This document provides an overview of cell biology. It defines the cell as the structural and functional unit of life. It describes the key differences between prokaryotic and eukaryotic cells. The structure and functions of major cell organelles like the cell membrane, nucleus, mitochondria and ribosomes are explained. The processes of cell division, transcription and translation are summarized. Different types of cell junctions and their roles are also outlined.
prokaryotes vs eukaryotes, animal vs plant, cell organelles and their function (with detailed diagrams), protein synthesis and export. Great for honors middle school 7th grade, or 9th grade biology, life science
prokaryotes vs eukaryotes, animal vs plant, cell organelles and their function (with detailed diagrams), protein synthesis and export. Great for honors middle school 7th grade, or 9th grade biology, life science
All living things are made of organized parts, obtain energy from their surroundings, perform chemical reactions, respond to their environment, grow and develop, change with time, and reproduce
All organisms are made of cells
All cells are produced from other cells (all cells arise from pre-existing cells by cell division)
The cell is the most basic unit of life
What is Cell?
Cell is the smallest unit of life that can live on its own and that makes up all living organisms and the tissues of the body.
An animals cell is a type of eukaryotic call that lacks a cell wall and has a true membrane bound nucleus along with other organelles.
A cell has three main parts:
The cell membrane, the nucleus, and the cytoplasm.
The nucleus is a structure inside the cell that contains the nucleolus and most of the cell's DNA.
All living things are made up of cells.
Cells are the smallest working units of all living things.
All cells come from preexisting cells through cell division.
Cells are the basis of life—the basic structural unit of living things. Molecules such as water and amino acids are not alive but cells are! All life is comprised of cells of one type or another.
One of the hallmarks of living systems is the ability to maintain homeostasis, or a relatively constant internal state. The cell is the first level of complexity able to maintain homeostasis, and it is the unique structure of the cell that enables this critical function.
In this section of the course, you will learn about the cell and all the parts that make it functional. You will also focus on the cell membrane, which is the structure that surrounds the cell and separates its internal environment from the external environment. It is a critical component because it controls what can enter and exit the cell. This section will also describe how cells reproduce to maintain homeostasis.Cells are the basis of life—the basic structural unit of living things. Molecules such as water and amino acids are not alive but cells are! All life is comprised of cells of one type or another.
One of the hallmarks of living systems is the ability to maintain homeostasis, or a relatively constant internal state. The cell is the first level of complexity able to maintain homeostasis, and it is the unique structure of the cell that enables this critical function.
In this section of the course, you will learn about the cell and all the parts that make it functional. You will also focus on the cell membrane, which is the structure that surrounds the cell and separates its internal environment from the external environment. It is a critical component because it controls what can enter and exit the cell. This section will also describe how cells reproduce to maintain homeostasis.
All living things are made of organized parts, obtain energy from their surroundings, perform chemical reactions, respond to their environment, grow and develop, change with time, and reproduce
All organisms are made of cells
All cells are produced from other cells (all cells arise from pre-existing cells by cell division)
The cell is the most basic unit of life
What is Cell?
Cell is the smallest unit of life that can live on its own and that makes up all living organisms and the tissues of the body.
An animals cell is a type of eukaryotic call that lacks a cell wall and has a true membrane bound nucleus along with other organelles.
A cell has three main parts:
The cell membrane, the nucleus, and the cytoplasm.
The nucleus is a structure inside the cell that contains the nucleolus and most of the cell's DNA.
All living things are made up of cells.
Cells are the smallest working units of all living things.
All cells come from preexisting cells through cell division.
Cells are the basis of life—the basic structural unit of living things. Molecules such as water and amino acids are not alive but cells are! All life is comprised of cells of one type or another.
One of the hallmarks of living systems is the ability to maintain homeostasis, or a relatively constant internal state. The cell is the first level of complexity able to maintain homeostasis, and it is the unique structure of the cell that enables this critical function.
In this section of the course, you will learn about the cell and all the parts that make it functional. You will also focus on the cell membrane, which is the structure that surrounds the cell and separates its internal environment from the external environment. It is a critical component because it controls what can enter and exit the cell. This section will also describe how cells reproduce to maintain homeostasis.Cells are the basis of life—the basic structural unit of living things. Molecules such as water and amino acids are not alive but cells are! All life is comprised of cells of one type or another.
