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The Science of Nutrition
Fifth Edition
Chapter 13
Achieving and Maintaining
a Healthful Body Weight
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
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Copyright © 2020 Pearson Education, Inc. All Rights Reserved
What Is a Healthful Body Weight? (1 of 3)
• Appropriate for age and physical development
• Achievable and sustainable without constant dieting
• Compatible with normal blood pressure, lipid levels, and
glucose tolerance
• Based on genetic background and family history of body
shape and weight
• Supported by good eating habits and allows for regular
physical activity
• Acceptable to you
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Evaluating Body Weight
• Determining if a person’s body weight is healthful should
include:
– Determining the body mass index (BMI)
– Measuring body composition
– Assessing the pattern of fat distribution
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Body Mass Index
• Represents the ratio of a person’s weight to the square of
his or her height
• 2
BMI = weight (kg)/heigh (m)
t
• a
2
BMI = weight lbs /height inch
[ ( ) ( ) ]
es × 703
• BMI values below 18.5 or above 30 have increased health
risks
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Figure 13.1
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What Is a Healthful Body Weight? (2 of 3)
• Underweight:
– BMI less than 2
18.5 kg/m
– Having too little body fat to maintain health
• Normal weight:
– BMI between 2
18.5 and 24.9 kg/m
• Overweight:
– BMI between 2
25 and 29.9 kg/m
– Having a moderate amount of excess body fat
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
What Is a Healthful Body Weight? (3 of 3)
• Obese:
– Class 1: BMI between 30 and 2
34.9 kg/m
– Class 2: BMI between 35 and 2
39.9 kg/m
– Having an excess of body fat that adversely affects
health, increasing disease risk significantly
• Morbid obesity:
– Class 3: BMI greater or equal to 2
40 kg/m
– Body weight exceeding 100% of normal, a very high
risk for serious health consequences
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Limitations of BMI
• Not an indication of body composition
• Not appropriate for use in older adults (bone and muscle
loss) and children (bone and muscle growth), athletes,
pregnant, and lactating women
• Doesn’t account for physical and metabolic differences in
ethnic backgrounds
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Body Composition
• Estimate body composition by assessing body fat and
lean body mass with
– Underwater weighing
– Skinfold measurements
– Bioelectrical impedance analysis
– Near-infrared reactance
– Dual-energy X-ray absorptiometry (DXA)
– Bod Pod™
• Norms vary according to gender and fitness
• Obesity: >25% for men and >32% for women
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Figure 13.2
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ABC News Video: Overweight and
Healthy?
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Fat Distribution Pattern (1 of 2)
• Apple-shaped fat patterning: upper body
– Increased risk for chronic diseases
– Men tend to store fat in the abdominal region
• Pear-shaped fat patterning: lower body
– No significant increased chronic disease risk
– Women tend to store fat in the lower body
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Fat Distribution Pattern (2 of 2)
• Abdominal fat increases risk for chronic disease
• Waist circumference
– Men: above 40 inches (or 102 centimeter)
– Women: above 35 inches (or 88 centimeter)
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Figure 13.3
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Energy Balance
• Fluctuations in weight depend on:
– Energy intake and energy expenditure
• Energy balance equation
– Energy intake = energy expenditure
– Energy intake is kcal from food and beverages
– Energy expenditure is energy expended at rest and
during physical activity
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Focus Figure 13.4
