Cloud computing :
Accessibility: Cloud computing facilitates the access of applications and data from any location worldwide and from any device with an internet connection.
Cost savings: Cloud computing offers businesses scalable computing resources hence saving them on the cost of acquiring and maintaining them.
Security: Cloud providers especially those offering private cloud services, have strived to implement the best security standards and procedures in order to protect client’s data saved in the cloud.
Disaster recovery: Cloud computing offers the most efficient means for small, medium, and even large enterprises to backup and restore their data and applications in a fast and reliable way.
Cloud computing :
Accessibility: Cloud computing facilitates the access of applications and data from any location worldwide and from any device with an internet connection.
Cost savings: Cloud computing offers businesses scalable computing resources hence saving them on the cost of acquiring and maintaining them.
Security: Cloud providers especially those offering private cloud services, have strived to implement the best security standards and procedures in order to protect client’s data saved in the cloud.
Disaster recovery: Cloud computing offers the most efficient means for small, medium, and even large enterprises to backup and restore their data and applications in a fast and reliable way.
On demand delivery of IT resources through the internet with payment depending on the use of the service is known as cloud computing.
The term cloud refers to a network or the internet.
It gives a solution for infrastructure at low cost.
Cloud computing refers to manipulating, configuring, and accessing the applications online. It offers online data storage, infrastructure and application.
Cloud computing is both a combination of software and hardware based computing resources delivered as a network service.
What is Virtualization and its types & Techniques.What is hypervisor and its ...Shashi soni
This PPT contains Following Topics-
1.what is virtualization?
2.Examples of virtualization.
3.Techniques of virtualization.
4.Types of virtualization.
5.What is Hipervisor.
6.Types of Hypervisor with Diagrams.
Some set of examples are there like Virtual Box with demo image.
This is summary on Virtualization. It contains benefits and different types of Virtualization. For example:Server Virtualization, Network Virtualization, Data Virtualization etc.
This PPT presentation gives you detail introduction to cloud computing. In this ppt we have covered different types of cloud computing and different services cloud computing provides, benefits of it and challenges it faces.
A basic concept of cloud computing can be learned by going through these slides that I have shared. If you have any argument regarding these slides, you can freely put forward. Last but not least I want to request you to appreciate our work.
Peace!
NASIM TAHIR
BS ENGLISH
NUML ISLAMABAD
On demand delivery of IT resources through the internet with payment depending on the use of the service is known as cloud computing.
The term cloud refers to a network or the internet.
It gives a solution for infrastructure at low cost.
Cloud computing refers to manipulating, configuring, and accessing the applications online. It offers online data storage, infrastructure and application.
Cloud computing is both a combination of software and hardware based computing resources delivered as a network service.
What is Virtualization and its types & Techniques.What is hypervisor and its ...Shashi soni
This PPT contains Following Topics-
1.what is virtualization?
2.Examples of virtualization.
3.Techniques of virtualization.
4.Types of virtualization.
5.What is Hipervisor.
6.Types of Hypervisor with Diagrams.
Some set of examples are there like Virtual Box with demo image.
This is summary on Virtualization. It contains benefits and different types of Virtualization. For example:Server Virtualization, Network Virtualization, Data Virtualization etc.
This PPT presentation gives you detail introduction to cloud computing. In this ppt we have covered different types of cloud computing and different services cloud computing provides, benefits of it and challenges it faces.
A basic concept of cloud computing can be learned by going through these slides that I have shared. If you have any argument regarding these slides, you can freely put forward. Last but not least I want to request you to appreciate our work.
Peace!
NASIM TAHIR
BS ENGLISH
NUML ISLAMABAD
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. 1.Traditional computing
..To run copies of software in our PC
2.PC –centric
..documents can be accessed in
computer on the network.
3. But with the help of cloud computing we can
use our files where ever in the world
3. 1.Concepts evolved in 1950(IBM) called RJE
(remote job entry process)
2. In 2006 Amazon provided First public
cloud AWS(Amazon Web Service)
4. 1. Distributed computing on internet Or
delivery of computing service over the
internet
Eg : AWS
2. Instead of saving programs in our own PC
we can save them in Cloud and access
anywhere in the world
5. Storage:- put some data on some where by
providing some security to our data
*.only storage
Computing:- not only store the data we can
manipulate and process of data called as
Computing
*.process and storage of data
eg : computer and pendrives
6.
7. 1. End users
… use of Applications or Software
2. Business
…Infrastructure
3. Developer
….Platform
9. There are 3 services models given as:
1. Software as a Service (SaaS)
2. Platform as a Service (PaaS)
3. Infrastructure as a Service (IaaS)
10. Defined as Service-on-demand
In this model cloud providers install and
operate application software in the cloud
--Not allow to change the cloud
infrastructure and platform of cloud
--Eliminates install and run applications on
the user PC
SaaS includes: Google Apps, Microsoft Office
365
11. In this model cloud provides deliver a
computing platform
..Including Operating System, programming
language execution environment on Cloud
..Developer run software without any cost
..Reducing buying and managing hardware
and software layers
Eg: AWS Elastic Beanstalk, Google App Engine
12. Iaas offers computers physical or virtual
machines and other resources
…such as disk image library, file based
Storage, firewalls, IP addresses
Eg : Amazon EC2,Google Compute Engine,
HP Cloud
13. 1.Create an Account
user name and password
2. Content lives with the
account in the cloud
3. Log onto any computer
in your account and get
your content
14. 1. Lower computer costs
2. Reduce software cost
3. Unlimited storage capability
4. Universal document access
5. Latest version of software availability
6. Device independent
7. Create our own computer with require
configuration on cloud anywhere
8. Secure and no data loss because they
maintain a copy of data
15. 1. Requires constant internet connection
2. Not work well in Low-speed Connections
3. They can charge amount based on usage of cloud
and features of cloud system
4. Software features might be limited
5. Can be slow
1. For regular usage of cloud the payment is high
16. Cloud computing provide a super computing
power
The applications and data served by the cloud
are available to broad group of users
CLOUD
17. 1.Cloud Computing Concepts , Technology &
Architecture
…..Thomas Erl
published in 2013
2.Online Websites
..Google , Slide Share