Bioinformatics for beginners (exam point of view)Sijo A
. The term bioinformatics is coined by…………………………….
Paulien Hogeweg
2. What is an entry in database?
The process of entering data into a computerised database or spreadsheet.
3. Define BLASTp
BLAST- Basic Local Alignment Search Tool
It is a homology and similarity search tool.
It is provided by NCBI.
It is used to compare a query DNA sequence with a database of sequences.
4. What is Ecogenes?
Ecogene is a database and website and it is developed to improve structural and functional annotation of E.coli K-12 MG 1655.
Bioinformatics for beginners (exam point of view)Sijo A
. The term bioinformatics is coined by…………………………….
Paulien Hogeweg
2. What is an entry in database?
The process of entering data into a computerised database or spreadsheet.
3. Define BLASTp
BLAST- Basic Local Alignment Search Tool
It is a homology and similarity search tool.
It is provided by NCBI.
It is used to compare a query DNA sequence with a database of sequences.
4. What is Ecogenes?
Ecogene is a database and website and it is developed to improve structural and functional annotation of E.coli K-12 MG 1655.
Basics of Data Analysis in BioinformaticsElena Sügis
Presentation gives introduction to the Basics of Data Analysis in Bioinformatics.
The following topics are covered:
Data acquisition
Data summary(selecting the needed column/rows from the file and showing basic descriptive statistics)
Preprocessing (missing values imputation, data normalization, etc.)
Principal Component Analysis
Data Clustering and cluster annotation (k-means, hierarchical)
Cluster annotations
Animal cell culture in Biopharmaceutical Industry in the Production of Therap...Shubham Chinchulkar
This presentation will help you to understand the basics of Animal cell culture along with its applicability in the diagnosis and treatment of cancer, and autoimmune diseases.
Mass Spectrometry-Based Proteomics Quantification: iTRAQ Creative Proteomics
For more information, please visit: https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm
iTRAQ (isobaric tag for relative and absolute quantitation), is an isobaric labeling method to determine the amount of proteins from different sources in just one single experiment by mass spectrometry, which was developed by Applied Biosystems Incorporation in 2004.
Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray samples. Weighted correlation network analysis (WGCNA) can be used for finding clusters (modules) of highly correlated genes, for summarizing such clusters using the module eigengene or an intramodular hub gene, for relating modules to one another and to external sample traits (using eigengene network methodology), and for calculating module membership measures. Correlation networks facilitate network based gene screening methods that can be used to identify candidate biomarkers or therapeutic targets.
more details:
https://youtu.be/IF_AR7iHMY8
References:
https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/Rpackages/WGCNA/
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-9-559
Visualizing Real Data in a Virtual WorldMelanie Swan
The wide range of structural building and interaction possibilities offered by virtual worlds has been explored.
The next obvious step in the evolution of virtual worlds is making them alive with real-time information, streaming in data and representing it visually.
So far, there are two main kinds of data visualization apps – first is virtual command centers –using virtual worlds as the front-end display for any variety of data applications such as an integration of SAP and SL; the second is data streamed into virtual worlds and represented visually.
“Biomedical engineering is a discipline that
advances knowledge in engineering, biology and medicine, and improves human health through cross-disciplinary activities that integrate the engineering sciences with the biomedical sciences and clinical practice.”
Basics of Data Analysis in BioinformaticsElena Sügis
Presentation gives introduction to the Basics of Data Analysis in Bioinformatics.
The following topics are covered:
Data acquisition
Data summary(selecting the needed column/rows from the file and showing basic descriptive statistics)
Preprocessing (missing values imputation, data normalization, etc.)
Principal Component Analysis
Data Clustering and cluster annotation (k-means, hierarchical)
Cluster annotations
Animal cell culture in Biopharmaceutical Industry in the Production of Therap...Shubham Chinchulkar
This presentation will help you to understand the basics of Animal cell culture along with its applicability in the diagnosis and treatment of cancer, and autoimmune diseases.
Mass Spectrometry-Based Proteomics Quantification: iTRAQ Creative Proteomics
For more information, please visit: https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm
iTRAQ (isobaric tag for relative and absolute quantitation), is an isobaric labeling method to determine the amount of proteins from different sources in just one single experiment by mass spectrometry, which was developed by Applied Biosystems Incorporation in 2004.
Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns among genes across microarray samples. Weighted correlation network analysis (WGCNA) can be used for finding clusters (modules) of highly correlated genes, for summarizing such clusters using the module eigengene or an intramodular hub gene, for relating modules to one another and to external sample traits (using eigengene network methodology), and for calculating module membership measures. Correlation networks facilitate network based gene screening methods that can be used to identify candidate biomarkers or therapeutic targets.
more details:
https://youtu.be/IF_AR7iHMY8
References:
https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/Rpackages/WGCNA/
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-9-559
Visualizing Real Data in a Virtual WorldMelanie Swan
The wide range of structural building and interaction possibilities offered by virtual worlds has been explored.
