This document discusses biosensors, including their structure, history, working principles, types, sensing elements, transducers, amplifiers, and applications. It defines a biosensor as a device that combines a biological component with a physicochemical detector to detect analytes. The key components are a biological recognition element, transducer to convert the biological response into a measurable signal, and amplifier. Major applications mentioned include glucose monitoring, environmental monitoring, drug discovery, and food/agriculture testing. Disadvantages include inability to use heat sterilization and stability issues with biological materials.
This ppt is about biosensors. A brief Introduction to biosensors, history of Biosensors, working of biosensors, usage of biosensors application of biosensors in medical and other fields
Biosensor is the Talk of The Day. It made possible, the conversion of yesteryear's cumbersome experiments to an easier, faster all the while improving its sensitivity and specificity. This article will help you to gain an acquaintance about it, its properties, etc.
Biosensors are the analytical device that are used to measure the concentration of analye , these type of biosensors are made with conjugation of enzymes as a biological eliment to quantify a (bio)chemical substance / analyte are reffered to as Enzyme-probe Biosensors .
Biosensors are of many types but focusing on Enzyme biosensors there are 4 main types which are briefly described in this power point presentation .
A Biosensor is a device for the detection of an analyte that combines a biological component with a physio-chemical detector component.
Download: https://www.topicsforseminar.com/2014/10/biosensors-ppt.html
This ppt is about biosensors. A brief Introduction to biosensors, history of Biosensors, working of biosensors, usage of biosensors application of biosensors in medical and other fields
Biosensor is the Talk of The Day. It made possible, the conversion of yesteryear's cumbersome experiments to an easier, faster all the while improving its sensitivity and specificity. This article will help you to gain an acquaintance about it, its properties, etc.
Biosensors are the analytical device that are used to measure the concentration of analye , these type of biosensors are made with conjugation of enzymes as a biological eliment to quantify a (bio)chemical substance / analyte are reffered to as Enzyme-probe Biosensors .
Biosensors are of many types but focusing on Enzyme biosensors there are 4 main types which are briefly described in this power point presentation .
A Biosensor is a device for the detection of an analyte that combines a biological component with a physio-chemical detector component.
Download: https://www.topicsforseminar.com/2014/10/biosensors-ppt.html
A sensor that integrates a biological element with a physiochemical transducer to produce an electronic signal proportional to a single analyte which is then conveyed to a detector.
A presentation on biosensors and its application,all datas r mainly collected from google search,and from some books by or teachers. Hope it will help you...leave your rply,, :)
A sensor that integrates a biological element with a physiochemical transducer to produce an electronic signal proportional to a single analyte which is then conveyed to a detector.
A presentation on biosensors and its application,all datas r mainly collected from google search,and from some books by or teachers. Hope it will help you...leave your rply,, :)
A biosensor is an analytical device containing an immobilized biological material (enzyme, antibody, nucleic acid, hormone, organelle or whole cell) which can specifically interact with an analyte and produce physical, chemical or electrical signals that can be measured. An analyte is a compound (e.g. glucose, urea, drug, pesticide) whose concentration has to be measured.
Austin Journal of Biosensors & Bioelectronics is an open access, peer reviewed, scholarly journal dedicated to publish articles related to original and novel fundamental research in the field of Biomarkers Research.
The aim of the journal is to provide a platform for research scholars, scientists and other professionals to find most original research in the field Biosensors & Bioelectronics.
Austin Journal of Biosensors & Bioelectronics accepts original research articles, review articles, case reports and short communication on all the aspects of Biosensors & Bioelectronics and its Research.
Austin Journal of Biosensors & Bioelectronics is an open access, peer reviewed, scholarly journal dedicated to publish articles related to original and novel fundamental research in the field of Biomarkers Research.
The aim of the journal is to provide a platform for research scholars, scientists and other professionals to find most original research in the field Biosensors & Bioelectronics.
Austin Journal of Biosensors & Bioelectronics accepts original research articles, review articles, case reports and short communication on all the aspects of Biosensors & Bioelectronics and its Research
Austin Journal of Biosensors & Bioelectronics is an open access, peer reviewed, scholarly journal dedicated to publish articles related to original and novel fundamental research in the field of Biomarkers Research.
The aim of the journal is to provide a platform for research scholars, scientists and other professionals to find most original research in the field Biosensors & Bioelectronics.