One of the hallmarks of living systems is the ability to maintain homeostasis, or a relatively constant internal state. The cell is the first level of complexity able to maintain homeostasis, and it is the unique structure of the cell that enables this critical function.
In this section of the course, you will learn about the cell and all the parts that make it functional. You will also focus on the cell membrane, which is the structure that surrounds the cell and separates its internal environment from the external environment. It is a critical component because it controls what can enter and exit the cell. This section will also describe how cells reproduce to maintain homeostasis.
The presentation includes the basics of cell: Definition, criteria for defining a cell, differences between prokaryotic cells and eukaryotic cells, plat and animal cells, structure and function of organelles, symbiont theory and MCQs.
DEFINITION:
Cell is a structural and functional unit of all living organisms.
STRUCTURE OF THE CELL:
PARTS OF THE CELL
Plasma Membrane
Cytoplasm
a. Cytosol
b. Organelles
Cytoskeleton
Endoplasmic Reticulum
Golgi Apparatus
Lysosome
Centrosome
Nucleus
Mitochondria
PLASMA MEMBRANE
Structure of Plasma Membrane
The Cell membrane also known as the Plasma membrane.
It is a Biological Membrane that separates the interior of all cells from the
outside environment.
It consists of a lipid bilayer with embedded proteins.
The Lipid layer made up of three types of lipid molecules such as Phospholipids,
Cholesterols and Glycolipids.
The bilayer arrangement occurs because the lipid are amphipathic molecule
(Both Polar and Nonpolar parts)
Phospholipids – Phosphate (Polar) – Head – Hydrophilic
Lipid (Non Polar) – Tail – Hydrophobic
Cholesterols – Slightly Amphipathic
Glycolipids – Carbohydrate (Polar) – Head
Lipid (Non Polar) – Tail
Functions of Plasma Membrane:
Acts as a barrier separating inside and outside of the cell.
Controls the flow of substances into and out of the cell.
Helps identify the cell to other cells (e.g., immune cells).
Participates in intercellular signalling.
CYTOPLASM
Cytoplasm consists of all the cellular contents between the plasma membrane
and the nucleus and has two components.
a) Cytosol
b) Organelles
a) Cytosol: (pH - 7)
The Cytosol (Intracellular fluid) is the fluid portion of the cytoplasm that
surrounds organelles.
Cytosol is 75 – 90% of water plus various dissolved and suspended components.
Among these are different types of ions, glucose, amino acid, fatty acid, protein,
lipid, ATP and waste products.
The cytosol is the site of many Chemical reactions for a cell existence.
b) Organelles
Cytoskeleton
Endoplasmic Reticulum
Golgi Apparatus
Lysosome
Centrosome
Nucleus
Mitochondria
CYTOSKELETON:
The cytoskeleton is a network of protein filaments.
It Consists of three types of filament proteins
1. Microfilament
2. Intermediate filament
3. Microtubules
1. Microfilament
Microfilaments are the thinnest elements of the cytoskeleton.
Diameter – 6nm
They are composed of protein Actin and Myosin.
Most Prevalent at the edge of a cell.
Functions of Microfilament:
They help generate movement and provide mechanical support.
Microfilaments are involved in muscle contraction, cell division and cell
locomotion.
The Mechanical support that is responsible for the basic strength and shape of
cells.
2. Intermediate filaments
Several different proteins such as keratin, collagen can compose intermediate
filament.
Diameter – 10 nm
Functions of Intermediate filaments:
They help stabilize the position of organelles such as the nucleus.
3. Microtubules
Largest cytoskeletal components.
Diameter – 25 nm
Unbranched hollow tubes composed mainly of the protein tubulin.
Functions of Microtubules
Microtubules help determine Cell shape.
