The new Biograph mCT from Siemens provides intelligently reproducible quantification through three key innovations: 1. Daily quality control scans normalize system performance to ensure consistent and accurate quantitative results over time. 2. Precise co-registration of PET and CT images through innovations like SMART registration technologies provide better attenuation correction for more reliable data. 3. Intelligent software applications in syngo.via like SUVpeak, myocardial blood flow quantification, and pending tools for neurology assist in standardized, reproducible interpretation across users and time. Maximum Speed Engineered Clinical Flexibility syngo.via Customer Care Molecular Imaging Biomarker Research 20

1. www.siemens.com/mi
Biograph mCT
molecular CT. quantification redefined.
Answers for life.

3. Biograph mCT –
molecular CT.
quantification redefined.
Quantificati

4. on Redefined

5. The Siemens
Inno
Molecular Imaging Leadership
Innovation Leadership
For more than 130 years, Siemens
Healthcare has been a recognized leader in
medical innovation. From the first
electromedical devices in 1896 to the latest
PET hybrid technologies, we have a long
history of pioneering technological
achievements that have helped make the
A Focus on Return on Innovation
Driven by this passion to make a difference,
the core of Siemens Molecular Imaging is
based upon the assumption that achieving
the highest technical performance is only
important when it meets the needs of our
customers and the patients they serve.
To gain a deep understanding of our
impossible possible. We have always customers’ needs and the environments
believed that even the farthest technical they work in, we collaborate closely with
horizons were temporary and could be leading medical experts from around the
surpassed with consistent dedication to world. This cooperation is the driving force
improved healthcare. This visionary behind our innovative solutions and
approach, backed up by the largest R&D services. From the earliest stages of
budgets in the medical imaging industry, research, product development and design,
has made Siemens an undisputed we rely upon the advice and
innovation leader in molecular imaging. recommendations of our customers to
determine our focus. As a result, our
products are able to offer you the highest
return on innovation possible.
Clinical Return Workflow Return Financial Return
4

6. ovation
From the beginning, one of the most
frequent demands of our customers has
been to improve diagnostic decision making
to enable greater confidence. At the same
time, healthcare is facing the dual mandates
to improve patient safety and increase
productivity, while ensuring the highest
quality and cost-efficient patient care.
Introducing the new Biograph mCT
Our dedicated team of molecular imaging
experts have helped shape the diagnostic
imaging world with their inventions and
ideas. And we are continuing this tradition
of innovation by continuously pioneering
new technologies. With the introduction of
the new Biograph™ mCT, we offer our
With a focus on fulfilling your clinical, customers ever-increasing opportunities to
workflow and financial needs, our mandate benefit from their investments in
is to deliver innovations that consistently innovation. No matter which way you look
meet the following three criteria: at it, Siemens Molecular Imaging is helping
you to expand your Return on Innovation.
• Lead the way in technological and medical
advancement
• Maximize workflow efficiency
• Make state-of-the-art molecular imaging
affordable
5

7. Biograph mCT – molecular CT.
quantification redefined.
With today’s PET/CT, the smallest details can go unnoticed, lowering diagnostic confidence. Inaccurate
quantification may mislead treatment response monitoring. Longer examination times lead to fewer
patients per day, and unnecessary dose could compromise patient safety. Addressing these challenges
requires a PET/CT designed from the ground up that improves diagnostic confidence by offering
reproducible quantification, the highest image resolution* and speed in both PET and CT, all while
minimizing radiation dose.
The new Biograph mCT. Bringing accurate and reproducible quantification to PET·CT imaging by
ensuring that each element of the measurement chain is optimized. Starting with the industry’s
highest volumetric image resolution*, Biograph mCT features unique daily quality control, SMART
registration technologies and intelligent software to bring accuracy and reproducibility to PET/CT
imaging. In addition, innovative CARE technologies ensure the lowest possible dose is administered.
With the new Biograph mCT, now you can detect, characterize and monitor the tiniest cancer lesions
with reproducible quantification, making cancer treatment more cost effective. Now you can quantify
absolute myocardial blood flow, making more accurate treatment decisions, minimizing risk to your
patients. Now you can potentially** quantify amyloid deposits in the brain, making dementia
diagnosis possible, slowing disease progression.
Now, more than ever, you are able to rely on molecular imaging with quantification that is accurate
and reproducible. For results that will redefine clinical decision making. The confirmation you need for
more diagnostic certainty and more informed treatment planning. Study after study. Scan after scan.
Without question.
6 * Based on competitive literature available **This product is under development and is not yet
at time of publication. Data on file. commercially available in the U.S. Due to regulatory
reasons its future availability cannot be guaranteed.

8. Content
Intelligently 8
Reproducible
Quantification
Finest Volumetric 24
Image Accuracy*
Minimum Dose and 42
Maximum Speed
Engineered Clinical 58
Flexibility
syngo®.via 72
Customer Care 74
Molecular Imaging 78
Biomarker Research
7

9. Intelligently Reproducible
Quantification
8

10. 9

11. Intelligently Reproducible
Quantification
Intelligently In order to help physicians make sound decisions, imaging must not only be quantifiable –
Reproducible it must be accurate and consistent. With conventional technology, customers face the issue
Quantification of variability in results due to both software and hardware challenges. Inherent scanner
drift and inaccurate attenuation correction through misregistration of anatomical and
Finest Volumetric functional images have a direct impact on reproducibility and accuracy of acquired
Image Accuracy quantitative data. In addition, standard measurement techniques and inter-user variability
affect accurate diagnostic results.
Minimum Dose and
Now, for the first time, Biograph mCT gives you quantifiable results that are precise.
Maximum Speed
Reproducible. And consistent over time. With its unique combination of intelligent
software, daily calibration and precise anatomical and functional co-registration
Engineered Clinical
Biograph mCT makes a quantifiable difference in diagnostic confidence, therapy planning
Flexibility
and treatment monitoring.
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
10

12. Return on
Innovation
Clinical Return Workflow Return Financial Return
• Increased confidence in quantitative • Fast and consistent perfusion results • Accurate and reproducible
results with automatic daily quality with automatic cardiac registration quantification attracts more
control with normalization referring physicians and patients
• Generate simultaneous PET and CT
• Enhanced precision in staging and results with intelligent one-click • Grow beyond oncology with unique
follow-up with inter-user segmentation quantitative offerings in neurology
reproducibility of SUV values and cardiology
11

13. Intelligently Reproducible
Quantification
Intelligently Daily calibration ensures consistent Better attenuation correction for more Quantitative assessments with syngo.via
Reproducible performance over time accurate, quantifiable data
Advanced syngo clinical applications provide
Quantification
Leaving nothing to chance, Biograph mCT’s The desire for perfect attenuation correction essential tools to get more accurate and
automatic quality check process was lies at the heart of our SMART (Siemens reproducible, quantifiable measurements in
Finest Volumetric
designed to provide confidence that Molecular & Anatomical Registration neurology, cardiology and oncology
Image Accuracy
performance is consistent and Technologies) research development imaging. SUVpeak, new in the syngo.mCT
measurements are accurate, day after day. philosophy. With SMART innovations, Oncology Engine, provides consistent and
Minimum Dose and
With Quanti•QC, you can begin each day Siemens continues to pioneer new ways to reproducible quantitative assessments of
Maximum Speed
knowing that overnight your scanner was address PET attenuation. From a unique hot spots. Myocardial Blood Flow (MBF) can
calibrated and tuned to precisely the right patient handling system that eliminates be used as an absolute quantification
Engineered Clinical
specifications, using phantom data that differential deflection to Auto Cardiac method to assess balanced disease in all
Flexibility
allows for daily PET normalization and Registration which automatically aligns CT areas of the heart. And an exciting
optimal performance. In addition the tightly and PET heart images and reduces variability quantative tool in neurology, part of the
syngo.via
regulated water-cooled gantry ensures between users. And Siemens novel SMART syngo.mCT Neurology Engine*,
system temperature stability for consistent Neuro AC enables you to correct automatically registers brain data to a
Customer Care
performance. neurological PET data without a CT scan*. normals database to assist in the assessment
The result in each case is accurate of neurological disorders.
Molecular Imaging
attenuation correction and reliable
Biomarker Research
quantitative measurements.
12 * SMART Neuro AC and syngo.mCT Neurology Engine are pending 510k clearance,
and are not yet commercial available in the United States.