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Energy Intake
• Calculating the energy that is in a particular food
– Carbohydrate is 4 kilocalories/gram
– Protein is 4 kilocalories/gram
– Fat is 9 kilocalories/gram
– Alcohol is 7 kilocalories/gram
• 1 cup of quick oatmeal has 142 kilocalories
– 6 grams protein × 4 kilocalories/gram = 24 kilocalories
– 25 grams carbohydrate × 4 kilocalories/gram = 100 kilocalories
– 2 grams fat × 9 kilocalories/gram = 18 kilocalories
– Total kilocalories = 24 kilocalories + 100 kilocalories + 18 kilocalories = 142 kilocalories
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Energy Expenditure (1 of 4)
• Energy is expended to maintain basic body functions and
to perform activities
• Total 24-hour energy expenditure is composed of three
components:
– Basal metabolic rate (BMR)
– Thermic effect of food (TEF)
– Energy cost of physical activity
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Figure 13.5
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Energy Expenditure (2 of 4)
• Direct calorimetry is a method that measures the
amount of heat the body releases
– Requires airtight chamber, rarely used in humans
• Indirect calorimetry estimates energy expenditure by
measuring oxygen consumption and carbon dioxide
production
– Less expensive and more accessible
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Energy Expenditure (3 of 4)
• Indirect calorimetry can be used to measure the components of
energy expenditure
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Basal Metabolic Rate (BMR)
• Energy expended to maintain basal (resting) functions of
the body
• Includes respiration, circulation, maintaining body
temperature, new cell synthesis, secretion of hormones,
and nervous system activity
• Primary determinant of BMR is the amount of lean body
mass
• Varies widely among people
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Table 13.1 Factors Affecting Basal
Metabolic Rate (BMR)
Factors That Increase BMR Factors That Decrease BMR
Higher lean body mass Lower lean body mass
Greater height (more surface area) Lower height
Younger age Older age
Elevated levels of thyroid hormone Depressed levels of thyroid hormone
Stress, fever, illness Starvation, fasting or very-low-Calorie diets
Male gender Female gender due to decreased lean tissue
Pregnancy and lactation Blank
Certain drugs, such as stimulants, caffeine, and
nicotine
Certain medications, such as steroids used for
asthma
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Energy Expenditure (4 of 4)
• Thermic effect of food (TEF)
– Energy expended to process food
– About 5–10% of the energy content of a meal
• Energy cost of physical activity
– About 15–35% of total daily energy output
– Non-exercise activity thermogenesis (NEAT) is
energy expended for activities above BMR and TEF
but excludes sporting activities, includes
spontaneous physical activity such as fidgeting and
shifting
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Table 13.2 Energy Costs of Various
Physical Activities
Activity Intensity Energy Cost (kilocalorie/kilogram
body weight/minute)
Sitting, studying (including reading or writing) Light 0.022
Cooking or food preparation (sitting or standing) Light 0.033
Walking (e.g., to neighbor’s house) Light 0.042
Stretching—Hatha yoga Moderate 0.042
Cleaning (dusting, straightening up, vacuuming, changing
linen, carrying out trash)
Moderate 0.058
Weight lifting (free weights, Nautilus, or universal type) Light or moderate 0.050
Bicycling, 10 milesperhour Leisure (work or pleasure) 0.067
Walking, 4 milesperhour (brisk pace) Moderate 0.083
Aerobics Low impact 0.083
Weight lifting (free weights, Nautilus, or universal type) Vigorous 0.100
Bicycling, 12 to 13.9 milesperhour Moderate 0.133
Running, 5 mph (12 minutes per mile) Moderate 0.138
Running, 6 mph (10 minutes per mile) Moderate 0.163
Running, 8.6 mph (7 minutes per mile) Vigorous 0.205
Source: Data from The Compendium of Physical Activities Tracking Guide. Healthy Lifestyles Research Center, College
of Nursing & Health Innovation, Arizona State University.
