Blue Brain is a project to develop the first artificial brain through simulations run on IBM's Blue Gene supercomputers. The project aims to reverse engineer the human brain through modeling its neuronal components and synaptic interactions. It requires specialized software like NEURON and BBP-SDK to model individual neurons and visualize simulations. The project also uses the JuQUEEN supercomputer to build realistic 3D brain models with the ultimate goal of fully simulating the human brain by 2023.