14. Summary
In order to help physicians make sound
decisions, imaging must not only be
quantifiable – it must be accurate and
reproducible. Siemens Biograph mCT has
been intelligently engineered to meet this
need. The new technologies incorporated in
Biograph mCT are an exciting step forward
in furthering the understanding of disease,
its progression and response to treatment.
From daily system normalization and precise
PET and CT alignment with SMART
innovations to intelligent software that
assists with the interpretation of dementia,
evaluation of balanced myocardial disease
and accurate assessment of treatment
response on oncology. Accuracy and
reproducibility is the key to precisely
assessing disease status.
13

15. How it works
Intelligently Reproducible
Quantification
Intelligently Biograph mCT gives you quantifiable precise PET and CT alignment with SMART • Daily calibration ensures consistent
Reproducible results that are accurate and reproducible innovations and intelligent software, performance over time
Quantification by overcoming inherent variabilities faced Biograph mCT brings accuracy and
• Better attenuation correction for more
by conventional PET/CT systems. By reproducibility to daily routine.
accurate, quantifiable data
Finest Volumetric incorporating daily system normalization,
Image Accuracy • Quantitative assessments with syngo.via
Minimum Dose and
Maximum Speed Quality Control PET and CT Registration Quantification Software
Engineered Clinical
Flexibility Daily SMART Intelligent Software
Normalization Correction
SUVpeak
syngo.via
No Detector Drift
OK
Customer Care
Absolute Perfusion
Molecular Imaging
Biomarker Research
Ratio Analysis*
14 * This feature is under development and is not yet commercially available in the United States.
Due to regulatory reasons its future availability cannot be guaranteed.

16. How it works
Quanti·QC
Biograph mCT’s Quanti•QC assures day-to- Environmental factors such as temperature Day Day Day Day
day consistency in your system response fluctuations in the scan room have long 01 16 30 90
18
F
and quantitative reproducibility. The been recognized as a potential source of
comprehensive daily quality check and system performance drift. Biograph mCT
calibration can be scheduled to run vastly reduces such influence with the Conventional
automatically overnight so the scanner is tightly regulated integrated water-cooling
ready to begin imaging before the first system which ensures system temperature
patient arrives. stability for consistent performance. Correlation of PET calibration
to initial cross calibration
Quanti•QC is performed with a 20 cm • Daily normalization is routine
Germanium-68 uniformity phantom of
• Can be scheduled to run overnight Day Day Day Day
known activity. This method allows for
01 16 30 90
correlation with the dose calibrator via daily • Allows for correlation with dose calibrator 18
F Ge
68
comparison to previously acquired cross via daily comparison to previously
calibration – bringing increased confidence acquired cross calibration for assurance of
Quanti•QC
in the quantification efficacy of the system. quantitative accuracy
Once the phantom scan is completed,
normalization results are reported, including
a PET calibration factor check confirming
correct computation of the absolute image
calibration.
15

17. How it works
SMART PHS
Intelligently Biograph mCT employs a SMART patient Conventional SMART PHS
Reproducible handling system (PHS) that was specifically
Quantification designed for use in PET/CT imaging. Its
unique cantilever design, in which the
Finest Volumetric pedestal and table move as one unit,
Image Accuracy supports a full 227 kg (500 lb) without any
differential deflection between PET and CT
CT PET CT PET
Minimum Dose and acquisitions. This no-flex feature ensures
Maximum Speed accurate attenuation correction for more
precise quantification.
Engineered Clinical
• Unique cantilever design
Flexibility
• Full 227 kg (500 Ib) table capacity
syngo.via
• No differential deflection
Customer Care
Molecular Imaging
Biomarker Research
16

18. How it works
SMART Auto Cardiac Registration
SMART Auto Cardiac Registration quickly, • Automatic and fast PET and
automatically and precisely registers CT and CT registration
PET scans during cardiac imaging. Using a
• Reproducible between users
proprietary algorithm, SMART Auto Cardiac
Registration identifies the heart and aligns • Consistently accurate quantification
the molecular and anatomical images for
optimal attenuation correction.
SMART Auto Cardiac Registration is
integrated within the cardiac acquisition
workflow. A rapid reconstruction of the non-
Conventional SMART Auto Cardiac Registration
attenuation corrected PET image is
automatically registered to the CT for
optimal registration confirmation. PET
attenuation corrected images are
reconstructed based on the confirmed
optimal registration.
SMART Auto Cardiac Registration reduces
the variability between users, providing
consistently accurate and reproducible
quantification.
17

19. Conventional CT AC
CT mu-map Attenuation-corrected PET
How it works
SMART Neuro AC
Intelligently SMART Neuro AC* enables quantification of SMART Neuro AC
Reproducible PET data without requiring a CT scan for
Quantification attenuation correction. The ability to
perform attenuation correction without a CT Calcualted mu-map Attenuation-corrected PET
Finest Volumetric scan avoids any co-registration problems
Image Accuracy that can occur due to patient motion.
Siemens SMART Neuro AC assesses and
Minimum Dose and applies an appropriate attenuation map to
Maximum Speed the PET data to make accurate corrections
without requiring a CT scan, relieving the
Engineered Clinical patient of further radiation exposure and
Flexibility eliminating the chance of registration
inaccuracies.
syngo.via
• Calculated attenuation correction
Customer Care • Quantitative PET data
• Minimize radiation dose
Molecular Imaging
Biomarker Research
18 * SMART Neuro AC is pending 510k clearance,
and is not yet commercially available in the United States.

20. How it works
SUVpeak
SUVpeak employs a 1 cm3 sphere volume of
interest (VOI) within a lesion for more
robust evaluation of uptake . SUVpeak
automatically identifies the peak value
within a VOI. Compared to the conventional
single pixel SUVmax, SUVpeak can decrease the
influences of noise and together with the
pre-set 1 cm3 volume and automatic peak
algorithm, can potentially reduce reader
variability. This method provides accurate
and reproducible information for therapy
response assessment.
• Automatic identification of 1 cm3
SUV peak volume within VOI
• Fixed dimensions of peak volume reduces
inter-operator variability
• Reduced susceptibility to noise
19

21. How it works
Myocardial Blood Flow
Intelligently Conventional myocardial perfusion imaging
Reproducible assesses the blood’s relative distribution,
Quantification assuming that at least one section of the
heart performs normally and can be used as
Finest Volumetric a reference. The myocardial blood flow
Image Accuracy (MBF) application is an absolute
quantification method that helps to
Minimum Dose and confidently assess balanced disease in all
Maximum Speed areas of the myocardium. This technology
now supports 82 Rubidium as well as 13N
Engineered Clinical Ammonia imaging.
Flexibility
• Non-invasive quantitative assessment of
myocardial blood flow and coronary flow
syngo.via
reserve
Customer Care • Supports 82Rb and 13N Ammonia biomarkers
Molecular Imaging
Biomarker Research
20

22. How it works
PET Neurology Quantification
syngo.PET Neuro DB Comparison* includes currently exist. Siemens is presently working
a PET FDG normals which database provides to develop another quantitative tool in
quantitative assessment of biomarker neurological imaging, which would assess
uptake in the brain to aid in the assessment the biomarker activity ratio** between two
of neurological disorders such as dementia. regions of the brain (i.e. a region of interest
The application registers brain data to a compared to a reference region such as the
normals database automatically, so regional cerebellum).
volume of interest (VOI) generation and
• Clear and quick assessment of hyper- and
statistical analysis can be obtained. The
hypo-metabolic brain regions
comparison quickly reveals abnormalities if
present. • Standard voxel-by-voxel reporting of
statistics
As an innovation leader, Siemens is
continually looking towards the future to • Predefined 3D anatomical brain regions
find ways to answer tomorrow’s challenges
sooner. New biomarkers are steadily being
researched and developed. Such biomarkers
often benefit from different tools than
* syngo.PET Neuro DB Comparison is pending 510k clearance, **This feature is under development and is not yet commercially available in the United States. 21
and is not yet commercial available in the United States. Due to regulatory reasons its future availability cannot be guaranteed.

