.
3D Bioprinting
Solutions
Russia
Aims to 3D print multiple human organs
Made the first mouse aa5thyroid gland, which they
implanted into a test subject (yes, another mouse)
Rokit S - Korea
Seeks to develop an in-situ 3D bioprinter by 2018, to make
human skin for burn victims / dermatological diseases.
3Dynamic Systems Wales, UK Creating on demand Human Bone, Skin & Muscle
TeVido USA Nipple replacement for breast cancer patients
55. CRISPR Cas9, Synthetic Biology, Gene
Editing & Bio-informatics
The transition from changing external elements to
changing core elements.
57. CRISPRs: Clustered regularly
interspaced short palindromic repeats.
CRISPR/Cas mechanism (Cas-"CRISPR
associated" genes) targets & splices
specific DNA strands — “edit” the
genome.
Set up cost for CRISPR editing-
order an RNA fragment (~$10)
off-the-shelf chemicals and enzymes
(~$30 ).
Cheap + quick + easy to use + more
accurate than previous methods
Reshaping biotech sector
Hundreds of millions of VC capital in
the past 3 years.
Key Players:
Jennifer Doudna, UCBerkeley
Feng Zhang, MIT
George Church, Harvard
58. What is CRISPR cas9 being used for?
Adjust genes to eliminate diseases, create hardier plants, wipe out
pathogens , etc….
Modified genes can be directly injected into fertilized zygotes to achieve
heritable gene modification.
April 10, 2014: replace defective genes with a correct sequence to treat
genetic disorders
June 19, 2014 : used to preventing HIV infection in human cells.
August 15, 2014: Genetically edited fruits. ….October 2015: DuPont
enters agreement with Caribou Biosciences, a spin-off lab. of Jennifer
Doudna. Says “Plants on Dinner Plates in Five Years”.
April 2015: Chinese scientists attempt to edit the DNA of a human embryo
August 2015: Editas Medicine, raises $120 million to create treatments for
cancer, retinal disease, sickle-cell anemia, autism, schizophrenia,
Alzheimer’s disease, and bipolar disorder.
59. Synthetic Biology
Producing standard biological components using the principles of computer
science and engineering.
Bits of Bases : From 0 & 1 to (A –T) and (C –G)
2010: Craig Venter Institute creates first self-replicating
synthetic cells
Along with learning how to read DNA, the drop in the price of computing has
lowered the price of sequencing DNA <$1000 (less than an X-ray). By 2020 < $1
We can now read DNA and see how one differs from another.
With all this data, Biology is no longer an analog science. It is an information
science. We can now read it, analyze it computationally and print it.
60. Genetic Engineering -- The next IT industry
Printing DNA---Array Synthesizer.
Individual strands of DNA are grown on chips that are
precise to the base pair. ….and the price is falling
(Carlson Curves)
This reduction in cost, is democratizing synthetic
biology. Eg: iGEM -Synthetic Biology competitions
Most of this info is available to anyone via GENBANK-
an annotated collection of all publicly available DNA
sequences.
Base Pairs Time (in years)
102
20
103
10
104
5
105
106
???
107
Proteins Viruses
Minimal
Life
Engineered
Life
What do we engineer?
61. Nano-Bio-Robo Technology
“The principles of physics as far as I can
see, do not speak against the possibility
of maneuvering things by the atom”…
There’s plenty of room at the bottom
MinION: Nanopore Sequencing of DNA
-Uses the fact that DNA is a negatively
charged polymer.
USB Sized DNA sequencing machine
Genome of Ebola Virus from 14 patients:
48 hrs
$3 billion and 13 yrs for 1st human genome
With this device: <$1000 and in a few
hours
Understand disease, personalize medicine,
sequence other species , understand
biodiversity
63. Virtual Reality in Biotech
Annually 40,000 people in ICU’s may die of a mis-diagnonsis…. just in the US .
A large percentage of mis-diagnosis happens because of insufficient visual inference of existing
data.
Education ,Simulate & repeat operations, Understand disease , Simulating drug delivery,
Understand the brain (economics, IT, education, society) , Safer for patient, faster diagnosis (5-
10 minutes instead of 30-40) & more efficient… No more image by image!!
