This slide is about introduction part of chemical incompatibility.. reference book: dispensing pharmacy by metha

1. Chemical
Incompatibility
ARG Pharma learn
GOMATHI A.R
DEPARTMENT OF PHARMACEUTICS
JKKM COLLEGE OF PHARMACY
ERODE

2. Definition

3. Definition
Chemical interaction between the ingredients in prescription
A toxic / inactive product may be formed
Due to oxidation reduction, acid base hydrolysis
Characterized by precipitation, effervescence, decomposition and
color change/ explosion

4. Types

5. Types
Tolerated changing the order of mixing or
mixing of solution in dilute form
Adjusted
addition/substitution of reacting
substance with other of equal
therapeutic value

6. Incompatibility may be….

7. Incompatibility may be….
Intentional
• When the prescriber knowingly
prescribe the incompatible drug
Unintentional
• When the prescriber prescribes the
drug unknowingly

8. Precipitates

9. Precipitates
Diffusible
Reaction between dilute solution proceed at a slower rate
Light precipitates
Diffuse readily in solution
Not soluble in water
Uniformly distributed
Indiffusible
Reaction between Strong solution proceed at a faster rate
Thick precipitates
Do not diffuse readily in solution
Not soluble in water
Not uniformly distributed

10. Precipitate yielding interaction

11. Precipitate yielding interaction
Method A
Reacting
substance
Reacting
substance
Add one by
one with rapid
stirring
Diffusible
precipitate
Label : Shake well
before use

12. Precipitate yielding interaction
Method B
Smooth
Mucilage
Reacting
substance
Add one by
one with rapid
stirring
Indiffusible
precipitate
Compound
tragacanth
1
2
2nd
portion
+
Reacting
substance Label : Shake well
before use

13. EXAMPLES

14. EXAMPLES
Alkaloidal Incompatibility
Soluble salicylate incompatibility
Soluble iodide incompatibility
Chemical incompatibility causing evolution of carbon dioxide gas
Miscellaneous
1
2
3
4
5

15. THANK YOU ………..