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Chapter 8
Cell Reproduction and Inheritance
Duplicating Genetic Information
The Cell Cycle
Cancer and the Cell Cycle
Mitosis
Meiosis
When Cell Division is not perfect
Duplicating Genetic Information

Information about you is in the sequence of
nucleotides in the DNA molecule
In each of your cells, there is about 2 meters of DNA
per nucleus
How does the DNA condense into such as small area?
DNA

histones

chromatin
Duplicating Genetic Information

Chromatin can condense into a chromosome
Telomere

Centromere

Telomere
Duplicating Genetic Information

Humans have 46 chromosomes
Chromosomes are characterized by
length
Position of the centromere
Banding pattern
Duplicating Genetic Information

So humans have 46 chromosomes
with 23 pairs.
You can see stained chromosomes and
these can be arranged in pairs.
The picture of arranged chromosomes is
called a karyotype.
Duplicating Genetic Information
Duplicating Genetic Information
Duplicating Genetic Information
Duplicating Genetic Information
Humans
Have 46 Chromosomes
23 pairs
2n = 46
2 is the number of copies of each chromosome
n = the number of different chromosomes
46 is the total number of chromosomes in the
cell
Let’s Try Some!
2n = 8
3n = 15
4n = 8
The Cell Cycle

The Cell Cycle
Phases include:
1. Interphase – Preparation phases for mitosis
2. Mitosis – Cell division or splitting

Interphase
1. G1 (Growth)
2. S
3. G2 (Growth)
The Cell Cycle
Cancer and the Cell Cycle
Cancer and the Cell Cycle

A cancer cell has unregulated cell growth
Often, the cell cycle checkpoints do not exist.
What is cancer?
Can you catch cancer?
What are the treatments for cancer?
What should I look for?

http://www.cancer.org/
1- 800 – 4 CANCER
Why Mitosis
Growth and Repair
Products are identical copies
Meiosis – a process that reduces the chromosome
number in such a way that the daughter nuclei only
receive one member of each homologous pair of
chromosomes. Think of it as a double mitotic
division with only a single S phase
Phases of meiosis
1. Prophase I

6. Prophase II

2. Metaphase I

7. Metaphase II

3. Anaphase I

8. Anaphase II

4. Telophase I

9. Telophase II

5. Interkinesis
Prophase I
Crossing over of non-sister chromatids
During prophase I, non-sister chromatids can
undergo synapsis, in which the chromatids line up
side-by-side & exchange genetic information
between them
This allows new combination of genetic material
which will become part of a new offspring
Prophase I & Metaphase I
Independent assortment
As the chromosomes are pushed around during
prophase I, eventually lining up along the metaphase
plate during metaphase I, their orientation is
different from that of mitosis metaphase
Instead of lining one on top of the other, the
replicated chromosomes line up side by side
according to their homologous characterstics
Meiosis I

Mitosis

Prophase I

Prophase

Pairing of chromosomes

No pairing

Metaphase I
Homologous chromosomes at
Metaphase plate

Metaphase
Duplicated chromosomes at
metaphase plate

Anaphase I
Homologous chromosomes separate

Anaphase
Sister chromatids separate, becoming
Daughter chromosomes

Telophase I

Telophase

Daughter cells are haploid

Daughter cells are diploid
Meiosis II

Mitosis

Prophase II

Prophase

No pairing of chromosomes

No pairing

Metaphase II

Metaphase

Haploid # of chromosomes at metaphase
chromosomes at plate

Diploid # of duplicated
metaphase plate

Anaphase II
Sister chromatids separate, becoming
daughter chromosomes

Anaphase
Sister chromatids separate, becoming
daughter chromosomes

Telophase I

Telophase

4 haploid daughter cells

Daughter cells are diploid

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Biomitosismeiosis

  • 1. Chapter 8 Cell Reproduction and Inheritance Duplicating Genetic Information The Cell Cycle Cancer and the Cell Cycle Mitosis Meiosis When Cell Division is not perfect
  • 2. Duplicating Genetic Information Information about you is in the sequence of nucleotides in the DNA molecule In each of your cells, there is about 2 meters of DNA per nucleus How does the DNA condense into such as small area? DNA histones chromatin
  • 3. Duplicating Genetic Information Chromatin can condense into a chromosome Telomere Centromere Telomere
  • 4.
  • 5. Duplicating Genetic Information Humans have 46 chromosomes Chromosomes are characterized by length Position of the centromere Banding pattern
  • 6. Duplicating Genetic Information So humans have 46 chromosomes with 23 pairs. You can see stained chromosomes and these can be arranged in pairs. The picture of arranged chromosomes is called a karyotype.
  • 11. Humans Have 46 Chromosomes 23 pairs 2n = 46 2 is the number of copies of each chromosome n = the number of different chromosomes 46 is the total number of chromosomes in the cell
  • 12. Let’s Try Some! 2n = 8 3n = 15 4n = 8
  • 13. The Cell Cycle The Cell Cycle Phases include: 1. Interphase – Preparation phases for mitosis 2. Mitosis – Cell division or splitting Interphase 1. G1 (Growth) 2. S 3. G2 (Growth)
  • 15. Cancer and the Cell Cycle
  • 16. Cancer and the Cell Cycle A cancer cell has unregulated cell growth Often, the cell cycle checkpoints do not exist. What is cancer? Can you catch cancer? What are the treatments for cancer? What should I look for? http://www.cancer.org/ 1- 800 – 4 CANCER
  • 17. Why Mitosis Growth and Repair Products are identical copies
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29. Meiosis – a process that reduces the chromosome number in such a way that the daughter nuclei only receive one member of each homologous pair of chromosomes. Think of it as a double mitotic division with only a single S phase Phases of meiosis 1. Prophase I 6. Prophase II 2. Metaphase I 7. Metaphase II 3. Anaphase I 8. Anaphase II 4. Telophase I 9. Telophase II 5. Interkinesis
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35.
  • 36.
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 42. Prophase I Crossing over of non-sister chromatids During prophase I, non-sister chromatids can undergo synapsis, in which the chromatids line up side-by-side & exchange genetic information between them This allows new combination of genetic material which will become part of a new offspring
  • 43.
  • 44.
  • 45.
  • 46.
  • 47. Prophase I & Metaphase I Independent assortment As the chromosomes are pushed around during prophase I, eventually lining up along the metaphase plate during metaphase I, their orientation is different from that of mitosis metaphase Instead of lining one on top of the other, the replicated chromosomes line up side by side according to their homologous characterstics
  • 48.
  • 49.
  • 50. Meiosis I Mitosis Prophase I Prophase Pairing of chromosomes No pairing Metaphase I Homologous chromosomes at Metaphase plate Metaphase Duplicated chromosomes at metaphase plate Anaphase I Homologous chromosomes separate Anaphase Sister chromatids separate, becoming Daughter chromosomes Telophase I Telophase Daughter cells are haploid Daughter cells are diploid
  • 51. Meiosis II Mitosis Prophase II Prophase No pairing of chromosomes No pairing Metaphase II Metaphase Haploid # of chromosomes at metaphase chromosomes at plate Diploid # of duplicated metaphase plate Anaphase II Sister chromatids separate, becoming daughter chromosomes Anaphase Sister chromatids separate, becoming daughter chromosomes Telophase I Telophase 4 haploid daughter cells Daughter cells are diploid