The next obvious step in the evolution of virtual worlds is making them alive with real-time information, streaming in data and representing it visually.
So far, there are two main kinds of data visualization apps – first is virtual command centers –using virtual worlds as the front-end display for any variety of data applications such as an integration of SAP and SL; the second is data streamed into virtual worlds and represented visually.
“Biomedical engineering is a discipline that
advances knowledge in engineering, biology and medicine, and improves human health through cross-disciplinary activities that integrate the engineering sciences with the biomedical sciences and clinical practice.”
3d Stock Charts - Life 2.0 Data Visualization PanelMelanie Swan
So far virtual worlds have been used mainly for architectural builds and interaction. The next obvious step is making them alive with data, streaming in data and representing it visually. Data visualization in Second Life is growing rapidly.
Wiki: http://sldataviz.pbwiki.com/
Conference link: http://www.life20.net
Synthetic Biology: Bringing Engineering Back Into Genetic EngineeringSachin Rawat
Genetic Engineering lacks a few elements of Engineering. Here is what those are and how Synthetic Biology (or Genetic Engineering v2.0) would account for those.
James J. Collins
Howard Hughes Medical Institute
Dept of Biomedical Engineering & Center of Synthetic Biology
Boston University
Wyss Institute for Biologically Inspired Engineering
Harvard University
Large Molecule Bioanalysis: LC-MS or ELISA? A Case StudyQPS Holdings, LLC
Both ligand binding assays (LBA) and mass spectrometry
(MS) methods are widely used in routine bionalysis with expanded applications of MS to large molecules in
the years ahead. In this presentation, PK parameters in the rart for three monoclonal antibodies (mAbs) are compared as derived from plasma concentration data as measured by LBA or Immunocapture LC-MS/MS.
TNO Triskelion BSL-3 lab tests anti-viral drugs in newly developed H7N9 influenza model
Human infections with a new avian influenza A (H7N9) virus were first reported in China in 2013, with the loss of 46 lives. In order to meet the growing needs to test new drugs against H7N9, TNO Triskelion has recently developed an H7N9 mouse model. This H7N9 model is suitable for testing new anti-virals such as vaccines, monoclonal antibodies and small molecules in our BSL-3 lab, in conformity with Good Laboratory Practice. TNO Triskelion has proven to be a successful partner in the development of new anti-viral and anti-bacterial vaccines for many years. Understanding the pressures on time lines, we support companies and institutes during the preclinical and clinical stages of drug development.
Leading & working virtual world: Traininglarssudmann
Slide from my one day intensive training on: Leading & working in the new world. The training includes full exercises on engaging leadership meetings in the virtual world as well as effective leadership strategies and watchouts. More on www.lars-sudmann.com
Design of Organ-On-A-Chip - Creative Biolabs.pptxCreative-Biolabs
Creative Biolabs has developed an extensive microfluidic technology platform, offering customers one-stop services covering all aspects of microfluidic research and evaluation. This includes the design and manufacturing of organ-on-a-chip (OOC) systems, as well as personalized, customized solutions tailored to individual needs.
This slide briefly introduces our OOC design concepts. If you require further details, products, and services related to OOC, please follow us to stay updated and informed.
Mapping Genotype to Phenotype using Attribute Grammar, Laura Adammadalladam
Defense -- thesis: “Mapping Genotype to Phenotype using Attribute Grammar.”
PhD degree in Genetics, Bioinformatics and Computational Biology (GBCB) in the tracks of Computer Science, Mathematics and Life Sciences.
Building a Community Cyberinfrastructure to Support Marine Microbial Ecology ...Larry Smarr
06.09.15
Invited Talk
2006 Synthetic Biology Symposium
Aliso Creek Inn
Title: Building a Community Cyberinfrastructure to Support Marine Microbial Ecology Metagenomics
Laguna Beach, CA
OVium Bio-Information Solutions use forefront algorithms to analyze key data resources such NCBI, EBLM and PDB to develop cell signal pathways.
OVium employs cloud and MPP computing solutions with homology and signal network mapping to develop chemical and protein pathways for discovery research.
Genomic Cytometry: Using Multi-Omic Approaches to Increase Dimensionality in ...Robert (Rob) Salomon
"Genomic Cytometry: Using Multi-Omic Approaches to Increase Dimensionality in Cytometry" was an Invited Tutorial given at the 2019 CYTO conference for the the International Society for the Advancement of Cytometry on the 22nd May 2019. This tutorial was recorded and we expect that it will be converted to a CYTOU webinar in the near future.