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Genetic Factors
• Influence height, weight, body shape, and metabolic rate
• BMI based on genetic factors and nongenetic,
environmental, and lifestyle factors (10 to 90%)
• Different ideas have been suggested to explain the
impact of genetics on body fat
– FTO gene
– Thrifty gene hypothesis
– Set-point hypothesis
– Protein leverage hypothesis
– Drifty gene hypothesis
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Fat Mass and Obesity (FTO)-Associate
Gene
• Common gene: 44–65% of people estimated to have at
least one copy
• May stimulate excessive food intake and reduce the
feeling of satiety
• Physical activity can reduce the influence of the gene on
obesity risk
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Thrifty Gene Theory
• Proposes that a gene (or genes) causes people to be
energetically thrifty
• People with this gene expend less energy at rest than
other people at rest
• Protects from starvation during times of extreme food
shortages
• A “thrifty gene” has not been identified
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Set-Point Theory
• Suggests that body weight stays within a narrow range
(set point)
• Compensates for changes in energy balance and keeps
a person’s weight at his or her set point
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Protein Leverage Hypothesis
• Suggests that humans have evolved to have fixed daily
dietary protein target for optimal physiological functioning
• Proposed that more kcal are consumed because the
body is tying to meet genetically programmed protein
target
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Drifty Gene Hypothesis
• Suggests an observation that in the current food
environment, some people become obese, but others do
not
• Proposes the effect is due to random mutation and drift in
the genes that control the upper limit of body fatness
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Metabolic Factors Influence Weight
• Relatively low metabolic rate
• Low level of spontaneous physical activity
• Low sympathetic nervous system activity
• Low fat oxidation
• Abnormally low level of thyroid hormone
• Certain prescription medications
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Physiologic Factors (1 of 2)
• Hunger and satiety
• Proteins affect the regulation of appetite and storage of
body fat
– Leptin: hormone produced by adipose tissue, acts to
reduce food intake
– Ghrelin: hormone produced in stomach, stimulates
appetite
– Peptide YY (PYY): protein produced in GI tract,
decreases appetite
– Uncoupling proteins in brown adipose tissue
increase energy expenditure
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Physiologic Factors (2 of 2)
• Increase satiety (or decrease food intake)
– Hormones: serotonin, cholecystokinin (CCK)
– Increase in blood glucose levels after meal
– Stomach expansion
– Nutrient absorption from the small intestine
• Decrease satiety (or increase food intake)
– Hormones: beta-endorphins
– Neuropeptide Y
– Decreased blood glucose levels
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Sociocultural Factors
• Learned food preferences
• Religious beliefs
• Fast-food culture
• Inactive lifestyle
• Economic status
• Pressures to maintain ideal body weight
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Social Factors
• Appetite: psychological drive to eat
• Meal timing and size: portion distortion
• Sight and fragrance of foods
• Mood and depression
• Barriers to physical activity
• Technological lifestyle
• Social pressures and underweight
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Obesity and Chronic Diseases
• Linked to many chronic diseases:
– CVD
– Hypertension
– Dyslipidemia
– Diabetes
– Gallbladder disease
– Osteoarthritis
– Sleep apnea
– Some cancers
– Depression
– Alzheimer’s, dementia, and cognitive decline
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Abdominal Obesity
• Central adiposity is characterized by large amount of
visceral fat stored in abdomen
• Releases excess fatty acids and adipokines, cell
signaling proteins secreted by adipose tissues, are pro-
inflammatory
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Metabolic Syndrome (1 of 2)
• A cluster of factors increases risk for heart disease, type
2 diabetes, and stroke:
– Abdominal obesity (waist circumference ≥40 inches
for men, 35 inches for women)
– Triglyceride levels (≥150 milligram/deciLiter)
– HDL cholesterol levels (<40 milligram/deciLiter in men and 50
milligram/deciLiter in women)
– Blood pressure (≥130/85 millimeter Hg)
