Child development occurs in distinct periods from prenatal to adolescence. It involves physical, cognitive, and social/emotional growth. During the prenatal period, the zygote develops into an embryo and fetus. Fetal development includes the growth of organs and reflexes. Infancy spans birth to 2 years and involves motor and language milestones. Toddlerhood from 1.5-3 years sees the development of autonomy and gender identity. Jean Piaget's theory of cognitive development describes stages from sensorimotor to formal operations. Attachment theory proposes that early relationships impact later relationships.
Growth and development of an infant in the various domains - physical, psychosocial, cognitive, psychosexual, spiritual and moral. Also discusses the special health concerns during infancy.
Growth and development of an infant in the various domains - physical, psychosocial, cognitive, psychosexual, spiritual and moral. Also discusses the special health concerns during infancy.
Prenatal development: germinal, embryonic &fetal period; Factors that can have a serious negative impact on the development of the unborn: maternal health, radiation, maternal nutrition, medication and drugs, age of the parents, diseases in the pregnant woman and the emotional state of the mother.
This presentation provides a brief overview of early brain development with links made to early years practice. Questions are included to help practitioners reflect on their role in helping to positively influence early brain development.
Prenatal development: germinal, embryonic &fetal period; Factors that can have a serious negative impact on the development of the unborn: maternal health, radiation, maternal nutrition, medication and drugs, age of the parents, diseases in the pregnant woman and the emotional state of the mother.
This presentation provides a brief overview of early brain development with links made to early years practice. Questions are included to help practitioners reflect on their role in helping to positively influence early brain development.
Psychology: It is the science dealing with human nature, function, and phenomenon of his soul in the main.
Child Psychology: It is science and study of Child’s mind and how it functions. It is also the science that deals with mental power or an interaction between the conscious and sub-conscious elements in a child.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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2. CHILD DEVELOPMENT
Definition:
Change in the child that occurs over time that moves
toward greater complexity and enhances survival.
Periods of development:
Prenatal: from conception to birth
Infancy and toddlerhood: birth to 2.5 years
Early childhood: 2.5-6 years old
Middle childhood: 6-12 years old
Adolescence: 12-18 years old
3. DOMAINS OF DEVELOPMENT
Development is described in three domains, but growth
in one domain influences the other domains.
Physical Domain:
body size, body proportions, appearance, motor development, coordination,
perception capacities, physical health.
Cognitive Domain:
thought processes and intellectual abilities including attention, memory,
problem solving, imagination, creativity, academic and everyday knowledge,
and language.
Social/Emotional Domain:
self-knowledge (self-esteem, sexual identity, ethnic identity), moral
reasoning, understanding and expression of emotions, self-regulation,
temperament, understanding others, interpersonal skills, and friendships.
4. PRENATAL DEVELOPMENT AND THE
NEWBORN
A single sperm cell penetrates the outer coating
of the egg and fuses to form one fertilized cell.
A zygote is a fertilized egg with 100 cells that
become increasingly diverse. At about 14 days
the zygote turns into an embryo.
At 9 weeks, an embryo turns into a fetus.
Teratogens are chemicals or viruses that can
enter the placenta and harm the developing
fetus.
5. FETAL LIFE:
1- Behavior
Women usually detect fetal movements 16 to 20
weeks into the pregnancy
The fetus may be able to hear by the 18th week,
and it responds to loud noises with muscle
contractions, movements, and an increased heart
rate.
Bright light flashed on the abdominal wall of the
20-week pregnant woman causes changes in fetal
heart rate and position
Eyelids open at 7 months. Smell and taste are
also developed at this time
6. Some reflexes present at birth exist in utero:
grasp reflex : 17 weeks
the Moro (startle) reflex, which appears at 25
weeks
the sucking reflex, which appears at about 28
weeks.
9. 3- Effect of maternal stress
Maternal stress correlates with high levels of
stress hormones in the fetal bloodstream
which act directly on the fetal neuronal
network
Mothers with high levels of anxiety are more
likely to have babies who are hyperactive,
irritable, and of low birthweight
fever in the mother causes the fetus's
temperature to rise.
10. 4- Genetic counseling
The diagnostic techniques used include
amniocentesis,ultrasound examinations, X-ray
studies, fetoscopy fetal blood and skin
sampling, chorionic villus sampling, and alpha
fetoprotein screening.
In about 2 percent of women tested, the results
are positive for some abnormality
11. 5- Maternal drug of abuse
Alcohol
Smoking
Marijuana , cocaine and heroin
Radiation : woman exposed to severe radiation
between weeks 2 and 15 of pregnancy, the baby
will be born with gross deformities or develop
cancer later in life.
Medications as : tetracyclines, valproate
[Depakene], carbamazepine [Tegretol],
phenytoin , progesterone-estrogens, lithium ,
13. INFANCY : 0 – 15 MONTHS
The average newborn weighs about 3,400 g
Premature infants are defined as those with a
gestation of less than 34 weeks or a birthweight
under 2,500 g
Such infants are at increased risk for learning
disabilities, such as dyslexia, emotional and
behavioral problems, mental retardation, and child
abuse.