This tutorial will begin by explaining why the emerging field of Genomic Cytometry, i.e. the measurement of cells using genomic techniques (e.g. sequencing), in conjunction with more traditional cytometry techniques such as fluorescence, mass and imaging cytometry is becoming a standard tool for biologists looking to unravel complex cellular processes and to develop a deeper understanding of heterogeneity.
We will give a detailed overview of the various technologies that have allowed the emergence of Genomic Cytometry as well as those that continue to push the boundaries of cellular characterisation.
We will then provide a basic overview of the sequencing process such that both research cytometerists and the staff for the cytometry SRL are better equipped to understand the downstream genomic component of Genomic Cytometry.
Finally, we will wrap up the session with case studies that illustrate the power of the genomic cytometry approach and will give a brief outline of where we feel the field needs to go as it matures. We expect attendees will gain a better understanding of 1) the rapidly maturing field of Genomic Cytometry and 2) how Genomic Cytometry should be leveraged into more traditional cytometry workflows.
Cross-Kingdom Standards in Genomics, Epigenomics and MetagenomicsChristopher Mason
Challenges and biases in preparing, characterizing, and sequencing DNA and RNA can have significant impacts on research in genomics across all kingdoms of life, including experiments in single cells, RNA profiling, and metagenomics. Technical artifacts and contaminations can arise at each point of sample manipulation, extraction, sequencing, and analysis. Thus, the measurement and benchmarking of these potential sources of error are of paramount importance as next-generation sequencing (NGS) projects become more global and ubiquitous.
Fortunately, a variety of methods, standards, and technologies have recently emerged that improve measurements in genomics and sequencing, from the initial input material to the computational pipelines that process and annotate the data.
This webinar will review work to develop standards and their applications in genomics, including the ABRF-NGS Phase II NGS Study on DNA Sequencing; the FDA’s Sequencing Quality Control Consortium (SEQC2); metagenomics standards efforts (ABRF, ATCC, Zymo, Metaquins), and the Epigenomics QC group of the SEQC2. The webinar will also review he computational methods for detection, validation, and implementation of these genomic measures.
AI Health Agents: Longevity as a Service in the Web3 GenAI Quantum RevolutionMelanie Swan
Health Agents are a form of Math Agent as the concept of a personalized AI health advisor delivering “healthcare by app” instead of “sickcare by appointment.” Mobile devices
can check health 1000 times per minute as opposed to the standard one time per year doctor’s office visit, and model virtual patients in the digital twin app. As any AI agent, Health Agents “speak” natural language to humans and formal language to the computational infrastructure, possibly outputting the mathematics of personalized homeostatic health as part of their operation. Health Agents could facilitate the ability of physicians to oversee the health of thousands of individuals at a time. This could ease overstressed healthcare systems and contribute to physician well-being and the situation that (per the World Health Organization) more than half of the global population is still not covered by essential health services.
The computational infrastructure is becoming a vast interconnected fabric of formal methods, including per a major shift from 2d grids to 3d graphs in machine learning architectures
The implication is systems-level digital science at unprecedented scale for discovery in a diverse range of scientific disciplines
We know that we are in an AI take-off, what is new is that we are in a math take-off. A math take-off is using math as a formal language, beyond the human-facing math-as-math use case, for AI to interface with the computational infrastructure. The message of generative AI and LLMs (large language models like GPT) is not that they speak natural language to humans, but that they speak formal languages (programmatic code, mathematics, physics) to the computational infrastructure, implying the ability to create a much larger problem-solving apparatus for humanity-benefitting applications in biology, energy, and space science, however not without risk.
This work introduces “quantum intelligence” as a concept of intelligence for operating in the quantum realm may help in a potential AI-Quantum Computing convergence (~2030e), and towards the realization of SRAI for well-being (economics, health, energy, space). “Scale-free intelligence” is formulated as a generic capacity for learning.
AI did not spring onto the scene with chatGPT, but is in an ongoing multi-year adoption. A transition may be underway from an information society to a knowledge society (one tempered and specifically using knowledge to improve the human condition). AI is a dual-use technology with both significant risk and upleveling possibilities.
SRAI for well-being is a social objective, and also a technological objective. SRAI is part of AI development and within the technological trajectory of harnessing all scales of physical reality ranging from quantum materials to space exploration.
Conceptually, thinking in quantum and relativistic terms expands the physical worldview, and likewise the social worldview of entities inhabiting the larger world. Practically, SRAI may be realized in phases: short-term regulation and registries, medium-term agents learning to implement human values with internal reward functions, and long-term responsible human-AI entities acting in partnership in a future of SRAI for well-being.