– Fasting blood glucose ≥100 milligram/deciLiter
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Metabolic Syndrome (2 of 2)
• Major component of cardiometabolic risk: development of
cardiovascular and metabolic disease
– Elevated LDL-cholesterol (≥ 130milligram/deciLiter)
– Inflammation
– Insulin resistance
– smoking
• Obesity associated with increased risk of premature
death
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Figure 13.6
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Obesity Is a Multifactorial Disease
• Variables include:
– Biology
– Physical activity environment
– Individual physical activity
– Individual psychology
– Societal influences
– Food environment
– Food consumption
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Obesity Treatment: Diet and Exercise
• 500–1000 kilocalories/day deficit
• Increase physical activity gradually
• Exercise at least 30 minutes/day, 5 days/week
• Counseling and support groups
• Psychotherapy
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Obesity Treatment: Medications
• Act as appetite suppressants and may increase satiety
• Physician involvement critical; many weight-loss drugs
have serious side effects
• Long-term safety of drugs being explored
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Obesity Treatment: Supplements
• Dangerous or ineffective supplements can be marketed
and sold without meeting the FDA’s strict safety and
quality standards
• Insufficient evidence to support their use
• Stimulants speed up metabolic processes, are
controversial, and may be dangerous
– Caffeine, phenylpropanolamine (PPA), and ephedra
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Obesity Treatment: Bariatric Surgery
• Considered a last resort for morbidly obese
• Surgery risks very high
• Surgery for morbid obesity
– Vertical banded gastroplasty
– Gastric bypass surgery
– Gastric banding
– Liposuction
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Figure 13.8
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Weight-Loss Diets (1 of 2)
• High-carbohydrate, moderate fat and protein diets
– Balanced in nutrients: 20–30% calories from fat,
55‒60% from carbohydrate, and 15–20% from
protein
– Weight Watchers, Jenny Craig, DASH diet, and the
USDA Food Guide
– Gradual weight loss (1–2 pounds per week)
– Typical energy deficits = 500–1,000 kilocalories per day
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Weight-Loss Diets (2 of 2)
• Low-carbohydrate, high fat, and protein diets
– 55–65% of total energy intake as fat and remaining
energy from protein
– Dr. Atkins’ Diet Revolution, Sugar Busters!, and Paleo
Diet
– Cause ketosis, which will decrease blood glucose and
insulin levels and reduce appetite
– Concerns about long-term compliance, potential
health risks, and side effects
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ABC News Video: Low-Carb Diet Trumps
Low-Far in Weight-Loss Study
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ABC News Video: Coconut: How Healthy
Is the Superfood?
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Achieve and Maintain Healthful
Weight (1 of 2)
• Set realistic and achievable goals that are:
– Specific
– Reasonable
– Measurable
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Achieve and Maintain Healthful
Weight (2 of 2)
• Control portion sizes
• Frequently choose foods that are relatively low in energy
density
• Participate in regular physical activity
• Incorporate appropriate behavior modifications into daily
life
• Intuitive eating
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ABC News Video: Experiment Shows
Portion Control is the Key to Healthy Eating
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ABC News Video: Fast-Paced Movies,
Television Shows May Lead to More Snacking
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Meal Focus Figure 13.9
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Underweight
• As harmful as obesity
• Can be due to many factors
– Genetics
– Consuming too few Calories for exercise level
– Heavy smoking
– Underlying disease
– Anorexia nervosa
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Safe and Effective Weight Gain
• Underweight: BMI of less than 2
18.5 kg/m
• Limit fat: <30% of total energy intake
• Eat 500 to 1,000 extra kilocalories/day
• Eat frequently throughout the day
• Avoid tobacco (depresses appetite and increases BMR)
• Exercise regularly with resistance training
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Protein Supplements
• Include amino acid supplements, anabolic steroids, and
androstenedione