23. Intelligently syngo.PET Neuro DB Comparison*
Reproducible automatically registers brain data
to a normals database so VOI can
Quantification
be generated for quantitative
assesment of biomarker uptake
Finest Volumetric
Image Accuracy
Minimum Dose and
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
22 * syngo.PET Neuro DB Comparison is pending 510k clearance, and is not yet commercial available in the United States.
Due to regulatory reasons its future availability cannot be guaranteed.

24. Volume of interest with
SUVpeak provides
robust and reproducible
quantification
Myocardial blood flow
provides an absolute
quantification method
to assess balanced
disease in the
myocardium
23

25. Finest Volumetric
Image Accuracy*
24 * Based on competitive literature available
at time of publication. Data on file.

26. 25

27. Finest Volumetric
Image Accuracy*
Intelligently An accurate diagnosis starts with an accurate image in all dimensions. With conventional
Reproducible technology, small or low-grade lesions can go undetected or lose definition towards the
Quantification edge of the FOV and are subject to motion blurring thereby lowing diagnostic confidence.
Siemens recognizes that at the core of a good image is an accurate detection system, which
Finest Volumetric begins with optimized components. From the very beginning of Siemens PET·CT
Image Accuracy technology, image quality has been the first priority, this is still true today. Biograph mCT
optimizes the components of the detection system into a superbly designed imaging chain.
Minimum Dose and From the design and configuration of the isotropic LSO crystals to the high speed
Maximum Speed electronics to the industry’s best 400 x 400 reconstruction matrix, all resulting in the finest
volumetric image accuracy*. Combined with high definition technologies that bring
Engineered Clinical uniform resolution and images virtually free of motion, it’s now possible to diagnose with
Flexibility the increased confidence that this exquisite molecular clarity provides.
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
26 * Based on competitive literature available
at time of publication. Data on file.

28. Return on
Innovation
Clinical Return Workflow Return Financial Return
• Superb visualization, particularly of • Reduced time to image review • Attract patients and referring
small tumors with industry-leading enabled by fast and consistent physicians with high-definition
87 mm3 volumetric resolution* reconstruction times image quality
• Increased diagnostic confidence • One-click gating integrated in daily • Reduction of false negatives
with the finest uniform resolution* routine associated with breathing artifacts
and a 4x increase in signal-to-noise
27

29. Finest Volumetric
Image Accuracy
Intelligently Patented OptisoHD Detection System highly renowned and compact STRATON™ No motion for full HD lesion detection,
Reproducible delivers the industry’s finest volumetric tube with z-Sharp™ delivers true temporal accurate SUV quantification
Quantification resolution* resolution of up to 150 ms for motion-
HD·Chest is a breakthrough technology from
artifact free CT imaging of the heart.
Siemens continues to deliver exquisite Siemens that eliminates the tradeoff
Finest Volumetric
diagnostic image quality. The unique between diagnostic confidence and
Image Accuracy Uniform resolution throughout
OptisoHD Detection System provides a examination time. An innovative
the field of view
robust foundation comprised of optimized combination of hardware and software,
Minimum Dose and
components enabling peak performance Siemens ultraHD·PET delivers increased HD·Chest virtually freezes respiratory
Maximum Speed
throughout the scanner. Biograph mCT image quality, easily outperforming motion, enabling full HD lesion detection
continues to set the standard for image conventional PET/CT technology. It and accurate standard uptake value (SUV)
Engineered Clinical
quality by delivering the finest NEMA* and combines two important innovations: quantification. Best of all, HD·Chest is
Flexibility
volumetric resolution in the market. HD·PET, which provides uniform resolution designed to be as fast as a conventional PET
throughout the FOV; and Time of Flight examination, so you can have increased
syngo.via
Excellence in Cardiac imaging (TOF), which doubles improvement in diagnostic confidence without affecting
signal-to-noise. Combined with z-Sharp™ your patient schedule.
Customer Care Biograph mCT provides excellence in cardiac
technology that provides an isotropic
imaging through innovative PET and CT
resolution of 0.33 mm at any position
Molecular Imaging technologies. The patented Prompts Gamma
within the scan field, Biograph mCT
Biomarker Research Correction provides clarity in PET cardiac
continues to push the boundaries of spatial
imaging with a reduction in noise while the
resolution.
28 * Based on competitive literature available
at time of publication. Data on file.

30. Summary
Image clarity and precise localization are key
to disease detection, accurate staging and
improved therapy planning. Biograph mCT’s
OptisoHD Detection System and innovative
technologies like Prompts Gamma
Correction, Time of Flight, z-Sharp and
HD·Chest work together to acquire and
reconstruct images that accurately represent
molecular processes with superb image
quality in all dimensions. So cardiac studies
are more exact. Tumors are more clearly
defined. Brain lesions can be precisely
mapped. Siemens new Biograph mCT is a
quantum leap forward, refining images and
setting another new standard in diagnostic
imaging.
29

31. How it works
OptisoHD Detection System
Intelligently Siemens OptisoHD Detection system is Ultrafast detector electronics, combined
Reproducible designed for optimum performance. The with the speed of LSO and the unique block
Quantification Lutetium Oxyorthosilicate (LSO) crystals – design of OptisoHD Detection System,
manufactured by Siemens and long allow fast coincidence timing with efficient
Finest Volumetric recognized for their density, fast scintillation rejection of random events. This provides
Image Accuracy decay time (the fastest of all PET scintillators very high count rates that are essential to
currently in use) and light output – are the high-speed PET scanning. Ultimately,
Minimum Dose and foundation of the system. These isotropic the result is superb clarity and better
Maximum Speed LSO crystal elements are tightly packed and localization of events. These events are then
incorporate Siemens patented air reflector reconstructed using the industry’s highest
Engineered Clinical technology which optimizes the light output matrix size of 400 x 400*, delivering superb
Flexibility for even greater timing performance and image quality with leading NEMA
energy resolution. resolution*.
syngo.via
• Patented air reflector technology
Customer Care • High resolution –
4 x 4 x 20 mm LSO crystals
Molecular Imaging
• Industry’s highest matrix size of
Biomarker Research
400 x 400*
30 * Based on competitive literature available
at time of publication. Data on file.

32. 135 mm3
In a three-dimensional world, decisions • Volume resolution 87 mm3 Conventional
should be made with three-dimensional
• Up to 35% finer volumetric resolution
information. And a simple comparison of
than conventional systems
voxel size helps explain the volumetric
resolution advantage of Biograph mCT. • Decreased partial volume effect
Conventional equipment uses larger, non-
isotropic elements; Biograph mCT employs
87 mm3
smaller isotropic elements. These smaller
elements and fine axial sampling help to
create extraordinary images in any
dimension, resulting in the industry’s finest
volumetric resolution* of only 87mm3,
up to 35% smaller than conventional
systems. Sampling statistics reduce partial
volume effects and achieve an increased
quantitative accuracy for detection of
smaller lesions.
Volume Resolution
31

