Basic science should guide evidence-based practice in Ayurveda. Science, not scientists, should drive research, with an external board overseeing grants for science-based studies. Standardizing diagnostics and evaluating classical drugs requires quality research on diagnostic and treatment principles. Policy support is needed for science-based clinical trials to optimize practices for individual cases. True evidence-based Ayurvedic medicine applies scientific diagnosis and treatment principles to specific clinical situations, rather than just evaluating products. Basic science is key to evidence-based Ayurveda and optimizing practices through robust studies with wider applicability and reduced health inequalities.