The Human-AI Odyssey: Homerian Aspirations towards Non-labor IdentityMelanie Swan
The visionary progression in The Odyssey from shipbuilding to seafaring to advanced civilization informs contemporary tension in the human-AI relation forcing a broader articulation of human-identity beyond labor-identity. Edith Hall analyzes why one of the earliest known literatures, The Odyssey, remains a central cultural trope with numerous references in the storytelling vernacular of all eras, ranging from 1860s British theater to a highly-watched 1990 episode of The Simpsons. The argument is that The Odyssey provides a constant aspirational reference for human identity – who we think we are and where we are going on the epic journey of life, especially at the current crossroad in our relationship with technology.
The contemporary moment finds humanity, and the humanities, experiencing an identity crisis in the relationship with technology. Information science is having an ever more pervasive role in academia, and the machine economy continues to offload vast classes of tasks to labor-saving technology giving rise to two questions. First, at the level of labor-identity, humans wonder who they are as they have long defined their sense of self through their professional participation in the economy. Second, at the level of human-identity, with AI now performing cognitive labor in addition to physical labor, humans wonder if there is anything that remains uniquely human.
The effect of The Odyssey is to provide world-expanding imaginaries to change the way we see ourselves as subjects; in this way, Homer is an early modernist in reconfiguring our self-concept.
This work applies a philosophy (of literature)-aided information science method to discuss how Homer’s Odyssey persists as a literary imaginary to help us think through potential futures of human-AI flourishing as rapid automation continues to impact humanity. The intensity of the human-AI relation is likely to increase, which invites thought leadership to steward the transition to a potential AI abundance economy with fulfilling human-technology collaboration.
The shipbuilding-seafaring-advanced civilization progression in The Odyssey identifies that the human-AI relation is not one of the labor-identity-crisis of “robots stealing our jobs,” but rather one of the more difficult challenge of envisioning who we can be in the new larger world of human-AI partnership addressing a larger set of planetary-scale problems. Towards this new configuration of human-AI relation, the longer-term may hold radically different notions of identity, as we become physical-virtual hybrids, augmented post-disease entities in the health-faring, space-civilizing, energy-marshalling post-scarcity cultures of the future.
AdS Biology and Quantum Information ScienceMelanie Swan
Quantum Information Science is a fast-growing discipline advancing many areas of science such as cryptography, chemistry, finance, space science, and biology. In particular AdS/Biology, an interpretation of the AdS/CFT correspondence in biological systems, is showing promise in new biophysical mathematical models of topology (Chern-Simons (solvable QFT), knotting, and compaction). For example, one model of neurodegenerative disease takes a topological view of protein buildup (AB plaques and tau tangles in Alzheimer’s disease, alpha-synuclein in Parkinson’s disease, TDP-43 in ALS). AdS/Neuroscience methods are implicated in integrating multiscalar systems with different bulk-boundary space-time regimes (e.g. oncology tumors, fMRI + EEG imaging), entanglement (correlation) renormalization across scales (MERA, random tensor networks, melonic diagrams), entropy (possible system states), entanglement entropy (interrelated fluctuations and correlations across system tiers), and non-ergodicity (implied efficiency mechanisms since biology does not cycle through all possible configurations per temperature (thermotaxis), chemotaxis, and energy cues); Maxwell’s demon of biology (partition functions), conservation across system scales (biophysical gauge symmetry (system-wide conserved quantity)), and the presence of codes (DNA, codons, neural codes). A multiscalar AdS/CFT correspondence is mobilized in 4-tier ecosystem models (light-plankton-krill-whale and ion-synapse-neuron-network (AdS/Brain)).
Humanity’s constant project is expanding the range of attainable geography. Melville’s romance of the sea gives way to Kerouac’s romance of the road, and now the romance of space. In expanding into new geographies, markets (commerce) is the driving impulse, entailing a legal and judiciary system to order the new larger continuous marketplace, which brings a bigger overall scope of world under our control, and hence a new idea of who we are as subjects in this bigger domain.
Space Humanism is a concept of humanism based on the principles of inclusion, progress, and equity posited as a condition of possibility for a potential large-scale human movement into space. A philosophy of literature approach is used to contextualize Space Humanism, first through Melville-Foucault to articulate the mind-frame of extra-planetary geographies as one of human expansion, and second through posthuman philosophy extending from Shakespeare’s Renaissance humanism to contemporary enhancement-based theories of subjectivation.
Historical imaginaries outline subjectivation moments that have changed the whole notion who we are as humanity. Four examples are: the concept of the “new world” in Hegel’s philosophy, von Humboldt’s infographic maps, Baudelaire as the Painter of Modern Life, and Keats’s seeing the world in a new way upon reading an updated translation of Homer.