33. How it works
Cardiac CT
Anode
Intelligently High quality cardiac CT depends on a decreasing the detector elements’ size to
Cathode Heat
Reproducible number of system performance features improve spatial resolution, z-Sharp utilizes
Quantification including high temporal resolution, fine two overlapping X-ray beams, resulting in
spatial resolution and flexible acquisition significantly increased spatial resolution
Finest Volumetric techniques that adapt to different patients. without a corresponding increase in dose.
Image Accuracy Biograph mCT addresses all these This provides you with the industry’s highest
requirements with 0.3 sec rotation speed, isotropic resolution of 0.33 mm at any scan
Minimum Dose and 0.33 mm isotropic resolution and up to 128 and rotation speed, and at any position
Maximum Speed acquired slices per rotation. within the scan field. This for instance
allows motion-artifact free imaging of the
The core technology that allows the new Cooling oil
Engineered Clinical heart to perform accurate stenosis
Biograph mCT to deliver clinical excellence
Flexibility measurements or stent planning with
in cardiac CT, is the highly renowned
outstanding precision.
STRATON™ tube with z-Sharp™. Its
syngo.via
revolutionary design based on a direct • Compact tube design with 0.3 sec rotation
anode cooling eliminates the need for heat speed
Customer Care
storage and results in an unmatched
• 150 ms temporal resolution
compact design thus allowing true temporal
Molecular Imaging
resolution of up to 150 ms. Instead of • 0.33 mm isotropic resolution
Biomarker Research
32

34. How it works
Prompts Gamma Correction
Siemens patented Prompts Gamma Conventional
Correction is the solution for cardiac
imaging with rubidium-82 (82Rb), providing
improved image accuracy through a
reduction in image noise. The third gamma
that 82Rb emits results in a additional and
incorrect lines of response to be calculated.
Left uncompensated, this additional gamma
leads to distortions with increased image More noise reduces image clarity
noise and possible quantitative errors.
Prompts Gamma Correction automatically Prompts Gamma Correction
addresses this anomaly in its scatter
correction algorithms, resulting in more
reliable, more accurate imaging.
• Noise reduction for improved image
contrast
• More quantitative accuracy
Less noise for greater image clarity
• Correction automatically incorporated in
patented scatter correction algorithm
33

35. Conventional Time of Flight
T1
How it works
Time T2
of Flight
Intelligently Siemens TOF measures the actual time
Reproducible difference between the detection of each
Quantification coincidence photon. This additional timing
information is used to better localize the
Finest Volumetric event within a small range along each line-
Image Accuracy of-response (LOR). The better localization of
each event using TOF reduces noise in the
Minimum Dose and reconstructed image.
Maximum Speed
• 2x improvement in signal-to-noise
Engineered Clinical • 2x improvement in contrast
Flexibility
• Signogram mode TOF with fixed and fast
reconstruction times
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
34

36. Conventional HD·PET
Crystals Crystals
Crystals Crystals
LOR Photon LOR Photon
Wrong
LOR
Crystals Crystals
Photon LOR Photon
How it works Wrong
LOR
HD·PET Photon LOR Photon
HD uniformity · HD resolution · 2x HD
contrast
• HD·PET improves resolution
• Delivers uniform resolution throughout
the FOV
• 2x improvement in signal-to-noise Without HD·PET With HD·PET
1
Measurements were
taken with a line source
suspended in air at radial
positions from the center
Average Resolution (mm FWHM)1
Conventional PET uses the same HD·PET incorporates millions of accurately
to 28 centimeters in
Conventional reconstruction principles across the entire measured point spread functions (PSF) in 4 centimeter steps. The
FOV and does not take into account the the reconstruction algorithms. Using Biograph HI-REZ-FBP data
detector geometry and mispositioning of measured PSFs, HD·PET effectively positions were reconstructed with
HD·PET and ultraHD·PET the LORs. This results in fuzzy edges and the LORs in their actual geometric location, a standard filtered
increased distortion further from the which dramatically reduces blurring and backprojection algorithm
center of the FOV. distortion in the final image. after FORE rebinning and
the HD·PET data were
reconstructed with the
TrueX algorithm using six
Radial Distance/cm iterations and 14 subsets.
35

37. How it works
ultraHD·PET TOF HD ultraHD·PET
Intelligently By combining Siemens HD·PET with TOF, the
Reproducible result is up to 4 times improvement in signal
+ =
Quantification to noise for ultraHD contrast and uniform
resolution throughout the FOV.
Finest Volumetric
• Uniform resolution throughout the FOV
Image Accuracy
• 4x improvement in signal-to-noise
Minimum Dose and
• Fast and consistent reconstruction time
Maximum Speed
Engineered Clinical Segments of Segments of Segments of
Flexibility response response response
(“time bins”) (“time bins”) (“time bins”)
syngo.via
Accurately locates the Effectively positions the line ultraHD·PET reduces blurring
Customer Care annihilation along the line of of response in it’s actual of the signal from all axis
response geometric location
Molecular Imaging
Biomarker Research
36

38. How it works Alternating focal spots
1 2
z-Sharp 0.4 mm objects
STRATON™ X-tay tube
0.4 mm objects
0.6 mm
Increased resolution without increased
Over-
dose. z-Sharp uses two intersecting X-ray
sampling
beams that produce isotropic resolution of
0.33 mm at any scan and rotation speed, 0.6 mm
and within any position in the scan field – Oversampling
all without an increase in dose.
conventional technology 128-channel data acquisition electronics
For wrist, joint or inner ear studies, Siemens
proprietary technology, z-UHR, adapts the Measured signal per detector element Measured signal per detector element
system for ultra-high resolution bone 0.6 mm 0.6 mm
1 1
imaging. In this case, providing 0.24 mm
istotropic resolution. 0 0
1 1 1 1 1 1 1 1 1 1 2 1 2 1 2 1 2 1 2 1 2 1 2 1 2 1 2
• Increased resolution without dose penalty
Resulting resolution Resulting resolution
• Isotropic 0.33 mm resolution throughout
the FOV
• z-UHR provides 0.24 mm Isotropic
resolution
37

39. How it works
HD·Chest
ex h a
ale
inh
le
Intelligently Full HD lesion detection Optimal
Reproducible Accurate SUV quantification Imaging
Quantification One-click routine Region
• Amplitude based gating automatically
Finest Volumetric 4D Gating 4D Gating
analyzes each patient’s individual
Image Accuracy Image Image
breathing pattern
Acquisition Reconstruction
Minimum Dose and • Identifies portion of the respiratory cycle
Maximum Speed with the least motion and the most data – HD·Chest HD·Chest
the optimum imaging area Image Image
Engineered Clinical Acquisition Reconstruction
Flexibility
syngo.via HD·Chest applies an innovative algorithm to With HD·Chest, image data from the optimal
analyze each patient’s individual breathing portion of the breathing cycle goes to make
Customer Care pattern and identify the portion of the up the image. The system then reconstructs
respiratory cycle with the least motion. a single, high resolution image with
Molecular Imaging This area of the cycle is where most data superior lesion conspicuity. The entire
Biomarker Research can be collected, without motion, in the process is automated, which means it is
shortest amount of time. operator independent, saving you valuable
time.
38

40. Conventional Examination HD·Chest
Full HD lesion detection
With less noise and more data, small
moving lesions are clearer and their edges
are sharper.
In the conventional scan, respiratory motion causes With HD·Chest, the lesion is clearly visible.
the lesion to be obscured.
Conventional Examination SUVmax4 HD·Chest SUVmax9
Accurate SUV quantification
HD·Chest’s motion freeze also enables
more accurate standard uptake value (SUV)
measurement.
In this example, the conventional scan shows a HD·Chest greatly improves quantification of lesions
single lesion blurred by respiratory motion. normally blurred by respiratory motion.
Clinical Workflow One-click routine
Patient 1 Patient 2
HD·Chest enables automatic acquisition
and reconstruction of virtually motion-free
images in less time than conventional
gating techniques.
Conventional
Full-count
HD·Chest
acquisition
HD·Chest
Accquisition Reconstruction and
(6 gates) manual selection of
the “best gate”
4D Gating
Preparation Acquisition Reconstruction
39

41. Superb visualization
of small tumors
with industry-leading
volumetric resolution*
Intelligently
Reproducible
Quantification
Finest Volumetric
Image Accuracy
Minimum Dose and
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
40 * Based on competitive literature available
at time of publication. Data on file.

