This document analyzes the efficiency of various prediction algorithms for mining biological databases. It discusses prediction through mining biological databases to identify disease risks. It then evaluates several prediction algorithms (ZeroR, OneR, JRip, PART, Decision Table) on a breast cancer dataset using measures like accuracy, sensitivity, specificity, and predictive values. The results show that the JRip and PART algorithms generally had the highest accuracy rates, around 70%, while ZeroR had the lowest accuracy. However, ZeroR had a perfect positive predictive value. The study aims to assess the most efficient algorithms for predictive mining of biological data.