Hirschsprung disease is a developmental disorder of the enteric nervous system characterized by the absence of ganglion cells in the distal colon, resulting in functional obstruction. It is caused by congenital aganglionosis of the distal bowel. Diagnosis involves symptoms of delayed meconium passage and chronic constipation, as well as barium enema and rectal biopsy showing aganglionosis. Treatment involves rehydration, colostomy, and resection of the aganglionic segment via procedures like Swenson or Duhamel. Imperforate anus is caused by defects in formation of the posterior urorectal septum. It can be low or high and is sometimes associated with VACTERL