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Metabolic Bone Disease Munro Peacock
Metabolic Bone Disease ,[object Object],[object Object],[object Object],[object Object]
Metabolic Bone Diseases ,[object Object],[object Object],[object Object],[object Object]
Metabolic Bone Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Fracture ,[object Object],[object Object]
Diseases of Mineralization:  Osteomalacia and Rickets   ,[object Object],[object Object]
Mineralization Calcification
Osteomalacia and Rickets ,[object Object],[object Object]
Osteomalacia and Rickets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vitamin D ,[object Object],[object Object],[object Object],[object Object]
Vitamin D Deficiency ,[object Object],[object Object],[object Object]
Impaired 25D production ,[object Object],[object Object],[object Object]
Impaired 1,25 D production ,[object Object],[object Object],[object Object]
BMD, g/cm 2 Age TOTAL BODY FEMORAL NECK LUMBAR SPINE Change in BMD  (mean ± 1SD)  with age in healthy male ( -- ) and female ( -- ) (DPX, Lunar)
Defective D receptor (VDR) ,[object Object],[object Object],[object Object]
Phosphate ,[object Object],[object Object]
Dietary Phosphate Depletion
Phosphate: Dietary P depletion ,[object Object],[object Object]
Phosphate: Neonatal Prematurity ,[object Object],[object Object]
Phosphate: Mesenchymal Tumor ,[object Object],[object Object]
Oncogenic Osteomalacia
Oncogenic Osteomalacia
Sporadic Hypophosphatemic  Osteomalacia
Phosphate: Fanconi Syndrome ,[object Object],[object Object]
Phosphate:  PHEX ,[object Object],[object Object]
Phosphate:  FGF 23 ,[object Object],[object Object]
Calcium ,[object Object],[object Object]
Acid ,[object Object],[object Object],[object Object]
Alkaline Phosphatase ,[object Object],[object Object]
Hypophosphatasia
Drugs and Toxins ,[object Object],[object Object]
Low bone mineral content  ,[object Object],[object Object]
Normal Bone Female, age 30 years
Moderate Osteoporosis Female, age 88 years
Osteoporosis
2500 0 500 1000 1500 2000 Femoral Neck BMD (   ) and Hip Fracture (   )  Age (years) BMD, g/cm 2 Fractures/100,000/year Kellie et al, AM J Pub Health 1990; 80:326
Hip Fractures/100,000/year Age (years) Kellie et al, AM J Pub Health 1990; 80:326-328 Orimo et al, Osteoporosis 1990: Osteoporosis pp 56-61
Fracture Risk ,[object Object],[object Object],[object Object],[object Object]
Osteoporosis ,[object Object],[object Object],[object Object]
Osteoporosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Osteoporosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
High Bone Mineral Content ,[object Object],[object Object],[object Object],[object Object]
Benign High Bone Mass
Benign High Bone Mass
Benign High Bone Mass
Osteopetrosis ,[object Object],[object Object],[object Object]
Diseases of Bone Turnover ,[object Object],[object Object],[object Object],[object Object]
Diseases of bone turnover ,[object Object],[object Object]
Pagets Disease ,[object Object],[object Object],[object Object],[object Object]
Paget’s Disease
Hyperparathyroid disease ,[object Object],[object Object],[object Object]
Secondary Hyperparathyroidism Renal osteodystrophy ,[object Object]
Hip fracture in dialysis:  ( 6,532 # in 326,463 patients)   Alem et al Kid Inter: 2000;58,396  relative risk 4.4
Mixed uremic osteodystrophy ,[object Object]
Ectopic calcification ,[object Object],[object Object],[object Object],[object Object]
 

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Metabolic Bone Disease