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Blood and Blood
Products
Transfusion
Nursing
Implications
An adult human has about 4–6An adult human has about 4–6
liters of blood circulating in theliters of blood circulating in the
body. Among other things, bloodbody. Among other things, blood
transports oxygen to varioustransports oxygen to various
parts of the body.parts of the body.
Blood consists of several types ofBlood consists of several types of
cells floating around in a fluidcells floating around in a fluid
called plasma.called plasma.
The red blood cellsThe red blood cells contain hemoglobin, acontain hemoglobin, a
protein that binds oxygen. Red blood cellsprotein that binds oxygen. Red blood cells
transport oxygen to, and remove carbontransport oxygen to, and remove carbon
dioxide from, the body tissues.dioxide from, the body tissues.
The white blood cellsThe white blood cells fight infection.fight infection.
The plateletsThe platelets help the blood to clot .help the blood to clot .
The plasmaThe plasma contains salts and various kindscontains salts and various kinds
of proteins.of proteins.
Blood Groups
AB blood are often called universal recipients
group O people are often called universal donors
The Rh factor is an inherited antigen in humanThe Rh factor is an inherited antigen in human
blood. Blood that contains the Rh factor isblood. Blood that contains the Rh factor is
known asknown as Rh positiveRh positive, when it is not present, when it is not present
the blood is said to bethe blood is said to be Rh – negativeRh – negative. Rh blood. Rh blood
does not naturally contain Rh antibodies. If Rh-does not naturally contain Rh antibodies. If Rh-
positive blood is injected into an Rh-negativepositive blood is injected into an Rh-negative
person, the recipient develops Rh antibodies.person, the recipient develops Rh antibodies.
Subsequent transfusion with Rh-positive bloodSubsequent transfusion with Rh-positive blood
may cause serious reactions with clumping andmay cause serious reactions with clumping and
hemolysis of red blood cells.hemolysis of red blood cells.
Rhesus (RH) Factor
 
Blood Transfusion
A blood transfusion is the infusion of
whole blood or its components into the
patient's venous circulation.
Blood components includes:
1.PRBC – Packed Red Blood Cell
2.Platelets
3.Fresh Frozen Plasma
4.Cryoprecipitate
Blood Transfusion
Procedures
- The nurse shall verify the physician's order in the patient's file.
The order should include:
Urgency of the transfusion, including date and time
Type of blood/blood products
Amount of blood to be transferred
The duration of the transfusion
Any special instructions (e.g. medication required
before or during the transfusion).
-Secure Informed consent for blood transfusion.
-Check for patient's blood type and collect sample for cross-
matching.
-Physician shall enter the ordered blood or blood products in the
computer.
Blood Transfusion
Procedures
- Blood transfusion request must be sent in the Blood Bank by
the responsible nurse. The blood or blood products is usually
ready;
Emergency request – 30 minutes
Routine request – 3 hours
-Start IV open by starting flow of Normal Saline solution.
18-20G size is recommended for adults.
22-24G or larger is recommended for pediatric patients
-Check the bag of the blood and compare it with Blood Bank
transfusion certificate with the following items:
Patient's name
File number
Serial number
Blood group and type
Expiry date
-Double check the blood against patient's data with the
physician with his signature on the Blood Transfusion
Blood Transfusion
Procedures
-Take baseline vital signs before beginning transfusion.
-Use warmer to warm blood not exceeding 41˚C
-Unused donor units must be returned to the Blood Bank within 30
minutes (not exposed to extreme heat)
-Identify the patient correctly (3 names, MRN,(medical record number)
-Then start the administration slowly (no more than 25-50ml for the
first 15 minutes). Stay with the patient for the first 15 minutes of
transfusion.
-Check vital signs at least every 15 minutes for the first half hour after
the start of the transfusion. Then every 30 minutes for the next hour
until stable.
- Observe patient for flushing, dyspnea, itching, hives, or rash, and back
pain.
A. Immediate reactionsA. Immediate reactions
– Febrile reactionFebrile reaction
– Allergic reactionsAllergic reactions
– Hemolytic transfusion reaction (HTR)Hemolytic transfusion reaction (HTR)
– Circulatory over loadCirculatory over load
– Air embolismAir embolism
– Potassium toxicityPotassium toxicity
– Citrate toxicityCitrate toxicity
– Reaction due to infected bloodReaction due to infected blood
Complication of Blood Transfusion
– ThrombophlebitisThrombophlebitis
– AIDS (HIV) Hepatitis (HBV, HCV)AIDS (HIV) Hepatitis (HBV, HCV)
Syphilis (Treponema pallidum / Spirochetes)Syphilis (Treponema pallidum / Spirochetes)
Malaria (M.P), C.M.V & otherMalaria (M.P), C.M.V & other
– Immunological sensitization or allImmunological sensitization or all
immunizationimmunization
– Transfusion haemosiderosisTransfusion haemosiderosis
– Post transfusion purpuraPost transfusion purpura
– HTRHTR
– Complication of massive transfusionComplication of massive transfusion
Delayed transfusion reactions
A.A. Incompatibility between donors and recipientIncompatibility between donors and recipient
99% caused of human error preventable by99% caused of human error preventable by
– Adequate knowledge of blood groupsAdequate knowledge of blood groups
– Careful attention to all details of theCareful attention to all details of the
techniquestechniques
– Blood group incompatibleBlood group incompatible
– Outdated and infected bloodOutdated and infected blood
– Haemolysed bloodHaemolysed blood
– Incorrect anticoagulantIncorrect anticoagulant
Hemolytic transfusion reactionHemolytic transfusion reaction
SymptomsSymptoms
– Severe aching in the transfused veinSevere aching in the transfused vein
– Pain in lumbar region & backPain in lumbar region & back
– DyspnoeaDyspnoea
– NauseaNausea
– VomitingVomiting
– Flushing of the faceFlushing of the face
– Chill & rigorsChill & rigors
– AnxietyAnxiety
– RestlessRestless
– Feeling of constriction of chestFeeling of constriction of chest
Hemolytic transfusion reactionHemolytic transfusion reaction
SignsSigns
– ↑↑ Temp.Temp.
