Humanity’s constant project is expanding the range of attainable geography. Melville’s romance of the sea gives way to Kerouac’s romance of the road, and now the romance of space. In expanding into new geographies, markets (commerce) is the driving impulse, entailing a legal and judiciary system to order the new larger continuous marketplace, which brings a bigger overall scope of world under our control, and hence a new idea of who we are as subjects in this bigger domain. Space Humanism is a concept of humanism based on the principles of inclusion, progress, and equity posited as a condition of possibility for a potential large-scale human movement into space. A philosophy of literature approach is used to contextualize Space Humanism, first through Melville-Foucault to articulate the mind-frame of extra-planetary geographies as one of human expansion, and second through posthuman philosophy extending from Shakespeare’s Renaissance humanism to contemporary enhancement-based theories of subjectivation. Historical imaginaries outline subjectivation moments that have changed the whole notion who we are as humanity. Four examples are: the concept of the “new world” in Hegel’s philosophy, von Humboldt’s infographic maps, Baudelaire as the Painter of Modern Life, and Keats’s seeing the world in a new way upon reading an updated translation of Homer. The reach to beyond-Earth geographies is a two-cultures project involving both arts and science. Technical competence is necessary to realize the aspirational, explorational, and survivalist aims of humanity pushing beyond planetary limits. Space was once a fantastic dream that is becoming quotidian with fourteen U.S. spaceports, six completed Blue Origin space tourist missions, and SpaceX having over 155 successful rocket launches including human space flights to and from the International Space Station. The notion of Space Human articulated through Shakespeare, Moby-Dick, and neuroenhancement informs the project of our reach to awaiting beyond-Earth geographies.