Introduction
Structure of Plasma Membranes
Functions of Plasma Membranes
Cytoplasm: Cytosol, Organelles
Functions of Cytoplasm
Ribosome, Functions of Ribosomes
2. Endoplasmic reticulum (ER)
a. Rough Endoplasmic Reticulum and its Functions
b. Smooth ER and its Functions
3. Golgi complex and its Functions
4.Lysosomes and its Functions
5. Peroxisomes and its Functions
6. Proteasomes and its Functions
7.Mitochondria and its Functions
8. Cytoskeletal
a. Microfilaments and its Functions
b. Intermediate filaments and its Functions
c. Microtubules and its Functions
9. Centrosome and its Functions
10. Cilia and Flagella and its Functions
11. Nucleus and its Functions
a. Nuclear Membrane and its Functions
b. Nucleoplasm and its Functions
c. Chromosomes and its Functions
d. Nucleolus and its Functions
Cell is basic structural and functional unit of all living organism. Cell is enclosed in a compartment containing aqueous fluid called as Cytosol which is surrounded by a cell membrane called Plasma membrane
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
Have you ever wanted a Ruby client API to communicate with your web service? Smithy is a protocol-agnostic language for defining services and SDKs. Smithy Ruby is an implementation of Smithy that generates a Ruby SDK using a Smithy model. In this talk, we will explore Smithy and Smithy Ruby to learn how to generate custom feature-rich SDKs that can communicate with any web service, such as a Rails JSON API.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more ‘mechanical’ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
5. CELL CYCLE
DIFFERENCE BETWEEN MITOSIS AND
MEIOSIS
LIST OF CHROMOSOMAL
ABNORMALITIES
CHROMOSOMAL ABERRATION
APOPTOSIS
CELL JUNCTON
VIRUS ENTRY TO CELL
6. TERM WAS COINED BY” ROBERT HOOK”
(1635-1703)
DEFINED AS STRUCTURAL AND
FUNCTIONAL UNIT OF LIFE
7. GENERAL CHARACTERISTICS OF CELL
• Needs nutrition & oxygen
• Eliminates carbon dioxide & other metabolic
wastes
• Shows immediate response to the entrance
of invaders
• Reproduces by division
9. Each cell is formed by a cell body and a
membrane covering the cell body known as cell
membrane or plasma membrane
The cell body has two parts namely the nucleus
and the cytoplasm surrounding the nucleus.
Thus the structure of a cell is studied under 3
headings…
I. Cell membrane
II. Cytoplasm
III. nucleus
10. CELL MEMBRANE
Protective sheath covering the cell body
Separates the fluid outside the cell called
extracellular fluid(ECF) and the fluid inside
the cell called intracellular fluid(ICF)
COMPOSITION OF CELL MEMBRANE
1. PROTEINS(55%)
2. LIPIDS(40%)
3. CARBOHYDRATES(5%)
11. STRUCTURE OF CELL MEMBRANE
THREE PROPSED MODELSW ARE
1.
Danielli-Davson model
2.
Unit membrane model
3.
The fluid mosaic model
THE CELL MEMBANE is a three layered membrane.
MICROSCOPIC STUDY REVEALS
Central electron-lucent layer called LIPID LAYER formed by lipid protein
•
MAJOR LIPIDS PRESENT ARE
1.
PHOSPHOLIPIDS
2.
CHOLESTROL
functional significance of this layer is that it forms a semi permeable membrane and allows only
fat soluble substances to pass through ie oxygen, carbon dioxide &alcohol
2 electron-dense layer one on either side of central layer called PROTEIN LAYER formed by protein
substances.
MAJOR PROTEIN PRESENT ARE
1.
Integral Protein
2.
Peripheral Protein
12. Functional significance of protein layer
1. Integral protein provide the structural
integrity of cell membrane
2. Channel protein- for diffusion of water
soluble substances like glucose and
electrolyte
3. Carrier protein
4. Receptor protein
5. Antigen
13. APPLIED PHYSIOLOGY ON CELL
MEMBRANE
LIPID soluble material in the ECE, when come in
contact with cell membrane get dissolved in the
oily cell membrane then enter the cytoplasm.
Thus lipid soluble drugs easily pass the bloodbrain barrier(BBB)
In the cell membrane of fungus ergosterol is
present instead of cholestrol, drugs are present
which get attached with ergosterol and damage
them and thus the fungal cell membrane is
damaged and last death
such drugs are AMPHOTERECIN B. AMB used
against fungal infection
14. 1. CYTOPLASM
ORGANELLES IN CYTOPLASM
1. ENDOPLASMIC RETICULUM
2 TYPES rough endoplasmic reticulum
smooth endoplasmic reticulum
function of rough endoplasmic reticulum
1.
synthesis of protein
2.
degradation of worn out organelles
function of smooth endoplasmic reticulum
1.
synthesis of lipids and steroids
2.
storage and metabolism of calcium
3.
degradation of toxic substances in liver
15.
