Jubair Sikdar presented on morphine alkaloids. Morphine is extracted from unripe poppy capsules. Structural changes to morphine's hydroxyl groups and other parts of the molecule impact its analgesic potency. Replacing the phenolic hydroxyl reduces analgesic effects, while replacing the alcoholic hydroxyl with a methoxy or ethoxy group increases potency. Morphine is used to reduce both acute and chronic pain, decrease shortness of breath symptoms, treat convulsions, enhance the efficacy of anesthetics, and counteract the effects of toxic alkaloids.

1. Presented by-
Name- Jubair Sikdar
Roll no-04
M. Pharm 1st semester
Department of Pharmaceutical Chemistry
TOPIC- MORPHINE ALKALOIDS
NETES Institute of Pharmaceutical Sciences, Mirza

2. CONTENTS:
 ISOLATION PROCEDURE OF ALKALOIDS
 STRUCTURAL ACTIVITY RELATIONSHIP OF
ALKALOIDS
 USES

3. BIOLOGICAL SOURCE:
 Morphine is a naturally occurring
substance extracted from the unripe but
fully grown capsules of Papaver
somniferum.
FAMILY: Papaveraceae

4. STRUCTURE
(4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-
Methanobenzofuro[3,2-e]isoquinoline-7,9-diol

5. ISOLATION PROCEDURE

6. STRUCTURALACTIVITY
RELATIONSHIP:
•Replacement of phenolic hydroxyl into –OCH3/-OC2H5 will
make the morphine less analgesic.

7. • Replacement of alcoholic hydroxyl with –OCH3 makes
the compound 5 times more active.
• Replacement of alcoholic hydroxyl with -OC2H5 makes
the compound 2.4 times more active than morphine.
• Replacement of alcoholic hydroxyl with –OCOCH3 will
also activates the compound by 4.2 times.
• Replacement of alcoholic hydroxyl with ketone group
inactivates the compound and makes it lesser active.
• By hydrogenation of alicyclic unsaturated linkage, activity
increases by 1.2 times.

8.  On replacement of the methyl group from tertiary
nitrogen by hydrogen atom, activity decreases.
USES:
• For the reduction of both, acute and chronic pain.
• In reducing the symptoms of shortness of breath
• Remedy in convulsions.
• Precede the use of anesthetics to increase their
efficacy
• Used as an antagonist for poisonous effects of
other alkaloids as strychnine, atropine,
Physostigmine.