– TachycardiaTachycardia
– ↓↓ B.PB.P
– Unexplained bleedingUnexplained bleeding
– Shock - ↓ urinary outputShock - ↓ urinary output
↓↓
AnuriaAnuria
↓↓
DeathDeath
Hemolytic transfusion reactionHemolytic transfusion reaction
Under anesthesia and sedationUnder anesthesia and sedation
– SymptomlessSymptomless
– SignsSigns
Bleeding from wound / needle sitesBleeding from wound / needle sites
Persistent hypotensionPersistent hypotension
TachycardiaTachycardia
Hemolytic transfusion reactionHemolytic transfusion reaction
FOR ANY BLOOD TRANSFUSION
ADVERSE REACTION
Localized Urticaria:
a.Do not discontinue the transfusion but infuse at a slower rate
b.Notify the physician
Generalized Urticaria:
a.Stop the transfusion
b.Notify the physician
-Notify Blood Bank of suspected reaction
-Collect blood sample from the patient.
Adult-2-5 ml
Pediatric -1 to 3 ml
-Fill up Transfusion Reaction Form and send to Blood Bank
together with the collected blood sample, the remaining blood bag
and its tubing as soon as possible.
FOR ANY BLOOD TRANSFUSION
ADVERSE REACTION
-Fill up Transfusion Reaction Form and
send to Blood Bank together with the
collected blood sample, the remaining
blood bag and its tubing as soon as
possible.
-HERF(Health care event reporting form).All
hospital organizations have their own criteria.
-Obtain urine specimen as soon as
possible and send to lab for urinalysis.
Blood transfusion

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Blood transfusion

  • 2.
  • 3. An adult human has about 4–6An adult human has about 4–6 liters of blood circulating in theliters of blood circulating in the body. Among other things, bloodbody. Among other things, blood transports oxygen to varioustransports oxygen to various parts of the body.parts of the body. Blood consists of several types ofBlood consists of several types of cells floating around in a fluidcells floating around in a fluid called plasma.called plasma.
  • 4. The red blood cellsThe red blood cells contain hemoglobin, acontain hemoglobin, a protein that binds oxygen. Red blood cellsprotein that binds oxygen. Red blood cells transport oxygen to, and remove carbontransport oxygen to, and remove carbon dioxide from, the body tissues.dioxide from, the body tissues. The white blood cellsThe white blood cells fight infection.fight infection. The plateletsThe platelets help the blood to clot .help the blood to clot . The plasmaThe plasma contains salts and various kindscontains salts and various kinds of proteins.of proteins.
  • 6. AB blood are often called universal recipients group O people are often called universal donors
  • 7. The Rh factor is an inherited antigen in humanThe Rh factor is an inherited antigen in human blood. Blood that contains the Rh factor isblood. Blood that contains the Rh factor is known asknown as Rh positiveRh positive, when it is not present, when it is not present the blood is said to bethe blood is said to be Rh – negativeRh – negative. Rh blood. Rh blood does not naturally contain Rh antibodies. If Rh-does not naturally contain Rh antibodies. If Rh- positive blood is injected into an Rh-negativepositive blood is injected into an Rh-negative person, the recipient develops Rh antibodies.person, the recipient develops Rh antibodies. Subsequent transfusion with Rh-positive bloodSubsequent transfusion with Rh-positive blood may cause serious reactions with clumping andmay cause serious reactions with clumping and hemolysis of red blood cells.hemolysis of red blood cells. Rhesus (RH) Factor  
  • 8. Blood Transfusion A blood transfusion is the infusion of whole blood or its components into the patient's venous circulation. Blood components includes: 1.PRBC – Packed Red Blood Cell 2.Platelets 3.Fresh Frozen Plasma 4.Cryoprecipitate
  • 9. Blood Transfusion Procedures - The nurse shall verify the physician's order in the patient's file. The order should include: Urgency of the transfusion, including date and time Type of blood/blood products Amount of blood to be transferred The duration of the transfusion Any special instructions (e.g. medication required before or during the transfusion). -Secure Informed consent for blood transfusion. -Check for patient's blood type and collect sample for cross- matching. -Physician shall enter the ordered blood or blood products in the computer.
