M.Pharm 1st Semester Department of Pharmaceutical Chemistry

1. Presented by-
Name- Jubair Sikdar
Roll no-04
M. Pharm 1st semester
Department of Pharmaceutical Chemistry
TOPIC- MORPHINE ALKALOIDS
NETES Institute of Pharmaceutical Sciences, Mirza

2. CONTENTS:
 ISOLATION PROCEDURE OF ALKALOIDS
 STRUCTURAL ACTIVITY RELATIONSHIP OF
ALKALOIDS
 USES

3. BIOLOGICAL SOURCE:
 Morphine is a naturally occurring
substance extracted from the unripe but
fully grown capsules of Papaver
somniferum.
FAMILY: Papaveraceae

4. STRUCTURE
(4R,4aR,7S,7aR,12bS)-3-Methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-
Methanobenzofuro[3,2-e]isoquinoline-7,9-diol

5. ISOLATION PROCEDURE

6. STRUCTURALACTIVITY
RELATIONSHIP:
•Replacement of phenolic hydroxyl into –OCH3/-OC2H5 will
make the morphine less analgesic.

7. • Replacement of alcoholic hydroxyl with –OCH3 makes
the compound 5 times more active.
• Replacement of alcoholic hydroxyl with -OC2H5 makes
the compound 2.4 times more active than morphine.
• Replacement of alcoholic hydroxyl with –OCOCH3 will
also activates the compound by 4.2 times.
• Replacement of alcoholic hydroxyl with ketone group
inactivates the compound and makes it lesser active.
• By hydrogenation of alicyclic unsaturated linkage, activity
increases by 1.2 times.

8.  On replacement of the methyl group from tertiary
nitrogen by hydrogen atom, activity decreases.
USES:
• For the reduction of both, acute and chronic pain.
• In reducing the symptoms of shortness of breath
• Remedy in convulsions.
• Precede the use of anesthetics to increase their
efficacy
• Used as an antagonist for poisonous effects of
other alkaloids as strychnine, atropine,
Physostigmine.