This document discusses several benign diseases of the vulva, vagina, and cervix. It describes conditions such as Bartholin's cyst, atrophic lichen (lichen sclerosus et atrophicus), and squamous cell hyperplasia. For each condition, it provides details on presentation, etiology, pathology findings, and treatment options. The document aims to comprehensively cover inflammatory diseases, blistering diseases, pigmentary changes, benign tumors, hamartomas and cysts, and congenital malformations that can affect the vulva, vagina, and cervix.
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Benign diseases-of-the-vulvavagina-and - copy
1. Benign diseases of theBenign diseases of the
vulva, vagina andvulva, vagina and
cervixcervix
Ahmad mukhtarAhmad mukhtar
MD.,M.B.B.Ch., M.Sc Obstetrics and GynecologyMD.,M.B.B.Ch., M.Sc Obstetrics and Gynecology
Consultant and Lecturer of Obstetrics and Gynecology,Consultant and Lecturer of Obstetrics and Gynecology,
Faculty ofFaculty of
MEDICINE, Zagazig University.MEDICINE, Zagazig University.
2. The vulvaThe vulva
• Is the part of the female genital tract located between the
genitocrural folds laterally, the mons pubis anteriorly, and the anus
posteriorly.
• Embryologically, it is the result of the junction of the cloacal
endoderm, urogenital ectoderm, and paramesonephric mesodermal
layers.
• This hollow structure contains
– LABIA MAJORA
– LABIA MINORA
– CLITORIS
– VESTIBULE
– URINARY MEATUS
– VAGINAL ORIFICE
– HYMEN
– BARTHOLIN GLANDS
– SKENE DUCTS.
3.
4. The vulvaThe vulva
• Different epithelia, from keratinized squamous epithelium
to squamous mucosa, cover the vulva.
• The labia minora are rich with sebaceous glands but
have few sweat glands and no hair follicles.
• The epithelium of the vestibule is neither pigmented nor
keratinized and contains eccrine glands.
5. BENIGN LESIONS OF THE VULVABENIGN LESIONS OF THE VULVA
• According to the International Society for the Study of
Vulvar Disease (ISSVD) in 1989:
– Inflammatory diseases.
– Blistering diseases.
– Pigmentary changes.
– Benign tumors, hamartomas and cysts
– Congenital malformations.
17. What isWhat is lichen?lichen?
A fungus, usually of the class Ascomycetes,
that grows symbiotically with algae, resulting
in a composite organism that
characteristically forms a crustlike or
branching growth on rocks or tree trunks.
19. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
• Most patients are post-menopausal women
• Stenosis of the introitus develops
20. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
Note the white, parchment-like or plaque-like lesion
21. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
• During early stages the patient may not have symptoms.
• Some patients develop intractable pruritus
• Burning and pain are less likely manifestations.
• Figure-of-8 or keyhole configuration.
• In late stages normal architecture may be lost
– atrophy of the labia minora, constriction of the vaginal orifice
(kraurosis), synechiae, ecchymoses, fissures.
• Squamous cell carcinoma develops in 3-6% cases
22. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
• Thinning of the surface epithelium with some
hyperkeratosis.
23. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
• Etiology
– Unknown. A higher prevalence of the disease in
postmenopausal women suggests hormonal factors,
but this has not been confirmed.
– Studies identifying an infection are inconclusive
– Weakly linked to autoimmune diseases and genetic
factors
– Local factors (eg, trauma, friction, chronic infection
and irritation)
– Recurrence near vulvectomy scars has been
observed.
24. Lichen Sclerosus etLichen Sclerosus et
AtrophicusAtrophicus
• Treatment
– Potent topical corticosteroids
– Testosterone propionate is ineffective and has
many adverse effects
– Close follow-up -----epithelial cancer.
26. Squamous HyperplasiaSquamous Hyperplasia
• This lesion produces hyperplastic thickening of the
superficial squamous epithelium.
• This lesion is a precursor of squamous cell carcinoma
of the vulva
28. Squamous HyperplasiaSquamous Hyperplasia
• ITCHING is a common symptom.
• If hyperkeratosis is not prominent, lesions may appear
as reddish plaques.
• The clitoris, labia minora, and inner aspects of the labia
majora are more commonly affected.
• Extensive lesions may result in stenosis of the vaginal
introitus.
30. Squamous HyperplasiaSquamous Hyperplasia
• Treatment
– The same as lichen sclerosus
– General attention to proper hygiene.
– If the skin is moist or macerated, aluminum acetate
5% solution applied 3-4 times daily for 30-60 minutes
is beneficial.
