Chronic suppurative otitis media (CSOM) is an infection of the middle ear characterized by ear discharge through a perforated eardrum for more than 3 months. It is caused by acute otitis media or middle ear effusions and is more common in developing countries. CSOM can be tubotympanic type, involving the front part of the middle ear, or atticoantral type, involving the back part and often associated with cholesteatoma. Treatment involves cleaning the ear, antibiotic ear drops, surgery to repair the eardrum or remove disease, and addressing underlying causes.
Chronic suppurative otitis media is a long standing infection of a part or whole of the middle ear cleft characterized by continuous or intermittent discharge through a persistent tympanic membrane perforation.
Incidence is higher in developing countries b/c of
Poor Socioeconomic standards, poor Nutrition, lack of health education
Affects both sexes
Affects all age groups
It is divided into two types
TUBOTYMPANIC : also called the safe or benign type; it involve anteroinferior part of middle ear cleft; i.e eustachian tube and mesotympanum and is associated with central perforation.
ATTICOANTRAL: also called unsafe or dangerous type; it involves posterosuperior part of the middle ear cleft; i.e. attic, antrum and mastoid. And is associated with an attic or marginal perforation and this type of CSOM is often associated with bone-eroding process such as cholesteatoma, granulation or osteitis
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Similar to Chronic Suppurative Otitis Media (CSOM)
Chronic suppurative otitis media is a long standing infection of a part or whole of the middle ear cleft characterized by continuous or intermittent discharge through a persistent tympanic membrane perforation.
Incidence is higher in developing countries b/c of
Poor Socioeconomic standards, poor Nutrition, lack of health education
Affects both sexes
Affects all age groups
It is divided into two types
TUBOTYMPANIC : also called the safe or benign type; it involve anteroinferior part of middle ear cleft; i.e eustachian tube and mesotympanum and is associated with central perforation.
ATTICOANTRAL: also called unsafe or dangerous type; it involves posterosuperior part of the middle ear cleft; i.e. attic, antrum and mastoid. And is associated with an attic or marginal perforation and this type of CSOM is often associated with bone-eroding process such as cholesteatoma, granulation or osteitis
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
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- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
2. OTITIS MEDIA: It is the inflammation of mucosal lining of
middle ear cleft.
Otitis Media
Suppurative
Acute
Chronic
Tubotympanic
type
Atticoantral
type
Non
Suppurative
3. • Chronic suppurative otitis media is an infection of
middle ear cleft characterized by otorrhea (ear
discharge) from a permanently perforated
tympanic membrane for more than 3 months.
• The perforation can occur from an acute otitis
media or a chronic middle ear effusion.
• Otorrhea can be the result of secretions entering
the middle ear from the eustachian tube or from
water exposure of the middle ear mucosa.
• EPIDEMIOLOGY: CSOM has higher incidence in
developing countries. It affects both sexes and all
age groups. CSOM is the most important cause of
hearing impairment mostly in rural population.
7. Tubotympanic (Safe or Benign)
• It involves anteroinferior part of middle ear cleft
i.e. eustachian tube and mesotympanum and is
associated with central perforation.
AETIOLOGY:
Acute otitis media
Ascending infection via eustachian tube
Allergy to ingestants such as milk, egg, fish etc.
8.
9. Pathology
• Perforation of Pars Tensa
• Middle Ear Mucosa
• Polyp
• Ossicular chain
• Tympanosclerosis
• Fibrosis and Adhesions
12. Assessment
• Examination under microscope: Provides useful
information regarding presence of granulations,
in-growth of squamous epithelium from the edges
of perforations, status of ossicular chain,
tympanosclerosis and adhesions.
• Audiogram: Degree of hearing and its type.
• Culture & Sensitivity of ear discharge: To select
proper antibiotic ear drops.
• Mastoid X-Rays/ CT Scan Temporal bone:
Mastoid is usually sclerotic but may be
pneumatized with clouding of air cells.
13. Treatment
Aural toilet
• Remove all discharge and debris by dry
mopping, suction clearance or irrigation.
Ear Drops
• Antibiotic ear drops containing neomycin,
polymyxin, gentamicin + steroids.
Systemic
Antiobiotics
• Useful for acute.
Precautions
• Keep water out of ear.
14. Treatment of
contributory
cause
•Such as infected tonsils, adenoids,
maxillary antra and nasal allergy.
Surgical
•Removal of aural polyp/
granulations.
Reconstructive
Surgery
•Myringoplasty with or without
ossicular reconstruction.
15. Atticoantral Type (Unsafe or Dangerous
type)
• It involves posterosuperior part of middle ear
cleft (attic, antrum, posterior tympanum and
mastoid) and is associated with cholesteatoma.
• This area of infection is lined by flat epithelium
that responds to infection by granulations and
exudations of scanty pus.
• Aetiology:
1. It is seen in sclerotic mastoid.
2. Cholesteatoma
16.
17. Pathology
• Cholesteatoma
• Osteitis and granulation tissue
• Ossicular necrosis
• Cholesterol granuloma
Bacteriology: Same as in tubotympanic.
Symptoms:
• Ear discharge
• Hearing loss
• Bleeding
19. • Retraction pockets: Invagination of tympanic
membrane in the attic or posterosuperior area of
pars tensa.
• Stages of retraction pockets
Stage I: TM retracted but does not contact the incus.
Stage II: TM retracted deep and contacts the incus.
Stage III ( Middle ear atelectasis): TM lies on promontory and
ossicles and middle ear space is obliterated.
Stage IV (Adhesive otitis media): Mucosal lining of middle ear is
absent and TM is adherent to promontory. Retraction pockets are
formed which may collect keratin plugs and form cholesteatoma.
20. Cholesteatoma
• Presence of keratinized
stratified squamous epithelium
in the middle ear cleft. It is a
skin in wrong place.
It is the main pathological
finding in atticoantral type of
CSOM.
Long process of incus is
commonly destroyed by
cholesteatoma.
Pearly white flakes of
cholesteatoma can be sucked
from the retraction pockets.
21. Assessment
• Examination under microscope: It reveals presence
of cholesteatoma, its site and extent, evidence of
bone destruction, granuloma, conditions of ossicles
and pockets of discharge.
• Tuning fork test and audiogram: Confirms the degree
and type of hearing loss.
• X-Ray mastoids/ CT Scan Temporal bone: They
indicate extent of bone destruction and degree of
mastoid pneumatization.
• Culture and sensitivity of ear discharge: Helps to
select proper antibiotic for local and systemic use.
22. Features Indicating Complications in
CSOM
• Pain
• Vertigo
• Persistent Headache
• Facial weakness
• A listless child refusing to take feeds
• Fever, Nausea and Vomiting
• Irritability and neck rigidity
• Diplopia
• Ataxia
• Abscess round the ear
24. Surgical
• Canal Wall Down
Procedure: Removal of
all or part of the
posterior bony canal
wall.
• Canal Wall Up
Procedure: The posterior
bony canal wall is not
removed.
25. • Reconstructive Surgery:
Hearing can be restored by
myringoplasty or tympanoplasty.
• Conservative treatment: Has
role in management of
cholesteatoma which is small
easily accessible to suction
clearance under operating
microscope.
Polyp and granulations can also
be surgically removed by cup
forceps or cauterized by chemical
agents.
Aural toilet and dry ear
precautions.