The document summarizes the recommendations from an October 2007 meeting at the National Cancer Institute to develop a uniform reporting system for thyroid fine needle aspiration biopsies. It outlines six diagnostic categories with implied cancer risks and descriptions. The categories include non-diagnostic or unsatisfactory, benign, atypia of undetermined significance or follicular lesion of undetermined significance, follicular neoplasm or suspicious for follicular neoplasm, suspicious for malignancy, and malignant. Criteria for each category are provided along with typical clinical management based on the cancer risk implication of each category.
This is a presentation on the topic of cytology of the breast, prepared by Dr Ashish Jawarkar, he is MD in pathology and a teacher at Parul institute of Medical sciences and research Vadodara.
endometrial stromal tumours review article
These tumours are very less in number. They are classified into endometrial stromal tumour, low grade endometrial stromal sarcoma, high grade stromal sarcoma and undifferentiated uterine sarcoma according to the 2014 WHO classification.
color atlas on bethesda system for reporting thyroid cytologyAshish Jawarkar
this is a color atlas on bethesda system for reporting thyroid cytology. there are nearly 300 images in atlas with explanatory text which will help students and practitioners alike. All images are taken from pap society web atlas.. and entire credit for this work should go to the society.. I have put together images available at one place..
THIS IS A PREVIEW ONLY..ENTIRE DOCUMENT IS AVAILABLE ON SCRIBD.. LINK PROVIDED IN DOCUMENT
This is a presentation on the topic of cytology of the breast, prepared by Dr Ashish Jawarkar, he is MD in pathology and a teacher at Parul institute of Medical sciences and research Vadodara.
endometrial stromal tumours review article
These tumours are very less in number. They are classified into endometrial stromal tumour, low grade endometrial stromal sarcoma, high grade stromal sarcoma and undifferentiated uterine sarcoma according to the 2014 WHO classification.
color atlas on bethesda system for reporting thyroid cytologyAshish Jawarkar
this is a color atlas on bethesda system for reporting thyroid cytology. there are nearly 300 images in atlas with explanatory text which will help students and practitioners alike. All images are taken from pap society web atlas.. and entire credit for this work should go to the society.. I have put together images available at one place..
THIS IS A PREVIEW ONLY..ENTIRE DOCUMENT IS AVAILABLE ON SCRIBD.. LINK PROVIDED IN DOCUMENT
Cellular adaptations, injury and death.. Lecture 1Ashish Jawarkar
This is a series of lectures on general pathology useful for undergraduate and postgraduate pathology students. The ppts here have are enriched with explanatory pictures as well as useful video links.. hope you find them useful
Interpretation of Pathology Reports in Biopsies for DermatitisMarco Fusaro
Dr. Jessica Spies – “Interpretation of Pathology Reports in Biopsies for Dermatitis” presented at The Oregon Society of Dermatology Associates November, 2014
The data on thyroid tumors in the fourth edition of the World Health Organization (WHO) classification of endocrine tumors published in 2017 contain significant revisions.
These revisions of the 2004 WHO classification were based on new knowledge about pathology, clinical behavior, and most importantly the genetics of the thyroid tumors.
CANCER: A REVIEW: WORLD'S SECOND MOST FEARED DIAGNOSISCharu Pundir
It is a basic review presentation on cancer, world's second most dreadful disease followed by cardiovascular events, involving basic defination, pathophysiology, screening methods, types of tumor, tumor origin, cancer cell lines, treatment, recent advancements made in the field and diagnosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. October 2007 meeting was organized at National
Cancer Institute (NCI), Bethesda, to address the
terminology and other issues in thyroid FNA
3. Idea behind uniform reporting system
• Facilitate effective communication among cytopathologist, radiologist,
endocrinologist and surgeon
• Facilitate Histocytological correlation for thyroid disease
• Facilitate research into epidemiology, molecular biology, pathology and
diagnosis of thyroid diseases
• Allow easy and reliable sharing of data from different laboratories for
national and international collaboration studies
4. Format of report
• Each report begin with six general categories
• Some categories have two alternative names as the consensus was
not reached at NCI conference on single name
• Each categories has implied cancer risk ( ranging from 0 to 3% for
benign categories to virtually 100% for malignant)
• Additional descriptive comments beyond such subcategorization are
optinal and left to discretion of pathologist
5. Recommended diagnostic categories
1. Non Diagnostic or Unsatisfactory (ND/UNS)
- Cystic fluid only
- Virtually acellular specimen
- Other (obscuring blood, clotting artifacts)
6. Recommended diagnostic categories
2. Benign
- Consistent with benign follicular nodule
- Consistent with lymphocytic ( Hashimoto’s thyroiditis)
in proper clinical context
- Consistent with granulomatous (sub acute) thyroiditis
- Others
11. CATEGORY I (Non Diagnostic or Unsatisfactory)
Causes of Unsatisfactory smears
- Obscuring blood
- Overly thick smears
- Air drying of alcohol fixed smears
- Inadequate number of follicular cells
12. Criteria for adequacy
• At least six groups of benign follicular cells is required with each
group composed of at least 10 cells.
