This document provides instructions for preparing and dispensing 20 ml of calamine lotion. It lists the ingredients needed which include calamine, ZnO, bentonite, glycerine and water. The procedure explains how to weigh and grind the dry ingredients, add the liquids to make a paste, transfer to a measuring cylinder and bottle, and label and dispense the finished lotion. Some key notes about calamine lotion are that it is used for conditions like eczema, sunburn and itching and works by forming a protective coating on the skin.

1. Calamine Lotion
Dr. Rahul Kumar Bhati

2. Aim: To prepare and dispense 20 ml of
calamine lotion.
Requirements:
• Apparatus: Dispensing balance and
fractional weights, mortar and pestle,
measuring cylinder, coloured dispensing
bottle with stopper, scissor, spatula,
pipette, gum, white paper etc.

3. • Ingredients & calculation:
For 100 ml For 20 ml
Calamine 15 g 3 g
ZnO 5 g 1 g
Bentonite 3 g 0.6 g
Glycerine 5 ml 1 ml
Aqua ad. 100 ml 20 ml

4. Procedure:
The balance was checked, appropriate corrections made
Required amounts of calamine, ZnO and bentonite were weighed,
placed in a mortar,
The mixture was grinded to make them fine paticles
1 ml of glycerine and 3-5 ml of water was added;
and a fine paste was made out of them
Transferred to measuring cylinder, mortar was rinsed with water
and rinsed water was transferred to the cylinder
volume was made upto 20 ml by adding water to the cylinder
Transferred to dispensing bottle
bottle was labeled and dispensed

5. Label:
The Lotion
Name: Mr. Raman
Age: 24 years
Sex : Male
Address: Safdarjung Enclv,
New Delhi-29
Date: 29/09/2009
Direction:- Apply on the affected area 2-3 times daily
Prepared at
Pharmacy Lab
VMMC
Dispensed by
Name
Regd. No.
FOR EXTERNAL USE ONLY
SHAKE WELL BEFORE USE

6. Prescription for 20 ml of Calamine Lotion
For
Name: Mr. Raman
Age: 25 years
Sex: Male
Address: Safdarjung Encl.,
New Delhi
Dr.Rahul Bhati; (MD)
Address: 615, VMMC, New
Delhi-29
Phone Number: 99999999
R
Calamine 15 g
ZnO 5 g
Bentonite 3 g
Glycerine 5 ml
Aqua ad. 100 ml
Mix and make lotion; send such 20 ml.
To be applied 2-3 times daily on the affected area.
Signature of Dr KC Sahoo
Regd. No: 123/07
Date: 28/09/2017
∕

7. Notes:
• Indications:
– Eczema
– Impetigo
– Sun burn
– Dermatitis
– Itching
– Varicose ulcers
– Psoriasis

8. • Calamine:
– ZnO (98%) + Fe2O3 (2%)
– Fe2O3 imparts color and it is irritant. So applied to
only over intact skin, not on open wound
• ZnO:
– Antiseptic, astringent.
– Protective and soothing agent.
– Substances that precipitate proteins
but do not penetrate cells, thus affecting superficial
layer only.

9. • Bentonite:
– Hydrated aluminium silicate.
– When water is added it, swells up to give a gel-
like but non-viscous consistency.
– It acts as suspending agent and reduce viscosity.
– It helps to make the lotion uniform.

10. • Glycerine:
– Hygroscopic in nature.
– Prevents drying of lotion, so lotion remains at the
site of application for a longer time.
– Also antiseptic and emollient (oily substance).
Sooths and softens the skin.
– Forms an occlusive film over skin and prevent
evaporation, thus restores elasticity of cracked
and dry skin.

11. • Precautions:
– Should not be applied on wounds or injured areas
because it precipitates proteins and form a layer
which prevents healing.
• Lactocalamine:
– Market preparation which contains casein and
phenol besides the normal constituents.
– Casein acts as soothing agent,
while phenol acts as a preservative and antiseptic.