– Systemic antihistamines or tricyclic antidepressants
– Refractory lesions, intralesional injections of
triamcinolone acetonide may be an alternative.
31. lichen simplex chronicuslichen simplex chronicus
• Hyperkeratotic, usually ill-defined,
grayish, thickened, and sometimes
excoriated lesion.
• Usually located over the labia
majora.
• Hyperpigmentation.
• Itching is always present and may
be intense.
32. lichen simplex chronicuslichen simplex chronicus
• Lichen simplex chronicus of the vulva is the end stage of
the itch-scratch-itch cycle.
• The initial stimulus to itch may be:
– Underlying seborrheic dermatitis.
– Intertrigo
– Tinea.
– Psoriasis.
– In most cases, the underlying cause is not evident and may have
been transient vulvitis or vaginal discharge.
• Any itching disease of the vulva may become
secondarily lichenified.
33. lichen simplex chronicuslichen simplex chronicus
• Epidermal and epithelial hyperplasia,
• Hyperkeratosis.
• Fibrotic vertical streaks of collagen between the
hyperplastic rete are present.
34. lichen simplex chronicuslichen simplex chronicus
• Treatment
– Includes removal of irritants and/or allergens
– Topical application of mild-to-high–potency corticosteroids.
– Avoid soaps and cleansing agents other than aqueous cream.
– Discourage excessive cleaning of the genital area; use of hot
water; overheating; and wearing of synthetic, rough, and/or tight
clothing.
• Lichen simplex chronicus may be associated with
underlying diseases (eg, Paget disease, Bowen disease)
35. Lichen planusLichen planus
• Three types:
– Papulosquamous
– Erosive
– Hypertrophic
• Malignancy is possible in long-standing and ulcerative
lichen planus.
36. Lichen planusLichen planus
• The papulosquamous form:
– Occurring as part of a generalized
disease
– Is the most common and is
characterized by:
• Flat-topped
• Polyhedral,
• Violaceous, shiny, and itchy papules
located on keratinized skin of the
labia and mons pubis. Delicate and
whitish reticulated papules may be
present on the mucosa, but no
atrophy or scarring is observed.
37. Lichen planusLichen planus
• The erosive form:
– Involves the mucous membranes of the mouth and vulvovaginal
area and may be locally destructive, leading to atrophy and
scarring.
– Synonyms include erosive vaginal lichen planus, desquamative
inflammatory vaginitis, vulvovaginal-gingival syndrome, and
ulcerative lichen planus.
–Itching is rare, but pain, burning,
and irritation occur and may be
responsible for dyspareunia and
dysuria.
38. Lichen planusLichen planus
• The rare hypertrophic form:
– Resembling lichen sclerosus, manifests
with extensive white scarring of the
periclitoral area with variable degrees of
hyperkeratosis.
– It may be very itchy.
– Extensive vaginal involvement may result
in a malodorous discharge.
– Large denuded areas may become
adherent, causing stenosis of the vaginal
introitus and dyspareunia.
– Marked atrophy may develop with time.
39. ID/CCID/CC A 75 year old woman visits her gynecologistA 75 year old woman visits her gynecologist
for a routine checkup and is found to havefor a routine checkup and is found to have
white spots on her genitaliawhite spots on her genitalia
HPIHPI She complains of slight outerShe complains of slight outer
vaginal itching but denies anyvaginal itching but denies any
postmenopausal bleeding, vaginalpostmenopausal bleeding, vaginal
discharge, or drug intakedischarge, or drug intake
PEPE Hypochromic macules on labiaHypochromic macules on labia
majora extending to perineum andmajora extending to perineum and
inner thighs in patchy distributioninner thighs in patchy distribution
with scale formation; skin iswith scale formation; skin is
thickenedthickened
40. PruritPrurituus vulvas vulva
• Causes:
– General
– Local
– Psychosomatic
– Idiopathic
• General Examination
• Local examination:
– Smears
– Culture and sensitivity
– BIOPSY: KEYE’s Dermatological knife
41. BENIGN LESIONS OF THE VaginaBENIGN LESIONS OF THE Vagina
• CYSTIC SWELLINGS
• SOLID TUMORS
• ATROPHIC VAGINITIS
• VAGINAL ADENOSIS
42. Cystic swellingsCystic swellings
• Gartner’s Cyst
– Dilatation of the Gartner’s (Wollfian) duct
– Anterior and lateral vaginal walls
• Epithelial inclusion cysts
• Endometrioma
• Uretheral diverticulum