The reach to beyond-Earth geographies is a two-cultures project involving both arts and science. Technical competence is necessary to realize the aspirational, explorational, and survivalist aims of humanity pushing beyond planetary limits. Space was once a fantastic dream that is becoming quotidian with fourteen U.S. spaceports, six completed Blue Origin space tourist missions, and SpaceX having over 155 successful rocket launches including human space flights to and from the International Space Station. The notion of Space Human articulated through Shakespeare, Moby-Dick, and neuroenhancement informs the project of our reach to awaiting beyond-Earth geographies.
Quantum Information Science and Quantum Neuroscience.pptMelanie Swan
Mathematical advance in quantum information science is proceeding quickly and applies to many fields, particularly the complexities of neuroscience (here focusing on image-readable physical behaviors such as neural signaling, as opposed to higher-order operations of cognition, memory, and attention). Quantum mathematical models are extensible to neuroscience problem classes treating dynamical time series, diffusion, and renormalization in multiscalar systems. Approaches first reconstruct wavefunctions observed in EEG and fMRI scans. Second, single-neuron models (Hodgkin-Huxley, integrate-and-fire, theta neurons) and collective neuron models (neural field theories, Kuramoto oscillators) are employed to model empirical data. Third, genome physics is used to study time series sequence prediction in DNA, RNA, and proteins based on 3d+ complex geometry involving fields, curvature, knotting, and information compaction. Finally, quantum neuroscience physics is applied in AdS/Brain modeling, Chern-Simons biology (topological invariance), neuronal gauge theories, network neuroscience, and the chaotic dynamics of bifurcation and bistability (to explain epileptic and resting states). The potential benefit of this work is an improved understanding of disease and pathology resolution in humans.
Quantum information science enables a new tier of scientific problem-solving as exemplified in early-adopter fields, foundational tools in quantum cryptography, quantum machine learning, and quantum chemistry (molecular quantum mechanics), and advanced applications in quantum space science, quantum finance, and quantum biology
Grammatology and Performativity: A Critical Theory of Silence: Silence is a crucial device for subversion, opposition, and socio-political commentary, the theoretical underpinnings of which are just starting to be understood. This work illuminates another position in the growing field of critical silence studies, theorizing silence as an asset whose ontological value has been lost in a world of literal and figurative noise. Part 1 philosophizes silence as a continuation of Derrida’s grammatology project. Such a grammatology of silence valorizes silent thinking over noisy speaking, and identifies the deconstructive binary pairing not as silence-speaking, but rather as silence-noise. Noise has a simultaneous physical-virtual existence as Shannon entropy calculates signal-to-noise ratios in modern communications networks. Part 2 employs the philosophy of noise to assess what is conceptually necessary to overcome noise in a critical theory of silence. Malaspina draws from Simondon to argue that noise is a form of individuation, essentially a living thing with unstoppable growth potential, not defined by a binary on-off switch but as a matter of gradation. Hence different theory resources are required to oppose it. Part 3 then develops a critical theory of silence to oppose noise in both its physical and virtual instantiations, with the two arms of a deeply human positive performativity (Szendy, Bennett) and a beyond-computational posthumanism (Puar). The result is a novel critical theory of silence as positive performativity that destabilizes noise and recoups the ontological status of silence as not merely an empty post-modern reification but a meaningful actuality.
Philosophy-aided Physics at the Boundary of Quantum-Classical Reality The philosophical themes of truth-knowledge and appearance-reality are used to interrogate the contemporary situation of the quantum-classical boundary, and more broadly the quantum-classical-relativistic stratification of physical scale boundaries. The contemporary moment finds us at breakneck pace in the industrial information revolution, digitizing remaining matter-based industries into a seamless exchange between physical-digital reality. Digitized news is giving way to digitized money and perhaps in the farther future, digitized mindfiles (such as personalized connectome files for precision medicine, autologous (own-DNA) stem cell therapies, and CRISPR for Alzheimer’s disease prevention). Our technologies are allowing us control over vast new domains, the relativistic with GPS and space-faring, and the quantum with quantum computing, harnessing the properties of superposition, entanglement, and interference. Philosophy provides critical thinking tools that can help us understand and master these rapid shifts in science and technology to avoid an Adornian instrumental reality (subsuming humanity under societal structures) and to maintain a Heideggerian backgrounded and enabling relation with technology (versus technology enframing us into mindless standing reserve).
