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Cardiac Biometry
Dr. Omneya Nagy Elmakhzangy
Special Fetal Care Unit
Ain Shams University
• Current practice guidelines for fetal
echocardiography are largely based on a
qualitative assessment of heart structures
using standardized procedures that may
include anatomic measurements for
suspected growth problems.
Sklansky M 2011
Statistical methods for determing
normal cardiac parameters
Percentiles
• A percentile (or a centile) is a measure used
in statistics indicating the value below which a
given percentage of observations in a group of
observations fall
Z-score
• A Z-Score is a statistical measurement of a
score's relationship to the mean in a group of
scores. A Z-score of 0 means the score is the
same as the mean. A Z-score can also be
positive or negative, indicating whether it is
above or below the mean and by how many
standard deviations.
Percentile or z-score?
• From a practical perspective, it is much easier
to interpret an aortic valve diameter that is2.5
standard deviations (SDs) below the mean as
opposed to simply knowing that measurement
is less than the 5th percentile for somatic size
or MA.
Normalization according to what?
• In fetal life, centiles are usually normalized to
gestational age. However, as the size of the
fetus can vary hugely with a several-fold
difference by late pregnancy.
• Interpretation of the size of the various
cardiac structures requires normalization
against some parameter of fetal size.(BPD, FL )
Components of Cardiac Biometry .
How to measure ? And How to
interpret?
Aortic and pulmonary valve
annulus
• When? During ventricular systole
• Where ? Just below the level of the cusps of
the valve
• Normal: Aortic valve is equal to or slightly
smaller than pulmonary valve
Long-axis view of the left
ventricle showing the aortic valve
Short-axis view, showing the pulmonary
valve
Aortic Valve Pulmonary valve
Tricuspid and Mitral valve
annulus
• When ? During ventricular Diastole
• Where? Just below the level of the cusps
• Normal : Mitral valve is equal to or slightly
smaller than tricuspid valve
Right and left ventricular
length
• Should be equal . The length is measured
above levels of the cusps
•
Cardiothoracic circumference
ratio
• Measured in the standard 4 chamber view
• The CT circumference ratio should be always
less then 0.5 throughout gestation. It slowly
increased through gestation
• ~ 11 weeks: 0.38
• ~ 17-20 weeks: 0.45
• term: 0.5
Aortic arch and isthmus
diameter
Main pulmonary artery and
ductus arteriosus measurements
End-diastolic ventricular
diameter
• Where? just inferior to the atrioventricular
valve leaflets
Thickness of the ventricular free
walls and interventricular
septum
• Where? just inferior to the atrioventricular
valves.
• Additional measurements if warranted,
including:
• ο Systolic dimensions of the ventricles;
• ο Transverse dimensions of the atria; and
• ο Diameters of branch pulmonary arteries.
Determining the standard Deviation (z-
score)
The Lee. et al study (2009)
• A retrospective cross-sectional study of 2735
fetuses was performed for standard biometry
(biparietal diameter (BPD) and femoral
diaphysis length (FDL)) and an assessment of
menstrual age (MA).
• The goal :The main goal was to develop new z-
score reference ranges for common fetal
echocardiographic measurements
Parameter Slope Intercep
t
Correlation
coefficient
Femoral diaphysis length
Aortic valve end-systolic diameter 0.0054 0.239 0.904
Pulmonary valve end-systolic diameter 0.0103 0.150 0.994
Left ventricular end-diastolic diameter 0.0135 0.395 0.991
Right ventricular end-diastolic diameter 0.0138 0.466 0.952
End-diastolic cardiac circumference 0.145 0.700 0.990
Menstrual age
Aortic valve end-systolic diameter 0.0165 0.064 0.948
Pulmonary valve end-systolic diameter 0.0253 −0.048 0.990
Left ventricular end-diastolic diameter 0.0394 0.059 0.993
Right ventricular end-diastolic diameter 0.0394 0.132 0.962
End-diastolic cardiac circumference 0.341 −1.456 0.992
Biparietal diameter
Aortic valve end-systolic diameter 0.0063 0.111 0.940
Pulmonary valve end-systolic diameter 0.0091 0.0338 0.988
Left ventricular end-diastolic diameter 0.0125 0.248 0.974
Right ventricular end-diastolic diameter 0.0147 0.198 0.988
End-diastolic cardiac circumference 0.118 −0.178 0.994
Forget about tables
• In summary : 2 tables were developed
• 1-Linear models for prediction of fetal cardiac dimensions based on
femoral diaphysis length, menstrual age and biparietal diameter
• 2-Linear models for predicted standard deviations of fetal cardiac
dimensions based on femoral diaphysis length, menstrual age and
biparietal diameter
• Somehow put these two together you get an equation to calculate
the z-score
• Once u got your z-score you now can know the standard deviation
of your measurement from the mean value for this measurement .
• Clinical example for z-score calculation
• Femoral diaphysis length (FDL) = 30 mm
• Aortic valve (Ao) diameter = 3.5 mm
• From Table 1
• Predicted Ao diameter = (0.119 × 30) − 0.577 = 3.0 mm
• From Table 2
• Predicted SD = (0.0054 × 30) + 0.239 = 0.4 mm
• z =Aoobserved − Aopredicted = 3.5 − 3.0 = 1.25
Predicted SD 0.4
• The aortic diameter z-score is +1.25 SDs above the
predicted mean for this femur length and therefore is
within the normal range.
Do I need to do this??
• Luckily “NO”
• All what you need is to get your
measurements and a software on your
machine will do the math.
