This document discusses the importance of practicing science-based Ayurvedic medicine. It argues that Ayurveda is a science-based medical system that relies on proven principles and reasoning based on cause, mechanism, and effect. True Ayurvedic practice emphasizes "Shasthrartha karma," or practice based on scientific principles, rather than "Karmartha shasthra," or science based on practice. It states that Ayurvedic diagnosis, principles, and treatments are fundamentally scientific and capable of accurate predictions. The document stresses that Ayurvedic evidence must guide medicine to achieve intended effects and prevent harm with certainty, rather than just showing probabilistic benefits outweighing risks. It contrasts Ayurved
SBEBA is the practice of Evidence Based Medicine in Ayurveda . It is for the first tiime that a systematically standardised scientific decision making methodology is developed in this system of Medicine. SBEBA is developed by Drs. Rajkumar and Remya Krishnan
SBEBA is the practice of Evidence Based Medicine in Ayurveda . It is for the first tiime that a systematically standardised scientific decision making methodology is developed in this system of Medicine. SBEBA is developed by Drs. Rajkumar and Remya Krishnan
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
A review presentation by an authority - Dr Ashok Vaidya,
for drug design based on therapeutic efficacy of ayurvedic herbs carrying out reverse engineering ...
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
WHY AYURVEDA DOCTORS NEED TRANSFORMATION?????
1. DR. REMYA KRISHNAN MD (AYU), PHDDR. REMYA KRISHNAN MD (AYU), PHD
Why Ayurveda doctors should Care aboutWhy Ayurveda doctors should Care about
practisingpractising Science Based MedicineScience Based Medicine
2. What is Science?What is Science?
Science is tested ,verified andScience is tested ,verified and
permanently proven and establishedpermanently proven and established
knowledge (set of rationale) based onknowledge (set of rationale) based on
reasoning by cause- mechanism – effect.reasoning by cause- mechanism – effect.
““Science" also refers to a body ofScience" also refers to a body of
knowledge itself, of the type that can beknowledge itself, of the type that can be
rationally explained and reliably applied inrationally explained and reliably applied in
every period .every period .
3. Ayurveda is Science Based MedicineAyurveda is Science Based Medicine
Ayurveda incorporates permanently proven andAyurveda incorporates permanently proven and
established theorems and principles for practice .established theorems and principles for practice .
In Ayurveda, Medicine is led by Science and notIn Ayurveda, Medicine is led by Science and not
the reverse .the reverse .
So Ayurveda isSo Ayurveda is Science Based MedicineScience Based Medicine
4. Science Based AyurvedaScience Based Ayurveda
Ayurveda advocates conscientious use of BasicAyurveda advocates conscientious use of Basic
science in making health care decisions .science in making health care decisions .
Ayurveda emphasises upon “ShasthrarthaAyurveda emphasises upon “Shasthrartha
karma” ( Science Based practice )and not “karma” ( Science Based practice )and not “
Karmartha shasthra” (Practice based Science)Karmartha shasthra” (Practice based Science)
The rationale for diagnosis, pathophysiologicThe rationale for diagnosis, pathophysiologic
principles and treatment principles in Ayurvedaprinciples and treatment principles in Ayurveda
are fundamentally correct and thus capable ofare fundamentally correct and thus capable of
accurate predictions .accurate predictions .
Thus Ayurveda is “Science Based EvidenceThus Ayurveda is “Science Based Evidence
Based”Based”
5. Science Based thinking is deterministic way of viewingScience Based thinking is deterministic way of viewing
Ayurveda advocates the scientific steps forAyurveda advocates the scientific steps for
deterministic way of exploring a human subjectdeterministic way of exploring a human subject
in his unique circumstances and the impact ofin his unique circumstances and the impact of
external environment upon him .external environment upon him .
Ayurveda thus deserves to be instigated inAyurveda thus deserves to be instigated in
schools to inculcate the fundamentalschools to inculcate the fundamental
knowledge of human being and his response toknowledge of human being and his response to
external environment in childrenexternal environment in children
6. Evidence Based MedicineEvidence Based Medicine
Evidence Based Medicine is Medicine based onEvidence Based Medicine is Medicine based on
evidence .evidence .
Evidence is required for intended action of theEvidence is required for intended action of the
medicine in a situation and not mere “efficacy” .medicine in a situation and not mere “efficacy” .
