This powerpoint contains general information for public awareness on scope of SBEBA in Type 2 Diabetes mellitus .
The author along with Dr. Rajkumar are the pioneers of Science Based Evidence Based Ayurveda , a novel methodology for Evidence Based Practice in Ayurveda emerged in 2012. Currently hundreds of patients of Type 2 Diabetes are out of drugs/ med and Insulin by this methodology with their HbA1c maintained below 6 .
A very necessary intellectual uplift in fertility work up for practitioners, faculties and students of Ayurveda based on Science Based Evidence Based Ayurveda
This powerpoint contains general information for public awareness on scope of SBEBA in Type 2 Diabetes mellitus .
The author along with Dr. Rajkumar are the pioneers of Science Based Evidence Based Ayurveda , a novel methodology for Evidence Based Practice in Ayurveda emerged in 2012. Currently hundreds of patients of Type 2 Diabetes are out of drugs/ med and Insulin by this methodology with their HbA1c maintained below 6 .
A very necessary intellectual uplift in fertility work up for practitioners, faculties and students of Ayurveda based on Science Based Evidence Based Ayurveda
Panchakarma Schlok in Ashtang Hrudaya Sutrasthan Part 2 -- By Prof.Dr.R.R.Deshpande
• This PPT includes most useful Schlokas or verses from Ashtanga Hrudaya Sutrasthana .These schlokas are very easy to learn by heart .Schlokas like formulae ,which gives a lot information in concise manner .In this second Part , Chapters from 17 to 24 & Chpter 27 of Ashtang Hrudaya are covered as follows – 17) Sweda Vidhi 18) Vaman Virechan Vidhi 19) Basti vidhi 20 ) Natsya vidhi 21) Dhumapan Vidhi 22) Gandusha aadi vidhi 23) Ashotan Anjan vidhi 24) Tarpan putapak vidhi 27) Siravyadha vidhi
• Visit – www.ayurvedicfriend.com
Phone – 9226810630
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Colonic and anorectal physiology with surgical implications
CME On Science Based Evidence Based Paediatric practice
1. Science Based Evidence BasedScience Based Evidence Based
Ayurveda- CME on PaediatricsAyurveda- CME on Paediatrics
Dr.Remya Krishnan
2. How do Ayurveda docs make clinicalHow do Ayurveda docs make clinical
decisions?decisions?
• Toss coins
• Guess
• My “ yukti” – what is that Yukti??!
• Ask colleagues
• Text books- Exclusively for exams
• Browse journals –charts and graphs of efficacy
• Surrendering to senior Vaidyas- “Experience”(of
what?) matters
3. CliniciansClinicians reallyreally need to learn and understandneed to learn and understand
shasthraarthasshasthraarthas
If learning and understanding in right
direction:
that will reflect in our clinical decisions
but we do not know what is “right”
direction
– “my textbooks are full of complexity and
sutelity
– “my time for learning is less- I have to attend
many OPDs a day ”
– “library who wants after degree ??? Life is to
enjoy !”
4. How many minutes a week did weHow many minutes a week did we
spend last week reading andspend last week reading and
working out on our patients?working out on our patients?
Medical students- Working out?! We observe what
others do
Interns – We practice what our seniors command
Medical Officers- We practice what we think as
right and what our colleagues do
Faculties- We teach Medicine based practice and
practice medicine based trial and error
Consultants- We hardly think what we do ! We are
busy in meeting two ends in living !
5. How many minutes a week did you spend last week workingHow many minutes a week did you spend last week working
out based on samhithas?out based on samhithas?
Medical students- We are
too young to do that ! We
learn shlokas often
Interns- for entrance to MD
Medical officers – Joking?
We attend 100 Opds a day,
no time
Faculties- We teach but
working out???? Why? teach
and forget
Consultants- does that make
6. The inevitable consequenceThe inevitable consequence
The translation of samhithas
into practice guidelines for
clinical situations of
physicians NEVER HAPPENS
in clinical practice and
teaching
7. Three solutionsThree solutions
Clinical performance can keep up to date:
1. by learning how to practice evidence-
based medicine which is primarily science
based .
2. by seeking and applying evidence-based
tools and techniques developed from
shasthra which is already existing in
SBEBA resources .
3. by knowing, understanding and translating
shasthraarthas into variable clinical
situations
8. What Is Science BasedWhat Is Science Based
Evidence Based Medicine?Evidence Based Medicine?
The conscientious, explicit, and
judicious use of best standardised
shasthrik evidence in three different
levels in making decisions about the
care of individual patients in
accordance to their unique cause and
circumstances
9. What Is Evidence BasedWhat Is Evidence Based
Medicine?Medicine?
The practice of EBM requires the
indepth accurate knowledge of
shasthraarthas
with the appropriate
Tools and techniques for their
translation into appropriate situations
NOBODY TEACH US THIS IN
COLLEGES OR SEMINARS .
10. WHAT ARE THE IMPORTANT ELEMENTS OF EBMWHAT ARE THE IMPORTANT ELEMENTS OF EBM??
‘SBEBA begins and ends with patient’
1) Appraise and know patient situation
based on intended shasthraarthas
2) Work out on intended shasthraarthas
3) Write down what you understood and
your conclusive judgement.
4) Translate judgement into clinical
situation.
5) Evaluate your performance based on
11. Practical SBEBAPractical SBEBA
1. Understanding situation based
shasthraarthas
2. Working out in shasthraarthas
3. Deriving conclusive judgement
4. Translating judgement into clinical
practice
5. Evaluating results based on inbuilt
scientific standards
12. Scenario 1Scenario 1
In the middle of the night you are called to
see a screaming, febrile 3 years with acute
shooting pain in ear. What outcomes are
you hoping to achieve by treating the
child?
– Reduce pain?
– Control fever?
– Prevent complications?
– Assure parents?
Which is the most important? Why and
how it is realised ?
13. Scenario 2Scenario 2
You get a patient aged 7 years with
fever, breathing discomfort and
absence of general wellbeing. On
auscultation bilateral rales and
rhonchi present . What is your
Ayurvedic diagnosis and how will you
manage by Evidence Based Ayurveda?
14. Training sessions inTraining sessions in
PaediatricsPaediatrics
Day 1 – October 1, 2016- 2pm to 5pm
– Fundamental lessons on practice of
Evidence Based Ayurveda. The
Evidence Triad Approach and
shasthrik standards in he practice of
Evidence Based Medicine developed
and published by the core faculties
themselves. This can be applied in any
named and unnamed disease in all
situations
15. Training sessions inTraining sessions in
PaediatricsPaediatrics
Day 2 – October 2- SBEBA guidelines
for evidence based practice in
Paediatrics
All the common paediatric ailments
will be discussed with science based
guidelines of diagnosis, differential
diagnosis and on the target
management
16. DO NOT MISS THISDO NOT MISS THIS
SBEBA wisdom series will transform
your current professional status by
raising your standards in the intended
practice of Science Based Medicine
Do not wait to register as
registration is in progress and we
admit only 50 Maximum candidates
So hurry up if you real wish for the
change to begin !
17. For more details on SBEBA Wisdom
series , visit our website sbeba.org
For registration to CME on
Paediatrics , mail to
drremyaraj@gmail.com
Venue- Thalassery, Kerala
WELCOME AND THANKYOU!