Cardiac biometry

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Cardiac biometry

  • 1. Cardiac Biometry Dr. Omneya Nagy Elmakhzangy Special Fetal Care Unit Ain Shams University
  • 2. • Current practice guidelines for fetal echocardiography are largely based on a qualitative assessment of heart structures using standardized procedures that may include anatomic measurements for suspected growth problems.
  • 4. Statistical methods for determing normal cardiac parameters
  • 5. Percentiles • A percentile (or a centile) is a measure used in statistics indicating the value below which a given percentage of observations in a group of observations fall
  • 6. Z-score • A Z-Score is a statistical measurement of a score's relationship to the mean in a group of scores. A Z-score of 0 means the score is the same as the mean. A Z-score can also be positive or negative, indicating whether it is above or below the mean and by how many standard deviations.
  • 7.
  • 8. Percentile or z-score? • From a practical perspective, it is much easier to interpret an aortic valve diameter that is2.5 standard deviations (SDs) below the mean as opposed to simply knowing that measurement is less than the 5th percentile for somatic size or MA.
  • 9. Normalization according to what? • In fetal life, centiles are usually normalized to gestational age. However, as the size of the fetus can vary hugely with a several-fold difference by late pregnancy. • Interpretation of the size of the various cardiac structures requires normalization against some parameter of fetal size.(BPD, FL )
  • 10. Components of Cardiac Biometry . How to measure ? And How to interpret?
  • 11. Aortic and pulmonary valve annulus • When? During ventricular systole • Where ? Just below the level of the cusps of the valve • Normal: Aortic valve is equal to or slightly smaller than pulmonary valve
  • 12. Long-axis view of the left ventricle showing the aortic valve Short-axis view, showing the pulmonary valve
  • 14. Tricuspid and Mitral valve annulus • When ? During ventricular Diastole • Where? Just below the level of the cusps • Normal : Mitral valve is equal to or slightly smaller than tricuspid valve
  • 15.
  • 16. Right and left ventricular length • Should be equal . The length is measured above levels of the cusps •
  • 17. Cardiothoracic circumference ratio • Measured in the standard 4 chamber view • The CT circumference ratio should be always less then 0.5 throughout gestation. It slowly increased through gestation • ~ 11 weeks: 0.38 • ~ 17-20 weeks: 0.45 • term: 0.5
  • 18. Aortic arch and isthmus diameter
  • 19. Main pulmonary artery and ductus arteriosus measurements
  • 20. End-diastolic ventricular diameter • Where? just inferior to the atrioventricular valve leaflets
  • 21. Thickness of the ventricular free walls and interventricular septum • Where? just inferior to the atrioventricular valves.
  • 22. • Additional measurements if warranted, including: • ο Systolic dimensions of the ventricles; • ο Transverse dimensions of the atria; and • ο Diameters of branch pulmonary arteries.
  • 23. Determining the standard Deviation (z- score)
  • 24. The Lee. et al study (2009) • A retrospective cross-sectional study of 2735 fetuses was performed for standard biometry (biparietal diameter (BPD) and femoral diaphysis length (FDL)) and an assessment of menstrual age (MA). • The goal :The main goal was to develop new z- score reference ranges for common fetal echocardiographic measurements
  • 25. Parameter Slope Intercep t Correlation coefficient Femoral diaphysis length Aortic valve end-systolic diameter 0.0054 0.239 0.904 Pulmonary valve end-systolic diameter 0.0103 0.150 0.994 Left ventricular end-diastolic diameter 0.0135 0.395 0.991 Right ventricular end-diastolic diameter 0.0138 0.466 0.952 End-diastolic cardiac circumference 0.145 0.700 0.990 Menstrual age Aortic valve end-systolic diameter 0.0165 0.064 0.948 Pulmonary valve end-systolic diameter 0.0253 −0.048 0.990 Left ventricular end-diastolic diameter 0.0394 0.059 0.993 Right ventricular end-diastolic diameter 0.0394 0.132 0.962 End-diastolic cardiac circumference 0.341 −1.456 0.992 Biparietal diameter Aortic valve end-systolic diameter 0.0063 0.111 0.940 Pulmonary valve end-systolic diameter 0.0091 0.0338 0.988 Left ventricular end-diastolic diameter 0.0125 0.248 0.974 Right ventricular end-diastolic diameter 0.0147 0.198 0.988 End-diastolic cardiac circumference 0.118 −0.178 0.994
  • 26.
  • 27. Forget about tables • In summary : 2 tables were developed • 1-Linear models for prediction of fetal cardiac dimensions based on femoral diaphysis length, menstrual age and biparietal diameter • 2-Linear models for predicted standard deviations of fetal cardiac dimensions based on femoral diaphysis length, menstrual age and biparietal diameter • Somehow put these two together you get an equation to calculate the z-score • Once u got your z-score you now can know the standard deviation of your measurement from the mean value for this measurement .
  • 28. • Clinical example for z-score calculation • Femoral diaphysis length (FDL) = 30 mm • Aortic valve (Ao) diameter = 3.5 mm • From Table 1 • Predicted Ao diameter = (0.119 × 30) − 0.577 = 3.0 mm • From Table 2 • Predicted SD = (0.0054 × 30) + 0.239 = 0.4 mm • z =Aoobserved − Aopredicted = 3.5 − 3.0 = 1.25 Predicted SD 0.4 • The aortic diameter z-score is +1.25 SDs above the predicted mean for this femur length and therefore is within the normal range.
  • 29. Do I need to do this?? • Luckily “NO” • All what you need is to get your measurements and a software on your machine will do the math.