  • 10. Blood Transfusion Procedures - Blood transfusion request must be sent in the Blood Bank by the responsible nurse. The blood or blood products is usually ready; Emergency request – 30 minutes Routine request – 3 hours -Start IV open by starting flow of Normal Saline solution. 18-20G size is recommended for adults. 22-24G or larger is recommended for pediatric patients -Check the bag of the blood and compare it with Blood Bank transfusion certificate with the following items: Patient's name File number Serial number Blood group and type Expiry date -Double check the blood against patient's data with the physician with his signature on the Blood Transfusion
  • 11. Blood Transfusion Procedures -Take baseline vital signs before beginning transfusion. -Use warmer to warm blood not exceeding 41˚C -Unused donor units must be returned to the Blood Bank within 30 minutes (not exposed to extreme heat) -Identify the patient correctly (3 names, MRN,(medical record number) -Then start the administration slowly (no more than 25-50ml for the first 15 minutes). Stay with the patient for the first 15 minutes of transfusion. -Check vital signs at least every 15 minutes for the first half hour after the start of the transfusion. Then every 30 minutes for the next hour until stable. - Observe patient for flushing, dyspnea, itching, hives, or rash, and back pain.
  • 12. A. Immediate reactionsA. Immediate reactions – Febrile reactionFebrile reaction – Allergic reactionsAllergic reactions – Hemolytic transfusion reaction (HTR)Hemolytic transfusion reaction (HTR) – Circulatory over loadCirculatory over load – Air embolismAir embolism – Potassium toxicityPotassium toxicity – Citrate toxicityCitrate toxicity – Reaction due to infected bloodReaction due to infected blood Complication of Blood Transfusion
  • 13. – ThrombophlebitisThrombophlebitis – AIDS (HIV) Hepatitis (HBV, HCV)AIDS (HIV) Hepatitis (HBV, HCV) Syphilis (Treponema pallidum / Spirochetes)Syphilis (Treponema pallidum / Spirochetes) Malaria (M.P), C.M.V & otherMalaria (M.P), C.M.V & other – Immunological sensitization or allImmunological sensitization or all immunizationimmunization – Transfusion haemosiderosisTransfusion haemosiderosis – Post transfusion purpuraPost transfusion purpura – HTRHTR – Complication of massive transfusionComplication of massive transfusion Delayed transfusion reactions
  • 14. A.A. Incompatibility between donors and recipientIncompatibility between donors and recipient 99% caused of human error preventable by99% caused of human error preventable by – Adequate knowledge of blood groupsAdequate knowledge of blood groups – Careful attention to all details of theCareful attention to all details of the techniquestechniques – Blood group incompatibleBlood group incompatible – Outdated and infected bloodOutdated and infected blood – Haemolysed bloodHaemolysed blood – Incorrect anticoagulantIncorrect anticoagulant Hemolytic transfusion reactionHemolytic transfusion reaction
  • 15. SymptomsSymptoms – Severe aching in the transfused veinSevere aching in the transfused vein – Pain in lumbar region & backPain in lumbar region & back – DyspnoeaDyspnoea – NauseaNausea – VomitingVomiting – Flushing of the faceFlushing of the face – Chill & rigorsChill & rigors – AnxietyAnxiety – RestlessRestless – Feeling of constriction of chestFeeling of constriction of chest Hemolytic transfusion reactionHemolytic transfusion reaction
  • 16. SignsSigns – ↑↑ Temp.Temp. – TachycardiaTachycardia – ↓↓ B.PB.P – Unexplained bleedingUnexplained bleeding – Shock - ↓ urinary outputShock - ↓ urinary output ↓↓ AnuriaAnuria ↓↓ DeathDeath Hemolytic transfusion reactionHemolytic transfusion reaction
  • 17. Under anesthesia and sedationUnder anesthesia and sedation – SymptomlessSymptomless – SignsSigns Bleeding from wound / needle sitesBleeding from wound / needle sites Persistent hypotensionPersistent hypotension TachycardiaTachycardia Hemolytic transfusion reactionHemolytic transfusion reaction
  • 18. FOR ANY BLOOD TRANSFUSION ADVERSE REACTION Localized Urticaria: a.Do not discontinue the transfusion but infuse at a slower rate b.Notify the physician Generalized Urticaria: a.Stop the transfusion b.Notify the physician -Notify Blood Bank of suspected reaction -Collect blood sample from the patient. Adult-2-5 ml Pediatric -1 to 3 ml -Fill up Transfusion Reaction Form and send to Blood Bank together with the collected blood sample, the remaining blood bag and its tubing as soon as possible.
  • 19. FOR ANY BLOOD TRANSFUSION ADVERSE REACTION -Fill up Transfusion Reaction Form and send to Blood Bank together with the collected blood sample, the remaining blood bag and its tubing as soon as possible. -HERF(Health care event reporting form).All hospital organizations have their own criteria. -Obtain urine specimen as soon as possible and send to lab for urinalysis.