42. Biograph mCT optimizes every ultraHD·PET brings uniform
componet of the detection resolution throughout the field
system into a superbly of view and 4 times the
designed imaging chain, improvement in signal-to-noise
for excellent image quality
41

43. Minimum Dose and
Maximum Speed
42

44. 43

45. Minimum Dose and
Maximum Speed
Intelligently Two of the most challenging issues facing healthcare today are the dual mandates to
Reproducible improve patient safety and increase productivity. From a patient care and economic
Quantification perspective, each is critically important. With conventional systems, clinicians have to
choose between protecting patients with minimum dose, or greater productivity with faster
Finest Volumetric scanning. The new Biograph mCT offers innovative imaging solutions where the lowest
Image Accuracy dose can be used, while still scanning patients faster than ever before. Now, clinicians can
have it all – scans with half dose and double speed. By reducing dose and increasing speed,
Minimum Dose and patient safety is improved, costs are dramatically reduced, while increased utilization can
Maximum Speed also be achieved.
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
44

46. Return on
Innovation
Clinical Return Workflow Return Financial Return
• Half the dose and the acquisition • Whole-body PET scans in only • Reduce imaging radioisotope costs
time while maintaining highest 5 minutes by reducing injected dose
image quality
• Lowest possible dose and high- • Attract more referrals by increasing
• Minimum dose, especially to critical speed workflow enabled by patient comfort with shorter exam
patients (children and patients with FAST CARE technologies times
frequent follow-up exams)
45

47. Minimum Dose and
Maximum Speed
Intelligently CARE FAST Half the dose, twice the speed
Reproducible
Achieving the highest technical An increasingly competitive and rapidly Biograph mCT is meeting both of the core
Quantification
performance is only important when it changing healthcare market requires needs of improving patient safety and
meets the needs of the patient and our improvements in quality and throughput. increasing productivity, at the same time,
Finest Volumetric
customers. In molecular imaging, patient Utilizing FAST (Fully Assisting Scanner through our commitment: “Minimum Dose
Image Accuracy
safety translates primarily into dose Technologies) innovations, typically time and Maximum Speed.” By combining FAST
reduction. consuming and complex procedures during and CARE technologies, Biograph mCT offers
Minimum Dose and
the scan process are extremely simplified innovative imaging solutions enabling half
Maximum Speed Principles such as “As Low as Reasonably
and automated, not only improving the dose to be used while doubling the scan
Achievable” (ALARA) have developed as a
workflow efficiency and scanner utilization, speed. By reducing dose and increasing
Engineered Clinical guideline to reduce all radiation exposure to
but optimizing the overall clinical outcome speed, costs are dramatically reduced, while
Flexibility the lowest possible level. With CARE
by creating reproducible results, making increased utilization can also be achieved.
(Combined Applications to Reduce
diagnosis more reliable and reducing patient
syngo.via Exposure), Siemens has been highly
burden through streamlined examinations.
successful in integrating many innovations
In addition, faster scans result in less patient
Customer Care into the Siemens scanners that significantly
motion, so image quality and the overall
reduce radiation dose in comparison to
patient experience can be optimized.
Molecular Imaging other systems available on the market.
Biomarker Research
46

48. Summary
In order to address two of the most
important concerns in healthcare today,
improving patient safety and increasing
productivity, Siemens lives by the
philosophy of minimum dose and maximum
speed, which benefits both the patient and
provider. At the core of this philosophy are
the innovative FAST and CARE technologies
which improve the patient experience
through increased scan speeds, while using
as little exposure as possible, all without
sacrificing image quality. For the provider,
increased speed improves throughput for
more efficient operation.
Siemens is moving the technology forward
– to create faster and safer imaging while
maintaining the highest of standards for
image quality.
47

49. How it works
Minimum Dose and
Maximum Speed
Intelligently
Reproducible
LSO True V ultraHD·PET
Quantification Without TrueV
• Cornerstone of • 2x lower dose • 2x lower dose
With TrueV T1
Finest Volumetric low-dose
or T2
• 2x faster scan
Image Accuracy imaging
speed
• 2x faster scan
• 8x faster crystal
Minimum Dose and speed
Maximum Speed
Engineered Clinical
Flexibility Dose Adaptive Dose SAFIRE** CARE Dose4D
Shield
Shield
syngo.via • Iterative • Up to 68% lower
• Up to 25% lower reconstruction dose
Customer Care dose Raw data Image data Image
software
Dose
recon recon correction
• Fully automated
Shield
• Fully automated • Fast recon in
Molecular Imaging
image and raw
Biomarker Research
data space
48 * SMART Neuro AC, FAST Planning, CARE kV, X-CARE, SAFIRE and FAST Cardio Wizard are
pending 510k clearance, and are not yet commercially available in the United States.

50. FAST Planning* Time of Flight CARE kV* SMART Neuro AC*
70 kV
80 kV
• Improves • 2x lower dose • Up to 60% lower • No CT dose
T1
100 kV
120 kV NO
workflow 140 kV dose CT
T2
• 2x faster scan • PET attenuation
efficiency
speed • Optimize ontrast-
c correction
• Minimizes wait to-noise-ratio without CT
times for
patients
Adaptive Cardio X-ray low
X-CARE* X-ray UFC FAST Cardio
Sequence wizard*
• Up to 60% lower • Up to 30% lower
• 1 – 3 mSv Cardio dose dose • Intuitive step-by-
UFC step guidance
• Fully automated • Reduce exposure • Fast acquisition
X-ray on
in sensitive areas • Higher reliability
and reproducibility
Light
in cardiac CT
49

51. How it works
TrueV
Intelligently TrueV high-speed technology widens the TrueV = ½ injected dose or 2x speed due to ultraHD·PET + TrueV = ½ injected dose AND
Reproducible axial FOV and features 30% fewer bed 70% increase in NEC performance. 2x speed due to 70% increase in NEC
Quantification positions when compared to a standard performance and 4x improved signal to
ultraHD·PET and TrueV as combined
FOV. With an increased count rate noise.
technologies make a 5-minute PET scan
Finest Volumetric performance of more than 70%, you can
possible – unprecedented for a routine Minimum Dose and Maximum Speed
Image Accuracy lower dose rates of scan time. For example,
clinical. benefits:
a scan time reduced to 10 minutes or a 50%
Minimum Dose and less injected dose to the patient. • Provides 2x lower dose
Maximum Speed
• Offers 2x faster scan speed
Engineered Clinical
Flexibility TrueV widens the axial field of view by 33% Conventional field of view Biograph with TrueV
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
50

52. How it works
ultraHD·PET =
HD·PET + Time of Flight
By combining Siemens HD·PET with Time of Conventional PET detects coincidence photons and
Flight (TOF), the result is up to 4 times records individual LORs between the crystals.
The actual location where the annihilation occurred
improvement in signal to noise for ultraHD
along the LOR is not measured, which inherently
contrast. Conventional PET
generates blurring in the reconstructed image.
Minimum Dose and Maximum Speed
Siemens ultraHD·PET with TOF measures the actual
benefits:
time difference between the detection of each
• Provides 2x lower dose coincidence photon. This additional timing
information is used to better localize the event
• Offers 2x faster scan speed within a small range along each LOR. The better
localization of each event using TOF reduces
• Enables a five-minute, whole-body scan blurring in the reconstructed image.
with TrueV
T1
ultraHD·PET
T2
51

53. How it works
Adaptive Dose Shield Conventional tube
collimation
Intelligently As part of the STRATON X-ray tube, the Pre-Spiral Dose Post-Spiral Dose
Reproducible unique Adaptive Dose Shield moves
Quantification collimators on the X-ray tube to block
Image area
unnecessary radiation dose. The shield
Finest Volumetric dynamically opens at the onset of a spiral
Image Accuracy range and dynamically closes at the end,
eliminating all clinically irrelevant dose. The
Conventional Technology
Minimum Dose and result can be up to 25% lower CT doses.
Maximum Speed
Minimum Dose and Maximum Speed
benefits:
Engineered Clinical
Flexibility • Reduces CT dose exposure by up to 25% STRATON with Adaptive
Dose Shield
• Significantly reduces the possibility of
syngo.via
over-radiation
Customer Care • Shields the patient from pre- and post- No Pre-Spiral Dose No Post-Spiral Dose
helical radiation
Molecular Imaging Image area
Biomarker Research
Adaptive Dose Shield
52