• Do not enhance muscle gain or result in improvements in
strength
• Cause major health problems: unhealthful changes in
blood cholesterol and mood disturbances
Copyright © 2020 Pearson Education, Inc. All Rights Reserved
Copyright
This work is protected by United States copyright laws and is
provided solely for the use of instructors in teaching their
courses and assessing student learning. Dissemination or sale of
any part of this work (including on the World Wide Web) will
destroy the integrity of the work and is not permitted. The work
and materials from it should never be made available to students
except by instructors using the accompanying text in their
classes. All recipients of this work are expected to abide by these
restrictions and to honor the intended pedagogical purposes and
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CHAPTER 13 Achieving and Maintaining a Healthful Weight.pptx

  • 1. The Science of Nutrition Fifth Edition Chapter 13 Achieving and Maintaining a Healthful Body Weight Copyright © 2020 Pearson Education, Inc. All Rights Reserved Slides in this presentation contain hyperlinks. JAWS users should be able to get a list of links by using INSERT+F7
  • 2. Copyright © 2020 Pearson Education, Inc. All Rights Reserved What Is a Healthful Body Weight? (1 of 3) • Appropriate for age and physical development • Achievable and sustainable without constant dieting • Compatible with normal blood pressure, lipid levels, and glucose tolerance • Based on genetic background and family history of body shape and weight • Supported by good eating habits and allows for regular physical activity • Acceptable to you
  • 3. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Evaluating Body Weight • Determining if a person’s body weight is healthful should include: – Determining the body mass index (BMI) – Measuring body composition – Assessing the pattern of fat distribution
  • 4. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Body Mass Index • Represents the ratio of a person’s weight to the square of his or her height • 2 BMI = weight (kg)/heigh (m) t • a 2 BMI = weight lbs /height inch [ ( ) ( ) ] es × 703 • BMI values below 18.5 or above 30 have increased health risks
  • 5. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.1
  • 6. Copyright © 2020 Pearson Education, Inc. All Rights Reserved What Is a Healthful Body Weight? (2 of 3) • Underweight: – BMI less than 2 18.5 kg/m – Having too little body fat to maintain health • Normal weight: – BMI between 2 18.5 and 24.9 kg/m • Overweight: – BMI between 2 25 and 29.9 kg/m – Having a moderate amount of excess body fat
  • 7. Copyright © 2020 Pearson Education, Inc. All Rights Reserved What Is a Healthful Body Weight? (3 of 3) • Obese: – Class 1: BMI between 30 and 2 34.9 kg/m – Class 2: BMI between 35 and 2 39.9 kg/m – Having an excess of body fat that adversely affects health, increasing disease risk significantly • Morbid obesity: – Class 3: BMI greater or equal to 2 40 kg/m – Body weight exceeding 100% of normal, a very high risk for serious health consequences
  • 8. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Limitations of BMI • Not an indication of body composition • Not appropriate for use in older adults (bone and muscle loss) and children (bone and muscle growth), athletes, pregnant, and lactating women • Doesn’t account for physical and metabolic differences in ethnic backgrounds
  • 9. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Body Composition • Estimate body composition by assessing body fat and lean body mass with – Underwater weighing – Skinfold measurements – Bioelectrical impedance analysis – Near-infrared reactance – Dual-energy X-ray absorptiometry (DXA) – Bod Pod™ • Norms vary according to gender and fitness • Obesity: >25% for men and >32% for women
  • 10. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.2
  • 11. Copyright © 2020 Pearson Education, Inc. All Rights Reserved ABC News Video: Overweight and Healthy?
  • 12. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Fat Distribution Pattern (1 of 2) • Apple-shaped fat patterning: upper body – Increased risk for chronic diseases – Men tend to store fat in the abdominal region • Pear-shaped fat patterning: lower body – No significant increased chronic disease risk – Women tend to store fat in the lower body
  • 13. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Fat Distribution Pattern (2 of 2) • Abdominal fat increases risk for chronic disease • Waist circumference – Men: above 40 inches (or 102 centimeter) – Women: above 35 inches (or 88 centimeter)