• Any specimen that contain abundant colloid is considered
adequate
• When a specific diagnosis (e.g. Lymphocytic thyroiditis) can be
given or when there is any atypia specimen is by definition
adequate
13. • Specimen containing cyst macrophages only are kept under
ND/UNS
• Unless specified in report specimen is considered adequate
14.
15.
16.
17.
18.
19. Category II ( Benign)
• An adequate cellular specimen composed of varying proportion of
colloid and benign follicular cells arranged in macro follicles or
macrofollicular fragments are considered as benign follicular
nodule
• If nodule shows significant growth or suspicious radiological
features then, a repeat FNA is considered
20. • Other benign categories include Hashimoto thyroiditis,
Granulomatous thyroiditis
• Infections, amyloid, black thyroid, reactive changes can be
mentioned as descriptive diagnosis
21.
22.
23.
24. Category III ( AUS/ FLUS)
Most common scenarios for this categorization are
• Prominent population of micro follicles in an aspirate that does
not otherwise fulfill the criteria for follicular neoplasm
• Predominance of Hurthle cell in a sparsely cellular smear with
scant colloid
• Interpretation of follicular cell atypia is hindered by air drying or
clotting artifacts
25. • A moderately or markedly cellular smear consisting of exclusive
population of Hurthle cells yet clinical setting suggest a benign
Hurthle cell nodule ( Lymphocytic thyroiditis, Multi nodular goiter)
• There are focal features suggestive of Papillary carcinoma
including nuclear grooves, enlarged nuclei with pale chromatin in
an other wise predominantly benign appearing sample. ( these
can be cyst lining cells)
26. • A minor population of follicular cells may show nuclear
enlargement often accompanied by prominent nucleoli
(radioactive iodine, carbamizole, cystic degeneration or
hemorrhage)
• There is atypical lymphoid infiltrate but degree of atypia is not
sufficient to categorize it as Suspicious for malignancy
27. • It is important that only nodules with atypical undetermined
significance should be placed in this category
• Recognizable benign changes like Hurthle cell change, Black
thyroid, Radiation changes should not be classified as AUS
• A moderate or markedly cellular specimen without any significant
nuclear or architectural atypia does not qualify for AUS
28. Category IV (FN/SFN)
• Purpose of this category is to identify a nodule that might be a
follicular carcinoma and triage it for surgical lobectomy
• Term suspicious for Follicular neoplasm is preferred over Follicular
neoplasm because a significant proportion of cases prove out to be
hyperplastic proliferation of follicular cells, most commonly those
of multi nodular goiter.
• Hallmark of this category is disturbed architecture – Follicular cells
predominantly arranges in micro follicles or trabeculae.
29. • Cytological preparations typically have high cellularity and scant to
absent colloid
• Cellular crowding and overlapping are conspicuous and follicular
cells are usually larger than normal
• Nuclear pleomorphism, and mitosis are uncommon
• Cases that demonstrate nuclear features of Papillary carcinoma are
excluded from this category
• If sample is cellular and mostly macro follicles benign interpretation
is appropriate
30.
31.
32.
33. Category V (Suspicious for malignancy)
• If only 1 or 2 characteristics of malignancy are present, if they are
only focal or if sample is sparsely cellular and a malignant diagnosis
cannot be made with certainty
34.
35. Category VI (Malignant)
• This category is used whenever cytomorphological features are
conclusive for malignancy
• Descriptive comments that follow are used to sub classify
malignancy and to summarize the results of special studies if any
36.
37. DIAGNOSTIC CATEGORY RISK OF MALIGNANCY USUAL MANAGEMENT
ND/ UNS 1-4 % Repeat FNA with ultrasound
guidance
Benign 0-3 % Clinical Follow up
AUS/ FLUS 5-15% Repeat FNA
FN/ SFN 15-30% Surgical lobectomy
Suspicious for Malignancy 60-75% Near total thyroidectomy /
Surgical lobectomy
Malignant 97-99% Near total thyroidectomy