Entirely virtual drug
discovery platform with no
lab
64. Deep Leaning and Bio informatics
• Dec 2014: Deep learning used to computational model and predict splicing
patterns based on genomic features
• Feburary 2015 : DANN: a deep learning algorithm that annotates pathogenicity
• August 2015: Deep learning to predict sequence specificity
• Early 2015: Company Deep Genomics - Uses deep learning & artificial intelligence
to map the genome and predict diseases.
Challenges addressed- the genetic determinants of autism, cancers and muscular
atrophy. Read the genome and find why we fall ill. Redefining personalized medicine.
Salaries of these specialists? ++ $250,000 a year (Washington Post)
Interdisciplinary Mindset = Good Business Sense
65. Big Data and Medicine
1. The Digitized Body
When every organ has an IP address and every data point is sent to the
cloud
2. Big Data Analytics
Mining our own business
3. Consumerization of Healthcare
Breaking down barriers of healthcare solutions
4. Open Table for Medicine
Emergence of the marketplace economy in healthcare
5. The Google Now of Healthcare
Remote technology, ambient intelligence, push notifications
67. A change in mindset
As a provider of healthcare:
1. Health Data in the Hands
of Patients.
2. Get Feedback from
Patients.
3. Have and Welcome a
Patient Advisory Council.
4. Resources in the Hands of
Patients.
As a receiver of healthcare:
1. Know and use my health
data.
2. Give Feedback.
3. Connect with Others who
share my health issues.
4. Between Visits, Use the
Resources My Providers
Give Me and the Resources I
Find.
68. Death is sooo 20th Century
Google's project Calico to ‘cure’ death,
announces $1.5 billion research center!
Projected Population growth 2010-2050: 39%
Growth of old-population (>>85) = +/- 400%
(relative to 2010)
Oct 2015: Scientists transform skin cells into
living cultures of aging human neurons—test
beds to reverse the effects of time.
AGESISM IS AN ISSUE …AND AN OPPORTUNITY
SEPTEMBER 30, 2015:
Treats 1st Patient with Gene
Therapy to Reverse Aging
Work space ergonomics, Spectacle
companies, elderly Healthcare, BEAM
(suitable tech), SE Asia (Vietnam )
Oct 2015: Human
Longevity, Inc.
Launches the
Health Nucleus
The platform uses whole genome
analysis, advanced clinical imaging
& machine learning together.
69. Your Opportunities.
• Develop solutions to a large-scale global challenge
• Address a significant public / industry issue with profound
health & economic consequences
• Use the Crowd! Not just Specialists!!
• Save lives and improve quality of life
70. 6D’s of Exponential Entrepreneurs
• Digitalization- Culture makes progress
cumulative. Innovation occurs as humans share
and exchange ideas.
• Deception- What follows digitalization is
deception, a period during which exponential
growth goes mostly unnoticed.
• Disruption- a technology is any innovation that
creates a new market and disrupts an existing
one. Unfortunately, as it follows deception, the
original technological threat often seems
laughably insignificant
SOURCE:P.Diamandis
71. • Demonetization- This means the removal of
money from the equation. Consider Kodak. Their
business evaporated when we replaced film with Pixels.
• Dematerialization- While demonetization
describes the vanishing of the money once paid for
goods and services, dematerialization is about the
vanishing of the goods and services themselves
…Who makes film?
• DEMOCRATIZATION – Crowd Source it and let
the users/people decide.
6D’s of Exponential Entrepreneurs
SOURCE:P.Diamandis
72.
73.
74.
75. A MUST FOR ANY ONE SERIOUS
about analysis of Data in the
Biotech field
http://www.nature.com/collection
s/qghhqm
Adapted from How to Study in College 7/e by Walter Pauk, 2001 Houghton Mifflin Company
SPRITAM manufacturing uses 3D printing to produce a porous formulation that rapidly disintegrates with a sip of liquid, making it easier to swallow. The “ZipDose Technology” allows for delivering a high drug load, up to 1,000 mg in a single dose, which is expected to help patients take their medication as prescribed. SPRITAM is expected to be available in the first quarter of 2016
Source. http://www.rand.org
Scientists can take skin cells from people of various ages and transform them into brain cells reflecting the ages of their donors. By creating neurons that retain the effects of aging. This technique opens up new avenues for studying aging, age-associated diseases, and the possibility that drugs might stave off what was once inevitable.