Austin Journal of Biosensors & Bioelectronics accepts original research articles, review articles, case reports and short communication on all the aspects of Biosensors & Bioelectronics and its Research
Austin Journal of Biosensors & Bioelectronics is an open access, peer reviewed, scholarly journal dedicated to publish articles related to original and novel fundamental research in the field of Biomarkers Research.
The aim of the journal is to provide a platform for research scholars, scientists and other professionals to find most original research in the field Biosensors & Bioelectronics.
Austin Journal of Biosensors & Bioelectronics accepts original research articles, review articles, case reports and short communication on all the aspects of Biosensors & Bioelectronics and its Research.
BIOSENSOR, PHARMACEUTICAL BIOTECHNOLOGY, B PHARAM, 6TH SEM
Basic components of Biosensor
Working of Biosensor
Types of Biosensor
Electrochemical biosensor
Optical biosensor
Thermal biosensor
Resonant biosensor
Ion-sensitive biosensor
Applications of Biosensor
Nano sensors
sensing device
Father of the Biosensor
components of BIOSENSOR
BASIC PRINCIPLE OF BIOSENSOR
BIO-ELEMENT
TRANSDUCER
DETECTOR
RESPONSE FROM BIO-ELEMENT
IDEAL BIOSENSOR
BASIC CHARACTERESTICS
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5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
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Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Contents
1. Sensor and Transducer
2. Biosensor
3. History of Biosensor
4. Working principle of Biosensor
5. Types of Biosensor
6. Sensing elements in Biosensor
7. Transducer
8. Amplifier
9. Applications
10. Disadvantages
3. Sensor & transducer
• A Sensor is an object whose purpose is to detect events or changes in its
environment, and then provide a corresponding output. e.g Pressure sensor,
Ultrasonic sensor, Humidity Sensor, Gas Sensor, Motion Sensor,
Biosensor, Acceleration sensor, Displacement sensor etc.
• A Transducer is a device that converts one form of energy to another. e.g
pressure sensor might detect pressure (a mechanical form of energy) and
convert it to electrical signal for display at a remote gauge.
• A sensor is a type of transducer.
4. Biosensor
• Biosensors are analytical tools for the analysis of bio-material
samples to understand their bio-composition, structure and
function by converting a biological response into an electrical
signal. Example: Enzyme- conductometric biosensor for
blood-glucose monitoring.
• A biosensor is an analytical device, used for the detection of
an analyte, that combines a biological componentwith a
physicochemical detector.
5. History of Biosensor
• Professor Leland C Clark Jnr is known as the father of the
biosensor . On 15 April 1956 the biosensor that he invented
was named after him as “Clark electrode”(measured oxygen
level in blood).
• 1975 Clark’s ideas became commercial reality with the
successful re-launch of the Yellow Springs Instrument
Company (Ohio) glucose analyser based on the amperometric
detection of H2O2
• 1977 Karl Cammann introduced term biosensor
6. Working Principal of
Biosensor
1. Biological reorganization of elements which is highly specific
towards the biological material analytes products.
2. Transducers detect the transduces signal from biological
receptor targets to electrical to reaction signal which is due
occur.
3. After transduction signal from biological to electrical signal
where its amplification is necessary and takes place and read
out in detector after processing the values are displayed for
monitor and controlling the system.
7.
8. Types of Biosensors
• Piezoelectric Sensors
• Calorimetric/Thermal Detection Biosensors
• Optical Sensors
• Electrochemical Sensors
o Conductometric Sensors
o Amperometric Sensors
o Potentiometric Sensors
CONTD.
9. • Piezoelectric Sensors: Piezoelectric biosensors are considered as mass-
based biosensors. Piezoelectric biosensors are based on the principle of
acoustics (sound vibrations), hence they are also called as acoustic
biosensors. Piezoelectric biosensors produce an electrical signal when a
mechanical force is applied .Example of piezoelectric sensor is quartz
crystal micro or nano balance.
• Calorimetric/Thermal Detection Biosensors: It works on the principal of
absorption/ production of heat.
• Optical Sensors: The optical fibers allow detection of analytes on the basis
of absorption, fluorescence or light scattering. The reaction causes a
change in fluorescence or absorbance resulting due to change in the
refractive index of the surface between two media which differ in density.
For Example, if antibodies bind on a metal layer, the refractive index of the
medium in contact with this layer will change.
