There are two main types of cells - eukaryotic and prokaryotic. Eukaryotic cells have a nucleus surrounded by a nuclear membrane, while prokaryotic cells do not have a nucleus. All cells contain organelles that perform specific functions, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, and ribosomes. Cells can also specialize to form tissues, organs and organ systems that carry out vital functions in living organisms.
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
Nucleus-the heart of the cell-cellular organellesbiOlOgyBINGE
In cell biology, the nucleus is a membrane-bound organelle found in eukaryotic cells.
The nucleus is found in all the eukaryotic cells of the plants and animals.
here u will find every detail of nucleus.
for more details ,visit @biOlOgy BINGE-insight learning (youtube channel)
Nucleus” is a Latin word meaning Kernel
It is the “CONTROL CENTER” of the cell
Average diameter of nucleus is 6um, which occupies around 10% of cell volume
Nuclear Envelope
Nuclear Pores and complex
Nuclear lamina
Chromosomes & Chromatin
Nucleolus
Nucleoplasm
Nucleus-the heart of the cell-cellular organellesbiOlOgyBINGE
In cell biology, the nucleus is a membrane-bound organelle found in eukaryotic cells.
The nucleus is found in all the eukaryotic cells of the plants and animals.
here u will find every detail of nucleus.
for more details ,visit @biOlOgy BINGE-insight learning (youtube channel)
Most relevant information about the cell, its discovery, types and various kinds of organelles and their function. it also focus on how molecules are transported across the cell membrane.
2018/2019
Discovered by an English biologist Robert Brown in 1831.
It is also know as the, “Brain of the cell” or “Control centre of the cell”
On the basis of absence and presence of nucleus cell may be divided into Prokaryotes and Eukaryotes respectively.
NUMBER- Mostly uninucleate
Binucleate – Hepatocytes,Chondryocytes, fungi
Polynucleate- Tapetal cell, myocytes
Anucleated Cell- Red Blood cell
Sieve tube element
Component of Nucleus Nuclear membrane
Nuclear pore
Nucleoplasm
Nucleolus
Chromatin
Nuclear Membrane :Also called the nuclear envelope, is a double membrane layer that separates the contents of the nucleus from the rest of the cell.
The nuclear membrane is a lipid bilayer, meaning that it consists of two layers of lipid molecules.
Outer Layer: The outer layer of lipids has ribosomes, structures that make proteins, on its surface. It is connected to the endoplasmic reticulum.
Inner Membrane: Network of fibers and proteins attached to the inner membrane is called the nuclear lamina. It structurally supports the nucleus, plays a role in repairing DNA, and regulates events in the cell cycle such as cell division and the replication of DNA.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
15. Organ systems.Organ systems.
-Circulatory system-Circulatory system
-Respiratory system-Respiratory system
-Digestive system-Digestive system
-Nervous system-Nervous system
-Reproductive system-Reproductive system
-Leaf canopy-Leaf canopy
16. DiffusionDiffusion Movement of particles fromMovement of particles from
an area of higheran area of higher
concentration to a area ofconcentration to a area of
lowerlower
Osmosis
Important for plants
18. Nucleus
• Almost all cells contain a single nucleus.
• Directs cell activities
• Separated from cytoplasm by nuclear membrane
• Function-Stores and transmits genetic information in the
form of DNA. Genetic information passes from the
nucleus to the cytoplasm
Nucleolus
• Inside nucleus
• Contains RNA to build proteins
19. Nuclear Membrane
• Surrounds nucleus
• Made of two layers
Nuclear envelope
Nuclear pores
• Openings allow material to
enter and leave nucleus
http://library.thinkquest.org/12413/structures.html
Chromosomes
• In nucleus
• Made of DNA
• Contain instructions for traits &
characteristics
20. Endoplasmic Reticulum
• Moves materials around
in cell
• Smooth type (Agranular):
lacks ribosomes. Site of
lipid molecule
synthesized
• Rough type (Granular):
ribosomes embedded in
surface. Packaging of
proteins to be secreted or
distributed.
http://library.thinkquest.org/12413/structures.html
21. Ribosomes
• Composed of proteins
and several RNA
molecules
• Proteins factories of
the cell
• Either bound to the
organelle or found
free in the cytoplasm
http://library.thinkquest.org/12413/structures.html
22. Golgi Apparatus
• Most cells have
single Golgi
apparatus.
• Protein 'packaging
plant'
• Move materials within
the cell
• Move materials out of
the cell
http://library.thinkquest.org/12413/structures.html
23. Lysosome
• Spherical or oval
• Typical cell may contain
several hundreds
• Digestive enzyme for
proteins, fats, and
carbohydrates
• Transports undigested
material to cell
membrane for removal
• Cell breaks down if
lysosome explodes
http://library.thinkquest.org/12413/structures.html
24. Mitochondria
• Spherical rode like structure
• Produces energy through
chemical reactions – breaking
down fats & carbohydrates
• Controls level of water and
other materials in cell
• Recycles and decomposes
proteins, fats, and
carbohydrates
http://library.thinkquest.org/12413/structures.html