16. GOLGI APPARATUS
present in all cells except red blood cells
2. has two faces or ends cis face and trans
face, cis face is close to endoplasmic
reticulum and trans face near the cell
membrane
function of golgi apparatus
• processing, labelling and delivery of
proteins and lipids in different parts of cell
1.
17.
18. LYSOSOMES
membrane bound vesicular organelles
found throughout the cytoplasm
2. Formed by golgi apparatus
3. Enzymes synthesized in RER are processed
and packed in the form of vesicles in the
golgi apparatus
4. Then these vesicles are pinched off from
golgi apparatus and become the lysosomes
1.
19. TYPES OF LYSOSOMES
1. PRIMARY LYSOSOMES -- one that is
pinched off from the golgi apparatus and is
inactive
2. SECONDARY LYSOSOMES – a active
lysosome formed by fusion of primary
lysosome with phagosome or endosome
20.
21. FUNCTION OF LYSOSOMES
1. Degradation on macromolecules like
bacteria
2. Degradation of worn out organelles
3. Secretory function
22. PEROXISOMES
FUNCTION OF PEROXISOMES
1. Degradation of toxic substances like hydrogen
2.
3.
4.
5.
6.
peroxide – present in liver cells which is a major
organ for detoxification
Oxygen utilization
Breakdown of excess fatty acids
Acceleration of gluconeogenesis from fats
Degradation of purin to uric acid
Role in the formation of myelin and bile acids
26. Rod like oval structure
Bilayered membranous organelle
Outer membrane smooth and encloses the
contents of mitocondria
Inner membrane folded in the form of shelf
called cristae
Cristae contains many enzymes and other
protein molecules which are involved in
respiration and synthesis of ATP
Move freely in cytoplasm and capable of self
reproduction
27. FUNCTION OF MITOCONDRIA
Production of energy– called POWER HOUSE
OF CELL – required for cellular function –
produced during oxidation of digested food
particles like proteins,crbohdrates and lipids
Synthesis of ATP
apoptosis
28. RIBOSOMES
Granular and small dot like structure
Made up of proteins(35%) and RNA(65%)
FUNCTION OF RIBOSOMES
SYNTHESIS OF PROTEIN
mRNA passes genetic code for protein synthesis
from nucleus to ribosome
Ribosomes arrange the amino acids into small units of
protein
Ribosomes attached with ER are involved in protein
synthesis like enzymatic protein,harmonal protein
and proteina of cell membrane
29.
30. There are two types of cells:
1) Prokaryotic Cells
2) Eukaryotic Cells
31. These are two distinct types of cells with
STRUCTURAL differences.
Prokaryotes
Bacteria
Eukaryotes
Animal
Plant
32.
33. Traits of Prokaryotes:
(pro-care-ee-ohts)
1.
They do not have a nucleus, and their genetic
material is not stored in the nucleus.
2.
They have some organelles, but not many.
3. They are less complicated that eukaryotes.
4.
All bacteria are prokaryotes.
35. Traits of Eukaryotes:
(you-care-ee-othts)
1. They all have a nucleus where the
genetic material of the cell is stored.
2. They have many organelles that work
together to help the cell function.
38. NUCLEUS
located near centre of cell
and is mostly spherical in
shape.
STRUCTURE OF NUCLEUS
Covered by nuclear
membrane and it encloses
the structures called nucleo
plasm and nucleolus
NUCLEAR MEMBRANE
Double layered and porous
in nature
Allows nucleoplasm to
communicate with
cytoplasm
39. NUCLEOPLASM
Gel like ground substance of the nucleus
Contains large quantities of the genetic
materials in the form of deoxyribonucleic
acid(DNA) which form the gene
DNA made of thread like material known as
chromatin
40. NUCLEOLI
o One or more nucleoli are present in each
nucleus
o Nucleolus contains ribonucleic acid(RNA) and
some proteins similar to those found in
ribosomes
41. FUNCTION OF NUCLEUS
1. Control of all the activities of the cell
2. Synthesis of RNA
3. Sending genetic instruction to the
cytoplasm for protein synthesis through
mRNA
4. Control of cell division through genes
5. Storage of hereditary information
42. DNA
Genetic information of an organism is stored in
genes of DNA
DNA forms the chemical basis of hereditary
characters
Carrier for genetic information to the offspring
Contains instruction for the synthesis of proteins
in the ribosome
DNA present in nucleus is responsible for
synthesis of RNA
43.