The philosophical theme underlying the investigation of the scales of planets, persons, and particles is the relationship between truth and knowledge (or appearance and reality). The truth-knowledge problem is whether knowledge of the truth, true knowledge, the reality under the appearance, is even possible. Three salient moments in the history of the truth-knowledge problem are examined here. These are the German idealism of Kant and Hegel, the deconstructive postmodernism of Foucault and Derrida, and the unclear leanings of the current moment. The German idealism lens incorporates the self-knowing subject as agent into the truth and knowledge problem. The postmodernist view breaks with the subject and emphasizes the hidden opposites in the formulations, the constant reinterpretation of meaning, and porous boundaries. The contemporary moment wonders whether truth-knowledge boundaries still hold, in a Benjaminian view of non-identity between truth and knowledge, and truth increasingly being seen as a Foucauldian biopolitical manufactured quantity. Contemporaneity has a bimodal distribution of the subject: the hyperself (the constantly digitally represented selfie self) and the alienated post-subject subject.
These moments in the truth and knowledge debate inflect into the scale considerations of relativity, classicality, and quantum mechanics. Whereas general relativity and quantum mechanics are domains of universality, totality, and multiplicity, everyday classical reality is squeezed in as a belt between the two multiplicities as the concretion of drawing a triangle or tossing a ball. Recasting truth and k
Comprehensive philosophical programs arise within a historical context (for Hegel and Derrida in the democracy-shaping moments of the French Revolution (1789) and the student-worker protests (1968) in which French politics serve as a global harbinger of contemporary themes). In the Derrida-Hegel relationship, there is more rapprochement concerning core notions of difference, history, and meaning-assignation than may have been realized. In particular, Hegel’s philosophy, despite being assumed to be a totalizing system, in fact indicates precisely some of the same kinds of revised metaphysics-of-presence formulations that Derrida exhorts, namely those that are flexible, expansive, and include non-identity and identity.
A crucial Derrida-Hegel interchange is that of différance and difference. Derrida develops the notion directly from Hegel (“Différance,” “The Pit and the Pyramid”), but only draws from the Encyclopedia, not Hegel’s masterwork, the Phenomenology of Spirit. For Derrida, the “A” in différance is inspired by the form of the pyramid in the capitalized letter and in Hegel’s comparing the sign “to the Egyptian Pyramid” (“Différance,” p. 3). Derrida invokes the symbolism of the pyramid, antiquity, and Egyptian hieroglyphics as an early semiotic system. However, when considering Hegel’s central definition of difference in the dialectical progression of thesis-antithesis-synthesis in the Phenomenology of Spirit (§§159-163), the articulations of différance and difference are remarkably aligned.
Parallel formulations are also seen in history as a series of reinterpretable events, and indexical wrappers as a mechanism for meaning assignation. The thinkers examine the universal and the particular by exploring regulative mechanisms such as law (natural and social). In Glas, Derrida highlights not the singular-universal relation, but the law of singularity and the law of universality relation as being relevant to Hegel’s Antigone interpretation (Glas, p. 142a), a theme continued in “Before the Law.” Finally (time permitting), there is a question whether the most valid critiques of Hegel (Nietzsche’s unreason and Benjamin’s non-synthesis), as alternatives to Hegelian dialectics, are visible in Derrida’s thought.
The upshot is that the two thinkers produce similar formulations, derived from different trajectories of philosophical work; a situation which points to the potential universality of fundamental solution classes to open-ended philosophical problems, including the future of democracy.
Quantum Moreness: Kantian Time and the Performative Economics of Multiplicity
There is no domain with greater moreness than that of the quantum. A philosophy-aided physics approach (postmodernism and Continental philosophy) examines the contemporary situation of quantum moreness (more time and space dimensions than are available classically). Quantum moreness is configured by quantum reality being probabilistic; a multiplicity of outcomes all co-existing in superposition until collapsed in measurement. The quantum mindset uses quantum moreness to solve problems by thinking in terms of the greater scalability afforded in time and space with the quantum properties of superposition, entanglement, and interference. Quantum studies fields proliferate in arts and sciences, raising the Levi-Straussian raw-cooked dilemma of how “traditional humanities” are to be named alongside “digital humanities” and “quantum humanities.” Kant facilitates the conceptualization of quantum moreness by insisting on the dual nature of time as transcendentally ideal and empirically real. Kant’s moreness is allness, the absolute totality and multiplicity of time at the ideal level. Each faculty (sensibility, understanding, reason) has its own species of the a priori synthetic unity of ideal time that precedes and conditions the operation of the faculty. Each faculty also has a concretized formulation of empirically-real time as the time series, which is the basis for the faculties to interoperate to perform the conception of any empirical object. Kant’s achievement of time interoperability has potential extensibility to other areas of temporal incompatibility such as the scales of general relativity, Newtonian mechanics (human-scale), and quantum mechanics. The quantum moreness mindset with which Kant connects the ideal-real is visible in the domain of economics, itself too an ideal-real construction. The quantum moreness of money configures the postmodern abstraction of global cryptocurrencies and smart contract pledges, the implicative hope of which is a post-debt capital world that restores the human esprit in the face of an increasingly intense technologized reality.
