This document discusses various topics related to drugs including drug discovery, development and testing, controversial and banned drugs, drug abuse and its effects, and drug trafficking. It provides details on the drug development process and lists some controversial and banned drugs in India such as nimesulide, phenylpropanolamine, and ayurvedic medicines containing heavy metals. The document also outlines illegal drugs and their effects as well as issues related to drug trafficking.

2. CONTENTS
Introduction
Drug discovery
Banned drugs
Controversial drugs
Drug abuse and its effects
Drug trafficking
Conclusion

3. EMPIRICAL
ANALYSIS:
PANACEA
OR
POISON

4. DRUG DISCOVERY
A substance used in the diagnosis, treatment,
prevention of a disease or as a component of a
medication.

5. DRUG DEVELOPMENT
 IN VITRO STUDIES
 ANIMAL TESTING
 CLINICAL TESTING
 MARKETING

9. CONTROVERSIAL
DRUGS
 NIMESULIDE
 GATIFLOXACIN
 SPARFLOXACIN
 PROPOFOL

10. NIMESULIDE
• Non steroidal anti inflammatory drug
• Analgesic & antipyretic properties
• Not used in US, Finland, Spain, Bangladesh,
Portugal, Singapore and Israel –
STILL USED IN INDIA
• Trade names: Nise, Nodard plus, Nimulid, nimed
etc

11. TOXIC EFFECTS OF
NIMESULIDE
Hepatotoxicity
Coagulopathy
Hepatocellular necrosis
Potential seizures in smokers
Colon cancer

13. ANALGIN
Generic name : Metamizole sodium
Indications: Toothache, Headache, Arthralgia
Reasons for ban:
Agranulocytosis
Leucopenia
Thrombocytopenia
Asthmatic attacks
Brand name: Novalgin, Dipyrone

14. CELECOXIB/ROFECOXIB
Non Steroidal Anti Inflammatory Drug (NSAID)
Indications: Osteoarthritis, Dental pain,
Dysmennorhoea
Reason for ban: Heart attack, stroke, allergies
Brand names: Celcoxx, Vioxx
AGAROL
Generic name: Phenolphthalein
Indication: Laxative
Reason for ban: Carcinogenicity

15. D’COLD
Generic name: Phenylpropanolamine
Indications: Coryza, Influenza, Sinusitis
Reasons for ban:
Allergy (Dyspnoea; Swelling of lips & tongue )
Hallucinations
Irregular/fast heartbeat
Brand name: Vicks Action – 500, Propagest

16. OXYTETRACYCLINE
Generic name:
Indications:
Dental infections
Acne vulgaris
Pneumonia
Reasons for ban:
Carcinogen
Developmental/Reproductive Toxin
Brand name:

17. QUINIDOCHLOR
Generic name : Quiniodochlor
Indications: Amoebic dysentery, Colitis
Reasons for ban:
Optic neuritis
Peripheral neuropathy
Anal irritation
Brand Name: Enteroquinol

18. AYURVEDIC MEDICINES
Lead
Arsenic
Mercury
BANNED
CONTROVERSIAL DRUGS
HAMDARD SAFI TONIC
MAHA SUDARSHAN CHURNA POWDER
KARELA TEBLETS
MALE FOETUS

19. SPECTRUM OF
ILLEGAL
DRUGS

20. BANNED
DRUGS

21. Hyperpigmentation of
Tongue
Perioral Dermatitis
Saddle Nose Deformity Necrosis of hand

22. ORAL MANIFESTATIONS

23. SPORTS DRUGS

24. MANUFACTURING DISTRIBUTING
DISPENSING
IMPORTING EXPORTING
DRUG TRAFFICKING/SPURIOUS DRUGS

25. BIK
RAHA
BHAGWAN

26. THANK YOU