  • 14. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.3
  • 15. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Balance • Fluctuations in weight depend on: – Energy intake and energy expenditure • Energy balance equation – Energy intake = energy expenditure – Energy intake is kcal from food and beverages – Energy expenditure is energy expended at rest and during physical activity
  • 16. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Focus Figure 13.4
  • 17. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Intake • Calculating the energy that is in a particular food – Carbohydrate is 4 kilocalories/gram – Protein is 4 kilocalories/gram – Fat is 9 kilocalories/gram – Alcohol is 7 kilocalories/gram • 1 cup of quick oatmeal has 142 kilocalories – 6 grams protein × 4 kilocalories/gram = 24 kilocalories – 25 grams carbohydrate × 4 kilocalories/gram = 100 kilocalories – 2 grams fat × 9 kilocalories/gram = 18 kilocalories – Total kilocalories = 24 kilocalories + 100 kilocalories + 18 kilocalories = 142 kilocalories
  • 18. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Expenditure (1 of 4) • Energy is expended to maintain basic body functions and to perform activities • Total 24-hour energy expenditure is composed of three components: – Basal metabolic rate (BMR) – Thermic effect of food (TEF) – Energy cost of physical activity
  • 19. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.5
  • 20. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Expenditure (2 of 4) • Direct calorimetry is a method that measures the amount of heat the body releases – Requires airtight chamber, rarely used in humans • Indirect calorimetry estimates energy expenditure by measuring oxygen consumption and carbon dioxide production – Less expensive and more accessible
  • 21. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Expenditure (3 of 4) • Indirect calorimetry can be used to measure the components of energy expenditure
  • 22. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Basal Metabolic Rate (BMR) • Energy expended to maintain basal (resting) functions of the body • Includes respiration, circulation, maintaining body temperature, new cell synthesis, secretion of hormones, and nervous system activity • Primary determinant of BMR is the amount of lean body mass • Varies widely among people
  • 23. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Table 13.1 Factors Affecting Basal Metabolic Rate (BMR) Factors That Increase BMR Factors That Decrease BMR Higher lean body mass Lower lean body mass Greater height (more surface area) Lower height Younger age Older age Elevated levels of thyroid hormone Depressed levels of thyroid hormone Stress, fever, illness Starvation, fasting or very-low-Calorie diets Male gender Female gender due to decreased lean tissue Pregnancy and lactation Blank Certain drugs, such as stimulants, caffeine, and nicotine Certain medications, such as steroids used for asthma
  • 24. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Energy Expenditure (4 of 4) • Thermic effect of food (TEF) – Energy expended to process food – About 5–10% of the energy content of a meal • Energy cost of physical activity – About 15–35% of total daily energy output – Non-exercise activity thermogenesis (NEAT) is energy expended for activities above BMR and TEF but excludes sporting activities, includes spontaneous physical activity such as fidgeting and shifting
  • 25. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Table 13.2 Energy Costs of Various Physical Activities Activity Intensity Energy Cost (kilocalorie/kilogram body weight/minute) Sitting, studying (including reading or writing) Light 0.022 Cooking or food preparation (sitting or standing) Light 0.033 Walking (e.g., to neighbor’s house) Light 0.042 Stretching—Hatha yoga Moderate 0.042 Cleaning (dusting, straightening up, vacuuming, changing linen, carrying out trash) Moderate 0.058 Weight lifting (free weights, Nautilus, or universal type) Light or moderate 0.050 Bicycling, 10 milesperhour Leisure (work or pleasure) 0.067 Walking, 4 milesperhour (brisk pace) Moderate 0.083 Aerobics Low impact 0.083 Weight lifting (free weights, Nautilus, or universal type) Vigorous 0.100 Bicycling, 12 to 13.9 milesperhour Moderate 0.133 Running, 5 mph (12 minutes per mile) Moderate 0.138 Running, 6 mph (10 minutes per mile) Moderate 0.163 Running, 8.6 mph (7 minutes per mile) Vigorous 0.205 Source: Data from The Compendium of Physical Activities Tracking Guide. Healthy Lifestyles Research Center, College of Nursing & Health Innovation, Arizona State University.