• Electrochemical Biosensors: Electrochemical Biosensors are integrated
receptor-transducer devices capable of providing selective and quantitative
analytical information using a biological recognition element.
CONTD.
10. • Electrochemical Biosensors: Electrochemical Biosensors are
integrated receptor- transducer devices – capable of providing
selective and quantitative analytical information using a biological
recognition element. A biomolecule is immobilized onto an
electrode that has been modified by coating it with an electronically
conducting, semiconducting, or ionically conducting chemical.
Coating materials that have been used include electrochemically
prepared polyaniline and polypyrrole films, or other conducting
polymers.
• Conductimetric Sensors: Conductometric biosensors measure
changes in the conductivity
• of a medium as a result of enzyme reactions that change its ionic
composition.
• Amperometric Sensors: Amperometric biosensors measure the
electric current associated with electron flow resulting from redox
reactions.
• Potentiometric Sensors: Potentiometric biosensors use ion
selective electrodes to determine changes in the concentration of
chosen ions.
11. SENSING ELEMENTS
1. Enzymes are proteins with high catalytic activity and selectivity towards
substrates . They have been used for decades to assay the concentration of
diverse analytes. Their commercial availability at high purity levels makes
them very attractive for mass production of enzyme sensors. Enzymes have
been immobilized at the surface of the transducer by adsorption, covalent
attachment, entrapment in a gel or an electrochemically generated polymer, in
bilipid membranes or in solution behind a selective membrane. Enzymes are
commonly coupled to electrochemical and fiber optic transducers.
CONTD.
12. Antibodies
• Antibodies are proteins that show
outstanding selectivity. Molecules
larger than about 10kDa can
stimulate an immune response.
• Many antibodies are commercially
available and commonly used in
immunoassays. Antibodies are
usually immobilized on the surface
of the transducer by covalent
attachment by conjugation of
amino, carboxyl, aldehyde, or
sulfhydryl groups. The surface of
the transducer must be previously
functionalized with an amino,
carboxyl, hydroxyl, or other
group.
CONTD.
13. Micro-organisms
• The use of micro-organisms as biological elements in
biosensors is based on the measurement of their metabolism.
Microbial cells have the advantage of being cheaper than
enzymes or antibodies,
• can be more stable, and can carry out several complex
reactions involving enzymes and cofactors. Conversely, they
are less selective than enzymes, they have longer response and
recovery times, and may require more frequent calibration.
CONTD.
15. AMPLIFIER
• An amplifier, is an electronic device that increases
the power of a signal
Power amplifier
Transistors amplifier
Operational amplifier
16. APPLICATIONS
• Glucose monitoring , pregnancy test in diabetes patients historical market
driver
• Environmental applications e.g. the detection of pesticides and river water
contaminants such as heavy metal ions
• Remote sensing of airborne bacteria e.g. in counter-bioterrorist activities
• Remote sensing of water quality in coastal waters by describing online
different aspects of clam ethology (biological rhythms, growth rates,
spawning or death records) in groups of abandoned bivalves around the
world
• Determining levels of toxic substances before and after bioremediation
• Routine analytical measurement of folic acid, biotin, vitamin B12 and
pantothenic acid as an alternative to microbiological assay
• Drug discovery and evaluation of biological activity of new compounds
• Detection of toxic metabolites such as mycotoxins
• Detecting levels of toxins in an ecosystem
• Detecting airborne pathogens (i.e. anthrax)
• Monitoring blood glucose levels
18. IN AGRICULTURE,FOOD
INDUSTRY
• DETECTION OF VIRAL FUNGAL BACTERIAL DISEASE
OF PLANTS
• DETECTION OF FOOD, TOTAL MICROBES IN SOFT
DRINKS
• DETERMINE FRESHNESS OF FRUIT,MEAT,FISH ETC.
• OPTICAL BIOSENSOR USES CYANIDE TO
• GLOW BACTERIAAND DETECT IT
20. Disadvantages
1. Heat sterilization is not possible because of denaturaization
of biological material.
2. Stability of biological material (such as enzyme, cell,
antibody, tissue, etc.), depends on the natural properties of
the molecule that can be denaturalized under environmental
conditions (pH, temperature or ions).
3. The cells in the biosensor can become intoxicated by other
molecules that are capable of diffusing through the
membrane
4. Fabrication is Costly