44. RNA
Formed from DNA
Regulates the synthesis of proteins in the
ribosome
TYPES
I.
MESSENGER RNA (mRNA)
carries genetic code of amino acid sequence for
synthesis of protein from the DNA to
cytoplasm
45. TRANSFER RNA(tRNA)
Responsible for decoding the genetic message
present in mRNA
RIBOSOMAL RNA(rRNA)
Present within ribosome and is responsible
for the assembly of proteins from amino acids
in the ribosomes
46.
47. TRANSCRIPTION
Copying of genetic material from DNA to RNA
Transcription of genetic codes in nucleus
formation of m RNA
copying of message from DNA to m RNA
m RNA enter the cytoplasm and activate the
ribosome for protein synthesis
48.
49. TRANSLATION
Process of protein synthesis in ribosomes
ribosomes get attached to mRNA
codons of mRNA recognized by
complimentary base of tRNA called anticodons
according to sequence of base of anticodon
different amino acids transported from
cytoplasm to ribosomes
rRNA assemble the proteins from amino acids
and attach to RER
58. LIST OF CHROSOMAL ABNORMALITIES
a)
b)
c)
a.
b.
c.
NUMERICAL ABNORMALITIES
Aneuploidy
Trisomic(2n+1)
Monosomic(2n-1)
STRUCTURAL ABNORMALITIES
DOWN’S SYNDROME
EDWARDS SYNDROME
PATAU’S SYNDROME
59. SEX CHROMOSOME DISORDER
1) KLINEFELTER’S SYNDROME
2) TURNER’S SYNDROME
3) FRAGILE X SYNDROME
60. CHROMOSOME ABERRATION
Useful marker for radiation injury
Observed in irradiated cells at the time of
mitosis when the DNA condenses to form
chromosome
If radiation exposure occurs after DNA
synthesis(ie in G2 or mid or late S) only one
arm of affected chromosome is broken
If radiation occurs before DNA replication(ie
in G1 or early S) then break in both the arms
61.
62. APOPTOSIS
Defined as programmed cell death under
genetic control
A normal phenomenon and in essential for
normal development of the body
FUNCTIONAL SIGNIFICANCE
Main function is to remove unwanted cells
without causing any stress or damage to the
neighboring cells
63. SIGNIFICANCE
1) Vital role in cellular homeostasis
2) Useful for removal of a cell that is damaged
by a virus of a toxin beyond repair
3) Essential event during the development and
in adult stage
64. ROLE OF MITOCONDRIA IN APOPTOSIS
external or internal stimuli initiate apoptosis by
activating the proteases CASPASES
Normally caspases suppressed by apoptosis
inhibiting factor(AIF)
WHEN CELL RECEIVE APOPTOSIS STIMULI…
mitochondria release two proteins
1. CYTOCHROME C
2. SECOND MITOCONDRIA-DERIVED
ACTIVATOR OF CASPASES(SMAC)
65. SMAC inactivates AIF
SMAC +AIF to form apoptosome activates
CASPASES
CYTOCHROME C also facilitate caspase
activation
67. CELL JUNCTION
It is the connection between the neighboring
cells
THREE TYPES
1. OCCLUDING JUNCTION- prevent intercellular exchange
of substances
2. COMMUNICATING JUNCTION-permits intercellular
exchange of substances
3. ANCHORING JUNCTION-provide strength to the cells
68. OCCLUDING JUNCTION
prevent movement of ions and molecule
from one cell to another cell
TIGHT JUNCTION/ZONA OCCLUDENS
belong to this category
Present in the apical margin of epithelial and
endothelial cells in intestinal mucosa,walls of
renal tubules,capillary wall
70. FUNCTION OF TIGHT JUNCTION
1. Holds the neighboring cell of tissues firmly for
strength and stability
2. In epithelial and endothelial cells function as
selective diffusion barrier between neighboring
cells
3. Prevents lateral movement of integral proteins
and lipids in cell membrane
4. In brain capillaries form blood-brain barrier
allowing only lipid soluble drugs and steroids to
pass through