  • 26. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Genetic Factors • Influence height, weight, body shape, and metabolic rate • BMI based on genetic factors and nongenetic, environmental, and lifestyle factors (10 to 90%) • Different ideas have been suggested to explain the impact of genetics on body fat – FTO gene – Thrifty gene hypothesis – Set-point hypothesis – Protein leverage hypothesis – Drifty gene hypothesis
  • 27. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Fat Mass and Obesity (FTO)-Associate Gene • Common gene: 44–65% of people estimated to have at least one copy • May stimulate excessive food intake and reduce the feeling of satiety • Physical activity can reduce the influence of the gene on obesity risk
  • 28. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Thrifty Gene Theory • Proposes that a gene (or genes) causes people to be energetically thrifty • People with this gene expend less energy at rest than other people at rest • Protects from starvation during times of extreme food shortages • A “thrifty gene” has not been identified
  • 29. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Set-Point Theory • Suggests that body weight stays within a narrow range (set point) • Compensates for changes in energy balance and keeps a person’s weight at his or her set point
  • 30. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Protein Leverage Hypothesis • Suggests that humans have evolved to have fixed daily dietary protein target for optimal physiological functioning • Proposed that more kcal are consumed because the body is tying to meet genetically programmed protein target
  • 31. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Drifty Gene Hypothesis • Suggests an observation that in the current food environment, some people become obese, but others do not • Proposes the effect is due to random mutation and drift in the genes that control the upper limit of body fatness
  • 32. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Metabolic Factors Influence Weight • Relatively low metabolic rate • Low level of spontaneous physical activity • Low sympathetic nervous system activity • Low fat oxidation • Abnormally low level of thyroid hormone • Certain prescription medications
  • 33. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Physiologic Factors (1 of 2) • Hunger and satiety • Proteins affect the regulation of appetite and storage of body fat – Leptin: hormone produced by adipose tissue, acts to reduce food intake – Ghrelin: hormone produced in stomach, stimulates appetite – Peptide YY (PYY): protein produced in GI tract, decreases appetite – Uncoupling proteins in brown adipose tissue increase energy expenditure
  • 34. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Physiologic Factors (2 of 2) • Increase satiety (or decrease food intake) – Hormones: serotonin, cholecystokinin (CCK) – Increase in blood glucose levels after meal – Stomach expansion – Nutrient absorption from the small intestine • Decrease satiety (or increase food intake) – Hormones: beta-endorphins – Neuropeptide Y – Decreased blood glucose levels
  • 35. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Sociocultural Factors • Learned food preferences • Religious beliefs • Fast-food culture • Inactive lifestyle • Economic status • Pressures to maintain ideal body weight
  • 36. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Social Factors • Appetite: psychological drive to eat • Meal timing and size: portion distortion • Sight and fragrance of foods • Mood and depression • Barriers to physical activity • Technological lifestyle • Social pressures and underweight
  • 37. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity and Chronic Diseases • Linked to many chronic diseases: – CVD – Hypertension – Dyslipidemia – Diabetes – Gallbladder disease – Osteoarthritis – Sleep apnea – Some cancers – Depression – Alzheimer’s, dementia, and cognitive decline
  • 38. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Abdominal Obesity • Central adiposity is characterized by large amount of visceral fat stored in abdomen • Releases excess fatty acids and adipokines, cell signaling proteins secreted by adipose tissues, are pro- inflammatory
  • 39. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Metabolic Syndrome (1 of 2) • A cluster of factors increases risk for heart disease, type 2 diabetes, and stroke: – Abdominal obesity (waist circumference ≥40 inches for men, 35 inches for women) – Triglyceride levels (≥150 milligram/deciLiter) – HDL cholesterol levels (<40 milligram/deciLiter in men and 50 milligram/deciLiter in women) – Blood pressure (≥130/85 millimeter Hg) – Fasting blood glucose ≥100 milligram/deciLiter
  • 40. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Metabolic Syndrome (2 of 2) • Major component of cardiometabolic risk: development of cardiovascular and metabolic disease – Elevated LDL-cholesterol (≥ 130milligram/deciLiter) – Inflammation – Insulin resistance – smoking • Obesity associated with increased risk of premature death
  • 41. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.6