54. How it works
SAFIRE
SAFIRE* – Sinogram Affirmed Iterative Standard Filtered SAFIRE
Reconstruction – should allow you to utilize Back Projection
raw-data information (which is visualized in
the so-called sinogram) in the iterative
image reconstruction process.
Raw data recon
Raw data recon Image data recon Image correction
* SAFIRE is pending 510k clearance, and is not yet commercially available in the United States. 53

55. How it works
CARE kV
Intelligently Siemens has introduced the first automated
Reproducible voltage setting to optimize contrast-to-
Quantification noise-ratio and reduce dose by up to 60%.
70 kV
The automated selection is based on patient 80 kV
Finest Volumetric habitus and specific exam. CARE kV* is 100 kV
Image Accuracy especially useful in pediatric imaging, 120 kV
sparing smaller patients from unnecessary 140 kV
Minimum Dose and exposure.
Maximum Speed
Minimum Dose and Maximum Speed
benefits:
Engineered Clinical
Flexibility • Optimize contrast-to-noise-ratio
• Up to 60% dose reduction
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
Example: For a contrast media enhanced vessel examination of a small patient,
CARE kV proposes to scan with 70 kV and sets the other values accordingly.
54 * CARE kV and FAST Planning are pending 510k clearance,
and are not yet commercially available in the United States.

56. How it works
FAST Planning
Siemens’ Fully Assisting Scanner
Technologies (FAST) features help
radiologists and technicians plan and
prepare for examinations and minimize the
wait time for patients.
FAST Planning* performs an immediate,
organ-based setting of the scan and
reconstruction ranges. The goal is a safer
and faster experience for the patient and
more predictable workflow at the scanner.
Minimum Dose and Maximum Speed
benefits:
• Minimizes wait times for patients
• Automatic detection of scan field based Conventional FAST Planning
on organ characteristics
55

57. Superb image quality
with 1/2 injected dose
using TOF technology
Intelligently
Reproducible
Quantification
Finest Volumetric
Image Accuracy
Minimum Dose and
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
56

58. Whole-body PET with half
injected dose and a 5-minute
acquisition time
57

59. Engineered Clinical
Flexibility
58

60. 59

61. Engineered
Clinical Flexibility
Intelligently In order to grow your business, you need a system that is flexible to accommodate all
Reproducible patients* and procedures in PET and CT, today and in the future. With a conventional PET/
Quantification CT system a standard bore size does not allow access to all patients, nor does it integrate
high-end CT. The new Biograph mCT is engineered as a true dual-use solution to help
Finest Volumetric customers multiply studies and increase business growth. Biograph mCT provides the
Image Accuracy clinical flexibility to use high resolution CT in conjunction with high definition PET imaging,
or as a standalone CT. And with the industry’s only 78 cm bore, Biograph mCT can
Minimum Dose and accommodate a wide range of patients, including bariatric for both PET and CT studies.
Maximum Speed The engineered flexibility and scalability allows customers to configure a system which best
meets their needs, and of course their patient needs today and tomorrow.
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
60 * Up to 227 kg (500 lb)

62. Return on
Innovation
Clinical Return Workflow Return Financial Return
• Improve diagnostic accuracy with • Image bariatric PET and CT patients • Increase revenue with a 78 cm bore
less patient movement enabled by without impacting schedule for imaging a wider variety of
large bore and fast scan times patients and procedures
• Streamline dual modality workflow
• Expand clinical capabilities on both with engineered integration of • Reduce operating cost by uniting
PET and CT with a complete portfolio state-of-the-art PET and premium CT stand-alone PET and CT services into
of advanced applications a single integrated offering
61

63. Engineered
Clinical Flexibility
Intelligently Maximizing patients base Maximize modality performance Flexible scalability and upgradeability
Reproducible
Today’s conventional technology often falls Biograph mCT is engineered as a true dual- Biograph mCT is designed as a remarkably
Quantification
short for a simple reason – it fails to modality scanner which integrates the best scalable PET·CT platform and is designed to
accommodate a wide patient demographic performance of both PET and CT modalities grow as business and clinical needs change.
Finest Volumetric
and therefore inhibits the growth a wider into a single compact system. Available in Biograph mCT offers a variety of in-field
Image Accuracy
referral base can generate. Siemens has CT configurations of up to 128 acquired upgrades, from increasing the number of CT
engineered Biograph mCT for clinical slices per rotation, it offers the capability of slices up to 128 to expanding the PET field
Minimum Dose and
flexibility and growth, with a large 78 cm entire-body CT scans in just 10 seconds, of view up to 21.6 cm. With such flexible
Maximum Speed
bore, short tunnel and a 227 kg (500 lb) and whole-body PET scans in as little as scalability and upgradability Biograph mCT
table capacity which improves patient 5 minutes. Biograph mCT transforms a provides returns and referrals now and well
Engineered Clinical
comfort and accessibility. Additionally, with single room into a fast, dual-modality into the future.
Flexibility
features such as a powerful 100 kW CT scanning facility. Now customers can offer
generator – which provides ample X-ray advanced CT and PET imaging with one
syngo.via
power reserves for high quality imaging and room; one team; one integrated system;
HD FoV* (field of view) which improves one schedule; and if required, one
Customer Care
image quality beyond the standard CT comprehensive exam. Such clinical flexibility
diagnostic FoV, Siemens is making bariatric saves precious space, time and cost while
Molecular Imaging
PET imaging more accurate with excellent maximizing dual-modality utilization and
Biomarker Research
image quality. enabling business growth.
62 * HD FoV is pending 510k clearance, and is not yet commercially available in the United States.

64. Summary
To enable growth a PET/CT system must be
able to accommodate even the most
challenging patient situations, such as
bariatric imaging, while providing high-end
imaging applications in both modalities.
The new Biograph mCT has been
engineered with the clinical flexibility to
meet these needs now and in the future. Its
large 78 cm bore and shorter tunnel
accommodate even the largest patient*,
so your referral base is greatly expanded.
And its multi-functionality (CT, PET and PET/
CT) delivers savings in space, staffing and
scheduling so clinical workflow is more
efficient. The bottom line however, remains
performance. Biograph mCT produces
superb image quality, precise quantification
and patient comfort and safety while
delivering clinical flexibility that benefits
everyone.
* up to 227 kg (500 lb) 63

65. How it works
Large Bore and
Short Tunnel
Intelligently The 78 cm bore of Biograph mCT can • Wide 78 cm bore
Reproducible comfortably accommodate a greater range
• Short tunnel
Quantification of patients in both PET and CT. Unlike
conventional systems, whose narrow bore • 227 kg (500 Ib) table capacity
Finest Volumetric and long tunnel can make patients feel
Image Accuracy claustrophobic, Biograph mCT features a
wider bore – 78 cm wide – and a shorter
Minimum Dose and tunnel for a more open scanning
Maximum Speed experience. The large bore also allows better Conventional Biograph mCT
positioning of RTP devices, such as breast
Engineered Clinical boards.
Flexibility
The wider bed provides comfortable support
even for obese patients and has a capacity
syngo.via
of up to 227 kg (500 lb). And the design of
the bed eliminates the CT and PET 70 cm 78 cm
Customer Care
registration artifacts that can occur in
bariatric imaging with a conventional
Molecular Imaging
system.
Biomarker Research
64

66. How it works
HD FoV
Conventional FOV for CT is 50 cm, but in • Improved CT image quality
some cases (e.g., with bariatric patients) CT and HU > 50 cm
measurements are truncated and image
• Enhanced PET image quality > 50 cm
artifacts in PET attenuation-corrected (AC)
images may result. Until now this problem • Advanced PET quantification
was addressed using the extended field of
view method (EFoV), but Siemens recently
introduced an improved way to process
truncated data sets in CT scans. This Conventional HD FoV
innovative new method, HD FoV*, provides
better image quality and improved
Houndsfield Unit (HU) stability between 50
and 65 cm resulting in more quantitative
PET images. This allows for more precise
radiation therapy planning for bariatric
patients and patients positioned outside the
Biograph mCT isocenter.
* HD FoV is pending 510k clearance, and is not yet commercially available in the United States. 65

