This document discusses key differences between Ayurveda and Western medicine in their approaches to research, diagnosis, treatment objectives, and evidence-based practice. It emphasizes that the goal of Ayurvedic research and treatment is to fully reverse a patient's morbidity by addressing underlying causes, not just alleviate symptoms. Ayurveda diagnoses seek to understand each unique patient and environment, while Western medicine focuses more on distinguishing diseases. The document argues that Ayurveda should be researched and practiced according to its own principles and not integrated with other medical systems without deep learning.
This powerpoint contains general information for public awareness on scope of SBEBA in Type 2 Diabetes mellitus .
The author along with Dr. Rajkumar are the pioneers of Science Based Evidence Based Ayurveda , a novel methodology for Evidence Based Practice in Ayurveda emerged in 2012. Currently hundreds of patients of Type 2 Diabetes are out of drugs/ med and Insulin by this methodology with their HbA1c maintained below 6 .
This powerpoint contains general information for public awareness on scope of SBEBA in Type 2 Diabetes mellitus .
The author along with Dr. Rajkumar are the pioneers of Science Based Evidence Based Ayurveda , a novel methodology for Evidence Based Practice in Ayurveda emerged in 2012. Currently hundreds of patients of Type 2 Diabetes are out of drugs/ med and Insulin by this methodology with their HbA1c maintained below 6 .
‘Allopathy’ is an archaic terminology only used in India. The correct terminology is Modern Medicine. Modern medicine requires that all drugs are proven effective and their safety well-established before they are administered to humans
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?
AYURVEDA IS NOT WHAT YOU THINK!
1. AYURVEDA IS NOT WHAT YOU
THINK
Dr. Remya Krishnan MD PhD
The Co-pioneer of SBEBA
2. RESEARCH IN AYURVEDA
• In Ayurveda , research is technically termed as pareeksha
• The very objective of research in Ayurveda is attaining Pratipattijnana.
• Pratipattijnana is technically defined as the knowledge of those specific
components of science of Ayurveda with regard to human subject and his
external environment, disease and medicine which when applied correctly
would instantly reverse the cause mechanisms of existing morbid condition in
the subject leading to health of the subject
• Ayurveda specifically emphasizes upon the need to conduct research also
specified that only a physician who does scientific research would only excel
in profession
3. Objective of research in Ayurveda
• Research in Ayurveda is not meant to develop “ this medicine in that disease”.
• Research in Ayurveda is to discover the most optimised application of
diagnostic and treatment principles of science of Ayurveda to reverse the
ENTIRE morbidity of the subject and thus enabling him to attain health.
• A subject might have multiple interlinked pathologies at the same time which
could be developed as a continuation of first developed disease pathology
unresolved or as a result of a method employed to treat the same or by both.
• It is therefore not possible to focus one disease alone in a subject with multiple
ones, if the intention is to enable him to get rid of morbidity because disease is
existing in dynamic human being and not a machine
4. Underlying difference in diagnosis
• Diagnosis in Ayurveda invariably differ from that of western medicine
• Diagnosis in western medicine is the process of determining which disease
explain a person’s signs and symptoms while diagnosis of Ayurveda is the
process of determining the nature (by signs and symptoms), mode of onset,
cause and course of the disease in relation to the internal and external
environment of the subject which constantly modify the nature of disease and
the subject as well.
• In western medicine, it is the disease which is discriminated and distinguished
by the diagnosis while in Ayurveda , it is the patient and his unique
environment which is distinguished by diagnosis
5. Difference in the objective of treatment
• The objective of drugs in Modern Medicine is emerging benefits outweighing
risks in the moment while that of Ayurveda is reversal of cause mechanisms of
disease and emerging health.
• The science of western medicine treats the body as a biochemical machine
and physicians as technicians who intend to repair the faults by doing some
adjustments.
• The approach of healing is the sick is replaced by the approach of making
patient comfortable as much as possible .
• The research papers on Medicine discuss the working of drugs and not healing
of patient
6. Underlying difference in approach of treatment
• First and foremost, it is only treatment and not any adjustment possible with
Ayurvedic science
• Hence identifying the initiating cause mechanisms responsible for chain of pathogenesis
based on unique environment of every subject is the crucial most part of Ayurvedic
diagnosis and reversal of the same is the sole method of Ayurveda in management.