Evidence must not mere lead the medicine “do moreEvidence must not mere lead the medicine “do more
good and less harm” in a probabilistic way .good and less harm” in a probabilistic way .
Instead, evidence must enable the medicine “doInstead, evidence must enable the medicine “do
the intended and thus protect from harm based onthe intended and thus protect from harm based on
certainity.certainity.
7. Do the intended &protect from allDo the intended &protect from all
harmharm
- This is the motto of AyurvedaThis is the motto of Ayurveda
- Evidence in Ayurveda is not information toEvidence in Ayurveda is not information to
support benefits of medicine .support benefits of medicine .
- Evidence in Ayurveda is “the systematicEvidence in Ayurveda is “the systematic
knowledge to do the intended and protect fromknowledge to do the intended and protect from
harm “.harm “.
- The systematic knowledge for the same isThe systematic knowledge for the same is
explained in the science of Ayurveda .explained in the science of Ayurveda .
- Ayurveda gives prime importnce toAyurveda gives prime importnce to ScienceScience
Based Evidence ,Based Evidence , not “Evidence based Science “not “Evidence based Science “
..
8. Evidence is notEvidence is not
Information supporting use of medicine .Information supporting use of medicine .
Information supporting the benefits of Medicine outweighing theInformation supporting the benefits of Medicine outweighing the
risks .risks .
Information showing 80% chance of certainityInformation showing 80% chance of certainity
Credibility of opinions offered by experts in the fieldCredibility of opinions offered by experts in the field
Evidence is :Evidence is :
Knowledge refined to guide the use of medicine .Knowledge refined to guide the use of medicine .
Knowledge refined to guide the use in specific individual.Knowledge refined to guide the use in specific individual.
Knowledge refined to guide the use in specific internalKnowledge refined to guide the use in specific internal
circumstances .circumstances .
Knowledge refined to guide the use for attainment of health ofKnowledge refined to guide the use for attainment of health of
subjectsubject
9. Ayurveda applies MATHEMATICAL THINKINGAyurveda applies MATHEMATICAL THINKING
Mathematical thinking is deductive: theMathematical thinking is deductive: the
inference of particular instances byinference of particular instances by
reference to a general law or principle.reference to a general law or principle.
““General to specific”.General to specific”.
10. Statistical Thinking vs. MathematicalStatistical Thinking vs. Mathematical
ThinkingThinking
Statistical thinking is inductive: theStatistical thinking is inductive: the
inference of general laws from particularinference of general laws from particular
instances.instances.
““Specific to general”Specific to general”
Application of statistical thinking isApplication of statistical thinking is
unscientific in Ayurvedaunscientific in Ayurveda
11. Why Should We Care AboutWhy Should We Care About
Teaching “Shasthraarthas” and notTeaching “Shasthraarthas” and not
shasthra ?shasthra ?
The teaching of shaasthararthas would equipThe teaching of shaasthararthas would equip
Ayurvedic medical graduates toAyurvedic medical graduates to
Understand algorithms of decision making inUnderstand algorithms of decision making in
diagnosis and treatment explained in shasthradiagnosis and treatment explained in shasthra
Understand and apply science based evidencesUnderstand and apply science based evidences
Translate shasthraarthas into everyday clinicalTranslate shasthraarthas into everyday clinical
situations which they encounter withsituations which they encounter with
Estimate and confirm the accuracy of theirEstimate and confirm the accuracy of their
calculations in decision making .calculations in decision making .
Effective communiction of shasthraarthas withEffective communiction of shasthraarthas with
colleagues and patientscolleagues and patients
12. NOT AYURVEDANOT AYURVEDA
Without the pertinent application ofWithout the pertinent application of
shathraarthas, there is no shatshra .shathraarthas, there is no shatshra .
So today, though there is a community toSo today, though there is a community to
learn, practice and propagate Ayurveda,learn, practice and propagate Ayurveda,
as they are not even getting to know aboutas they are not even getting to know about
and practice shasthraarthas, what theyand practice shasthraarthas, what they
practice is not Ayurveda !!!!!!!!!!!!!!!!!!!!!!!!!!!!practice is not Ayurveda !!!!!!!!!!!!!!!!!!!!!!!!!!!!
There is no solution other than learningThere is no solution other than learning
shaasthraarthas and their pertinentshaasthraarthas and their pertinent
application rather than read shaasthra !!!!application rather than read shaasthra !!!!