67. How it works
High End CT
Intelligently The premium CT integrated into Biograph • Isotropic 0.33 mm resolution Speed 0.30 s Resolution 0.24 mm
Reproducible mCT is based on Siemens SOMATOM® anywhere in the scan field
Quantification Definition AS platform, offering full CT
• High temporal resolution
functionality with up to 128 acquired slices
of 150 ms
Finest Volumetric per rotation, into a compact dual modality
Image Accuracy design. • 128 slices per rotation
Scan any
The revolutionary design of the STRATON
Minimum Dose and patient with:
X-ray tube features a direct anode cooling 78 cm opening,
Maximum Speed
which eliminates the need for heat storage 227 kg weight limit,
and results in a compact design thus 198 cm co-scan
Engineered Clinical
allowing true temporal resolution of up to range**
Flexibility
150 ms. z-Sharp technology delivers the
industry’s highest isotropic resolution of
syngo.via
0.33 mm* at any scan and rotation speed,
and at any position within the scan field.
Customer Care
Engineered to deliver such high
performance and clinical flexibility, Biograph Coverage 128-slice Power 100 kW
Molecular Imaging
mCT opens doors to growth in all areas of
Biomarker Research
PET and CT imaging.
66 * Based on Competitive Literature available at time of publication. **With TrueV and utilizing pallet extensions.
Data on file.

68. How it works
Dual Use – Room CT Room PET/CT Room
By seamlessly integrating high end PET and
premium CT, Biograph mCT provides the
power of two high-end modalities in a single
solution, thereby offering efficiencies in
square footage, utilities, service and
staffing. Now you can offer high quality PET
and CT in one room. With one schedule.
One team. One user interface that has been
engineered for simplicity and speed. And
with Biograph mCT’s new FAST CARE Biograph mCT Room
technologies, every step of the examination
process has been streamlined, from scan
preparation to image review.
• Single room
• High-end PET
• Premium CT
67

69. How it works
Acculine RT
Intelligently Biograph mCT offers a comprehensive
Reproducible solution for Radiation Oncology, from the
Quantification wide 78 cm bore for ease of positioning and
patient access, motion management with
Finest Volumetric PET and CT respiratory gating to the unique
Image Accuracy canti-lever designed SMART PHS (patient
handling system) with radiation therapy
Minimum Dose and planning pallet and conforming to TG-66
Maximum Speed requirements.
Biograph mCT extends beyond these
Engineered Clinical
offerings with Acculine RT – accurate multi-
Flexibility
component alignment for high precision
radiation therapy planning. Acculine RT
syngo.via
ensures accurate alignment between gantry
components, RTP room lasers, SMART PHS
Customer Care • Comprehensive radiation oncology
and RTP pallet as well as virtual image
solution
alignment and alignment to simulation
Molecular Imaging
system and treatment room. • Accurate multi-component alignment for
Biomarker Research
high precision radiation therapy planning
• Accuracy phantom for alignment
measurements
68

70. How it works
Flexible Scalibility
and Upgradeability
Biograph mCT offers a scaleable and flexible Biograph mCT Available Options
range of CT and PET features, giving 128-slice configuration
ultraHD·PET
customers the assurance that they will have
access to features which enable business HD·PET
growth as their needs change. All advanced
TrueV
CT and PET features can be configured at
system purchase or are available as an HD·Chest
in-field upgrade. These flexible upgrade Biograph mCT
64-slice configuration Advanced Cardio Sequence
opportunities provide the best possible
investment protection to keep the system SAFIRE**
clinically relevant for years to come.
Adaptive 4D Spiral
Scaleable range of features:
SMART Auto Cardiac Registration
• In-field upgrades for high end CT features
Biograph mCT
SMART Neuro AC*
• In-field upgrades for high end PET 40-slice configuration FAST Planning*
features
FAST Spine*
X-Care*
* SMART Neuro AC, FAST Planning, FAST Spine, CARE kV, X-CARE SAFIRE and FAST Cardio Wizard are pending 69
510k clearance, and are not yet commercially available in the United States.

71. Intelligently Advanced technologies for
Reproducible bariatric imaging including
high generator power provides
Quantification
superb image quality
in obese patients
Finest Volumetric
Image Accuracy
Minimum Dose and
Maximum Speed
Engineered Clinical
Flexibility
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
70

72. Expand clinical flexibility with
premium CT and advanced
applications
71

73. syngo.via
Images, my way
Anywhere, Anytime Access to
Integrated PET·CT Reading with
Revolutionary Ease-of-Use
Intelligently syngo.via is a multimodality reading
Reproducible solution that supports PET and CT on
Quantification a unified platform, even on unified
applications, which results in an
Finest Volumetric effective and integrated workflow.
Image Accuracy
As a client-server-based platform,
syngo.via provides collaboration
Minimum Dose and
and automation features that enable
Maximum Speed
the full diagnostic and productive
potential of hybrid scanners.
Engineered Clinical
Flexibility My cases – ready
syngo.via
My images – networked
Customer Care
My needs – anticipated
Molecular Imaging
Biomarker Research
72

74. syngo.via provides a multimodality platform
for hybrid applications in molecular imaging
syngo.via
• syngo.via can be used as
a standalone device or
together with a variety of
syngo.via based software
options, which are
medical devices in their
own rights. These
products are pending
regulatory clearance in
some countries and
therefore not yet
commercially available
in all countries. Usage of
syngo.via in an operating
room or for an
Advanced automation for high-volume Reproducible results with integrated, End-to-end workflow support emergency case requires
hybrid studies quantitative tools from case preparation to results sharing that the customer
provides respective
Hybrid exams consist of two data sets, To maximize the benefit from PET’s syngo.via is more than a diagnostic emergency measure in
which already double the available quantitative capabilities and the tool: it supports your workflow all the case of non-availability of
diagnostic information. In addition, reproducibility of follow-up assessments, way to the tumor board presentation. the system or network.
oncology studies are often whole-body syngo.via provides state-of-the-art From processing to diagnosis and sharing,
• syngo.via can be used
exams, further increasing the volume. quantification tools for PET and CT in syngo.via provides a single common
anywhere if the following
And many patients have a history of unified applications for the most intuitive platform. Working on the same data prerequisites are given:
prior studies for comparison. syngo.via anatomical and functional assessment. set preserves results and eliminates Internet connection to
automates all necessary preparation steps You can take SUVpeak and SUVmax as well as redundancies. First, the technologist clinical network, DICOM
so your workflow starts where it should – RECIST and WHO measurements with a can prepare the case. Next, the reading compliance, meeting of
with reading. When selecting a patient, single stroke of the mouse – all without physician creates findings and documents Siemens minimum
syngo.via: changing tools or taking your eyes off the the diagnosis. Finally, the case and its hardware requirements,
and adherence to local
image. results can be elegantly presented in
• Provides pre-fetched prior exams and data security regulations.
the tumor board meeting.
displays up to eight time points
• Fuses hybrid studies and registers
them across time points
• Starts the appropriate reading
environment: for example, the
syngo.mCT Oncology Engine
• Displays prior findings
73

75. Siemens Guardian Program
Including TubeGuard
Intelligently Biograph mCT comes with the dependability
Reproducible of TubeGuard, a unique remote service that
Quantification provides real-time condition reports of the
scanner’s STRATON X-ray tube. TubeGuard
Finest Volumetric employs more than 10 proactive sensors to
Image Accuracy monitor the performance of the tube and
assess its longevity. Based on real-time data
Minimum Dose and from sensors and other complex algorithms,
Maximum Speed TubeGuard estimates how long the tube will
last and when it is due for replacement. This
Engineered Clinical helps schedule service and maintenance
Flexibility appointments and virtually eliminates the
possibility of a sudden tube failure.
syngo.via
Customer Care
Molecular Imaging
Biomarker Research
74