  • 42. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity Is a Multifactorial Disease • Variables include: – Biology – Physical activity environment – Individual physical activity – Individual psychology – Societal influences – Food environment – Food consumption
  • 43. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity Treatment: Diet and Exercise • 500–1000 kilocalories/day deficit • Increase physical activity gradually • Exercise at least 30 minutes/day, 5 days/week • Counseling and support groups • Psychotherapy
  • 44. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity Treatment: Medications • Act as appetite suppressants and may increase satiety • Physician involvement critical; many weight-loss drugs have serious side effects • Long-term safety of drugs being explored
  • 45. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity Treatment: Supplements • Dangerous or ineffective supplements can be marketed and sold without meeting the FDA’s strict safety and quality standards • Insufficient evidence to support their use • Stimulants speed up metabolic processes, are controversial, and may be dangerous – Caffeine, phenylpropanolamine (PPA), and ephedra
  • 46. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Obesity Treatment: Bariatric Surgery • Considered a last resort for morbidly obese • Surgery risks very high • Surgery for morbid obesity – Vertical banded gastroplasty – Gastric bypass surgery – Gastric banding – Liposuction
  • 47. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Figure 13.8
  • 48. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Weight-Loss Diets (1 of 2) • High-carbohydrate, moderate fat and protein diets – Balanced in nutrients: 20–30% calories from fat, 55‒60% from carbohydrate, and 15–20% from protein – Weight Watchers, Jenny Craig, DASH diet, and the USDA Food Guide – Gradual weight loss (1–2 pounds per week) – Typical energy deficits = 500–1,000 kilocalories per day
  • 49. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Weight-Loss Diets (2 of 2) • Low-carbohydrate, high fat, and protein diets – 55–65% of total energy intake as fat and remaining energy from protein – Dr. Atkins’ Diet Revolution, Sugar Busters!, and Paleo Diet – Cause ketosis, which will decrease blood glucose and insulin levels and reduce appetite – Concerns about long-term compliance, potential health risks, and side effects
  • 50. Copyright © 2020 Pearson Education, Inc. All Rights Reserved ABC News Video: Low-Carb Diet Trumps Low-Far in Weight-Loss Study
  • 51. Copyright © 2020 Pearson Education, Inc. All Rights Reserved ABC News Video: Coconut: How Healthy Is the Superfood?
  • 52. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Achieve and Maintain Healthful Weight (1 of 2) • Set realistic and achievable goals that are: – Specific – Reasonable – Measurable
  • 53. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Achieve and Maintain Healthful Weight (2 of 2) • Control portion sizes • Frequently choose foods that are relatively low in energy density • Participate in regular physical activity • Incorporate appropriate behavior modifications into daily life • Intuitive eating
  • 54. Copyright © 2020 Pearson Education, Inc. All Rights Reserved ABC News Video: Experiment Shows Portion Control is the Key to Healthy Eating
  • 55. Copyright © 2020 Pearson Education, Inc. All Rights Reserved ABC News Video: Fast-Paced Movies, Television Shows May Lead to More Snacking
  • 56. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Meal Focus Figure 13.9
  • 57. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Underweight • As harmful as obesity • Can be due to many factors – Genetics – Consuming too few Calories for exercise level – Heavy smoking – Underlying disease – Anorexia nervosa
  • 58. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Safe and Effective Weight Gain • Underweight: BMI of less than 2 18.5 kg/m • Limit fat: <30% of total energy intake • Eat 500 to 1,000 extra kilocalories/day • Eat frequently throughout the day • Avoid tobacco (depresses appetite and increases BMR) • Exercise regularly with resistance training
  • 59. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Protein Supplements • Include amino acid supplements, anabolic steroids, and androstenedione • Do not enhance muscle gain or result in improvements in strength • Cause major health problems: unhealthful changes in blood cholesterol and mood disturbances
  • 60. Copyright © 2020 Pearson Education, Inc. All Rights Reserved Copyright This work is protected by United States copyright laws and is provided solely for the use of instructors in teaching their courses and assessing student learning. Dissemination or sale of any part of this work (including on the World Wide Web) will destroy the integrity of the work and is not permitted. The work and materials from it should never be made available to students except by instructors using the accompanying text in their classes. All recipients of this work are expected to abide by these restrictions and to honor the intended pedagogical purposes and the needs of other instructors who rely on these materials.

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