Postmature infants are defined as infants born 2
weeks or more beyond the expected date of birth.
postmature baby typically has long nails, scanty
lanugo hair, more scalp hair than usual, and
increased alertness.
14. DEVELOPMENTAL LANDMARKS
Reflexes: rooting , grasp , planter , abdominal ,
startle , tonic neck reflexes are present at birth.
Survival systems: breathing , sucking ,
swallowing , circulatory and temperature
homeostasis are functional at birth.
Sensory organs : are incompletely developed
but at 1 day : can detect the smell of mother’s
milk and at 3 days: distinguish the mother’s
voice
Language and Cognitive Development
At birth, infants can make noises, such as
crying, but they do not vocalize until about 8
weeks.
By the end of infancy (about 2 years), infants
15.
16. JEAN PIAGET
Schemas are mental molds into which we pour our
experiences.
Example: living things move
17. ASSIMILATION AND
ACCOMMODATION
The process of
assimilation involves
incorporating new
experiences into our
current understanding
(schema). The process of
adjusting a schema and
modifying it is called
accommodation.
Jean Piaget with a subject
BillAnderson/PhotoResearchers,Inc.
19. Emotional and social development
• By the age of 3 weeks, infants imitate the
facial movements of adult caregivers
• These imitative behaviors are believed to be
the precursors of infants' emotional life.
• The smiling response : endogenous –2
months.
exogenous - 4
20. Temperamental Differences
There are strong suggestions of inborn
differences and wide variability in autonomic
reactivity and temperament among individual
infants.
Chess and Thomas identified nine behavioral
dimensions
Activity level , distractibility , adaptability
, attention span , intensity , threshold of
responsiveness , quality of mood ,
rhythmicity.
21. Stranger anxiety is the fear of strangers that
develops at around 8 months. This is the age
at which infants form schemas for familiar
faces and cannot assimilate a new face.
Margaret Mahler’s stages of separation –
individuation…till reach object constansy
based on watching interaction of children and
their mothers.
22. Origins of Attachment
Harlow (1971) showed that infants bond
with surrogate mothers because of bodily
contact and not because of nourishment.
Like bodily contact, familiarity is another
factor that causes attachment.
23. TYPES OF ATTACHMENT
Placed in a strange situation, 60% of children
express secure attachment, i.e., they explore
their environment happily in the presence of
their mothers. When their mother leave, they
show distress.
The other 30% show insecure attachment. These
children cling to their mothers or caregivers and
are less likely to explore the environment.
• Insecure / Avoidant attachment
• Insecure / Ambivalent attachment
25. DEPRIVATION OF ATTACHMENT
What happens when circumstances prevent a
child from forming attachments?
In such circumstances children become:
1. Withdrawn
2. Frightened
3. Unable to develop speech
26. PARENTAL FIT AND GOOD ENOUGH MOTHERING.
Parental fit describes how well the mother or
father relates to the newborn or developing
infant; the idea takes into account
temperamental characteristics of both parent
and child
Difficult children : 10 percent.. Must be
recog.
Easy children : 40 percent
The other 50 percent of children are
mixtures of these two types.
27. TODDLER PERIOD:15 MONTHS – 2 ½ YEARS
The second year of life is marked by
accelerated motor and intellectual
development.
The ability to walk gives toddlers some
control over their own actions
Parenting: Parents need to balance between
punishment and permissiveness and set
realistic limits on a toddler’s behavior.
28. DEVELOPMENTAL LANDMARKS
Language and Cognitive Development
create new behaviors from old ones (originality) and
engage
in symbolic activities.
Emotional and Social Development
pleasure and displeasure become further differentiated.
Social referencing is often apparent at this age; the child
looks to parents and others for emotional cues about how
to respond to novel events.
Toddlers show exploratory excitement, pleasure in
discovery and in developing new behavior (e.g., new
games)
organized demonstration of love and of protest
29. SEXUAL DEVELOPMENT
Through imitation & reward children assume the
behaviors that their cultures define as
appropriate for their sexual roles
Children exhibit curiosity about anatomical sex.
When their curiosity is met with honest, age-
appropriate replies… sense of the wonder of life
and are comfortable with their own roles.
If the subject of sex is taboo and children's
questions are rebuffed…shame and discomfort
may result.
30. Gender identity, the unshakable conviction of
being male or female, begins to manifest at 18
months and is often fixed by 24 to 30 months.
Gender role describes the behavior that society
deems appropriate for one sex or another
• Boys are more likely than girls to engage in
rough play
• Mothers talk more to girls than to boys
• by the time the child is 2 years of age, fathers
generally pay more attention to boys.
• girls want to play with dolls, boys with guns.
31. SPHINCTER CONTROL AND SLEEP
Control of daytime urination at age of 2.5
control of nighttime urination at age of 4
years.
Toddlers may have sleep difficulties related
to fear of the dark,managed by using a
nightlight.
Most toddlers generally sleep about 12 hours
a day, including a 2-hour nap
reassurance before going to bed