Blockchain Crypto Jamming: Subverting the Instrumental Economy
The ultimate subversion is money, refusing the pecuniary resources of the state. This project applies a philosophical and critical theory lens to examine the use of nomenclature in one of the most radical longitudinal transformations in contemporary times, the shift away from state-run monetary resources towards cryptocurrencies and smart contracts in citizen-determined decentralized financial networks.
A Cryptoeconomic Theory of Social Change is presented in which linguistic progression serves as a tracking mechanism. The steps to lasting change have their own vocabulary (Brandom). First, there is the social critique, the complaint about what is wrong, the negative side (Adorno and Horkheimer highlight instrumental reason and the empty culture industry). Second, there is the antidote, an alternative that can overcome the complaint, the positive side. Third, the solution becomes the new reality, and as a consequence, the whole of reality is now seen in this context, adopting its vocabulary (“fiat health” system for example, referring to the antiquated method). The social movement graduates from language game (Wittgenstein) to form of life (Jaeggi).
Blockchains are Occupy with teeth, notable in the level of personal responsibility-taking by individuals to steward their own financial resources. The crypto citizen is not merely trading CryptoKitties and Bored Ape Yacht Club tokens, but getting blocktime loans through DeFi liquidity pools instead of fiat banks, earning labor income in crypto, and shifting all economic activity to blockchain networks. The artworld signals mainstream acceptance with Christie’s non-fungible token digital artwork auctioned from Beeple for $61 million. At the global level, coin communities constitute a new form of Kardashev-level (planetary-scale) democracy. Blockchains emerge as a robust smart network automation technology for super-class projects ranging from space-faring to quantum computing and thought-tokening. The further stakes of this work are having a language-based theory of social change with broad applicability to social transformation.
This work argues that the emerging understanding of time in quantum information science can be articulated as a philosophical theory of change. Change and time are interrelated, and one can be used to interrogate the other, namely, a theory of change can be derived from a theory of time. What is new in quantum science is time being regarded as just another property to be engineered. At the quantum scale, time is reversible in certain ways, which is quite different from the everyday experience of time whose unidirectional arrow does not allow a dropped egg to reassemble. At the quantum scale of atoms, though, a particle retains the history of its trajectory, which may be retraced before collapsed in measurement.
Quantum scientists evolve systems backward and forward in time, controlling phase transitions with Floquet engineering. Quantum systems are entangled in time and space, with temporal correlations exhibiting greater multiplicity than spatial correlations. The chaotic time regimes of ballistic spread followed by saturation are implemented in quantum walks for faster search and heightened cryptosecurity. In quantum neuroscience, seizure may be explained by chaotic dynamics and normal resting state by Floquet-like periodic cycles. Time is revealed to have the same kinds of repeating structures as space (described by entanglement, symmetry, and topology), differently instantiated and controlled.
The quantum understanding of time can be propelled into a macroscale-theory of change through its connotation of a more flexible, malleable, probabilistic interface with reality. Change becomes less rigid. Probability is the lever of change, but notoriously difficult for humans to grasp, as we think better in storylines than statistics. The idea of manipulating quantum system properties in which time, space, dynamics (change), are all just parameters, is an empowering frame for the acceptance of change. The quantum mindset affords greater facility with probability-driven events (change).
Blockchains in Space: Non-Euclidean Spacetime and Tokenized Thinking - Two requirements for the large-scale beyond-terrestrial expansion of human intelligence into the universe are the ability to operate in diverse spatiotemporal regimes and to instantiate thinking in various formats. Newtonian mechanics describe everyday reality, but Einsteinian physics is needed for GPS and the orbital technologies of telescopes and spacecraft. Space agencies already integrate the Earth-day and the slightly-longer Martian-sol. A more substantial move into space requires facility with non-Euclidean spacetimes. One challenge is that general relativity and quantum mechanics are non-interoperable. However, the theories can be formulated together when considering black holes and quantum computing since geometric theories and gauge theories are both field-based. Quantum blockchains instantiate blockchain logic in quantum computational environments. Blockchains have their own temporal regime (blocktime: the number of blocks for an event to occur), and hence quantum blocktime is a non-classical functionality for operating in diverse spatiotemporal regimes. Thinking is a rule-based activity that is unrestricted by medium. Central to thinking is concepts, which are referenced by words. Word-types include universals, particulars, and indexicals which can be encoded into a formal system as thought-tokens, and registered to blockchains. Blockchains are contemplated as an automation technology for asteroid mining and space settlement construction, and thought-tokening adds an intelligence layer. Time and tokenized thinking come together in the idea of smart networks in space. In blockchain quantum smart networks, spatiotemporal regimes and thought-tokens are simply different value types (asset classes) coordinated with blockchain logic, towards the aim of extending human capabilities into the farther reaches of space.