76. Hight voltage
breakdown
Cooling
Problem
Oil
pressure
Oil Anode
temperature rotation
High voltage
Gantry Drive
temperature Cooling Anode current
Predictable failures
Vacuum Drive
loss Vacuum failure
Filament Drive Tube functions
Rotation
current Filament temperature
Focal spot TubeGuard sensors
Tube Test image
current analysis
Emitter Dose
breakdown monitor
Dose Focal spot
decay stability
75

77. Customer Care
Dedicated to Your Success
Intelligently Remain one step ahead and tap the full Software Updates Information and
Reproducible potential of your Biograph mCT system from
Quantification Siemens with our customer care program. and Hardware Upgrades Communication
As a worldwide innovation leader in
Finest Volumetric medical imaging, Siemens has gained Stay competitive with up-to-date systems Be informed – get connected
Image Accuracy remarkable knowledge in molecular Due to increasing healthcare demands, To ensure you are always up-to-date on
imaging. You can profit from excellent you have to stay on the cutting edge to be what is happening in the PET·CT world,
Minimum Dose and PET·CT systems and innovative, flexible competitive. We will help you to keep your we offer you a variety of information
Maximum Speed and comprehensive service solutions that solutions up-to-date and to stay abreast of services including easily accessible
enable you to concentrate on what is the latest technological advancements. With information portals, monthly newsletters,
Engineered Clinical most important for you: patient care. our technology portfolio, you can be sure our customer magazine Imaging Life and
Flexibility The customer care program, is a unique that workflow improvements, clinical the Biograph World Summit, our global
solution from Siemens that helps you applications and diagnostic functions are PET·CT users forum on clinical trends and
syngo.via maximize return on innovation throughout all embedded into advanced technologies best practices. Customer communities
the entire life cycle of your system. for equipment and IT. With our syngo help you explore new technologies and
Customer Care Evolve program we offer you certainty in share clinical cases with your peers and
budget planning, feature enhancements for global experts.
Molecular Imaging your PET·CT, access to new applications and
Biomarker Research lower cost upgrades for your PET·CT system.
76

78. Education and Training Services and Support
Broaden your knowledge and expertise Feel confident
with our proactive service solutions
Know-how is the key to success. With
our extensive portfolio of education and High system availability, diagnostic
training programs you can deepen your confidence and optimized workflow are
knowledge and clinical expertise. We crucial for the success of your PET·CT
show you how to maximize the benefits service. To meet your performance
that can be achieved with our advanced expectations, we systematically focus on
technology. Classroom trainings, workshops being proactive. Based on real-time system
and seminars are only a few examples of monitoring we detect system errors and
our broad portfolio. Valuable knowledge alert you before problems occur. The
transfer through hands-on workshops with Siemens Guardian Program helps to make
renowned clinical experts will also help you unplanned downtime a thing of the past.
to optimize your workflows so you can offer
an even higher quality of care for your
patients.
77

79. The Era of Personalized Medicine Starts Today
Molecular Imaging
Biomarker Research
Intelligently Siemens Molecular Imaging Biomarker Biograph mCT
Reproducible Research
Siemens maximizes your return on
Quantification
Siemens Molecular Imaging Biomarker innovation by incorporating from the
Research is a leader in the discovery and earliest stages of product development and
Finest Volumetric
development of new imaging biomarkers for design of the Biograph mCT the technology
Image Accuracy
applications in oncology, cardiology and to support the use of future imaging
neurology. These novel imaging biomarkers, biomarkers in oncology, cardiology and
Minimum Dose and
when approved for clinical use, will advance neurology, to ensure the best patient care
Maximum Speed
molecular imaging to a completely new throughout the life of the system. This
level by enabling targeted therapies via obsolescence protection is made possible
Engineered Clinical
more personalized clinical assessment of through the collaboration between Siemens
Flexibility
disease and improving therapy MIBR scientists and engineers to make sure
management. that Biograph and our imaging biomarkers
syngo.via
are designed to work together.
Customer Care
Personalized
Molecular Imaging
Biomarker Research
78

80. Oncology Cardiology Neurology
Siemens is investigating new imaging Cardiology-related procedures represent the Neurological-related procedures are
biomarkers that address the fundamental highest potential of growth for molecular expected to grow due to the rise of
hallmarks of cancer beyond metabolism. imaging. New imaging biomarkers are being dementia cases resulting from the increase
Among the areas being explored are cell investigated to improve patient risk in the global aging population. The
proliferation biomarkers to help oncologists stratification in CAD with perfusion, development of new imaging biomarkers
assess the replicative potential of tumors, an enhance viability, and support vulnerable designed for neurological studies will
imaging biomarker to identify hypoxic plaque studies providing the clinician with provide a non-invasive imaging test to help
(oxygen deprived) areas of tumors to assess all necessary information in a single imaging in the assessment of dementia in patients.
the insensitivity to anti-growth signals and device to personalize treatment for each Siemens is investigating the development of
an imaging biomarker to better specific patient. imaging biomarkers with the goal to
understanding of angiogenesis, which quantify the degree of beta amyloid and tau
details how blood is supplied to tumors. proteins certain regions of the brain thought
to be a precursor to certain types of
dementia such as Alzheimer’s disease.
medicine 79

82. Trademarks and service marks used in this material contained herein without prior notice. As is generally Note: Original images always lose a certain amount
are property of Siemens Medical Solutions USA or true for technical specifications, the data contained of detail when reproduced.
Siemens AG. All other company, brand, product herein varies within defined tolerances. Some
All photographs © 2011 Siemens Medical Solutions
and service names may be trademarks or registered configurations are optional. Product performance
USA, Inc. All rights reserved.
trademarks of their respective holders. depends on the choice of system configuration.
Please contact your local Siemens Sales
All comparative claims derived from competitive data
Representative for the most current information
at the time of printing. Data on file. Siemens reserves
or contact one of the addresses listed below.
the right to modify the design and specifications
Images courtesy Global Business Unit
St. Claraspital, Basel, Switzerland - Page 8, 21 Siemens Medical Solutions USA, Inc.
Cleveland Clinic, Cleveland, Ohio, USA - Page 9, 23, 65
Molecular Imaging
Princess Grace Hospital, Monaco, Monaco - Page 18
University of Tennessee, Knoxville, Tennessee, USA - Page 19
2501 N. Barrington Road
Central Manchester University Hospital, Manchester, United Kingdom - Page 20 Hoffman Estates, IL 60192-5203
Royal North Shore Hospital, Sydney, Australia - Page 22 USA
Northern California PET Imaging Center, Sacramento, CA, USA - Page 23, 41 (middle) Telephone: +1 847 304 7700
University of Michigan, Ann Arbor, Michigan - Page 39 www.siemens.com/mi
Comanche County Memorial Hospital, Lawton, Oklahoma, USA - Page 40
Groene Hart Ziekenhuis, Gouda, The Netherlands - Page 56
Universitair Medisch Centrum Groningen, The Netherlands - Page 57
Baylor Irving, Irving, Texas USA - Page 70
Suburban Imaging Southdale, Edina, MN, USA - Page 71
Global Siemens Headquarters Global Siemens Healthcare Legal Manufacturer
Siemens AG Headquarters Siemens Medical Solutions USA, Inc.
Wittelsbacherplatz 2 Siemens AG Molecular Imaging
80333 Munich Healthcare Sector 810 Innovation Drive
Germany Henkestrasse 127 Knoxville, TN 37932-2751
91052 Erlangen USA
Germany Telephone: +1 865 218 2000
Telephone: +49 9131 84-0 www.siemens.com/mi
www.siemens.com/healthcare
Order No. A91MI-10341-2C-7600 | Printed in USA | MI-005-NW-WB-TW-3M | © 11.2011, Siemens AG
www.siemens.com/mi