• In Western Medicine at the same time , the drug treatment is mostly focused on the
blocking, suppressing, altering enzymes, hormones, channels, immune mechanisms etc ‘
• The use of such kind of drugs for doing different adjustments is given as prominence in
treatment and many times this necessitates polypharmacy to block/ suppress/ modify
pathologies of various system in variable manner.
7. Evidence Based Medicine
• Evidence Based Medicine in Ayurveda is not the data of benefit risks of unknown
compound/ treatment after administering the same in an unknown/ less known
population.
• Evidence Based Medicine in Ayurveda which is Ayurvedic science based is the very
foundation of practice of Ayurvedic science based Medicine . It recommends all the
doctors to engage in a continuous process of education in order to select and apply
the optimised evidence from the science to understand and reverse the particular
clinical situation in particular subject .
• Or in other words, physician of Ayurveda should be thoroughly conscious of every pros
and cons of his therapeutic decision and action which is to be based on transparent and
reproducible innate logics of the science
8. Evidence Based Medicine
• Evidence Based Medicine of Ayurveda is of two levels- the Primary and the
Secondary ones
• The primary evidence is entirely meant for the physician who must intellectually
depend upon accurate and appropriate contemplation and translation of
appropriate Science Based Evidence ( SBE) to the clinical situation and employ it
pertinently for the fasta nd on the target “intended effect”.
• Thus primary evidence is originally the integration of most suited algorithm of
science of Ayurveda to the situation in particular subject and therefore requires
precision, attention and responsibility for the physician
9. IMPORTANCE OF PRIMARY EVIDENCE
• The primary physician oriented evidence of Science Based Medicine is the
powerful most tool with the potential to maximise the quality and scientificity of
Ayurvedic medical practice ultimately to secure fast and intended recovery and
health of the people .
• Faulty employment of primary evidence by the physician will lead to several
medical errors like delay in recovery, aggravation of diseases and absence of
intended effects
• When the primary evidence is faulty or application is flawed , secondary
evidence which is the response of the subject to the primary evidence gets
naturally invalid.
10. Secondary evidence
• Secondary evidence of Evidence Based Medicine of Ayurveda is the highly specific individual
response of the subject towards the applied primary evidence.
• Secondary evidence of effectiveness of treatment is the onset of “intended effect”( not
benefit- risks) in intended time.
• A medicine/ treatment of Ayurveda is not unknown like that of western medicine ;rather it
has documented specific logical strategies ( guidelines and protocols) and standards
explained in Ayurvedic science for their manufacturing , choice and application which are
developed by both basic and applied research for centuries and established by Science
Based Evidences.
• Applied research in Ayurveda is intended for optimising primary science based evidence to
attain the “intended effects” in the subject in all the contemporary disease care situations
11. BASIC DIFFERENCE
• Western Medicine is a science of uncertainity and art of probability while Ayurveda is a
science of logicality and art of predictability.
• Discovering the patient and not merely the disease is the way of Ayurveda and thus paves for
the endless possibilities to explore and reverse the entire morbidity in man instead of doing
analytic reductionism.
• The research in Ayurveda gets scientific only when it terminates conventional stupidity of
analysing whether medicine X works in disease Y and instead intiatiate focus upon the
subject with disease Y and reversal of his morbidity .
• The highly specific and specialized principles of diagnostics and therapeutics in Ayurveda are
not written in a probability setting , rather they are thoroughly explained in an inbuilt science
based on proven algorithms of the inbuilt science of man instead of the very outbuilt
generalized data of population
12. • For all these reasons , Ayurveda is an entirely independent science of man
with its own theoretical and practical solid framework of theorems, laws and
algorithms for its independent mode of decision and application.
• Trying to forcibly interpret or integrate this medical science with that of the
infrastructure of different medical system is foolish and aimless .
• An alien science can never be learnt, mastered and applied by the world
without deep learning and comprehension of the same. There are no short
cuts for it .
13. CONCLUSION MESSAGE
If Ayurveda is not learnt, comprehended, researched and practiced as
Ayurveda , then do not call i Ayurveda