Cryptography, entanglement, and quantum blocktime: Quantum computing offers a more scalable energy-efficient platform than classical computing and supercomputing, and corresponds more naturally to the three-dimensional structure of atomic reality. Blockchains are a decentralized digital economic system made possible by the 24-7 global nature of the internet.
Quantum Neuroscience: CRISPR for Alzheimer’s, Connectomes & Quantum BCIsMelanie Swan
This talk provides an introduction to quantum computing and how it may be deployed to study the human brain and its diseases of pathology and aging. Refined to its present state over centuries, the brain is one of the most complex systems known, with 86 billion neurons and 242 trillion synapses connected in intricate patterns and rewired by synaptic plasticity. Research continues to illuminate the mysteries of the brain. Quantum computing provides a more capacious architecture with greater scalability and energy efficiency than current methods of classical computing and supercomputing, and more naturally corresponds to the three-dimensional structure of atomic reality. The vision for quantum neuroscience is to model the nature of the brain exactly as it is, in three-dimensional atomically-accurate representations. Neuroscience (particularly genetic disease modeling, connectomics, and synaptomics) could be the “killer application” of quantum computing. Implementations in other industries are also important, including in quantum finance, quantum cryptography using Shor’s factoring algorithm (“the Y2K of Crypto”), Grover’s search, quantum chemistry, eigensolvers, quantum machine learning, and continuous-time quantum walks. Quantum computing is a high-profile worldwide scientific endeavor with platforms currently available via cloud services (IBM Q 27-qubit, IonQ 32-qubit, Rigetti 19Q Acorn) and is in the process of being applied in various industries including computational neuroscience.
Art Theory: Two Cultures Synthesis of Art and ScienceMelanie Swan
Thesis: Aesthetic resources contribute broadly to the human endeavor of progress, self-understanding, and science, beyond the immediate experience of art. Aesthetic Resources are frameworks, concepts, and modes of expression in art, literature, and philosophy that capture the imagination and the intellect through the senses. The role of art is to inspire the future: the romance of the sea, the open road, space.
The arts are a hallmark of civilization, but can their benefit be crystallized as aesthetic resources that can be mobilized to new situations? How can aesthetic resources help in moments of crisis?
A worldwide social identity crisis has been provoked by pandemic recovery, politics, equity, and environmental sustainability. Philosophical and aesthetic resources can help. Understanding art as a reflection of who we are as individuals and groups, this talk explores conceptualizations of art, with examples, in different periodizations from the 1800s to the present. A marquis definition as to what constitutes an artwork is Adorno’s, for whom the work must promulgate its own natural law and engage in novel materials manipulation. For many theorists, art is the pressing of our self-concept into concrete materiality (whether pyramids, sculpture, or painting). What do contemporary periodizations of art mean to our current and forward-looking self-concept? Recent eras include the neo-avant-gardes of 1945, the conceptual art of the 1960s, and post-conceptual art starting in the 1970s, produced generatively with found materials, the digital domain, and audience interactivity. What is the now-current idea of art? Is today’s Baudelairian flâneur and Balzacian modern hero incarnated in the quantum aesthetic imaginary and the digital cryptocitizen? Far from an “end of art” thesis sometimes attributed to Hegel, aesthetic practices are more relevant than ever. Individually and societally, we are reinventing creative energy and productive imagination in venues from science, technology, health, and biology to the arts.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024Albert Hoitingh
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
Have you ever wanted a Ruby client API to communicate with your web service? Smithy is a protocol-agnostic language for defining services and SDKs. Smithy Ruby is an implementation of Smithy that generates a Ruby SDK using a Smithy model. In this talk, we will explore Smithy and Smithy Ruby to learn how to generate custom feature-rich SDKs that can communicate with any web service, such as a Rails JSON API.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...
Bioengineering: making life from scratch
1. Bioengineering: making life from scratch Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008 Must build it to understand it
9. Repressilator schema “ Noisy” cells Michael Elowitz Stanislas Leibler Repressilator A synthetic oscillatory network of transcriptional regulators Michael B. Elowitz & Stanislas Leibler Nature. 2000 Jan 20;403(6767):335-38. http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html
10. Construction of a genetic toggle switch in Escherichia coli Gardner TS, Cantor CR, Collins JJ Nature. 2000 Jan 20;403(6767):339-42. http://www.ncbi.nlm.nih.gov/pubmed/10659857 Toggle switch induction threshold Toggle switch plasmid Gardner Cantor Collins Genetic toggle switch
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13. Further applications of bioengineering Coli-roid microbial camera Landmine sensing plant: Arabidopsis thaliana Amorphous computing Cellular colonies Natural genetic engineering Ciliate
15. Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008